Multifactorial Rare Diseases: Can Uncertainty Analysis Bring Added Value to the Search for Risk Factors and Etiopathogenesis?Review Published on 2021-01-282022-10-30 Journal: Medicina [Category] COVID-19, [키워드] acute inflammatory syndrome Analysis approach Can children Community complex correlation data-poor scenarios develop environmental factor Factor Familial Mediterranean fever Genetic predisposition genetic risk factors Health healthcare impacts implication increasingly Inflammatory inherent initial knowledge limitation Mediterranean fever multifactorial Neural tube defects Open Science outcome rare disease Research risk risk analysis risk factor SARS-CoV-2 syndrome Uncertainty value [DOI] 10.3390/medicina57020119 PMC 바로가기 [Article Type] Review
Self-Amplifying Pestivirus Replicon RNA Encoding Influenza Virus Nucleoprotein and Hemagglutinin Promote Humoral and Cellular Immune Responses in PigsImmunology Published on 2021-01-282022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] animal Antigen antigen expression antigens assessment breadth c-di-AMP adjuvant cell cultures cellular cellular response classical concerning coronavirus DCs dendritic cell dimeric employment encoding Fever FIVE hemagglutinin Host human cells humans humoral humoral and cellular immune response immune immune responses immunological induce influenza vaccines Influenza virus influenza virus H5N1 inherent monocyte monophosphate mRNA nucleoprotein offer packaged pandemic Particle Pestivirus pig polyplexes promote question receiving remained replicative replicon reported response RNA self-amplifying replicon RNA target Vaccine design virus virus replicon particle [DOI] 10.3389/fimmu.2020.622385 PMC 바로가기 [Article Type] Immunology
Decision Model for Allocation of Intensive Care Unit Beds for Suspected COVID-19 Patients under Scarce ResourcesResearch Article Published on 2021-01-272022-10-31 Journal: Computational and Mathematical Methods in Medicine [Category] Coronavirus, [키워드] allocation approach build COVID-19 COVID-19 pandemic decision defined evidenced expert Healthcare system ICU information inherent intensive care intensive care unit knowledge Model Patient performed Probability provided resource survival Suspected theory [DOI] 10.1155/2021/8853787 PMC 바로가기 [Article Type] Research Article
A pilot trial of human amniotic fluid for the treatment of COVID-19COVID-19 치료를 위한 인간 양수의 파일럿 시험Clinical Trial Published on 2021-01-222022-09-10 Journal: BMC Research Notes [Category] 바이오마커, 임상, [키워드] adverse event adverse events amniotic Amniotic fluid C-reactive protein Case series case sery clinical outcomes coronavirus COVID-19 COVID-19 patient determine discharge dose enrolled hospitalized patient hospitalized patients Human hypoxia Inflammation Inflammatory response inherent intravenous IRB limitation objective Observing one patient Patient Prospective trial Randomized reductions reductions in Registration Result SARS CoV SARS CoV-2 scaled severe hypoxia Study design survived the disease therapy for COVID-19 Treatment Trial ventilatory support vertical transmission virus with COVID-19 women [DOI] 10.1186/s13104-021-05443-9 PMC 바로가기 [Article Type] Clinical Trial
A pilot trial of human amniotic fluid for the treatment of COVID-19Clinical Trial Published on 2021-01-222022-10-27 Journal: BMC Research Notes [Category] COVID-19, MERS, [키워드] adverse event amniotic Amniotic fluid C-reactive protein Case series case sery clinical outcomes coronavirus COVID-19 COVID-19 patient determine discharge dose enrolled hospitalized patient Human Inflammation Inflammatory response inherent intravenous IRB limitation objective Observing Patient Prospective trial Randomized reductions in Registration Result scaled severe hypoxia Study design survived the disease therapy for COVID-19 Treatment Trial ventilatory support vertical transmission virus with COVID-19 women [DOI] 10.1186/s13104-021-05443-9 PMC 바로가기 [Article Type] Clinical Trial
