Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain OrganoidsArticle Published on 2020-12-292022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] active against acute respiratory syndrome Antiviral antiviral activity Antiviral compound Antiviral treatment antivirals Brain brain organoids Cell cells Compound coronavirus disease Ebola virus expand flavivirus hallmark impairing infect mechanism of action mode-of-action neurological defects neuronal new virus Organoid outbreak Particles pathogenic pathogenic RNA viruses phenotypic progenitor cells reduced Release rescued RNA virus RNA viruses SARS-CoV-2 small molecule inhibitor Spread therapeutic window transfer Virus life cycle WHO World Health Organization Zika Zika virus ZIKV [DOI] 10.3390/v13010037 PMC 바로가기 [Article Type] Article
Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA VirusesArticle Published on 2020-12-102022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Antiviral antiviral activity Antiviral compound Antiviral compounds Antiviral strategies antiviral therapies antivirals approach caused cellular cellular pathway complex coronavirus Ebola virus Effect effort Essential Factor health emergency Hemorrhagic fever virus highlighting host cell Hsp70 identify Interaction knowledge novel outbreak pathogenic pathogenic RNA viruses pathway phenotypic Protein recent RNA RNA virus RNA viruses SARS-CoV-2 small molecule inhibitor target Target identification targeting Treatment Viral proteins viral replication virus Virus-host interactions [DOI] 10.3390/v12121423 PMC 바로가기 [Article Type] Article
COVID-19-Induced ARDS Is Associated with Decreased Frequency of Activated Memory/Effector T Cells Expressing CD11a +COVID-19 유발 ARDS는 CD11a +를 발현하는 활성화된 기억/이펙터 T 세포의 빈도 감소와 관련이 있습니다Article Published on 2020-12-022022-09-12 Journal: Molecular therapy : the journal of the American So [Category] MERS, SARS, 진단, [키워드] accompanied activated acute respiratory distress analyzed Antiviral ARDS ARDS patient CD4 CD8 Characteristics circulating circulation COVID-19 COVID-19 patients COVID-19-associated ARDS Decreased demonstrated expressing flow cytometry Frequency functional generate identify immune cells immune signature Immunity intensive care marker Migration outcome Patient patients Peripheral blood phenotypic Predictive Preventing Prognostic marker progression Quantitative S-protein-reactive T cells SARS-CoV-2 significantly higher survival syndrome T cell T cell subset tissue two groups [DOI] 10.1016/j.ymthe.2020.10.001 PMC 바로가기 [Article Type] Article
Phenotypic Characteristics and Development of a Hospitalization Prediction Risk Score for Outpatients with Diabetes and COVID-19: The DIABCOVID StudyArticle Published on 2020-11-202022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] AUC BMI build Care Characteristics clinical parameter clinician Cohort cohorts collected Complication complications COVID-19 death development diabete diabetes Diabetic DIABSCORE FIVE General population glycemic control Health help Hospitalization hospitalization risk score hypertension Inpatients Insulin therapy Laboratory less medical records multivariate logistic regression obesity Older Outpatient outpatients Patient patients performed peripheral oxygen saturation phenotypic predicted prediction prevalent reduce retrospective risk risk factor ROC analysis score sensitivity severe COVID-19 specificity T2D Type variable [DOI] 10.3390/jcm9113726 PMC 바로가기 [Article Type] Article
Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers, and convalescent plasma donorsCOVID-19 환자, 의료 종사자 및 회복기 혈장 기증자의 SARS-CoV-2 급증에 대한 중화 항체Technical Advance Published on 2020-11-192022-09-12 Journal: JCI Insight [Category] SARS, 진단, [키워드] antibody Antibody testing Cellular immune response cohorts convalescent plasma COVID-19 COVID-19 pathogenesis COVID-19 patients COVID-19 symptoms Donor donors Efficacy evaluate followed by glycoprotein HCWs Health care Health care worker health care workers highest highlight HIV-1 hospitalized patients human antibody response ICU ICU Patients individual individuals intensive care intensive care unit intron lentiviral lentivirus Neutralization assay neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Patient phenotypic phenotypic variation pseudotype pseudotyped Rapid reporter SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 spike SARS-CoV-2 strain secreted serological survey Serological surveys serum the SARS-CoV-2 Treatment Variation Virus neutralization was used [DOI] 10.1172/jci.insight.143213 PMC 바로가기 [Article Type] Technical Advance
