NK cell – Page 14 – Communicable Diseases Research

Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection

인간화 COVID-19 미끼 항체는 바이러스 침입을 효과적으로 차단하고 SARS-CoV-2 감염을 예방합니다

Article

Published on 2020-11-302022-09-11
Journal: EMBO Molecular Medicine [Category] SARS, 변종, 진단,

Circulating Cytokines and Lymphocyte Subsets in Patients Who Have Recovered from COVID-19

Research Article

Published on 2020-11-262022-10-27
Journal: BioMed Research International [Category] COVID-19,

[키워드] Alpha Analysis analyzed B cell B cells CD19 CD3 CD4 CD56 CD8 circulating Cohort Concentration consequence correlation COVID-19 COVID-19 infections cytokine decrease discharge Efficacy flow cytometry growth factor healthy controls hospital Hyperinflammatory IFN IL-10 IL-17 IL-2 IL-4 IL-6 IL-8 Immune status immune system increases in independent predictor Infection interferon gamma longitudinal study lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Necrosis NK cell NK cells observation Patient patients positively correlated recovered recovered patient recruited rehabilitation remained ROC Curve serum significantly higher significantly lower sustained T cell T cells TGF TNF- α
[DOI] 10.1155/2020/7570981 PMC 바로가기 [Article Type] Research Article

Circulating Cytokines and Lymphocyte Subsets in Patients Who Have Recovered from COVID-19

Research Article

Published on 2020-11-262022-10-27
Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS,

[키워드] Alpha Analysis analyzed B cell B cells CD19 CD3 CD4 CD56 CD8 circulating Cohort Concentration consequence correlation COVID-19 COVID-19 infections cytokine decrease discharge Efficacy flow cytometry growth factor healthy controls hospital Hyperinflammatory IFN IL-10 IL-17 IL-2 IL-4 IL-6 IL-8 Immune status immune system increases in independent predictor Infection interferon gamma longitudinal study lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Necrosis NK cell NK cells observation Patient patients positively correlated recovered recovered patient recruited rehabilitation remained ROC Curve serum significantly higher significantly lower sustained T cell T cells TGF TNF- α
[DOI] 10.1155/2020/7570981 PMC 바로가기 [Article Type] Research Article

Dynamics of NK, CD8 and Tfh cell mediated the production of cytokines and antiviral antibodies in Chinese patients with moderate COVID‐19

NK, CD8 및 Tfh 세포의 역학은 중등도 COVID-19 환자에서 사이토카인 및 항바이러스 항체 생성을 매개합니다

Original Article

Published on 2020-11-032022-09-12
Journal: Journal of Cellular and Molecular Medicine [Category] MERS, SARS, 진단,

[키워드] abnormal increase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed antibody antiviral antibody B‐cell benefit caused CD226 CD4 CD8 Cell cell count cellular change Chinese patient contribute control patient control patients convalescent convalescent patient coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 cytokine cytokine level cytokine levels Cytokines decrease demonstrated Dynamics effector effector memory electrochemiluminescence immunoassay enrolled expression flow cytometry iCoS immune responses increase in Inflammatory cytokine Inflammatory cytokines inhibitory innate immune response lymphocyte maintenance memory moderate NK NK cell NK cells Patient patients with moderate peripheral lymphocyte Pneumonia Prevent recent respiratory RT‐PCR SARS‐CoV‐2 SARS‐CoV‐2‐specific antibodies SARS‐CoV‐2‐specific antibody severe acute respiratory syndrome Coronavirus Severe case severe cases significantly higher significantly increased subset T cell T cells T‐cell Tfh TIM‐3
[DOI] 10.1111/jcmm.16044 PMC 바로가기 [Article Type] Original Article

BCG revaccination of health workers in Brazil to improve innate immune responses against COVID-19: A structured summary of a study protocol for a randomised controlled trial

COVID-19에 대한 타고난 면역 반응을 개선하기 위해 브라질에서 의료 종사자의 BCG 재접종: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2020-10-262022-08-13
Journal: Trials [Category] MERS, SARS, 임상,

[키워드] accompany activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Admission Antibiotics antiviral immune response approved assigned Autoimmune Autoimmune diseases Bacillus BCG BCG revaccination BCG vaccination bcg vaccine blinded Blinding block blocks both groups Brazil Breastfeeding carried CFU Characteristics Chemotherapy childhood city clinical trial Committee Comorbidities Comorbidity confirmation Contact contact with control group Coronavirus-2 COVID-19 COVID-19 patient COVID-19 severity COVID-19 symptoms COVID-19 test cross-protection determined by diagnosed direct contact disease disease severity Diseases dissemination dose doses Effectiveness element elicited eligibility criteria Fever health worker health workers healthcare providers HIV hospital Hypothesis ICU identification number IgG and IgM IgM and IgG IgM test immunosuppressive IMPROVE in both group incidence incidence of COVID-19 Inclusion inclusion criteria India induce Infection infections information innate immune response investigator Laboratory lateral flow less macrophages medication meet memory monocyte Monocytes Mortality naso-oropharyngeal swab neutrophil Neutrophils NK NK cell number Nurses objective Open-label outcome outcomes pandemic parallel-group participant physiotherapists platform presenting Prevent Primary outcome Primary outcomes professional protocol randomisation randomised randomised controlled trial randomization Randomized receive recruit recruitment reduce Registered registration number researcher researchers respiratory revaccination right arm RT-PCR Sample size SARS-CoV-2 scar sealed Secondary objective Secondary objectives secondary outcome severe acute respiratory syndrome Coronavirus severity solid tumour specimen statistical analyses status steroid Study protocol Symptom symptomatic infection the disease the vaccine Trial Trial registration Tuberculosis two groups vaccination Vaccine virus virus infection virus infections was performed website WHO
[DOI] 10.1186/s13063-020-04822-0 PMC 바로가기 [Article Type] Letter

