High-Resolution Transcriptome Maps Reveal Strain-Specific Regulatory Features of Multiple Campylobacter jejuni Isolates고해상도 전사체 지도는 여러 Campylobacter jejuni 분리주의 균주 특이적 조절 기능을 보여줍니다Research Article Published on 2013-05-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation addition Analysis analysis analyzed approach Author automated Bacterial bioinformatics Campylobacter Campylobacter jejuni compared consequence conservation conserved contribute CRISPR different DNA ecological niche ecological niches eukaryote eukaryotes facilitate feature functional gastroenteritis Gene Gene Expression Gene regulation Genetic Genome genome sequence Genome sequences genomic variation genomic variations genotypic genotypic variations growth Host hosts humans immune system IMPROVE include integration isolate isolates lead Map maturation modulate Multiple organism Organisms Pathogens pathway phenotypic phenotypic diversity phenotypic variation promoter promoter regions promoters provide Regulation related reveal RNA RNA sequencing RNase similarities similarity small RNA SNP sRNA strain Strains stress conditions time-consuming transcribed transcriptional Transcriptome transcriptomes TSS unique upstream Variation whole-genome [DOI] 10.1371/journal.pgen.1003495 PMC 바로가기 [Article Type] Research Article
RpoS Plays a Central Role in the SOS Induction by Sub-Lethal Aminoglycoside Concentrations in Vibrio choleraeRpoS는 Vibrio cholerae에서 치명적이지 않은 아미노글리코사이드 농도에 의한 SOS 유도에서 중심 역할을 합니다Research Article Published on 2013-04-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addressed Aminoglycoside Antibiotic resistance Antibiotics Author Bacteria Bacterial caused cellular mechanism cellular mechanisms CENTRAL Concentration connection conserved corollary different DNA DNA damage DNA damaging E. coli Escherichia coli flow cytometry found Frequency fusion gene transfer Genetic Genome genomic plasticity gram growth guanine horizontal gene Horizontal gene transfer increase in induce induction inhibit inhibitory concentration Klebsiella pneumoniae leads low dose Mutation mutations Other over-expression oxidative oxidative stress oxidative stress response oxidized oxygen paradigm pathogen Pathogens pathway Pathways physiological effect physiological effects physiological response pneumoniae Prevent promoter Protein reactive oxygen specy regulated related role RpoS shown SOS SOS response Stress stress conditions stress response Testing tobramycin transfer V. cholerae Vibrio cholerae [DOI] 10.1371/journal.pgen.1003421 PMC 바로가기 [Article Type] Research Article
SARS Coronavirus 3b Accessory Protein Modulates Transcriptional Activity of RUNX1bResearch Article Published on 2012-01-122022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Accessory accessory protein activity acute respiratory syndrome Affect AP-1 binding Cell cells cellular chemokine co-immunoprecipitation cytokine dendritic cells downstream genes elevated ENCODE ERK expressing finding found functions Genome Host IL2 increase in Infected Infection inhibitor Interaction interferon isoform kinase lab led to MIP-1α monocyte mRNA level Pathogenesis pharmacological Phosphorylation physiological promoter Protein recruitment related reporter gene assay Runt RUNX1 SARS Coronavirus SARS virus SARS-CoV target gene transcription factor transcriptional activity Treatment unique upregulated upregulating upregulation yeast [DOI] 10.1371/journal.pone.0029542 PMC 바로가기 [Article Type] Research Article
Genetic Variation of the Human α-2-Heremans-Schmid Glycoprotein (AHSG) Gene Associated with the Risk of SARS-CoV InfectionResearch Article Published on 2011-08-172022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] 95% CI 95% confidence interval adjusted odds ratio affected After age and sex AHSG Analysis AOR association Beijing Cohort cohort study Concentration CYP4F3 cytochrome P450 demonstrated family found Gene Genotype genotype data genotyped Guangzhou HCW healthy control Human human neutrophil inflammation-associated gene Inflammatory investigated leukotriene Linkage disequilibrium liver LTB4 Macrophage nucleocapsid protein polymorphism promoter Protein regulated Regulation required SARS Coronavirus SARS virus SARS-CoV SARS-CoV infection selected serum Serum level significantly SNP statistical analysis supported susceptibility the patient transcriptional activity variant [DOI] 10.1371/journal.pone.0023730 PMC 바로가기 [Article Type] Research Article
