Risk-benefit analysis of the AstraZeneca COVID-19 vaccine in Australia using a Bayesian network modelling framework베이지안 네트워크 모델링 프레임워크를 사용한 호주 AstraZeneca COVID-19 백신의 위험-편익 분석Article Published on 2021-12-172022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 진단, [키워드] Adverse adverse events age age and sex Analysis AstraZeneca Atypical AZ vaccine Bayesian Bayesian network Bayesian networks benefit blood clot Blood clots Case fatality rate CFR COVID-19 COVID-19 vaccine death doses Effectiveness estimate Evidence example Fatality rate first dose Government group groups incidence International knowledge Local Model Other outcomes outcome portal Portal vein portal vein thrombosis portal vein thrombosis) prevented Probability reported Risk-benefit analysis SARS-CoV-2 SARS-CoV-2 variant severe disease Sex significantly Sinus thrombosis thrombocytopenia thrombosis Thrombosis/thrombocytopenia syndrome Transmission vaccination Vaccine vaccine doses Vaccines Variation venous venous sinus was used [DOI] 10.1016/j.vaccine.2021.10.079 PMC 바로가기 [Article Type] Article
Foxp3 + CD4 + regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigensFoxp3 + CD4 + 조절 T 세포는 새로운 SARS-CoV-2 항원에 대한 항원 특이적 면역을 유도하는 수지상 세포를 제어합니다Research Article Published on 2021-12-092022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, [키워드] absence activate activating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immune response adaptive immune responses adjuvant adjuvants Administered administration antibody Antigen antigens approach Autoimmune diseases B cell responses CD4 CD8 cells cellular immunity Combination coronavirus DCs dendritic cell dendritic cells draining lymph node draining lymph nodes effective Efficacy ENhance examined expressing follicular FOXP3 Germinal center help helper T cell highlight humoral immune response immune responses Immunity immunological immunological tolerance IMPROVE induce initiated interferon interferon-γ investigated live SARS-CoV-2 lymph nodes maturation mechanisms mice naïve T cells neutralized Neutralizing antibodies neutralizing antibody present antigen prevented produced Protective receptor Regulatory respiratory response responses SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 spike protein SARS-CoV-2 variants self-tolerance severe acute respiratory syndrome Coronavirus Spike protein stimulate suppress T cell T cells therapy These data transcription factor Transient Treg Treg cell Treg cells vaccination Vaccine variants [DOI] 10.1371/journal.ppat.1010085 PMC 바로가기 [Article Type] Research Article
Effectiveness of BNT162b2 and ChAdOx1 Vaccines against Symptomatic COVID-19 among Healthcare Workers in Kuwait: A Retrospective Cohort StudyArticle Published on 2021-12-072022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] 95% CI acute respiratory syndrome adjusted age Analysis BNT162b2 ChAdOx1 ChAdOx1 vaccine coronavirus coronavirus disease Coverage COVID-19 Cox regression dose Effectiveness eligible Factor Factors female groups hazard ratio HCW HCWs healthcare professionals healthcare worker hospital Infectious diseases Kuwait Middle East of BNT162b2 percentage prevented public health reported SARS-CoV-2 SARS-COV-2 infection significantly lower Sociodemographic symptomatic infection the disease vaccination Vaccine vaccine dose vaccine effectiveness was used worker [DOI] 10.3390/healthcare9121692 PMC 바로가기 [Article Type] Article
Cell fusion as a link between the SARS-CoV-2 spike protein, COVID-19 complications, and vaccine side effectsResearch Perspective Published on 2021-12-072022-10-28 Journal: Oncotarget [Category] COVID-19, [키워드] Cancer Cell fusion cells COVID-19 complication COVID-19 complications COVID-19 patients COVID-19 vaccines Effect Neuropathy prevented producing Side effect Spike protein Syncytia the SARS-CoV-2 thrombosis Vaccine Vaccines [DOI] 10.18632/oncotarget.28088 PMC 바로가기 [Article Type] Research Perspective
Impact of vaccine prioritization strategies on mitigating COVID-19: an agent-based simulation study using an urban region in the United StatesCovid-19 : 미국의 도시 지역을 이용한 에이전트 기반 시뮬레이션 연구에 대한 백신 우선 순위 화 전략의 영향Research Published on 2021-12-052022-09-10 Journal: BMC Medical Research Methodology [Category] Fulltext, SARS, 변종, [키워드] a minor Agent-based simulation model approved calibrated circulation Community Comparisons Contact tracing COVID-19 cumulative death disease Efficacy eligible examined Face mask focus granular growth Hope Hospitalized hypothesis test Impact individuals Infection infections Intervention Isolation mimicking minor Moderna natural history no significant difference notable novel vaccines observation occurred pairwise comparisons pandemic parameter Pfizer/BioNTech prevented public health quarantine random reduce reduced reducing reported Result significantly spread of COVID-19 supplementary material susceptible the United State the vaccine the vaccines threshold vaccination Vaccination policies Vaccination prioritization Vaccination strategies Vaccine Vaccines variant Viral Viral transmission was used [DOI] 10.1186/s12874-021-01458-9 PMC 바로가기 [Article Type] Research
