inhibitory – Page 14 – Communicable Diseases Research

Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins

렉틴 경로는 SARS-CoV-2 단백질에 의한 보체 활성화를 매개합니다

Immunology

Published on 2021-07-052022-09-11
Journal: Frontiers in Immunology [Category] SARS, 바이오마커,

[키워드] activate Activation acute respiratory distress acute respiratory distress syndrome addition antibody antiviral drug antiviral drugs ARDS bind block C3b cause Cell cell surface cellular clinical trials complement Complement activation Complement activation product Complement activation products complement system Corticosteroid Corticosteroids COVID-19 Critical cytokine Cytokine storm disease severity early stage early stages Efficacy endothelial injury enzyme event expressing FACS analyses FACS analysis HEK-293 cell HEK-293 cells immune system Infection inflammatory phenotype Inflammatory response inhibited inhibition inhibitor inhibitory Innate immunity lectin lectin pathway maintenance MASP-2 microangiopathy monoclonal antibody N-protein Narsoplimab Pathogenesis pathogenesis of COVID-19 pathology pathophysiological Patient progressed proinflammatory provide respiratory distress Respiratory distress syndrome robust S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 S protein severe COVID-19 shifting shown subsequent syndrome targeting the cell the cytokine storm therapeutic efficacy Treatment triggering
[DOI] 10.3389/fimmu.2021.714511 PMC 바로가기 [Article Type] Immunology

Interaction of selected terpenoids with two SARS-CoV-2 key therapeutic targets: An in silico study through molecular docking and dynamics simulations

두 개의 SARS-CoV-2 주요 치료 표적과 선택된 테르페노이드의 상호 작용: 분자 도킹 및 역학 시뮬레이션을 통한 in silico 연구

Article

Published on 2021-07-012022-09-11
Journal: Computers in biology and medicine [Category] SARS, 신약개발,

[키워드] 3CL hydrolase ACE2 receptor Amino acid amino acid residue amino acid residues Analysis Antiviral approved drug binding catalytic dyad caused Complete Compound Computational approaches confirmation Contact contact with contrary Course COVID-19 disease docking docking score Drug repurposing effective enzyme growth hydrolase in silico in vitro in vivo inhibit inhibitors inhibitors of SARS-CoV-2 inhibitory Interaction interfere lack Limonoids molecular molecular docking molecular dynamics Molecular dynamics simulation MPro outbreak pharmacokinetic predicted profiles protease Protein provided RBD SARS-CoV-2 SARS-CoV-2 Mpro SARS-CoV-2 replication selected spike Spike protein terpenoids the spike protein therapeutic therapeutic target
[DOI] 10.1016/j.compbiomed.2021.104538 PMC 바로가기 [Article Type] Article

Discovery of naturally occurring inhibitors against SARS-CoV-2 3CL pro from Ginkgo biloba leaves via large-scale screening

대규모 스크리닝을 통해 Ginkgo Biloba 잎에서 SARS-COV-2 3CL Pro에 대한 자연 발생 억제제 발견

Article

Published on 2021-07-012022-08-31
Journal: Fitoterapia [Category] SARS, 치료제,

Synthesis and molecular docking study of novel COVID-19 inhibitors

Article

Published on 2021-06-302022-10-28
Journal: Turkish Journal of Chemistry [Category] COVID-19,

Potential In Vitro Inhibition of Selected Plant Extracts against SARS-CoV-2 Chymotripsin-Like Protease (3CL Pro ) Activity

Communication

Published on 2021-06-292022-11-01
Journal: Foods [Category] COVID-19,

[키워드] 3CL acting activity acute respiratory syndrome allyl isothiocyanate approach Brassica nigra calculated clinical trials complementary component concentrations contribute coronavirus coronavirus disease 19 COVID-19 Curcuma Curcumin energy transfer evaluated Extract FRET assay hydrolysis identify in vitro in vivo inhibited inhibiting inhibition inhibitors of SARS-CoV-2 inhibitory inhibitory effect main role molecule mustard mustard seeds natural compounds pandemic plant plant extracts Potential Pro protease Protease activity reducing Replication resulting SARS-CoV-2 SARS-CoV-2 3CL^Pro SARS-CoV-2 replication Sinigrin the SARS-CoV-2 Treatment turmeric vaccination wall rocket
[DOI] 10.3390/foods10071503 PMC 바로가기 [Article Type] Communication

Disordered eating & body image of current and former athletes in a pandemic; a convergent mixed methods study – What can we learn from COVID-19 to support athletes through transitions?

Research Article

Published on 2021-06-242022-10-31
Journal: Journal of Eating Disorders [Category] COVID-19,

[키워드] acute COVID-19 affected analysed Analysis assist athlete athletic body composition Body image change club collected connection COVID-19 COVID-19 pandemic cross-sectional described determine disorder Disordered disordered eating Eating Disorder English events female group increase indicate indicated individual inhibitory Injury International Isolation lockdowns male mental health National no difference occur occurred offer pandemic participant positive Pregnancy promote Psychological psychologically qualitative analysis Quantitative reduced resource Result Retired athlete significant difference sport suggested supplementary material Support Tokyo treated variety was collected worsened
[DOI] 10.1186/s40337-021-00427-3 PMC 바로가기 [Article Type] Research Article

Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1

Research Article

Published on 2021-06-162022-10-30
Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS,

Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein

SARS-CoV-2 NSP14 단백질에 의한 타고난 면역 반응의 번역 차단 및 회피

423

Published on 2021-06-152022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 유전자 메커니즘,

[키워드] active site active sites activities acute respiratory syndrome acute respiratory syndrome coronavirus addition Antiviral antiviral proteins antiviral response causative agent caused complex conserved coronavirus COVID-19 COVID-19 pandemic Critical demonstrated ENhance evade ExoN Exoribonuclease Health Health crisis Host host antiviral responses Host immune response host immune responses host protein human coronaviruses IFN-I IFN-I responses immune evasion immune responses Infection inhibit inhibition activity inhibitor inhibitory innate immune response Innate immunity interferon interferon-stimulated gene interferon-stimulated genes ISGs mechanism nsp14 overcome Pathogenesis pathogenesis of SARS-CoV-2 pathogenic virus pathogenic viruses Pathogens previous study Protein Proteins replicate required respiratory reveal SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance subversion synthesis the SARS-CoV-2 translation translation inhibition translational type I interferon Viral viral pathogens virus replication viruses
[DOI] 10.1073/pnas.2101161118 PMC 바로가기 [Article Type] 423

Anti-Inflammatory, Antiallergic, and COVID-19 Main Protease (M pro ) Inhibitory Activities of Butenolides from a Marine-Derived Fungus Aspergillus terreus

Article

Published on 2021-06-022022-10-30
Journal: Molecules [Category] COVID-19, MERS, SARS,

Intestinal Microbiota—A Promising Target for Antiviral Therapy?

장내 미생물군—항바이러스 치료의 유망한 표적인가?

Review

Published on 2021-05-122022-09-11
Journal: Frontiers in Immunology [Category] SARS, 치료제,