Human induced pluripotent stem cells as a tool for disease modeling and drug screening for COVID-19Articles Published on 2020-11-162022-10-31 Journal: Genetics and Molecular Biology [Category] COVID-19, [키워드] affected Brazil cell type Compound contribute COVID-19 COVID-19 pandemic disease Drug screening generate Host Human human pluripotent stem cells immortalized cell line in vitro in vivo Interaction performed phenotypic platform pluripotent stem cell Prevent Research resulting SARS-CoV-2 Screening Stem cell differentiation the disease Therapeutic strategies tissue viral infection virus [DOI] 10.1590/1678-4685-GMB-2020-0198 PMC 바로가기 [Article Type] Articles
Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibilityArticle Published on 2020-11-102022-10-04 Journal: Cell Discovery [Category] 변종, 유전자 메커니즘, 임상, 치료기술, [키워드] accounted Affect allele allele frequency Analysis association Asymptomatic Asymptomatic disease bioinformatics Chinese Chinese patient complex diseases conducted confounding factors COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 severity Critical Critically ill death disease severity DPP7 effort FIVE General population Genetic genetic architecture genetic study genetic variants Genome-wide association studies genomic GOLGA3 group help Host IL-1 ill patient Infection initial Interaction International involved Laboratory limitation locus loss of function manifestation Mechanisms of disease Mild missense variant moderate outbreak outcome Patient patients phenotypic provide Sequencing Severe patient severity Shenzhen signaling pathway significantly stability suggested susceptibility TMPRSS2 protein Variability variant whole-genome sequencing [DOI] 10.1038/s41421-020-00231-4 PMC 바로가기 [Article Type] Article
Phenotypic characterization of acute headache attributed to SARS-CoV-2: An ICHD-3 validation study on 106 hospitalized patientsSpecial Section Articles Published on 2020-11-042022-10-31 Journal: Cephalalgia [Category] COVID-19, SARS, [키워드] 24 hour acute respiratory syndrome age classification Cohort consecutive patient coronavirus Course COVID-19 criteria cross-sectional described Diagnosis explained female headache Headache disorders Hospitalized hospitalized patient Infection intensity migraine disorders Most patient Nervous system diseases occur occurred Patient patients phenotype phenotypic positive Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test screened secondary Study design Symptom tension-type headache the disease validation study viral infection [DOI] 10.1177/0333102420965146 PMC 바로가기 [Article Type] Special Section Articles
Organoid based personalized medicine: from bench to bedsideReview Published on 2020-11-022022-10-31 Journal: Cell Regeneration [Category] COVID-19, [키워드] accumulating addition application Biobanks Cancer CRISPR-Cas9 disease modeling Diseases Evidence fibrosis Genetic in vitro in vivo malignant diseases Organoid organoids organs Personalized medicine phenotypic pluripotent stem cell regenerative Research stem cell stem cells tissues translational [DOI] 10.1186/s13619-020-00059-z PMC 바로가기 [Article Type] Review
The global population of SARS-CoV-2 is composed of six major subtypesArticle Published on 2020-10-262022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] accumulate amino acid replacement approach candidate vaccine characterized Clustering compose composed Computational biology and bioinformatics confounding effect COVID-19 drugs early stage Effectiveness Evolution Genes Genetic Genetic variation Genome informatics Genotype Implications Mutation nucleocapsid ORF8 pandemic phenotypic polymorphism Polymorphisms Population Population genetics populations Protein provide Randomly reduce responsible robust SARS-CoV-2 sequence subtype Subtypes the SARS-CoV-2 the Spike Trial virus World Health Organization [DOI] 10.1038/s41598-020-74050-8 PMC 바로가기 [Article Type] Article