Heightened Circulating Interferon-Inducible Chemokines, and Activated Pro-Cytolytic Th1-Cell Phenotype Features Covid-19 Aggravation in the Second Week of Illness

Immunology

Published on 2020-10-202022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] activated adaptive aggravation CD4+ chemokine circulating COVID-19 Critical CXCL10 CXCL8 CXCL9 cytokine cytolytic disease disease pathogenesis disease severity enrolled event feature Frequency IFN IL-10 IL-6 illness immune Immunity immunopathology individual Inflammatory responses investigated Mild mild illness monocyte NK cell no difference Non-classical monocytes observation paO2/fiO2 PaO2/FiO2 ratio pathogenic Patient PBMC phenotype plasma Protective reactive oxygen specy response ROS S/M/N protein-reactive T-cells SARS-CoV-2 SARS-CoV-2-specific T-cell response second significantly increased Symptoms T-cells target Th1 Th1 cell therapy trifunctional Vaccine development Week were assessed were measured
[DOI] 10.3389/fimmu.2020.580987 PMC 바로가기 [Article Type] Immunology

The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing

Article

Published on 2020-10-202022-10-04
Journal: Cell Discovery [Category] 치료제,

[키워드] activated association BALF bioinformatics Blood CCL4 CCL5 CD4 CD8 Cell cell death characterized chemokines correlated COVID-19 COVID-19 patient cytokine DCs dendritic cell effective Frequency healthy controls IFNg Immune cell immune dysfunction immune response immunology indicated Inflammation interferons lung lymphopenia mechanism monocyte monocyte-macrophage mononuclear cell NK cell PBMCs Peripheral blood produced proportion recruitment secreted severe coronavirus disease severe COVID-19 severe COVID-19 patients significantly Single-cell RNA sequencing T cell T cell subset TCR Th1 Th2 TNF Treatment understanding uninfected control
[DOI] 10.1038/s41421-020-00225-2 PMC 바로가기 [Article Type] Article

Reduced numbers of T cells and B cells correlates with persistent SARS-CoV-2 presence in non-severe COVID-19 patients

Article

Published on 2020-10-192022-10-04
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 임상, 치료기술,

Unique immunological profile in patients with COVID-19

COVID-19 환자의 독특한 면역 프로필

Clinical Trial

Published on 2020-10-152022-08-13
Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 바이오마커, 임상, 치료제,

[키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptive Analysis CD56 CD57 CD69 CD8 Cell contraction Coronavirus-2 COVID-19 COVID-19 patient Cytokines Deceased disease distribution driven by effective expansion expression FcεRIγ Frequency healthy subject healthy subjects help host immunity IL-1β IL-6 IL-8 IL6 immature immune response immune responses Immunoglobulin immunological profile Increased Infection Inflammatory cytokine Inflammatory cytokines interferon Interleukins lectin Lymphocytes monocyte Monocytes Monocytes and macrophages mucin natural killer NK cell NK cells NKG2D outcome overexpressed Patient patients with COVID-19 PD-1 performed Peripheral blood peripheral blood lymphocytes positive cell positive cells programmed cell death programmed cell death protein proportion Protein reduced respiratory restoration SARS-CoV-2 SARS-COV-2 infection secrete secreted secretion Serum level Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe COVID-19 severe SARS severe SARS-CoV-2 sialic acid Survivors T cell T cells T-cell TIM-3 Treatment unique viral infection with COVID-19
[DOI] 10.1038/s41423-020-00557-9 PMC 바로가기 [Article Type] Clinical Trial

Elevated Exhaustion Levels of NK and CD8 + T Cells as Indicators for Progression and Prognosis of COVID-19 Disease

COVID-19 질병의 진행 및 예후 지표로서의 NK 및 CD8 + T 세포의 고갈 수준 증가

Immunology

Published on 2020-10-142022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술,

[키워드] (PD-1) acute respiratory syndrome coronavirus analyzed association Blood CD16 CD244 CD3 CD4 CD56 CD8 Cell cell population Characteristics circulating Clinical data collected contribute coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient Critical Critical illness cytokine Cytokines demographic disease disease severity dysregulation effector molecule elevated eliminating enrolled evaluated Exhaustion expression flow cytometry functional IL-10 IL-6 immune dysregulation immune system IMPROVE Indicator infected cells Level Logistic regression logistic regression model lymphocyte Lymphocyte subset Lymphocyte subsets natural killer natural killer (NK) cells NK cell NK cells NKT cell NKT cells Pathogenesis Patient patients with COVID-19 PD-1 percentage percentages perforin phenotypic predict Prognosis progression public health reduced Regulatory respiratory Result risk factor Risk factors SARS-CoV-2 screened serum Serum IL-6 Serum level serum levels severe acute respiratory syndrome coronavirus 2 Severe case severe cases severe COVID-19 patients severe patients severe symptoms severity of COVID-19 significantly significantly increased subset T cell T cells TNF-α Union Hospital virus Wuhan
[DOI] 10.3389/fimmu.2020.580237 PMC 바로가기 [Article Type] Immunology