A Phase II Study on the Use of Convalescent Plasma for the Treatment of Severe COVID-19- A Propensity Score-Matched Control AnalysisArticle Published on 2021-04-112022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] adverse event Analysis conducted Control control group convalescent plasma COVID-19 CP group CP infusion death death rate demonstrated effective Efficacy Efficacy and safety evaluate Follow-up global pandemic ICU Intervention levels of antibody median median time morbidity and mortality multicenter Patient patients with COVID-19 phase plasma Probability propensity score analysis recipient reduced risk remained resolved Safe SARS-CoV-2 antibodies severe COVID-19 significantly survival symptom onset Therapeutic benefit Treatment Trial was used [DOI] 10.3390/microorganisms9040806 PMC 바로가기 [Article Type] Article
The Healing Hearts Together Randomized Controlled Trial and the COVID-19 Pandemic: A Tutorial for Transitioning From an In-Person to a Web-Based Intervention마음을 치유하는 무작위 통제 시험과 COVID-19 전염병: 대면에서 웹 기반 개입으로 전환하기 위한 자습서Tutorial Published on 2021-04-062022-09-10 Journal: Journal of Medical Internet Research [Category] MERS, SARS, 임상, [키워드] adaptation analyses assessments assist behavioral medicine cardiac event cardiovascular disease Cardiovascular health cardiovascular rehabilitation Chronic illness clinical Clinical research consultation Controlled COVID-19 COVID-19 pandemic Data collection Digital medicine Efficacy example healing heart implementation IMPROVE Internet-Based Intervention Intervention life Measures mental health pandemic privacy Quality of life Randomized controlled trial recruitment reduced risk Research Research Ethics researcher secondary prevention step telehealth Telemedicine therapeutic therapeutic aspects tutorial usual care Virtual care Web-based intervention [DOI] 10.2196/25502 PMC 바로가기 [Article Type] Tutorial
Corticosteroids in patients hospitalized for COVID-19 pneumonia who require oxygen: observational comparative study using routine care dataObservational Study Published on 2021-04-012022-10-05 Journal: Clinical microbiology and infection : the official [Category] 임상, [키워드] 95%CI Analysis assigned association baseline C-reactive protein Causal Causal inference characteristics of patient coronavirus disease Corticosteroid Corticosteroids COVID-19 cumulative death death rate Effectiveness event France hazard ratio hospital Hospitalized inclusion criteria Infection intensive care units intubation Luxembourg main analysis mechanical ventilation observational study outcome oxygen oxygen only Patient patients hospitalized patients with COVID-19 Pneumonia Prednisone Primary outcome Probability reduced risk Research risk routine care significantly Standard of care subgroups of patient Therapeutic evaluation. Treatment use of corticosteroid Weighting with COVID-19 [DOI] 10.1016/j.cmi.2020.11.035 PMC 바로가기 [Article Type] Observational Study
Outcomes of Vascular and Endovascular Interventions Performed During the Coronavirus Disease 2019 (COVID-19) PandemicObservational Study Published on 2021-04-012022-10-05 Journal: Annals of surgery [Category] 임상, [키워드] 95% CI 95% confidence interval age Analysis anticoagulation antiplatelet carotid chronic Community conditions confirmed COVID-19 case Confirmed COVID-19 infection COVID-19 example identify implication in-hospital mortality Infection initial international multi-center Intervention lower limb Lower respiratory tract lower risk male Mortality Obstructive outcome pandemic pulmonary disease recommendation reduced risk surgical survival Suspected threshold Vascular [DOI] 10.1097/SLA.0000000000004722 PMC 바로가기 [Article Type] Observational Study
Common hematological values predict unfavorable outcomes in hospitalized COVID-19 patients일반적인 혈액학적 값은 입원한 COVID-19 환자의 불리한 결과를 예측합니다Article Published on 2021-04-012022-08-31 Journal: Clinical immunology (Orlando, Fla.) [Category] MERS, SARS, 바이오마커, [키워드] Admission Asymptomatic biochemical marker biochemical markers Blood blood cell CBC Cell common Complete blood cell (CBC) count count Course COVID-19 Critical Critical care Critical illness death develop evaluated forms hematological higher risk hospitalized COVID-19 patient life-threatening lymphocyte Mortality predictors neutrophil on admission outcome Patient predict Predictive progression reduced risk resource SARS-CoV-2 severe disease severity troponin troponin I [DOI] 10.1016/j.clim.2021.108682 PMC 바로가기 [Article Type] Article
