COVID-19 patient serum less potently inhibits ACE2-RBD binding for various SARS-CoV-2 RBD mutantsCOVID-19 환자 혈청은 다양한 SARS-CoV-2 RBD 돌연변이에 대한 ACE2-RBD 결합을 덜 강력하게 억제합니다Article Published on 2022-05-032022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 ACE2 binding ACE2 receptor ACE2-RBD ACE2-RBD binding Affect Analysis analyzed antibody bead binding classical correlated COVID-19 patient COVID-19 patient serum disease severity displaying E484K E484K mutation examined extension IgG levels immune protection increasingly Infectious virus inhibit Interaction less Longevity mimicking multiplex Multiplex assay mutant NAbs neutralization test neutralization tests Neutralizing activity Neutralizing antibodies positively correlated proceed protective immunity RBD RBDs Receptor binding domain reduced SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 variants serological serum sample serum samples severity the RBD therapy vaccination variant variants variants of interest virus neutralization test VoC VOCs VOIs was reduced WHO wild-type [DOI] 10.1038/s41598-022-10987-2 PMC 바로가기 [Article Type] Article
Antibody Profiling in COVID-19 Patients with Different Severities by Using Spike Variant Protein Microarrays스파이크 변이 단백질 마이크로어레이를 사용한 다양한 중증도의 COVID-19 환자에서 항체 프로파일링Article Published on 2022-05-032022-09-11 Journal: Analytical Chemistry [Category] MERS, 변종, 진단, [키워드] ACE2 ACE2 binding antibody antibody isotypes collected competition COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical critical cases death demonstrated Disease progression dose-dependent inhibition Drug screening elevated evaluated except for healthy subject healthy subjects humoral Humoral immunity immune inhibitors Microarray Mild Neutralizing activity Neutralizing antibodies nonstructural protein 3 patients Perindopril Profiling Protein protein 3 ramipril serum serum IgG severity Specificities specificity spike spike variant spike variants variant [DOI] 10.1021/acs.analchem.1c05567 PMC 바로가기 [Article Type] Article
Seroprevalence of SARS-CoV-2 IgG Antibodies and Factors Associated with SARS-CoV-2 IgG Neutralizing Activity among Primary Health Care Workers 6 Months after Vaccination Rollout in France프랑스에서 백신 접종 6개월 후 1차 의료 종사자들 사이에서 SARS-CoV-2 IgG 항체 및 SARS-CoV-2 IgG 중화 활성과 관련된 인자의 혈청유병률Article Published on 2022-05-032022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] 95% CI 95% confidence interval activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antibody association booster dose booster doses capillary blood Care conducted coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 vaccine cross-sectional survey Factor Factors France Health Health care Health care worker health care workers highlight Immunoglobulin Immunoglobulin G immunoglobulin G response Month multivariate N protein Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody nucleocapsid Odds ratio participant presence of antibody primary care Primary Health Care Protein questionnaire regression analysis respiratory S protein S-1 SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 IgG SARS-COV-2 infection sera Seroprevalence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly significantly more tested the N protein the S protein vaccination vaccine dose vaccine doses worker [DOI] 10.3390/v14050957 PMC 바로가기 [Article Type] Article
Humoral Response to BNT162b2 Vaccine Against SARS-CoV-2 Variants Decays After Six MonthsSARS-CoV-2 변이체에 대한 BNT162b2 백신에 대한 체액 반응은 6개월 후 쇠퇴합니다.Article Published on 2022-05-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] addition Against age age and gender Alpha Alter analyzed B.1 BNT162b2 BNT162b2 vaccine carried changes in Complete D614G decay decrease Delta determine Effectiveness evade evaluated Evidence FIVE Follow-up Gamma GraphPad humoral immune response immune escape mutation immune escape mutations immune response Immunity immunization immunogenicity individual men Month Neutralization assay Neutralizing Neutralizing activity Neutralizing antibodies neutralizing capacity Neutralizing titer Older participant plaque reduction neutralization Prospective Study protocols raised reduction response SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants serum serum sample serum samples severity shown Support titer titers Transmissibility vaccination Vaccine variant variants Viral viral variant Viral variants was measured [DOI] 10.3389/fimmu.2022.879036 PMC 바로가기 [Article Type] Article
Cross-Variant Neutralizing Serum Activity after SARS-CoV-2 Breakthrough InfectionsSARS-CoV-2 돌발 감염 후 교차 변이 중화 혈청 활성Article Published on 2022-05-012022-09-11 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 2019 novel coronavirus disease activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 B cell Breakthrough infection comparable coronavirus coronavirus disease correlated COVID-19 determine Immunity interval mRNA Neutralizing Neutralizing activity neutralizing antibody neutralizing titers Novel coronavirus novel coronavirus disease respiratory respiratory infections SARS-CoV-2 serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 tested vaccination Vaccines variants of concern viruses zoonoses [DOI] 10.3201/eid2805.220271 PMC 바로가기 [Article Type] Article