A three-layer system to win the war against COVID-19 and invest in health systems of the futureCOVID-19와의 전쟁에서 승리하고 미래의 의료 시스템에 투자하기 위한 3계층 시스템Article Published on 2021-12-012022-09-11 Journal: BMJ Global Health [Category] SARS, 치료기술, [키워드] approach Community control strategies country COVID-19 COVID-19 pandemic detect Epidemic Epidemics function Health health economics Health policy health system health systems highlight human population Impact Intervention outbreak Pandemics Prevent prevented priority public health Resilience resource significantly Spread the SARS-CoV-2 Threats [DOI] 10.1136/bmjgh-2021-007365 PMC 바로가기 [Article Type] Article
COVID-19 prevention with subcutaneous administration of the monoclonal antibodies casirivimab and imdevimab: Subgroup analysis in participants with cardiovascular disease and diabetesConference abstract Published on 2021-12-012022-10-05 Journal: American heart journal [Category] 임상, [키워드] 1:1 Administered administration adverse event Analysis Asymptomatic Asymptomatic COVID-19 baseline Baseline serology cardiovascular disease COVID-19 CVD diabete diabetes diagnosed Efficacy Evidence figure headache hypertension Immunity increased risk index case individual monoclonal antibody monoclonal antibody combination participant performed phase Placebo positive post-hoc analysis prevented primary endpoint proportion Randomized reduced REGEN-COV reported Result risk risk reduction RT-qPCR SARS-CoV-2 seronegative severe disease study participant subcutaneously symptomatic infection symptomatic SARS-CoV-2 infection table Treatment Trial [DOI] 10.1016/j.ahj.2021.10.067 [Article Type] Conference abstract
Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial입원한 성인 COVID-19(COV-BARRIER) 치료를 위한 바리시티닙의 효능 및 안전성: 무작위, 이중 맹검, 병행군, 위약 대조 3상 시험Clinical Trial Published on 2021-12-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] Fulltext, SARS, 임상, 치료법, 치료제, [키워드] 1:1 95% CI Abstract addition all-cause mortality anti-inflammatory properties antivirals Asia assigned available data Baricitinib baseline Care Combination company Corticosteroids country death defined Dexamethasone Disease progression dose double-blind Efficacy and safety enrolled Europe evaluate event exploratory Follow-up French frequencies Frequency hazard ratio High-flow oxygen hospitalised inhibitor intention-to-treat population Invasive mechanical ventilation Janus kinase Japanese Lilly material Mortality non-invasive ventilation North America Odds ratio oxygen parallel-group participant Participants Phase 3 phase 3 trial Placebo placebo group placebo-controlled placebo-controlled trial prevented primary endpoint progressed proportion randomised Randomly receive receiving reduced reduction in Registered Remdesivir risk risk difference safety analyses safety analysis safety population safety profile secondary endpoint selective Serious Adverse Event Serious Adverse Events serious infection serious infections South America Spanish Standard Standard of care study drug systemic corticosteroid systemic corticosteroids the placebo group the primary endpoint thromboembolic translation Treatment two groups venous thromboembolic were assessed with COVID-19 [DOI] 10.1016/S2213-2600(21)00331-3 PMC 바로가기 [Article Type] Clinical Trial
Validation of expert system enhanced deep learning algorithm for automated screening for COVID-Pneumonia on chest X-rays전문가 시스템의 유효성 검증 흉부 X- 레이에서 코비드 석판을위한 자동 스크리닝을위한 강화 된 딥 러닝 알고리즘Article Published on 2021-12-012022-09-01 Journal: Scientific Reports [Category] SARS, 진단, 치료기술, [키워드] absence Accuracy Algorithm Algorithms artificial intelligence automated biomedical engineering Care chest X-ray curated datasets deep learning Diagnosis diagnosis of COVID-19 effective Effectiveness independent datasets initial limitation Medical imaging Negative predictive value pandemic path positive predict Predictive value prevented provide quarantine radiological Radiological Diagnosis Randomly Referral RT-PCR SARS-CoV2 second selected sensitivity training data Translational research Usage validation [DOI] 10.1038/s41598-021-02003-w PMC 바로가기 [Article Type] Article
Mobility in Blue-Green Spaces Does Not Predict COVID-19 Transmission: A Global AnalysisArticle Published on 2021-11-292022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] affected aggregate ambient Analysis approach country COVID-19 COVID-19 case COVID-19 pandemic COVID-19 transmission dataset ecological environmental factors Evidence greater growth rates increases in Intervention linear mental health mixed-effects model Mobility Non-pharmaceutical interventions Outdoor pandemic physical Policy Pollution predict predictor prevented public health Recreation regression analysis Research resolved restrict risk SARS-CoV-2 Space Spread Support temperature the disease Transmission Ultraviolet radiation UV [DOI] 10.3390/ijerph182312567 PMC 바로가기 [Article Type] Article