Immunogenicity and Adverse Effects of the 2-Dose BNT162b2 Messenger RNA Vaccine Among Liver Transplantation Recipients간 이식 환자에서 BNT162b2 메신저 RNA 백신 2회 투여 시 면역원성과 부작용Article Published on 2022-02-012022-09-12 Journal: Liver transplantation : official publication of th [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome administration Adverse adverse effect antibodies antibody Antibody Response BNT162b2 BNT162b2 mRNA vaccine BNT162b2 vaccine Control control group controls coronavirus defined dose Effect effective Efficacy geometric IgG IgG antibody titer immune response immune responses immunogenicity Immunoglobulin Immunosuppression infected with SARS-CoV-2 Liver transplantation median time men messenger Messenger RNA Mild mRNA neutralizing antibody occurred Patient patients positive positive antibody response RBD RBD IgG receiving recipient recipients reduced renal function responses RNA Safe SARS-CoV-2 second dose second vaccination shown study period the receptor-binding domain the vaccine therapy transplantation Vaccine women [DOI] 10.1002/lt.26366 PMC 바로가기 [Article Type] Article
Covid-19 and Artificial Intelligence: Genome sequencing, drug development and vaccine discovery코비드-19와 인공 지능: 게놈 시퀀싱, 약물 개발 및 백신 발견Review Published on 2022-02-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] abacavir agility Almitrine applied approval article artificial artificial intelligence Atazanavir bioinformatics Care challenges clinical trial clinical trials collecting data COVID-19 COVID-19 pandemic COVID-19 virus databases deep learning difficulty dolutegravir drug Drug development Drug repurposing drugs efavirenz Genome sequencing genomic genomic sequence genomic sequencing Google Google Scholar growth Health Health care help hydrochloride inhibitor internal and external interpretability machine learning Messenger RNA mesylate Olaparib omicron PARP1 provide recognize Remdesivir Ritonavir Roflumilast SARS- CoV-2 SARS-CoV-2 proteome sequence Sequencing strain structural proteins therapeutic agent therapeutic effect Vaccine Vaccines variants variants of concern Viral vector vaccines VoC was done [DOI] 10.1016/j.jiph.2022.01.011 PMC 바로가기 [Article Type] Review
Association of Human Milk Antibody Induction, Persistence, and Neutralizing Capacity With SARS-CoV-2 Infection vs mRNA VaccinationArticle Published on 2022-02-012022-11-15 Journal: JAMA Pediatrics [Category] COVID19(2023년), SARS, 진단, [키워드] age anti-SARS-CoV-2 antibody Antibody Response BNT162b2 Capacity Cohort cohort study collected Concentration convenience COVID-19 infection COVID-19 vaccine diagnosed Diagnosis domain exhibited first dose fraction functional Human human milk IgA IgA response IgG IgG antibody IgG response individuals induction Infant Infection lactating live SARS-CoV-2 median Messenger RNA microneutralization milk mRNA mRNA vaccination mRNA-1273 neutralization activity outcome parent parental parents participant polymerase chain prevaccination recruited robust SARS-CoV-2 second dose the vaccine vaccination Vaccine vaccine dose virus while [DOI] 10.1001/jamapediatrics.2021.4897 PMC 바로가기
Lower Serologic Response to COVID-19 mRNA Vaccine in Patients With Inflammatory Bowel Diseases Treated With Anti-TNFα항-TNFα 치료를 받은 염증성 장 질환 환자의 코로나19 mRNA 백신에 대한 혈청학적 반응 감소Observational Study Published on 2022-02-012022-09-11 Journal: Gastroenterology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] administration adverse event adverse events AEs all subject all subjects Anti-spike anti-spike antibody anti-TNF antibody BNT162b2 booster dose comparable coronavirus disease COVID-19 dose doses drug level drug levels enrolled function functional groups HCs healthy control healthy controls high risk IBD infection rate infections Inflammatory bowel disease inflammatory bowel diseases inhibitory Lower magnitude Messenger RNA mounted mRNA mRNA-BNT162b2. multicenter Necrosis not affect Patient patients treated Pfizer Pfizer/BioNTech Prospective Prospective Study remained response Safe safety profile second dose serologic Serologic response serologic responses seronegative seropositive significantly lower stratified therapy TNFα treated treated patients Treatment Vaccine vaccine dose vaccine response vaccine responses [DOI] 10.1053/j.gastro.2021.10.029 PMC 바로가기 [Article Type] Observational Study
Comparison of SARS-CoV-2 antibody response after two doses of mRNA and inactivated vaccines in multiple sclerosis patients treated with disease-modifying therapies질병 조절 요법으로 치료받은 다발성 경화증 환자에서 mRNA와 불활성화 백신 2회 투여 후 SARS-CoV-2 항체 반응의 비교Article Published on 2022-02-012022-09-12 Journal: Multiple sclerosis and related disorders [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Antibody titer BNT162b2 collected COVID-19 cross-sectional decrease Disease-modifying therapy dose greater healthy controls immune response immune system inactivated Inactivated vaccine Messenger RNA mRNA mRNA vaccine Multiple multiple sclerosis participant patients treated Pfizer/BioNTech Protective risk SARS-CoV-2 SARS-CoV-2 antibody second dose seronegative serum sample significant difference single-center Sinovac the vaccine therapy treated Treatment untreated patient Vaccine vaccine group Vaccines [DOI] 10.1016/j.msard.2022.103486 PMC 바로가기 [Article Type] Article
