High frequency of neutralizing antibodies to type I Interferon in HIV-1 patients hospitalized for COVID-19COVID-19로 입원한 HIV-1 환자에서 I형 인터페론에 대한 중화 항체의 높은 빈도Article Published on 2022-08-012022-09-11 Journal: Clinical immunology (Orlando, Fla.) [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Co-infection contribute COVID-19 COVID-19 patients Critically ill critically ill COVID-19 patients exhibited expression Frequency greater HIV-1 HIV-1 and SARS-CoV-2 co-infection IFN-I IFN-stimulated genes IFN-α IFN-β infected patients interferon ISGs males NAb titer Neutralizing antibodies neutralizing antibody Oropharyngeal oropharyngeal samples Patient patients hospitalized reduction in reported SARS-CoV-2 serum severity of COVID-19 Subtypes type I [DOI] 10.1016/j.clim.2022.109068 PMC 바로가기 [Article Type] Article
Crosstalk between the innate immune system and selective autophagy in hepatitis B virus infectionComment Published on 2022-08-012023-06-12 Journal: Autophagy [Category] B형 간염, Fulltext, [키워드] BRET Hepatitis B virus interferon selective autophagy Xenophagy [DOI] 10.1080/15548627.2022.2059747 PMC 바로가기 [Article Type] Comment
High-cited favorable studies for COVID-19 treatments ineffective in large trialsResearch article Published on 2022-08-012022-10-05 Journal: Journal of clinical epidemiology [Category] 신약개발, 유전자 메커니즘, 임상, 치료법, [키워드] Altmetric article benefit bias citation citations clinical study clinical trial Colchicine convalescent plasma coronavirus disease correlated correlated strongly COVID-19 COVID-19 treatment Critical Effectiveness eligible evaluate examined Features Hydroxychloroquine interferon Intervention large trial Lopinavir-ritonavir nine Nonrandomized studies objective observational study patients Randomized controlled trial Randomized controlled trials randomized trial RCT RCTs Remdesivir Result setting Study design subsequent Treatment [DOI] 10.1016/j.jclinepi.2022.04.001 [Article Type] Research article
Hepatitis B and C in ChildrenReview Published on 2022-08-012023-06-09 Journal: Clinics in Liver Disease [Category] B형 간염, [키워드] hepatitis B hepatitis C interferon Vaccine vertical transmission Viral hepatitis [DOI] 10.1016/j.cld.2022.03.005 [Article Type] Review
Robust long-term immunity to SARS-CoV-2 in patients recovered from severe COVID-19 after interleukin-6 blockade인터루킨-6 차단 후 중증 COVID-19에서 회복된 환자에서 SARS-CoV-2에 대한 강력한 장기 면역Article Published on 2022-08-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료법, [키워드] 1:1 Affect anti-IL-6 anti-IL-6 therapy anti-IL6 antibody Antibody responses blockade conducted COVID-19 Critical deleterious effect deleterious effects domain Effect evaluated Follow-up greater humoral IgG IgG antibody IL-6 IL-6 blockade Immunity incidence increase in Infection interferon interferon-γ interleukin interleukin-6 Interleukin-6 blockade Laboratory longitudinal cohort study magnitude median Neutralizing antibodies neutralizing antibody no increase Patient patients hospitalized patients with COVID-19 positive proportion Prospective protective immunity receiving Reinfection responded to vaccination response responses risk robust SARS-CoV-2 SARS-COV-2 infection Seropositivity severe COVID-19 Spain subject subjects T-cell T-cell immunity T-cell Response T-cell responses therapy Tocilizumab treated [DOI] 10.1016/j.ebiom.2022.104153 PMC 바로가기 [Article Type] Article
Early and Rapid Identification of COVID-19 Patients with Neutralizing Type I Interferon Auto-antibodiesArticle Published on 2022-08-012022-11-15 Journal: Journal of Clinical Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] affected analyzed auto-antibody autoantibodies benefit Biomarker circulating Clinical outcome clinical parameter clinically Cohort COVID-19 COVID-19 patient Critical Critically ill critically ill patients defined detectable disease Effect ELISA evaluated FIVE hospital Hospital admission hospitalized COVID-19 patient identification IFN-α interferon male Neutralization assay Neutralizing Neutralizing activity Oxygen requirement Patient post-symptom onset Prevalence probability of survival Rapid reduced SARS-CoV-2 SARS-CoV-2 antibody sera severe COVID-19 specificity subsequent survival Therapeutic plasma exchange Therapies TPE Type type I interferon undetectable uninfected control WHO [DOI] 10.1007/s10875-022-01252-2 PMC 바로가기
