Antimicrobial peptides: A plausible approach for COVID-19 treatmentReview Published on 2022-03-092023-07-01 Journal: Expert opinion on drug discovery [Category] COVID19(2023년), SARS, [키워드] antivirals coronavirus COVID-19 peptides SARS-CoV-2 [DOI] 10.1080/17460441.2022.2050693 PMC 바로가기 [Article Type] Review
Persistence of Immune Response in Health Care Workers After Two Doses BNT162b2 in a Longitudinal Observational Study종단 관찰 연구에서 BNT162b2 2회 투여 후 의료 종사자의 면역 반응 지속Observational Study Published on 2022-03-042022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] age All participants Analysis antibody average binding binding antibody BNT162b2 BNT162b2 vaccine booster dose booster doses booster vaccinations Care cellular Cellular immune response Course COVID-19 disease declining described detectable dose Efficacy evaluated Follow-up groups Health Health care Health care worker hospital humoral humoral and cellular immunity humoral immune response immune response immunological Immunological memory individual interferon Interferon-gamma longitudinal mRNA mRNA-based vaccine Neutralizing antibodies obesity observational study of BNT162b2 Older age participant Participants peptide peptides persistence Pfizer Quantitative response response rate resulting SARS-CoV-2 SARS-COV-2 infection second dose semi-quantitative Serological testing shown vaccination Vaccine worker [DOI] 10.3389/fimmu.2022.839922 PMC 바로가기 [Article Type] Observational Study
The vital role of animal, marine, and microbial natural products against COVID-19Covid-19에 대한 동물, 해양 및 미생물 천연 제품의 중요한 역할Review Published on 2022-03-022022-09-10 Journal: Pharmaceutical Biology [Category] 신약개발, 치료제, [키워드] 3CLpro animal Anti-inflammatory Antiviral approach Bromelain carrageenan clinical trial clinical trials Combination combination treatment Context COVID-19 COVID-19 therapy COVID19 database derivative Direct Drug development Effect Efficacy evaluated flavonoids hACE2 highlighting host proteins immunomodulatory properties in silico inhibitory less management mechanism microbial microbial products microorganisms MOST nasal Nasal spray NF-κB objective omega-3 omega-3 supplementation organism outbreak pandemic Pathogenesis peptide peptides pharmacological plants PLPro Prevent profile quercetin raw data researcher Result SARS-CoV-2 SARS-CoV-2coronavirus Science Science Direct searched synergistic synergistic effects tannins target tested therapy these compound these compounds Treatment Viral viral entry Vitamin C Zinc [DOI] 10.1080/13880209.2022.2039215 PMC 바로가기 [Article Type] Review
Gramicidin S and melittin: potential anti-viral therapeutic peptides to treat SARS-CoV-2 infectionGramicidin S 및 Melittin : SARS-COV-2 감염을 치료하는 잠재적 항 바이러스 치료 펩티드Article Published on 2022-03-022022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] Analysis Anti-SARS-CoV-2 Activity Anti-viral Antibacterial Antiviral approach Bacillus brevis candidate Cell Biology COVID19 cytotoxicity de novo decrease drug Drug discovery GRAMICIDIN in vitro indicated Infection less melittin molecules mRNA pandemic peptide peptides post infection Protein regulated SARS-CoV-2 SARS-COV-2 infection Significant significant decrease the disease the SARS-CoV-2 therapeutic treat treated Treatment Vero Cell Vero cells Viral viral clearance viral infections Viral load [DOI] 10.1038/s41598-022-07341-x PMC 바로가기 [Article Type] Article
Impact of SARS-CoV-2 on saliva: TNF-⍺, IL-6, IL-10, lactoferrin, lysozyme, IgG, IgA, and IgMSARS-CoV-2가 타액에 미치는 영향: TNF-⍺, IL-6, IL-10, 락토페린, 리소자임, IgG, IgA 및 IgMArticle Published on 2022-03-012022-09-11 Journal: Journal of oral biosciences [Category] MERS, SARS, 진단, 치료기술, [키워드] acute SARS-CoV-2 infection airway Alter Analysis antimicrobial antimicrobial peptides Asymptomatic carried Chain Reaction components Concentration Control control group COVID-19 COVID-19 symptom COVID-19 symptoms Defense detect diagnosis of SARS-CoV-2 ELISA evaluate female group IgA IgG IgM IL-10 IL-6 immune immunoglobulins Impact increase in Infection Interleukins lactoferrin less longitudinal study lysozyme male Patient patients with COVID-19 PCR peptides polymerase chain polymerase chain reaction Prognosis Real-time PCR recovered patient Saliva salivary SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic significantly symptoms of COVID-19 understanding Volunteer [DOI] 10.1016/j.job.2022.01.007 PMC 바로가기 [Article Type] Article
