Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: a multicentre cohort studySARS-CoV-2 감염 후 다기관 염증 증후군이 있는 소아의 중증 질환 예측인자: 다기관 코호트 연구Multicenter Study Published on 2022-04-112022-09-11 Journal: CMAJ : Canadian Medical Association journal = jour [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval adjusted Admission age Canada changes in Characteristics children children with MIS-C cohort study Comorbidities died disease severity evaluated ferritin ferritin level greater hospital ICU ICU admission increased risk Inflammatory initial intensive care intensive care unit Iran male median age MIS-C multicentre multivariable analyses Patient risk risk difference risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants severity significantly higher study period syndrome [DOI] 10.1503/cmaj.210873 PMC 바로가기 [Article Type] Multicenter Study
Clinical characteristics of children hospitalized for COVID-19Case Reports Published on 2022-04-082022-10-04 Journal: Medicina clínica [Category] COVID19(2023년), SARS, 임상, [키워드] Administered Admission age Asymptomatic Characteristics children clinical Clinical data clinical manifestation collected Comorbidity compatible symptoms Contact COVID-19 described diagnosis of SARS-CoV-2 early diagnosis epidemiological Evolution expression of SARS-CoV-2 greater group hospital Hospitalización Hospitalization Hospitalized Infection Inflammatory Laboratory lymphopenia mild symptoms MIS-C MOST Older pandemic Patient patients patients with pneumonia Pediatría. pediatric Pediatric patient Prognosis proportion respiratory infection SARS-COV-2 infection secondary case Severe case severity syndrome Treatment [DOI] 10.1016/j.medcli.2021.11.016 PMC 바로가기 [Article Type] Case Reports
Clinical Features of Multisystem Inflammatory Syndrome in Children Associated with COVID-19 in Indonesia인도네시아 코로나19 관련 소아 다기관 염증 증후군의 임상적 특징Article Published on 2022-04-052022-09-11 Journal: Journal of tropical pediatrics [Category] COVID19(2023년), SARS, 치료기술, [키워드] activated Admitted Patient age Asian characteristics of patient children clinical Clinical course Clinical outcome clinical outcomes Coagulation coagulation factor collected data coronavirus disease Coronavirus disease 2019 country COVID-19 cross-sectional cross-sectional study diagnosed Diagnosis elevated highlight hospital Indonesia Inflammatory inflammatory markers intubation IQR male mechanical ventilation median age median time MIS-C Most patient Most patients neutrophil neutrophil counts non-survivor Non-survivors outcome parameter Patient patients positive prothrombin Prothrombin time reported required study period survivor syndrome tertiary referral hospital the median those who survived Treatment two groups Vasopressor vasopressors while White blood cells with COVID-19 [DOI] 10.1093/tropej/fmac025 PMC 바로가기 [Article Type] Article
Arrhythmic myocarditis in an adolescent male: A unique presentation of multi-organ inflammatory syndrome (MIS-C)Case Reports Published on 2022-04-012023-07-08 Journal: The American journal of emergency medicine [Category] COVID19(2023년), [키워드] Arrhythmias COVID-19 MIS-C myocarditis pediatrics [DOI] 10.1016/j.ajem.2022.01.061 PMC 바로가기 [Article Type] Case Reports
SARS-CoV-2 Spike Protein in Intestinal Cells of a Patient with Coronavirus Disease 2019 Multisystem Inflammatory Syndrome코로나바이러스 질환 2019 다계통 염증 증후군 환자의 장 세포에서 SARS-CoV-2 스파이크 단백질Case Reports Published on 2022-04-012022-09-11 Journal: The Journal of pediatrics [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Autopsy coronavirus COVID-19 Gut healthy Hypothesis immunologic response Inflammation Inflammatory intestinal cells intracardiac Kawasaki disease MIS-C pathology pathophysiology SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein syndrome Thrombus viral presence [DOI] 10.1016/j.jpeds.2021.11.058 PMC 바로가기 [Article Type] Case Reports
The difference of the inflammatory milieu in MIS-C and severe COVID-19 Research Published on 2022-03-292022-10-05 Journal: Pediatric Research [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Biomarker characterized chemokine children children with MIS-C coronavirus disease 19 Course COVID-19 COVID-19 group COVID-19 pandemic cytokine disease groups HCs healthy control identify IFN-γ IL-1 IL-10 IL-17A IL-18 immune response Impact Inflammation Inflammatory IP-10/CXCL10 life-threatening management MIS-C MOST pathophysiology pathway Patient profile Result risk Sample severe COVID-19 severe SARS-CoV-2 significantly higher syndrome [DOI] 10.1038/s41390-022-02029-4 [Article Type] Research