Interferon Regulatory Factor 8 Regulates Pathways for Antigen Presentation in Myeloid Cells and during Tuberculosis인터페론 조절 인자 8은 골수 세포 및 결핵 기간 동안 항원 제시 경로를 조절합니다Research Article Published on 2011-06-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (major histocompatibility complex activate Activation allele Analysis Antigen presentation antigen processing Author binding binding site cellular pathway cellular pathways chromatin chromatin immunoprecipitation class Combination component Critical cytokine Defense dendritic cell dendritic cells differentiation early response endomembrane eQTLs expressed expression F2 Factor fixed functional Gene gene transcription GTPase GTPases histocompatibility complex Host–pathogen interaction identify IFNγ IL-12 IL12 immune response Infected Infection interferon gamma interferon regulatory factor interleukin intracellular pathogens intrinsic investigated IRF8 lipopolysaccharide LPS lung tissue lung tissues Lungs Macrophage macrophages major histocompatibility complex maturation member MHC mice Microarray Microarrays microbial motif mutant Mycobacterium tuberculosis myeloid myeloid cell myeloid cells ontogeny Pathogens pathway Pathways presentation priming progenitor cells promoter promoters Proteins pulmonary tuberculosis regulated Regulation represse required resistance to infection resistance to infections significantly Stimulation susceptible target transcript Transcription transcriptional treated Tuberculosis wild-type [DOI] 10.1371/journal.pgen.1002097 PMC 바로가기 [Article Type] Research Article
A −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood MalariaA −436C>심각한 아동기 말라리아와 관련된 인간 FAS 유전자 프로모터의 다형성Research Article Published on 2011-05-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95% confidence interval A allele a major activated affected allele Analysis Anemia Apoptosis applied assigned association Author carried Case-control caused CD69 Cell cell surface receptor cerebral malaria childhood children Community compared complex interplay complications Control Donor ENCODE Endemic Express expression FACS analysis FAS fatality found functional Genetic variant genetic variants genetics Health healthy individual help heterozygote homozygote homozygous Human Human genetics immune regulation immune response immune responses increased expression individual Infection investigated involved life-threatening locus lymphocyte Lymphocytes malaria molecule mononuclear cell mononuclear cells naïve nucleotide Occurrence Odds ratio outcome Pediatric case Peripheral blood Peripheral blood mononuclear cells phenotypic Plasmodium Plasmodium falciparum predisposition programmed cell death promoter promoter region proportion PROTECT Protective protective immune response Replication risk severe severe malaria significantly significantly higher Single nucleotide variant sub-Saharan Africa subgroup surface receptor susceptibility susceptible syndrome T-lymphocyte the disease Transmission dynamics variant West [DOI] 10.1371/journal.pgen.1002066 PMC 바로가기 [Article Type] Research Article
Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivoResearch Published on 2009-08-242022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] Bacterial caused cDNA Cell Cell culture cells changes in chromosome cleavage cloned compared contributed deleted downstream early phase explain Frame full-length protein Genetic Genome genomic hamster identify In-vitro induction of apoptosis Infection Infectious virus inoculated interferon beta intranasally lung observation ORF outbreak over-expressed parental Patient plaque forming unit promoter Protein prototype virus reconstructed replicate replicative reveal RNA SARS-CoV secretion Spread strain Strains suggested supernatant T7 RNA polymerase the SARS epidemic transcribed transfection transmembrane domain type I interferon variant Vero cells Viral RNA virulence virus virus isolate virus replication virus RNA [DOI] 10.1186/1743-422X-6-131 PMC 바로가기 [Article Type] Research