MERS-CoV: epidemiology, molecular dynamics, therapeutics, and future challengesReview Published on 2021-01-182022-10-28 Journal: Annals of Clinical Microbiology and Antimicrobials [Category] COVID-19, MERS, [키워드] affected Betacoronavirus challenges changes in Cluster Community coronavirus coronavirus 2 Cross-species transmission effective Epidemic Epidemiology event Factor Fatality rate genetic variability Genome highest highly pathogenic immunological inherent membrane MERS MERS-CoV Middle East molecular molecular dynamics Nosocomial infection nucleocapsid nucleotide occur open reading frames outbreak pandemic pathology Phylogeny predicted progression Protein Region reported Research respiratory respiratory sample SARS-CoV-2 Saudi Arabia Seven spike Spike protein structural proteins subsequent therapeutic Therapeutics Transmission viral infection zoonotic zoonotic transmission [DOI] 10.1186/s12941-020-00414-7 PMC 바로가기 [Article Type] Review
Brazil’s Actions and Reactions in the Fight against COVID-19 from January to March 2020Case Report Published on 2021-01-112022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] Action added Brazil causes COVID-19 epidemiological exacerbated Fatality rate global health Health Health policy Healthcare system highest incidence rate inherent International measure mitigate novel coronavirus SARS-CoV-2 outbreak outcome public health public health emergency reaction SARS-CoV-2 Spread the disease virus website World Health Organization [DOI] 10.3390/ijerph18020555 PMC 바로가기 [Article Type] Case Report
Comprehensive Meta-Analysis of COVID-19 Global Metabolomics DatasetsArticle Published on 2021-01-092022-10-30 Journal: Metabolites [Category] COVID-19, [키워드] age Analysis biological interpretation Brazil China clinical care clinical outcomes clinical presentation Comprehensive conducted coronavirus country COVID-19 dataset datasets Disease progression disease severity facilitate Factor Genetic variations global pandemic heterogeneity Host identify immune Immunity inherent knowledge mass spectrometry Meta-analysis metabolomics molecular novel coronavirus SARS-CoV-2 overcome Pathogenesis pathway performed progression response robust Spread the disease United States viral infection Viral load [DOI] 10.3390/metabo11010044 PMC 바로가기 [Article Type] Article
An epidemic model integrating direct and fomite transmission as well as household structure applied to COVID-19Research Published on 2021-01-052022-10-30 Journal: Journal of Mathematics in Industry [Category] COVID-19, [키워드] accumulating activities applied Asymptomatic Asymptomatic case attribute basic reproductive number calculated Community condition Contact Contamination country COVID-19 dataset death Direct transmission disease Diseases early infection effective Epidemic Final Focusing fomite transmission Germany high risk include individual infection rate inherent intensity Interaction Local mathematical model modulated parameter Parameter estimation physical distancing raise raised reducing sneezes structures susceptible symptomatic the disease Transmission variable [DOI] 10.1186/s13362-020-00097-x PMC 바로가기 [Article Type] Research
Perspective Adjunctive Therapies for COVID-19: Beyond Antiviral TherapyReview Published on 2021-01-012022-10-29 Journal: International Journal of Medical Sciences [Category] COVID-19, MERS, [키워드] anti-inflammatory activity approach Asymptomatic boost coronavirus disease COVID-19 COVID-19 infection demographic Deterioration Disease progression disease severity distribution drug effective Health healthy Immune cell Immunity immunomodulatory indomethacin Infection Infection prevention Inflammatory inflammatory reaction inherent intensive care Interaction medication Medicine melatonin Mild symptom organ pandemic pathophysiological pathway Prevent PROTECT provided reduce Region statins Support the disease therapeutic agent therapy traditional medicines Treatment vitamins and minerals [DOI] 10.7150/ijms.51935 PMC 바로가기 [Article Type] Review