Cytokine cascade in Kawasaki disease versus Kawasaki-like syndrome가와사키병 대 가와사키 유사 증후군의 사이토카인 캐스케이드Review Published on 2022-03-252022-09-11 Journal: Physiological research [Category] SARS, 유전자 메커니즘, [키워드] acquired heart disease acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Aneurysm autoantibody Autoimmunity cardiovascular complications cascade caspase caspase 3 cause caused Cell Characteristics characterized children Coronary artery coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine cytokine level Cytokine release syndrome Cytokine storm Cytokines defined Diagnosis Factor febrile FIVE Genetic heart disease hypercytokinemia Hyperinflammatory Hypothesis IFN-gamma IL-10 IL-2 IL-4 IL-6 immunothrombosis induce Infection Inflammatory Kawasaki disease Kawasaki-like syndrome medium MIS-C myocarditis occur Pathogenesis pathogenic mechanism pathophysiology pediatric PIMS protocol respiratory virus respiratory viruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus Shock susceptibility syndrome systemic inflammatory response systemic vasculitis the disease TNF-alpha Treatment triggered Vasculitis vessel [DOI] 10.33549/physiolres.934672 PMC 바로가기 [Article Type] Review
Innate lymphoid cells and COVID-19 severity in SARS-CoV-2 infectionObservational Study Published on 2022-03-112022-10-05 Journal: eLife [Category] SARS, 임상, [키워드] Adults adults hospitalized age age and sex amphiregulin Blood cell type cell types children with COVID-19 children with MIS-C contribute Control controls correlated correlations COVID-19 COVID-19 severity decrease determine disease disease tolerance duration of hospitalization Effect explain female females Follow-up greater homeostatic Hospitalization Hospitalized Human ILC ILCs immunology implicated increase independent Inflammation Innate innate lymphoid cell Innate lymphoid cells less lung lymphoid lymphoid cell lymphopenia male males marker Massachusett Medicine MIS-C morbidity and mortality mRNA Multiple NIH Outpatient pediatric phenotype produced Protein readiness recovering from COVID-19 SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severity Sex subset supported systemic inflammation T cell subset T cells these cell tissue homeostasis Tolerance treated uninfected control was used with COVID-19 [DOI] 10.7554/eLife.74681 PMC 바로가기 [Article Type] Observational Study
Autoantibodies Against Proteins Previously Associated With Autoimmunity in Adult and Pediatric Patients With COVID-19 and Children With MIS-CCOVID-19가 있는 성인 및 소아 환자와 MIS-C를 가진 어린이에서 이전에 자가면역과 연관되었던 단백질에 대한 자가항체Article Published on 2022-03-112022-09-11 Journal: Frontiers in Immunology [Category] MERS, 진단, 치료제, [키워드] administration Against Analysis antibody Antigen antigens ATPase autoantibodies autoantibody autoantigen Autoantigens Autoimmune Autoimmune disease Autoimmune diseases Autoimmunity both groups children COVID-19 declined defined detect diabetes gastritis human protein human proteins IgA antibodies IgA antibody IgG Immunoglobulin in both group in vivo Inflammatory insulin-dependent diabetes Intravenous immunoglobulin IVIG Kawasaki disease KCNRG KLHL12 lung MIS-C MIS-C multisystem inflammatory syndrome in children monitoring Patient patients patients with COVID-19 Protein responsible Ro60 subset syndrome target therapy troponin undetectable while with COVID-19 [DOI] 10.3389/fimmu.2022.841126 PMC 바로가기 [Article Type] Article
Italian intersociety consensus on management of long covid in childrenReview Published on 2022-03-092022-10-29 Journal: Italian Journal of Pediatrics [Category] COVID-19, MERS, SARS, [키워드] abdominal pain acute infection acute phase all subject arthralgia chest pain children clinical manifestation Complete Consensus COVID COVID-19 COVID-19 pandemic defined Diagnosis diagnosis of SARS-CoV-2 diarrhea disease evidenced explained fatigue Government headache Health authority identify in-depth analysis include Infection Inflammatory Italian knowledge Laboratory less Local Long Long COVID management Mental mental health MIS-C myalgia normality organized Pain pediatric Pediatric infectious diseases persistent Prevalence primary care problem problems proportion psychological support public health radiological SARS-CoV-2 skin lesion Sleep disturbance Stress subject supplementary material Symptom syndrome the disease treat undergo [DOI] 10.1186/s13052-022-01233-6 PMC 바로가기 [Article Type] Review