Promising Assays for Examining a Putative Role of Ribosomal Heterogeneity in COVID-19 Susceptibility and SeverityReview Published on 2022-01-282022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] analyses Antiviral treatment arise assays for proteins assays for RNA sequence and structure caused Characteristics characterized clinical sample clinical setting component concurrent COVID-19 COVID-19 disease Critical detect droplet Efficacy element environmental cues Examining generate heterogeneity Host host susceptibility identify include Infection Messenger RNA modifications mRNA Nanopore organism post-translational modification protocol responses ribosomal heterogeneity ribosomal protein ribosomal proteins ribosomal RNA ribosomal RNAs ribosome ribosomes RNA genome RNA sequencing role rRNA rRNAs SARS-CoV-2 SARS-CoV-2 coronavirus selected sequence Sequencing severity of symptoms Side effect Single Cell Statistical power structural variations structures substrate Symptoms the disease the SARS-CoV-2 transcript translate translation translation machinery translational Transmissibility unique vaccine immunogenicity vaccine response variant viral infectivity [DOI] 10.3390/life12020203 PMC 바로가기 [Article Type] Review
Humoral response to the SARS-CoV-2 BNT162b2 mRNA vaccine: Real-world data from a large cohort of healthcare workersSARS-CoV-2 BNT162b2 mRNA 백신에 대한 체액 반응: 대규모 의료 종사자 집단의 실제 데이터Article Published on 2022-01-282022-09-12 Journal: Vaccine [Category] SARS, 진단, [키워드] accelerated age Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 IgG anti-Spike IgG antibody Blood BNT162b2 mRNA CMIA cohorts COVID-19 death determine elevated ENCODE Factor group groups healthcare healthcare worker humoral immune response Humoral immunity Humoral response IgG IgG antibody immune response immunological increase in independent large cohort median titer men Messenger RNA mRNA vaccine multivariate logistic regression participant pre-vaccination RBD real-world data Receptor binding domain reduction responsible S1 subunit SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 pandemic significantly Support susceptibility tested the SARS-CoV-2 the spike protein timepoints titer vaccination Vaccine Vaccines virus was collected women [DOI] 10.1016/j.vaccine.2021.12.014 PMC 바로가기 [Article Type] Article
Comparative Effectiveness of BNT162b2 and mRNA-1273 Vaccines in U.S. Veterans미국 제대군인에서 BNT162b2 및 mRNA-1273 백신의 비교 효과Observational Study Published on 2022-01-132022-09-11 Journal: The New England Journal of Medicine [Category] 변종, 임상, [키워드] 1:1 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus Admission Affair Alpha B.1.1.7 B.1.617.2 BNT162b2 Comparative coronavirus coronavirus disease Coronavirus disease 2019 death Department effective Effectiveness Electronic health record Electronic health records event first dose Follow-up Hospitalization ICU ICU admission Infection intensive care intensive care unit involved Kaplan-Meier estimator Messenger RNA mRNA mRNA-1273 mRNA-1273 vaccine of BNT162b2 outcome over Population recipient recipients risk Risk factors SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 symptomatic COVID-19 the SARS-CoV-2 Trial vaccination Vaccine vaccine group variant veteran veterans [DOI] 10.1056/NEJMoa2115463 PMC 바로가기 [Article Type] Observational Study
Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in AdolescentsMulticenter Study Published on 2022-01-122022-10-04 Journal: The New England Journal of Medicine [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] 95% CI 95% confidence interval acute respiratory syndrome Admission Adolescent age B.1.617.2 BNT162b2 BNT162b2 vaccine caused center Control controls coronavirus coronavirus disease death dose effective Effectiveness eligible enrolled extracorporeal membrane oxygenation hospital Hospitalization Hospitalized ICU ICU admission incidence intensive care Intervention laboratory-confirmed log mechanical ventilation Messenger RNA occurred of BNT162b2 offered Patient patients pediatric required Result resulting SARS-CoV-2 screened Support Symptom the United State vaccination Vaccine variant vasopressors [DOI] 10.1056/NEJMoa2117995 PMC 바로가기 [Article Type] Multicenter Study
Inactivated SARS-CoV-2 vaccines elicit immunogenicity and T-cell responses in people living with HIV비활성화된 SARS-CoV-2 백신은 HIV에 감염된 사람들에게 면역원성과 T 세포 반응을 유발합니다Clinical Trial Published on 2022-01-012022-09-12 Journal: International immunopharmacology [Category] MERS, SARS, 임상, 진단, [키워드] Adenovirus Analysis antibody B cells booster dose caused CD4 CD45RO CD8 Community comparable COVID-19 cytokine determine dose Effect elicit ELISA Enumeration evaluated exhibited expression flow cytometry healthy donor HIV HIV-positive individual IFN-γ IL-2 inactivated individuals influences on Laboratory lymphocyte magnitude memory T cell Messenger RNA mRNA neutralization Neutralization antibody Neutralizing antibodies neutralizing antibody Pearson correlation Peripheral blood PLWH positive rate positive rates recruited required response SARS-2-S SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 vaccines. Spearman Spike protein staining T-cell Response Th1 Th17 Th17 response Th2 TNF-α Treg Vaccine Vaccines was used with HIV [DOI] 10.1016/j.intimp.2021.108383 PMC 바로가기 [Article Type] Clinical Trial