Identification of a Membrane Binding Peptide in the Envelope Protein of MHV CoronavirusArticle Published on 2020-09-222022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Amino acid Antigen binding Cell cholesterol coding sequence coronavirus CoV CoVs distribution DPPC E protein Endoplasmic reticulum envelope envelope protein ERGIC expressing expression full-length function Giant Golgi GUV identification identify in silico insect cells intestinal mammal mammalian membrane MHV mouse mutant Neurological disease peptide peptides positive predicted Replication RNA virus sphingomyelin tested Vesicle virus were expressed wild type [DOI] 10.3390/v12091054 PMC 바로가기 [Article Type] Article
Airborne Aerosolized Mouse Cytomegalovirus From Common Otolaryngology Procedures: Implications for COVID-19 InfectionSpecial Section on COVID-19 Published on 2020-09-152022-10-29 Journal: Otolaryngology--Head and Neck Surgery [Category] COVID-19, [키워드] aerosol aerosol exposure aerosol-generating procedure aerosolization airborne BALB/c mice collected common Concentration concentrations COVID-19 cytomegalovirus determine Device distribution generate health care workers identify increases in Infection inoculated Laboratory mouse murine objective otolaryngology otolaryngology surgical procedures p value Particle polymerase chain Result setting statistically significant university Utah viral culture viral DNA viral titer virus [DOI] 10.1177/0194599820957966 PMC 바로가기 [Article Type] Special Section on COVID-19
Reactive oxygen species oxidize STING and suppress interferon productionarticle Published on 2020-09-042024-09-02 Journal: eLife [Category] 대상포진, [키워드] herpesvirus interferon mouse reactive oxygen species redox regulation STING [DOI] 10.7554/eLife.57837 PMC 바로가기 [Article Type] article
Of Mice and Men: The Coronavirus MHV and Mouse Models as a Translational Approach to Understand SARS-CoV-2Review Published on 2020-08-122022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] acute respiratory syndrome addressed approaches caused Clinical course clinical disease coronavirus Course COVID-19 COVID-19 patients detrimental develop disease highlighting Host Human humanized humans Infection lack lesson MHV mice mitigate Model mortality rate mouse mouse hepatitis virus mouse hepatitis virus (MHV) mouse model murine murine model murine models offer organotropism pandemic Pathogenesis pathology provide Respiratory Coronavirus rising SARS-CoV SARS-CoV-2 SARS-CoV-2 transmission similarities Therapeutic strategies therapy translational Transmission Treatment Vaccine viral infection while World Health Organization [DOI] 10.3390/v12080880 PMC 바로가기 [Article Type] Review
Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies로피나비르에 대한 임신초기 노출(다루나비르 아님)은 탈락막화를 손상시킵니다: HIV 양성 임신에서 출산 결과가 좋지 않을 수 있는 잠재적 기전Article Published on 2020-08-012022-09-11 Journal: Human reproduction (Oxford, England) [Category] Coronavirus, 비임상, [키워드] Activation Administered Affect age alteration Analysis Angiogenesis animal model Antiretroviral therapy approval Biomarker Biomarkers biopsy birth outcomes breath cART cause caution Cell Cell culture cells chance clinical implications clinical trial clinical trials clinically co-culture Combination complement Complement activation conception contributing to correlation COVID-19 COVID-19 pandemic Culture culture system current darunavir decidualization decrease drug candidate Drug safety dysregulation early pregnancies early pregnancy early stage early stages Effects Efficacy ELISA evaluate evaluated event Evidence evidence of Ex vivo experimental models expression Factor Factors female first trimester flow cytometry for inclusion foundation funding gestational age Health care Health care worker health care workers healthy highest highlight HIV HIV infection HIV protease inhibitor HIV protease inhibitors immune cell population immune cell populations immune dysregulation Immunohistochemical analysis immunohistochemistry impair impairment implication in vitro in vivo include Inflammation initiated lack leads Lopinavir Luminex assay Lye matter maturation mechanism media mice Migration modify mouse natural killer Natural killer cells offered once daily outcome outcomes Participation placental placentation potential mechanism pregnancies Pregnancy pregnant women prophylactically protease PROTECT quantified reduced regimen regulate reported reproductive resource Respiratory disease sacrifice Safe selective specific effect specific effects spiral spiral artery spiral artery remodeling STAT3 Stephen Support supported TANK termination of pregnancy therapeutic potential Think tank tissue transcription factor Transgender Treatment Trial trophoblast trophoblasts uterine uterine natural killer cells. Vascular viability was measured was obtained was used water were used with HIV women [DOI] 10.1093/humrep/deaa151 PMC 바로가기 [Article Type] Article
Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoproteinArticle Published on 2020-07-172022-10-04 Journal: Nature Communications [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome Analysis Antigen caused Cell conserved contribute coronavirus Coronaviruses Cryo-electron microscopy cryo-EM structure Cryoelectron microscopy form glycoprotein Health Hepatitis highly pathogenic Host information linker mechanism membrane membrane fusion MERS-CoV MHV motif mouse Protein Proteins receptor respiratory syndrome coronavirus responsible S2 subunit SARS virus SARS-CoV SARS-CoV S SARS-CoV-2 SARS-like coronaviruses significantly spike glycoprotein Structure target therapeutic therapy trimer upstream Vaccine viral entry viral membrane virus [DOI] 10.1038/s41467-020-17371-6 PMC 바로가기 [Article Type] Article
Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers성숙하는 배 중심에서 B 세포 친화도 분포에 대한 항원 투여량의 효과에 대한 정량적 모델링Article Published on 2020-06-152024-07-28 Journal: eLife [Category] 파상풍, [키워드] Affinity maturation antigen dosage B-cell mouse statistical inference systems modeling [DOI] 10.7554/eLife.55678 PMC 바로가기
Formin-like 1 mediates effector T cell trafficking to inflammatory sites to enable T cell-mediated autoimmunityArticle Published on 2020-06-082023-08-30 Journal: eLife [Category] E형 간염, [키워드] Actin Autoimmunity Cell migration cytoskeleton FMNL1 mouse T cell [DOI] 10.7554/eLife.58046 PMC 바로가기
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across TissuesArticle Published on 2020-05-282022-10-31 Journal: Cell [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 expression acute respiratory syndrome airway epithelial cell angiotensin-converting enzyme 2 Anti-viral bind cause Cell cells cellular cellular entry clade coronavirus COVID-19 dataset disease ENhance Enterocyte epithelia epithelial Factor goblet secretory cells Health Host host proteases host response host tissue Human identify ileal absorptive enterocytes implication Infection Influenza interferon interferon-stimulated gene ISG lung Lung injury lung tissue mechanism mouse mouse single-cell RNA-sequencing nasal non-human primate Pathogenesis Pneumocytes promote Protein raising regulate SARS-CoV-2 SARS-CoV-2 spike scRNA-seq single-cell RNA-seq dataset Specific subset target the disease tissue tissues TMPRSS2 TMPRSS2 expression transmembrane serine protease Type type II pneumocytes upregulated upregulation urgency viral infections [DOI] 10.1016/j.cell.2020.04.035 PMC 바로가기 [Article Type] Article
SARS-CoV-2 strategically mimics proteolytic activation of human ENaCShort Report Published on 2020-05-262022-10-31 Journal: eLife [Category] COVID-19, MERS, SARS, [키워드] ACE2 Activation acute respiratory distress syndrome adopted Affect airway Amino acid Analysis block cause Cell cell type cells cellular cleavage cleavage site cleave conditions coronavirus COVID-19 COVID-19 infections COVID-19 pandemic COVID-19 patients Critical diagnose dysregulation ENaC enzyme epithelial explain expression global pandemic Health help highlight highlighting homeostasis Host host cell Human human cell human lung human proteins human respiratory cells identify identifying infect interfere lifecycle lung Lungs mechanism molecular mimicry mouse organ overlap pathophysiology patients peptide Prevent protease Protein Proteins proteolytic proteolytic activation receptor ACE2 remained respiratory tract respiratory tract cell resulting RNA-Seq S1/S2 cleavage site SARS-CoV-2 sequence sequenced severe respiratory symptoms sodium spike the SARS-CoV-2 the spike protein treat unique virus [DOI] 10.7554/eLife.58603 PMC 바로가기 [Article Type] Short Report