RAMIC: Design of a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of ramipril in patients with COVID-19RAMIC: COVID-19 환자에서 라미프릴의 효능을 평가하기 위한 무작위, 이중 맹검, 위약 대조 시험 설계Article Published on 2021-04-012022-09-11 Journal: Contemporary clinical trials [Category] MERS, SARS, 바이오마커, 임상, [키워드] ACE Adult patients angiotensin Complication composite endpoint coronavirus disease Coronavirus disease 2019 COVID-19 death decrease diastolic double-blind Efficacy emergency department Endpoint evaluate exclusion criteria filtration rate glomerular filtration rate hospital ICU admission include Informed consent inhibitor Invasive mechanical ventilation Mechanical mechanical ventilation mechanical ventilator mitigate Mortality multicenter Novel coronavirus novel coronavirus disease occur patients with COVID-19 Personal protective equipment Placebo placebo-controlled trial PPE primary composite endpoint ramipril Randomized receive reduced risk risk risk of infection risk of transmission SARS-CoV-2 transmission SARS-CoV2 shown study population study visit Systolic blood pressure Treatment Virtual visit. [DOI] 10.1016/j.cct.2021.106330 PMC 바로가기 [Article Type] Article
Can bilirubin nanomedicine become a hope for the management of COVID-19?빌리루빈 나노의약품이 코로나19 관리의 희망이 될 수 있을까?Article Published on 2021-04-012022-09-11 Journal: Medical Hypotheses [Category] 치료제, [키워드] administration Anti-inflammatory antioxidant antiviral activities Bilirubin Biliverdin Can cardiovascular diseases clinical study complications COVID-19 diabetes disorders dysfunction Efficacy intravenous Intravenous administration management metabolic syndrome nanomedicine Nanomedicine. Nanotechnology obesity offer organ pharmacological efficacy reduced risk syndrome target organ therapeutic Toxicity unique with COVID-19 [DOI] 10.1016/j.mehy.2021.110534 PMC 바로가기 [Article Type] Article
Changes in 25-(OH) Vitamin D Levels during the SARS-CoV-2 Outbreak: Lockdown-Related Effects and First-to-Second Wave Difference—An Observational Study from Northern ItalyArticle Published on 2021-03-192022-10-28 Journal: Biology [Category] COVID-19, [키워드] 25-hydroxy vitamin D addition age allergy approach area of interest association Biological functions change changes in Concentration Daily dose Effect excluded experimental evidence feature First wave group groups Health hospital individual investigated Italy less Level lockdown obesity pandemic Patient protective role recorded reduced risk Respiratory tract infections SARS-COV-2 infection SARS-CoV-2 positivity second wave severity of COVID-19 simple sun exposure susceptibility sustained the SARS-CoV-2 variable Vitamin D vitamin D level Vitamin D status Vitamin D supplementation was obtained Wave [DOI] 10.3390/biology10030237 PMC 바로가기 [Article Type] Article
Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in EnglandResearch Published on 2021-03-182022-10-28 Journal: The BMJ [Category] COVID-19, Fulltext, SARS, [키워드] 1.26 95% confidence interval absolute increase acute respiratory syndrome Admission age Care cause causes children Cohort cohort study coronavirus coronavirus disease death England Evidence hazard ratio hospital Hospital admission Hospital admissions increase in increased risk intensive care lower risk Mortality NHS objective OpenSAFELY outcome outcome measure pandemic participant Population recorded reduced risk Registered reported Result risk risk of infection SARS-CoV-2 SARS-COV-2 infection setting translate [DOI] 10.1136/bmj.n628 PMC 바로가기 [Article Type] Research
Antibodies to neutralising epitopes synergistically block the interaction of the receptor‐binding domain of SARS‐CoV‐2 to ACE 2Original Article Published on 2021-03-072022-10-31 Journal: Clinical & Translational Immunology [Category] COVID-19, [키워드] ACE ACE‐2 ACE2 African antibody Antibody Response antigenic approach asked B‐cell binding blocked Blood Contact convalescent patient Convalescent patients COVID‐19 defined disease effective enzyme epitope exacerbate Identified identify immune response immunogens immunopathology induce Interaction memory B cells mice neutralising neutralising antibody objective overlapping peptide peptide epitopes peptides plasma Prevent Protein raised RBD receptor‐binding domain receptor‐binding domain reduced risk Region Result safety profile SARS‐CoV‐2 SARS‐CoV‐2‐specific antibody SARS‐CoV‐2 sera significantly South specificity Strains T‐cell responses tested tetramer staining the RBD the Spike the vaccine vaccinate Vaccine Vaccine development [DOI] 10.1002/cti2.1260 PMC 바로가기 [Article Type] Original Article