In vitro metabolism and in vivo pharmacokinetics of bentysrepinine (Y101), an investigational new drug for anti-HBV-infected hepatitis: focus on interspecies comparisonArticle Published on 2020-04-012023-06-13 Journal: Xenobiotica; the fate of foreign compounds in biol [Category] B형 간염, [키워드] metabolic profile pharmacokinetics species differences toxicokinetics. Y101 [DOI] 10.1080/00498254.2019.1646946 PMC 바로가기
Safety, efficacy, and pharmacokinetics of pradefovir for the treatment of chronic hepatitis B infectionClinical Trial Published on 2020-02-012023-06-13 Journal: Antiviral Research [Category] B형 간염, [키워드] clinical trial pharmacokinetics prodrug Safety Viral hepatitis. [DOI] 10.1016/j.antiviral.2019.104693 PMC 바로가기 [Article Type] Clinical Trial
A First-in-Human Trial of GLS4, a Novel Inhibitor of Hepatitis B Virus Capsid Assembly, following Single- and Multiple-Ascending-Oral-Dose Studies with or without Ritonavir in Healthy Adult VolunteersRandomized Controlled Trial Published on 2019-12-202023-06-16 Journal: Antimicrobial Agents and Chemotherapy [Category] B형 간염, [키워드] CYP 3A4 GLS4 HBV pharmacokinetics Ritonavir Safety. [DOI] 10.1128/AAC.01686-19 PMC 바로가기 [Article Type] Randomized Controlled Trial
Safety and Pharmacokinetics of Glecaprevir/Pibrentasvir in Adults With Chronic Genotype 1–6 Hepatitis C Virus Infections and Compensated Liver Disease만성 유전자형 1-6형 C형 간염 바이러스 감염 및 대상성 간 질환이 있는 성인에서 Glecaprevir/Pibrentasvir의 안전성 및 약동학Major Articles and Commentaries Published on 2019-11-152022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] adverse event Analysis Antiviral Child-Pugh A chronic chronic hepatitis Chronic kidney disease cirrhosis CKD class clinical clinical trials clinically Combination compensated compensated cirrhosis demonstrated direct-acting Drug-induced liver injury Efficacy Efficacy and safety evaluate fatigue Frequency Genotype glecaprevir glecaprevir/pibrentasvir HCV headache hepatitis C hepatitis C virus increase in Infection Kidney disease lead liver Liver Biopsy Liver damage Liver disease Liver injury Patient patients pharmacokinetics phase pibrentasvir PK analysis regimen Registration Result ribavirin SAE SAEs Safe Safety serious AE serum biomarkers Stage sustained Treatment was determined [DOI] 10.1093/cid/ciz022 PMC 바로가기 [Article Type] Major Articles and Commentaries
Tenofovir Exposure during Pregnancy and Postpartum in Women Receiving Tenofovir Disoproxil Fumarate for the Prevention of Mother-to-Child Transmission of Hepatitis B VirusRandomized Controlled Trial Published on 2018-11-262023-06-18 Journal: Antimicrobial Agents and Chemotherapy [Category] B형 간염, [키워드] Hepatitis B virus pharmacokinetics Pregnancy tenofovir. [DOI] 10.1128/AAC.01686-18 PMC 바로가기 [Article Type] Randomized Controlled Trial
Determination of telbivudine in the plasma of chronic hepatitis B patients in long-term treatment by high-performance liquid chromatographic-tandem mass spectrometryArticle Published on 2018-04-012023-06-19 Journal: Biomedical chromatography : BMC [Category] B형 간염, [키워드] creatine kinase Mitochondrial toxicity Myopathy pharmacokinetics quantitation telbivudine. [DOI] 10.1002/bmc.4140 PMC 바로가기
Pharmacokinetic evaluation of besifovir for the treatment of HBV infectionReview Published on 2018-01-012023-06-19 Journal: Expert opinion on drug metabolism & toxicology [Category] B형 간염, [키워드] adverse effects Besifovir Carnitine Efficacy Hepatitis B virus humans nucleotide analogue pharmacokinetics renal toxicity. [DOI] 10.1080/17425255.2018.1417983 PMC 바로가기 [Article Type] Review
Pharmacokinetics and Safety of Amenamevir in Healthy Subjects: Analysis of Four Randomized Phase 1 StudiesClinical Trial Published on 2017-12-012023-06-01 Journal: Advances in therapy [Category] 두창, 수두, 홍역, [키워드] amenamevir Japanese participants pharmacokinetics Safety Varicella–zoster virus. [DOI] 10.1007/s12325-017-0642-4 PMC 바로가기 [Article Type] Clinical Trial
The Influence of Hepatic and Renal Impairment on the Pharmacokinetics of a Treatment for Herpes Zoster, Amenamevir (ASP2151): Phase 1, Open-Label, Single-Dose, Parallel-Group StudiesClinical Trial Published on 2017-12-012023-06-01 Journal: Advances in therapy [Category] 두창, 수두, 홍역, [키워드] amenamevir hepatic impairment herpes zoster pharmacokinetics renal impairment Safety. [DOI] 10.1007/s12325-017-0643-3 PMC 바로가기 [Article Type] Clinical Trial
Safety, Tolerability, and Pharmacokinetics of ARC-520 Injection, an RNA Interference-Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy VolunteersClinical Trial Published on 2017-07-012023-06-19 Journal: Clinical pharmacology in drug development [Category] B형 간염, [키워드] hepatitis B pharmacokinetics Pharmacology Phase 1 RNA interference RNAi Safety Tolerability Treatment Viral hepatitis volunteers. [DOI] 10.1002/cpdd.318 PMC 바로가기 [Article Type] Clinical Trial