Discovery of a Natural Product with Potent Efficacy Against SARS-CoV-2 by Drug Screening약물 스크리닝을 통해 SARS-CoV-2에 강력한 효능을 지닌 천연물 발견Article Published on 2022-03-012022-09-11 Journal: Interdisciplinary sciences, computational life sci [Category] SARS, 신약개발, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against alveolar epithelial cells Analysis angiotensin angiotensin-converting enzyme-2 Antiviral antiviral peptides antiviral properties attachment AVP binding binding affinity binding free energies binding free energy caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cyanovirin-N demonstrated domain drug Drug screening enzyme epithelial cells half-maximal inhibitory concentration host cell host cells human Angiotensin-converting enzyme Infection inhibit inhibited Interaction Molecular simulation natural Novel coronavirus novel coronavirus disease peptide peptides potent Prevent product provided RBD RBD binding RBD complex Receptor-binding domain recruitment residue SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S Screening severe acute respiratory syndrome Coronavirus spike glycoprotein Spread Structural analysis suppressed Therapeutic approach [DOI] 10.1007/s12539-021-00477-w PMC 바로가기 [Article Type] Article
COVID-19 Pandemic: Escape of Pathogenic Variants and MHC EvolutionCOVID-19 팬데믹: 병원성 변이체의 탈출 및 MHC 진화Hypothesis Published on 2022-02-282022-09-10 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] allele frequency bind constitution COVID-19 escape Evolution explain fitness HLA Hypothesis immune memory Immunity individual Infection lead leads less Lymphocytes maintenance memory MHC MHC evolution mutated Mutation occur pandemic pathogen pathogenic escape peptide peptides polymorphism predict Probability recognize Reinfection repertoire respond SARS-CoV-2 pandemic Support T lymphocyte T lymphocytes the SARS-CoV-2 These data vaccination variant variants Variation variations [DOI] 10.3390/ijms23052665 PMC 바로가기 [Article Type] Hypothesis
Limited induction of SARS-CoV-2–specific T cell responses in children with multisystem inflammatory syndrome compared with COVID-19COVID-19에 비해 다기관 염증 증후군 아동에서 SARS-CoV-2-특이 T 세포 반응의 제한된 유도Research Article Published on 2022-02-222022-09-10 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 치료법, [키워드] Adaptive immunity B cell responses CD4 CD8 Cellular immune response children contribute convalescent COVID-19 cytokine cytokine production cytokine response demonstrated develop full-length functional healthy controls Inflammatory Limited MIS-C mononuclear cell mononuclear cells nucleocapsid participant Pathogenesis peptides Peripheral blood Peripheral blood mononuclear cells plasma predominant quantified RBD Receptor binding domain responses against SARS-CoV-2 antigen SARS-COV-2 infection serologic Serologic response serologic responses significantly lower Spike receptor binding domain subset Support syndrome T cell T cell response T cell responses T cells Th1 Viral Viral proteins was reduced with COVID-19 [DOI] 10.1172/jci.insight.155145 PMC 바로가기 [Article Type] Research Article
Developing an Effective Peptide-Based Vaccine for COVID-19: Preliminary Studies in Mice ModelsCOVID-19에 대한 효과적인 펩티드 기반 백신 개발: 마우스 모델의 예비 연구Article Published on 2022-02-222022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] adjuvant affinity antibody Antibody Response autoimmune responses B cell epitope B cell epitopes B cell response C57BL/6 caused convalescent individuals coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated Developing effective Effectiveness epitope epitope mapping Epitopes flexibility generate Health HLA Human in silico mice Model Neutralizing Neutralizing activity peptide peptide-based vaccine peptides plasma predicted Prevent produced Protein Respiratory Coronavirus Safe SARS-CoV-2 SARS-CoV-2 variant selected Spike protein Spread stimulated T and B cell responses T and B cells T cell T cell responses tested two group two groups Vaccine viral variant Viral variants virus wild-type [DOI] 10.3390/v14030449 PMC 바로가기 [Article Type] Article
Higher SARS-CoV-2 Spike Binding Antibody Levels and Neutralization Capacity 6 Months after Heterologous Vaccination with AZD1222 and BNT162b2Article Published on 2022-02-172022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] anti-spike IgG levels AZD1222 BNT162b2 breakthrough infections Capacity Cellular immune response clinically evaluated comparable COVID-19 Delta delta variant Efficacy group Health care worker heterologous prime-boost Heterologous prime-boost vaccination highest homologous humoral humoral and cellular immune response IFNγ Level magnitude Month neutralizing capacity offered peptide peptides question Receptor binding domain recruited regimen resulting SARS-CoV-2 SARS-CoV-2 vaccine secretion significantly significantly higher spike symptomatic disease the vaccine vaccination Vaccinations Vaccine variant of concern variants of concern viral neutralization wild type Wuhan-Hu-1 [DOI] 10.3390/vaccines10020322 PMC 바로가기 [Article Type] Article