SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodiesSARS-CoV-2 숙주 차단은 타고난 NK 세포 기능에 영향을 미치지만 항체 의존적 NK 활성은 스파이크가 아닌 항체를 통해 강력하게 활성화됩니다Article Published on 2022-05-192022-09-11 Journal: eLife [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료법, [키워드] a minor activated activating Activation ADCC ADNKA Analysis antibody Cell cellular immunity correlated cytokine dependent on Depletion Disease progression dominant downregulation Effect Efficacy epithelial cells evade expression functions genetic risk factors identify immune response Immunity immunology Impact implication infected cell Infection Infectious disease Inflammation Innate immunity interferon interferon response Ligand Lung epithelial cells mechanism membrane MHC-I MICA Microbiology minor Most patients natural infection Nectin1 neutralisation NK cell NK cells nsp1 nsp14 nucleocapsid occurred ORF3a outcome overcome Pathogenesis patients pro-inflammatory cytokine protein synthesis Proteins proteomic reduction in response SARS-CoV-2 SARS-CoV2 second dose specific antibodies spike-specific antibodies Spike-specific antibody surface protein sustained the disease ULBP2 understanding vaccination Vaccine Vaccine design vaccine efficacy Vaccine-induced immunity virus viruses [DOI] 10.7554/eLife.74489 PMC 바로가기 [Article Type] Article
Fibronectin as a Marker of Disease Severity in Critically Ill COVID-19 Patients중환자 COVID-19 환자의 질병 중증도 지표로서의 피브로넥틴Article Published on 2022-05-062022-09-11 Journal: Cells [Category] Coronavirus, COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, [키워드] Alter APACHE II Bacterial Bacterial sepsis Biomarker Biomarkers can be used cellular clinical setting clinical settings correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 sample COVID-19 samples Critically ill Critically ill patient critically ill patients disease severity ELISA etiology expression of gene Extracellular matrix Fibronectin form help Ill immune response immunoblotting Infection Intensive intensive care intensive care unit knowledge MONITOR Mortality mortality prediction no significant difference no significant differences Non-survivors outcomes Patient plasma predict Proteins proteolytic Research SARS-CoV-2 virus Sepsis significantly higher SOFA scores treated Treatment Treatment outcome Viral was related were measured [DOI] 10.3390/cells11091566 PMC 바로가기 [Article Type] Article
An antibody-based proximity labeling protocol to identify biotinylated interactors of SARS-CoV-2SARS-CoV-2의 비오틴화된 상호작용자를 식별하기 위한 항체 기반 근접 라벨링 프로토콜Article Published on 2022-05-022022-09-12 Journal: STAR protocols [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Analysis approach biotinylated Complete Host identify labeling mass mass spectrometry mechanism Microbiology molecular interaction Molecular/Chemical Probes non-specific peptide Protein Biochemistry Proteins proteomics protocol SARS-CoV-2 SARS-CoV-2 protein viral pathogenesis Viral proteins virus [DOI] 10.1016/j.xpro.2022.101406 PMC 바로가기 [Article Type] Article
Shedding light on the toxicity of SARS-CoV-2-derived peptide in non-target COVID-19 organisms: A study involving inbred and outbred mice비표적 COVID-19 유기체에서 SARS-CoV-2 유래 펩타이드의 독성에 대한 조명: 근친교배 및 근친교배 마우스를 대상으로 한 연구Article Published on 2022-05-012022-09-11 Journal: Neurotoxicology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] acetylcholinesterase activated administration alteration animals antidepressant antioxidant anxiolytic applied biochemical Biomarker Brain C57Bl/6 J mice catalase consequence COVID-19 demonstrated depressive dismutase dispersion Effect Environmental Toxicology evaluate evaluated Evidence evidence of exposure to Field test genetic profile greater homeostasis hydrogen hydrogen peroxide Impact Laboratory locomotor maintain male mammalian mechanism memory memory deficit mice natural environments open oxidative stress Pandemic COVID-19 PCA peptide Principal component principal component analysis Protein Proteins provide reactive reduction in Research response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 particle SARS-CoV-2 particles sensitivity shedding Spike protein Superoxide Superoxide Dismutase Swiss mice. the Spike the vaccine Therapeutic strategies therapeutic strategy Toxicity Viral [DOI] 10.1016/j.neuro.2022.03.012 PMC 바로가기 [Article Type] Article
Recombinant subunits of SARS-CoV-2 spike protein as vaccine candidates to elicit neutralizing antibodies중화 항체를 유도하기 위한 백신 후보로서의 SARS-CoV-2 스파이크 단백질의 재조합 소단위Article Published on 2022-05-012022-09-12 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] anti-SARS-CoV-2 antibody anti-spike antibody antibody Antibody titer checked Combination COVID-19 COVID-19 patient Critical effective Efficiency elicit evaluated fusion peptide in silico in vitro in vivo experiments Infection injected injection Live virus long-lasting mice neutralization neutralize Neutralizing neutralizing antibody neutralizing antibody responses produced Protein Proteins RBD recombinant Recombinant protein recombinant proteins reported robust S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 virus serum serum samples shown Spike protein stimulate subunit Subunit vaccine target the SARS-CoV-2 vaccination against COVID-19 Vaccine vaccine candidate Vaccine design VNT was increased were measured were used [DOI] 10.1002/jcla.24328 PMC 바로가기 [Article Type] Article
