Association between tocilizumab treatment and clinical outcomes of COVID-19 patients: a systematic review and meta-analysisCOVID-19 환자의 토 실리 주맙 치료와 임상 결과 사이의 연관성 : 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-01-312022-09-01 Journal: Aging (Albany NY) [Category] 임상, 진단, [키워드] adverse events Affect all-cause mortality Analysis association benefit carried Clinical outcome clinical outcomes control group COVID-19 COVID-19 patients death decrease discharge Efficacy heterogeneity hospital discharge infection risk intubation medRxiv Meta-analysis nine Patient patients with COVID-19 peer-reviewed performed Randomized controlled trial RCT RCTs reduced reductions reductions in risk searched Secondary infection secondary infections Serious Adverse Events significantly significantly increased Still systematic review Tocilizumab treat Treatment treatment with tocilizumab [DOI] 10.18632/aging.203834 PMC 바로가기 [Article Type] Meta-Analysis
Efficacy of antiviral therapies for COVID-19: a systematic review of randomized controlled trialsCOVID-19에 대한 항 바이러스 요법의 효능 : 무작위 대조 시험의 체계적인 검토Research Published on 2022-01-312022-09-10 Journal: BMC Infectious Diseases [Category] SARS, 임상, 치료제, [키워드] Administered Antiviral antiviral therapy Antiviral treatment approved article Clinical improvement clinical outcomes controlled trials coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 mortality COVID-19 patients COVID-19 treatment daclatasvir demonstrated Descriptive statistics disease course effective Efficacy Evidence examined exhibited guideline heterogeneity identify improve clinical outcome include inferential statistics network not performed patients performed public health randomized clinical trial randomized clinical trials Randomized controlled trial Randomized controlled trials RCT reducing reducing mortality Remdesivir Result retrieved SARS-CoV-2 Scottish sofosbuvir sofosbuvir/daclatasvir Statistical power study heterogeneity suggested supplementary material systematic literature search systematic review the disease therapeutic Time to recovery Treatment trials was performed were excluded were expressed [DOI] 10.1186/s12879-022-07068-0 PMC 바로가기 [Article Type] Research
Rationale, design and methods of VA-BRAVE: a randomized comparative effectiveness trial of two formulations of buprenorphine for treatment of opioid use disorder in veteransRandomized Controlled Trial Published on 2022-01-312022-10-04 Journal: Addiction Science & Clinical Practice [Category] SARS, 임상, [키워드] Buprenorphine clinical effectiveness clinician Comparative effectiveness trial conducted Cooperative COVID-19 pandemic criminal decrease disorder effective Effectiveness Epidemic evaluate facilitate Formulation Guidance hepatitis B HIV IMPROVE include Injectable measure medication moderate Open-label opioid Opioid use disorder outcome outcomes parallel group prevalence rate Prevent Primary outcome Program Psychiatric Psychological Randomized Randomized controlled trial rationale RCT reduce secondary Standard of care Symptoms treating Treatment Trial unique veteran veterans widespread [DOI] 10.1186/s13722-022-00286-6 PMC 바로가기 [Article Type] Randomized Controlled Trial
Psychological Effects of Online-Based Mindfulness Programs during the COVID-19 Pandemic: A Systematic Review of Randomized Controlled Trials코로나19 팬데믹 기간 동안 온라인 기반 마음챙김 프로그램의 심리적 효과: 무작위 통제 시험의 체계적인 검토Review Published on 2022-01-312022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 임상, [키워드] Anxiety caused complementary conducted Controlled Controlled trial COVID-19 COVID-19 outbreak COVID-19 pandemic Depression Effect English language Evidence favorable effect healthcare worker Healthcare workers healthy individuals high risk Intervention item mindfulness online mindfulness populations Program Psychological psychological problem Psychological problems Quality Randomized controlled trial Randomized controlled trials ranged RCT RCTs reducing Reporting retrieved review risk of bia searched Stress systematic review systematic reviews [DOI] 10.3390/ijerph19031624 PMC 바로가기 [Article Type] Review
Development and Validation of a Treatment Benefit Index to Identify Hospitalized Patients With COVID-19 Who May Benefit From Convalescent Plasma회복기 혈장의 혜택을 받을 수 있는 COVID-19 입원 환자를 식별하기 위한 치료 혜택 지수의 개발 및 검증Research Published on 2022-01-252022-09-12 Journal: JAMA Network Open [Category] SARS, 진단, [키워드] adults hospitalized age approach authorization baseline baseline characteristics benefit Blood blood type can be used CCP Characteristics clinical benefit clinical status clinical trials clinical utility Cohort collected Combination condition conducted convalescent plasma convalescent plasma treatment COVID-19 COVID-19 convalescent plasma COVID-19 stage credible interval CrI dataset Day death derivative develop development diabetes Emergency Emergency use authorization Expanded access Expanded Access Program expected exposure finding gradation group health condition Health Organization Hospitalization Hospitalized identifying Importance index information measure mechanical ventilation Meta-analysis moderate objective Odds ratio Odds ratios Ordinal Scale outcome pandemic participant Participants Patient patient data patient information patients hospitalized patients with COVID-19 Point Precision predict Primary outcome prognostic provided public health pulmonary diseases randomization randomized clinical trial RCT RCTs receipt receiving recommendations Relevance Result selected setting Stage supported Testing Treatment used data validation was used WHO with COVID-19 women World Health Organization [DOI] 10.1001/jamanetworkopen.2021.47375 PMC 바로가기 [Article Type] Research
Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): protocol for a randomised controlled trial확인 된 또는 의심되는 박테리아 감염 (Batch)으로 입원 한 어린이의 바이오 마커 유도 항생제 치료 기간 : 무작위 대조 시험을위한 프로토콜Paediatrics Published on 2022-01-252022-09-10 Journal: BMJ Open [Category] Fulltext, SARS, 바이오마커, 임상, [키워드] Adverse drug reactions adverse effect Algorithm Analysis Antibiotic treatment antibiotic use Antibiotics approved Bacterial infection best Biomarker C reactive protein children clinician commenced conducted conjunction control arm Controlled COVID-19 pandemic death Diagnostic microbiology discharge dissemination East Ethics Follow-up Health hospital Hospital stay HRA include infections Infectious diseases International Intervention intravenous antibiotics National Health Service NHS North outcome paediatric intensive & critical care PCT peer-reviewed procalcitonin protocol public health randomised controlled trial RCT REC recruit reduce registration number Relapse Research respond Safety measure secondary Secondary outcomes treated Treatment trial protocol Two-arm utility West [DOI] 10.1136/bmjopen-2020-047490 PMC 바로가기 [Article Type] Paediatrics
Evaluating the Evidence in Clinical Studies of Vitamin D in COVID-19Review Published on 2022-01-212022-10-31 Journal: Nutrients [Category] COVID-19, SARS, [키워드] 25-hydroxyvitamin D administration Asymptomatic COVID-19 benefit cholecalciferol clinical clinical study clinical trials condition Controlled trial COVID-19 COVID-19 pandemic deficiency dose Epidemiology Evaluating Evidence General population greater group hospitalized patients Infection infection rates Interaction lower risk Mild Mortality MOST nutrition observational studies observational study other treatments outcome outcomes overcome Placebo provide RCT RCTs receiving reduced reduced risk respiratory infections risk risk of COVID-19 serum severity of COVID-19 shown Study design Vitamin D Vitamin D status Vitamin D supplementation with COVID-19 [DOI] 10.3390/nu14030464 PMC 바로가기 [Article Type] Review
Oral Chinese Herbal Medicine on Immune Responses During Coronavirus Disease 2019: A Systematic Review and Meta-AnalysisMedicine Published on 2022-01-212022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] “medicine all-cause mortality analyzed approach CD3 CD4 CD4—CD8 ratio certainty of evidence Chest Chinese Chinese traditional” CHM clinical parameter Clinical practice clinical symptom Confidence intervals coronavirus disease Coronavirus disease 2019 Coronavirus infection cough COVID-19 Critical database disease Efficacy eligible evaluated fatigue Fever function Herbal heterogeneity immune effector cell immune response Immunity Immunotherapy IMPROVE Jadad scale lower risk lymphocyte lymphocyte counts Lymphocytes mean difference Medicine Meta-analysis moderate Modification Mortality Newcastle-Ottawa Scale observational studies oral outcome Patient performed profiles random effect Randomized controlled trial RCT RCTs reduced response Result review risk of bia SARS-CoV-2 searched secondary standardized mean difference Symptom systematic review therapeutic effect TNF-α Treatment was used were measured were used [DOI] 10.3389/fmed.2021.685734 PMC 바로가기 [Article Type] Medicine
Involving older people in co-designing an intervention to reverse frailty and build resilienceRandomized Controlled Trial Published on 2022-01-192022-10-05 Journal: Family practice [Category] SARS, 임상, [키워드] age approach build contributed dietary enrolment evaluated Exercise intervention feasibility feedback female females Follow-up frailty Gender group discussion Guidance Health IMPROVE Intervention Involvement Involving nine Older older people pandemic Patient PPI primary-care Public public and patient involvement randomised RCT Research Resilience resistance exercise stages supported systematic review technology Trial [DOI] 10.1093/fampra/cmab084 PMC 바로가기 [Article Type] Randomized Controlled Trial
Echinacea as a Potential Force against Coronavirus Infections? A Mini-Review of Randomized Controlled Trials in Adults and ChildrenReview Published on 2022-01-192022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Echinacea 229E Administered Antiviral antiviral activity appear AUC blinded children clinical evidence clinical study collected control group Controlled coronavirus Coronavirus infection Coronavirus infections Ct-value Echinacea Effect force in vitro incidence Infection inhibit membranous viruses nasal Nasopharyngeal swab NL63 OC43 occurred Placebo Potential prevention Randomized RCT reduced respiratory respiratory pathogen Respiratory tract infections Result review RT-PCR SARS-CoV-2 SARS-CoV-2 infections secretion shown significantly significantly lower Symptom symptom severity Treatment Viral load viral respiratory virus infection was recorded were measured [DOI] 10.3390/microorganisms10020211 PMC 바로가기 [Article Type] Review