Repurposing the antibacterial drugs for inhibition of SARS-CoV2-PLpro using molecular docking, MD simulation and binding energy calculation분자 도킹, MD 시뮬레이션 및 결합 에너지 계산을 사용하여 SARS-COV2-PLPRO의 억제를위한 항균제를 재사용Article Published on 2022-08-012022-08-31 Journal: Molecular diversity [Category] SARS, 신약개발, [키워드] acetic acid Amino acid amino acids Antibacterial Antibacterial compounds aromatic rings benzofuran best binding energy cleavage collected complex Compound conserved docked downregulating downregulation drug effective effective inhibitor feature filtered function GRL0617 Host hydrophobic hydrophobic interaction immune system indol inhibitor Interaction interferon interferon-stimulated gene IRF3 ISG15 key amino acid key amino acids MD simulation molecular molecular docking molecular dynamics Molecular dynamics simulation non-structural protein novel corona virus Papain Papain-like protease Papain-like protease (PLpro) PLPro produced promoted protease Protein protein-ligand Proteins removal Replication reported repurposing SARS-CoV SARS-CoV-2 SARS-CoV-2 novel corona virus. SARS-CoV2 similarity stability type I interferon Viral viral growth Zinc ZINC database [DOI] 10.1007/s11030-021-10325-0 PMC 바로가기 [Article Type] Article
Emerging Therapies for COVID-19: The Value of Information From More Clinical TrialsCOVID-19에 대한 새로운 치료법: 더 많은 임상 시험에서 얻은 정보의 가치Article Published on 2022-08-012022-09-11 Journal: Value in health : the journal of the International [Category] 임상, 진단, [키워드] Analysis approval approved Baricitinib benefit Casirivimab clinical clinician Cohort consequence Cost-benefit analysis COVID-19 COVID-19 pandemic decision support techniques Dexamethasone drug approval. effective Emergency use authorization Evidence Health healthcare hospitalized patient hospitalized patients Hydroxychloroquine Imdevimab implementation information interferon interferon beta Interferon beta-1a Lopinavir Lopinavir-ritonavir outcome pandemic Perspective Randomized controlled trial RCT RCTs Remdesivir Research Ritonavir seeking Support therapy threshold Tocilizumab usual care value with COVID-19 [DOI] 10.1016/j.jval.2022.03.016 PMC 바로가기 [Article Type] Article
Prognostic Value of Mid-Region Proadrenomedullin and In Vitro Interferon Gamma Production for In-Hospital Mortality in Patients with COVID-19 Pneumonia and Respiratory Failure: An Observational Prospective StudyCOVID-19 폐렴 및 호흡부전 환자의 병원 내 사망률에 대한 중간 지역 Proadrenomedullin 및 체외 인터페론 감마 생산의 예후적 가치: 관찰적 전향적 연구Observational Study Published on 2022-07-302022-09-11 Journal: Viruses [Category] MERS, 바이오마커, 임상, [키워드] 95%CI Admission Adult patients adverse outcome adverse outcomes AUROC best Biomarker cause characterized Coagulopathy Comorbidity coronavirus coronavirus disease COVID-19 COVID-19 pneumonia COVID-19 vaccination cut-off cut-off point Deceased dysregulation endothelial damage enrolled Enrollment Evidence evidence of females Gamma groups Hospital mortality Hospitalization IFNγ immune dysregulation Immune suppression Immunocompromised patients in vitro in-hospital mortality infection risk interferon interferon gamma median age mid-region proadrenomedullin MONITOR Mortality MR-proADM Negative predictive value Non-COVID-19 observational study PaO2:FiO2 Patient patients with COVID-19 Pneumonia predict Predictive value predictive value) Production Prognostic factor Prospective quantiferon monitor. radiologic respiratory Respiratory failure SARS-CoV-2 sensitivity significantly specificity subset survivor the median value were measured with COVID-19 with infection [DOI] 10.3390/v14081683 PMC 바로가기 [Article Type] Observational Study
IFNAR2 relevance in the clinical outcome of individuals with severe COVID-19중증 COVID-19 환자의 임상 결과에서 IFNAR2 관련성Article Published on 2022-07-292022-09-11 Journal: Frontiers in Immunology [Category] 변종, 치료제, [키워드] amplify Antiviral antiviral response assays association beta receptor Clinical outcome COVID-19 COVID-19 mortality cytokine Cytokines determined by ELISA evaluate Genetic genetic susceptibility Genetic variant genetic variants Hospitalized IFN IFNAR1 IFNAR2 IFNs immunomodulatory activities individual individuals Innate immunity interferon Interferon alpha interferon alpha-beta interferons investigated Mortality mortality risk Non-survivors Patient patients hospitalized plasma sample plasma samples Protein receptor receptors severe COVID-19 severity SNP subject subunit survivor the disease Type type I IFNs variant with COVID-19 [DOI] 10.3389/fimmu.2022.949413 PMC 바로가기 [Article Type] Article