Computational prediction of the molecular mechanism of statin group of drugs against SARS-CoV-2 pathogenesisSARS-CoV-2 병인에 대한 약물의 스타틴 그룹의 분자 메커니즘의 컴퓨터 예측Article Published on 2022-04-142022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] antiviral efficacy binding affinity Clinical data Clinical outcome complex computational analysis contribute COVID-19 patient COVID-19 patients Critical Delta docking docking score docking tool drug fluvastatin functional protein Helicase highest affinity indicated inhibit SARS-CoV-2 mechanism molecular dynamics Molecular dynamics simulation molecular mechanism Mortality mutant mutant proteins mutants Pathogenesis performed pitavastatin predict protease Protein protein complex Proteins reduction in risk RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 pathogenesis Spike proteins spike variants statin statins target protein target proteins the Spike therapy VOCs wild type [DOI] 10.1038/s41598-022-09845-y PMC 바로가기 [Article Type] Article
High Titers of Low Affinity Antibodies in COVID-19 Patients Are Associated With Disease SeverityCOVID-19 환자에서 낮은 친화도 항체의 높은 역가는 질병 중증도와 관련이 있습니다Article Published on 2022-04-132022-09-12 Journal: Frontiers in Immunology [Category] Coronavirus, COVID19(2023년), SARS, 진단, [키워드] addition Affect affinity analyzed antibodies antibody production Antibody Response Antibody titer Antigen association binding clinical information coronavirus disease COVID COVID-19 COVID-19 patient Critically ill critically ill patients disease Disease progression disease severity domain epitope mapping humoral IgA IgA antibody IgG IgG antibody titer IgM immunoassay Infectious diseases Interaction investigated isotype material maturation pandemic Patient peptide positive Prognostic marker Protein Proteins RBD SARS-CoV2 sera severity specific antibody SPRi (surface plasmon resonance imagery) the RBD titer viral infection [DOI] 10.3389/fimmu.2022.867716 PMC 바로가기 [Article Type] Article
CHARM: COVID-19 Health Action Response for Marines-Association of antigen-specific interferon-gamma and IL2 responses with asymptomatic and symptomatic infections after a positive qPCR SARS-CoV-2 testCHARM: qPCR SARS-CoV-2 테스트 양성 후 무증상 및 증상 감염에 대한 항원 특이적 인터페론-감마 및 IL2 반응의 해병을 위한 COVID-19 건강 조치 대응Article Published on 2022-04-072022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] Action All participants Asymptomatic Asymptomatic cases Cell mediated immunity class correlated COVID-19 COVID-19 symptoms COVID-19 vaccine COVID-19 vaccines dropped enrolled Enrollment epitope Epitopes Follow-up frequencies Frequency IFN-γ IFN-γ response IFN-γ responses IL2 immune response include Infection membrane N and M N and S proteins N protein nucleocapsid occurred participant Participants peaked peptide peptide pool peptides positive Post-infection predicted Protein Proteins qPCR qPCR test Responder response responses S proteins S, N and M proteins SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 test significantly Study participants subjects Support symptomatic symptomatic and asymptomatic symptomatic infection symptomatic participants T cell T cell response T cell responses tested the N protein These data were measured with COVID-19 [DOI] 10.1371/journal.pone.0266691 PMC 바로가기 [Article Type] Article
In silico analysis of the interactions of certain flavonoids with the receptor-binding domain of 2019 novel coronavirus and cellular proteases and their pharmacokinetic properties특정 플라보노이드와 2019년 신종 코로나바이러스 수용체 결합 도메인의 상호작용 및 세포성 프로테아제 및 이들의 약동학적 특성에 대한 실리코 분석Article Published on 2022-04-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] 2019 2019 novel coronavirus 2019-nCoV acute respiratory syndrome coronavirus Analysis binding blood-brain barrier cathepsin B caused cellular protease cellular proteases Compound conducted coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 death drug-likeness eukaryotic cells evaluated FIVE flavonoid flavonoids gallate glycoprotein hepatotoxicity hydrogen Hydrogen bond inhibit Interaction interactions microorganism MM/PBSA molecular molecular docking molecular dynamics Molecular mechanics nCoV P-glycoprotein pharmacokinetic Protein Proteins RBD Receptor binding domain respiratory SARS-CoV-2 Serine serine protease severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike glycoprotein subgroup substrate supported surface area target proteins the receptor-binding domain TMPRSS2 Toxicity transmembrane serine protease transmembrane serine protease 2 Van [DOI] 10.1080/07391102.2020.1840444 PMC 바로가기 [Article Type] Article
Differential expression and regulation of MS4A family members in myeloid cells in physiological and pathological conditions생리학적 및 병리학적 조건에서 골수 세포에서 MS4A 패밀리 구성원의 차등 발현 및 조절Article Published on 2022-04-012022-09-11 Journal: Journal of leukocyte biology [Category] MERS, 바이오마커, [키워드] Analysis Arthritis Bioinformatics analysis CD20 cellular circulating monocyte circulating monocytes circulating neutrophils COVID-19 differentially expressed ENCODE expressed expression family family members functional gene expression regulation gene family glucocorticoid Hormones immature Immunity in vitro increase in marker monocyte Monocytes monocytes/Mϕs MS4A1 MS4A14 MS4A2 MS4A3 MS4A4A MS4A4E MS4A6A MS4A7 myeloid cell myeloid cells myeloid precursors Neutrophils pathological condition patients physiological Protein Proteins regulated Regulation reported rheumatoid arthritis RT-PCR severe disease therapeutic targets tissue were expressed [DOI] 10.1002/JLB.2A0421-200R PMC 바로가기 [Article Type] Article