Predicted antiviral drugs Darunavir, Amprenavir, Rimantadine and Saquinavir can potentially bind to neutralize SARS-CoV-2 conserved proteinsResearch Published on 2021-08-042022-10-30 Journal: Journal of Biological Research [Category] COVID-19, [키워드] Abstract active site Amprenavir analyzed anti-viral drug antiviral drug antiviral drugs binding conserved Coronavirus disease 2019 COVID-19 COVID-19 patient darunavir drug drug target drugs enzyme Enzymes Helicase Host humans include life cycle methyltransferase Mortality motif neutralize non-structural proteins novel Papain-like protease pathogenicity predicted Prevent protease Protein Proteins replicase repurposing Result Rimantadine RNA-dependent RNA polymerase saquinavir SARS-CoV-2 supplementary material target the SARS-CoV-2 treat Trial [DOI] 10.1186/s40709-021-00149-2 PMC 바로가기 [Article Type] Research
B cell receptor (BCR) guided mechanotransduction: Critical hypothesis to instruct SARS-CoV-2 specific B cells to trigger proximal signalling and antibody reshapingB 세포 수용체(BCR) 유도 기계 변환: SARS-CoV-2 특이적 B 세포가 근위 신호 전달 및 항체 재형성을 촉발하도록 지시하는 중요한 가설Article Published on 2021-08-012022-09-12 Journal: Medical Hypotheses [Category] MERS, SARS, 진단, [키워드] activate Activation acute respiratory syndrome antibody antibody production antigens APCS approval B cell B cell receptor BCR BCR dynamics BCR spatiotemporal dynamics binding cause consequence coronavirus COVID-19 develop event globe Health Hypothesis immune immune mechanism Immunity In-vitro Infection Interaction Mechanotransduction motif mRNA vaccine neutralizing antibody Pathogens Phosphorylation Prevent proximal receptor Region respond SARS-CoV-2 SARS-CoV-2 infected patient Signal transduction spatiotemporal Spread Structure targeting therapeutic translate triggered tyrosine undergo Vaccine entanglements. virus receptor [DOI] 10.1016/j.mehy.2021.110640 PMC 바로가기 [Article Type] Article
A computational analysis of molecular evolution for virulence genes of zoonotic novel coronavirus (COVID-19)Research article Published on 2021-08-012022-10-05 Journal: Computational biology and chemistry [Category] SARS, 변종, 유전자 메커니즘, [키워드] Adaptive molecular evolution Affect Amino acid Analysis coated computational analysis Coronaviridae family coronavirus disease COVID COVID-19 Diagnosis distribution Evolution genomic RNA hemagglutinin highly pathogenic homology Host Hypothesis Likelihood ratio test LRT Markov model Maximum likelihood MERS-CoV molecular motif Mutation Non-synonymous novel Novel coronavirus nucleocapsid protein nucleotide substitutions null hypothesis pandemic disease positive Positive selection Radiation Ratio RdRP reported respiratory tract selected silent single-stranded synonymous Test virulence gene virulence genes virus were used zoonotic [DOI] 10.1016/j.compbiolchem.2021.107532 [Article Type] Research article
Inflammatory biomarkers in COVID-19-associated multisystem inflammatory syndrome in children, Kawasaki disease, and macrophage activation syndrome: a cohort studyResearch article Published on 2021-08-012022-10-05 Journal: The Lancet Rheumatology [Category] 바이오마커, [키워드] Acute kidney injury Altered mental status Analysis approach Biomarker center characteristic chemokine children Cincinnati clinical Coagulopathy cohort of patient cohort study Concentration concentrations conditions CXCL9 Deutsche Forschungsgemeinschaft diagnosed Diagnosis eight elevated ELISA enrolled family finding FIVE foundation Frequency funding Hyperinflammatory Hyperinflammatory syndrome IL-18 IL-6 Inflammatory Inflammatory biomarker juvenile idiopathic arthritis Kawasaki disease Laboratory laboratory feature Ligand macrophage activation macrophage activation syndrome management median median age MIS-C motif Myocardial dysfunction nine non-parametric test occur Pathogenesis pathophysiology Patient potentially life-threatening prospective cohort Protein provide S100A12 SARS-COV-2 infection Sensitivity and specificity Seven severity Shock significantly higher skin Stratification Support syndrome systemic inflammatory marker USA was done were assessed [DOI] 10.1016/S2665-9913(21)00139-9 [Article Type] Research article
Non-neutralizing SARS CoV-2 directed polyclonal antibodies demonstrate cross-reactivity with the HA glycans of influenza virusArticle Published on 2021-07-292022-10-04 Journal: International immunopharmacology [Category] MERS, SARS, 진단, [키워드] ADCC ADE antibody antibody-dependent cellular cytotoxicity Antibody-dependent enhancement Antigen contribute convalescent COVID-19 COVID-19 infected individual cross-neutralize cross-protection cross-react cross-reactive cross-reactive antibody cross-reactivity Donor elicited Epidemiological study epitope function glycan Glycan dependent glycosylation pathway hemagglutinin HIV-1 Human immune immune evasion immune responses immunized mice Infection Influenza Influenza virus motif Neutralizing antibodies non-neutralizing antibody non-neutralizing antibody response observation polyclonal antibody Potential Protein reported responses RNA virus SARS CoV-2 SARS-CoV-2 SARS-CoV2 sera Spike protein the SARS-CoV-2 the SARS-CoV-2 virus therapeutic Vaccine viral neutralization [DOI] 10.1016/j.intimp.2021.108020 PMC 바로가기 [Article Type] Article
Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library사전 구조화된 DNA 라이브러리의 야생형 및 B.1.1.7 SARS-CoV-2 스파이크 단백질에 대한 다양한 고친화성 DNA 앱타머AcademicSubjects/SCI00010 Published on 2021-07-212022-09-10 Journal: Nucleic Acids Research [Category] SARS, 변종, 진단, 치료기술, [키워드] adopted affinity B.1.1.7 B.1.1.7 variant binding comparable COVID-19 diagnostic DNA DNA library DNA sequences enrichment exhibited experiment hairpin structure heat human saliva identify in vitro lentivirus limit of detection motif performed pool pseudotyped random S1 protein S1 subunit Saliva SARS-CoV-2 SARS-CoV-2 spike protein secondary secondary structure selection experiment selection pressure sequence Spike protein the S1 protein the S1 subunit the SARS-CoV-2 Trimeric spike protein were assessed wild-type wildtype [DOI] 10.1093/nar/gkab574 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
SARS-CoV-2: from its discovery to genome structure, transcription, and replicationReview Published on 2021-07-192022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] abundance ACE2 acute respiratory syndrome Atypical cleaved complex conducted contagious coronavirus COVID-19 COVID-19 pandemic Efficiency ENCODE exhibit expressing full-length function Genetic Genome genome structure genomic RNA gRNA infected cell infected cells Interaction isolates motif mRNA non-structural protein Nsp12 nsp13 Nsp9 ORF ORF1a ORF1b Pneumonia polyprotein positive-sense protease Proteins Replication respiratory virus responsible RNA RNA primer RNA synthesis RTC SARS-CoV-2 SARS-CoV-2 genome sgRNA sgRNAs single-stranded subgenomic RNA susceptible cell synthesis the SARS-CoV-2 genome TMPRSS2 Transcription transcription regulatory sequence translate translation TRS upstream Vesicle viral genome viral genome replication viral replication [DOI] 10.1186/s13578-021-00643-z PMC 바로가기 [Article Type] Review
SARS-CoV-2 Cellular Entry Is Independent of the ACE2 Cytoplasmic Domain SignalingArticle Published on 2021-07-172022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] ACE2 ACE2 internalization acute respiratory syndrome angiotensin-converting enzyme 2 BHK21 bind binding bioinformatics Cell cells cellular Clathrin-mediated endocytosis conserved coronavirus coronavirus entry CoV cytoplasmic cytoplasmic tail deleted demonstrated Dipeptidyl peptidase 4 domain eight Endosomal acidification HEK293T Host host cell host cells independent of Infection inhibited inhibitor motif pathway phosphorylation sites pseudotyped RBD receptor SARS-CoV SARS-CoV antibody SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 Signaling significantly spike glycoprotein Spike protein Transmission Treatment understanding viral pathogenesis virus infection [DOI] 10.3390/cells10071814 PMC 바로가기 [Article Type] Article
Natural Transmission of Bat-like Severe Acute Respiratory Syndrome Coronavirus 2 Without Proline-Arginine-Arginine-Alanine Variants in Coronavirus Disease 2019 Patients코로나바이러스 질병 2019 환자에서 프롤린-아르기닌-아르기닌-알라닌 변이체가 없는 박쥐 유사 중증 급성 호흡기 증후군 코로나바이러스 2의 자연 전염Article Published on 2021-07-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Alanine arginine Chain Reaction cleavage Cluster Coronaviral coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 patients ENhance Evolution of SARS-CoV-2 Frequency furin furin cleavage PRRA motif hamster hamsters Human humans implication isolates motif Mutation natural natural infection organoids patients polymerase chain polymerase chain reaction Prevalence prevalence rate proline PRRA Quasispecies quasispecy respiratory S1/S2 SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Transmission transmitted upstream variant variants Vero VERO-E6 viral pathogenicity Viral variants virus wild-type zoonotic origin [DOI] 10.1093/cid/ciaa953 PMC 바로가기 [Article Type] Article
A Fungal Defensin Targets the SARS−CoV−2 Spike Receptor−Binding DomainArticle Published on 2021-07-122022-10-30 Journal: Journal of Fungi [Category] COVID-19, [키워드] ACE2 antiviral agent antiviral drug approaches binding affinity Combination coronavirus coronavirus 2 defensin dermatophytic fungus domain drugs elicited enzyme exhibited fungal high affinity highlight host cell human ACE2 hydrogen bond network hydrophobic interacting residue Interaction interactions micasin Microsporum canis motif Point mutation predicted Prevent Protein RBD RBD binder RBM resource respiratory SARS−CoV−2 significantly spike target viral entry [DOI] 10.3390/jof7070553 PMC 바로가기 [Article Type] Article