Induction of humoral and cellular immune responses to COVID-19 mRNA and vector vaccines: A prospective cohort study in Bulgarian healthcare workersCOVID-19 mRNA 및 벡터 백신에 대한 체액 및 세포 면역 반응의 유도: 불가리아 의료 종사자를 대상으로 한 전향적 코호트 연구Article Published on 2022-05-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] advanced age age anti-SARS-CoV-2 immune responses anti-SARS-CoV-2 vaccine anti-SARS-CoV-2 vaccines BNT162b2 Bulgarian cellular Cellular immune response circulating Cohort comparable Complete coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 COVID-19 vaccine Donor donors dose Enumeration evaluated healthcare worker humoral humoral immune response IFNγ IgA immune responses Immunity immunization Immunoglobulin immunoglobulin A increased risk induce induction Infection Installing interferon gamma Longevity Messenger RNA mRNA mRNA vaccine Neutralizing activity neutralizing antibody overcome Pandemics participant peaking priming prospective cohort study protective immunity Receptor-binding domain SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 specific T-cell significantly single dose T cell T cells tested Vaccine vaccine cohort virus-neutralizing virus-neutralizing antibody virus-neutralizing antibody. [DOI] 10.1002/jmv.27572 PMC 바로가기 [Article Type] Article
Boosting of serum neutralizing activity against the Omicron variant among recovered COVID-19 patients by BNT162b2 and CoronaVac vaccinesBNT162b2 및 CoronaVac 백신으로 회복된 COVID-19 환자 중 Omicron 변이체에 대한 혈청 중화 활성 증가Article Published on 2022-05-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Analysis Antibody test Beta Beta variant BNT162b2 characteristic CoronaVac country COVID-19 Cutoff Delta delta variant detectable determine dose evade geometric geometric mean greater Immunity Inactivated vaccine individual induce Infection Live virus Michael mRNA vaccine NAb titer Neutralizing activity neutralizing antibody of BNT162b2 omicron Omicron variant prospective cohort study Protein receiver receiver operating characteristic Receptor binding recipient recovered COVID-19 patient Recovered COVID-19 patients Reinfection Richard risk SARS-CoV-2 Sensitivity and specificity seropositive serum Serum neutralizing antibody significantly higher spike Spike protein Spike protein receptor binding domain statistically subgroup analysis surrogate Surrogate neutralizing antibody test vaccination Vaccine variant variants virus with COVID-19 [DOI] 10.1016/j.ebiom.2022.103986 PMC 바로가기 [Article Type] Article
Neutralizing antibodies to SARS-CoV-2 Omicron variant after third mRNA vaccination in health care workers and elderly subjects의료 종사자 및 노인 대상에서 세 번째 mRNA 백신 접종 후 SARS-CoV-2 Omicron 변이체에 대한 중화 항체Article Published on 2022-05-012022-09-11 Journal: European Journal of Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] administration age antibody Antibody responses B.1.1.529 Beta booster booster vaccination Breakthrough infection breakthrough infections collected Concentration Coronavirus disease 2019 COVID-19 cross-protective cross-reactive Delta detectable dose expected HCW HCWs Health care Health care worker health care workers IgG IgG antibody mRNA vaccination mRNA vaccine Mutation NAb NAb titer NAb titers NAbs neutralization Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody nursing home omicron Postinfection raised reduced remained SARS-CoV-2 severe COVID-19 significantly Spike protein subject subjects subsequent the antibody response the spike protein vaccination vaccine dose variant variants variants of concern WT virus [DOI] 10.1002/eji.202149785 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron variant: recent progress and future perspectivesSARS-CoV-2 오미크론 변종: 최근 진행 상황 및 미래 전망Review Published on 2022-04-282022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibody B.1.1.529 cell tropism Clinical characteristics convalescent serum coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta dominant variant exhibit immune evasion Infection molecular mutated Neutralizing activity omicron Omicron variant outbreak pandemic pathogenicity Perspective raised reduced regions replaced SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus shown therapeutic Therapies Transmissibility Vaccines variant [DOI] 10.1038/s41392-022-00997-x PMC 바로가기 [Article Type] Review
Virological and Clinical Determinants of the Magnitude of Humoral Responses to SARS-CoV-2 in Mild-Symptomatic Individuals경증-증상이 있는 개인의 SARS-CoV-2에 대한 체액 반응의 바이러스학적 및 임상적 결정인자Article Published on 2022-04-282022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] acute infection age anti-SARS-CoV-2 antibody Antibody titer clinical cohort study contribute COVID-19 determinant duration of symptom ELISA female group healthy individual humoral Humoral response humoral responses individual magnitude median Mild mild COVID-19 patients Negative PCR Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing response Neutralizing titer Older age plasma positive PCR pseudovirus recruited response RT-qPCR SARS-CoV-2 SARS-CoV-2-infected individuals Seroconversion symptom duration Symptoms viral dynamics Viral load [DOI] 10.3389/fimmu.2022.860215 PMC 바로가기 [Article Type] Article