Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike proteinArticle Published on 2006-04-172022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] affected Anti-viral antiviral activity Asia Atypical cell cytotoxicity Class I viral fusion protein Concentration concentrations coronavirus CoV domain dose-dependent Effect Europe fusion peptide fusion protein glycoprotein heptad repeat hydrophobicity IC50 identify inhibited inhibition inhibitor membrane membrane fusion MHV murine hepatitis virus N-terminus North America peptide Peptide inhibitor Pneumonia provide recent Receptor binding Region regions responsible S2 subunit SARS-CoV severe Severe acute respiratory syndrome-associated coronavirus six-helix bundle tested the S protein viral infectivity viral spike viral spike protein was used white [DOI] 10.1016/j.virusres.2006.03.001 PMC 바로가기 [Article Type] Article
A simple and rapid approach for screening of SARS-coronavirus genotypes: an evaluation studyResearch Article Published on 2005-10-182022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] accurate allelic Analysis approach assay can be used carried caused characteristic clinical sample Cohort different Epidemic epidemiological epidemiologically Epidemiology Genotype genotypes Infection Infectious disease information isolate MONITOR outbreak Patient probe recruited related reported respiratory Result SARS patient SARS-coronavirus Sequencing Sequencing analysis severe TaqMan the epidemic viral evolution [DOI] 10.1186/1471-2334-5-87 PMC 바로가기 [Article Type] Research Article
Molecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV)Research Article Published on 2005-09-212022-10-28 Journal: BMC Genomics [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome approach Asia biological systems Blood caused change changes in Clinical severity Clustering Control controls coronavirus correlated disease distress Epidemic expression profile Gene Gene Expression Genes Host human disease immunopathological damage Innate immunity International involved mortality rate Novel coronavirus pathophysiology Patient Peripheral blood Pulmonary infection recovering patient regulated reported Result SARS patient SARS patients SARS-CoV several gene severe severity significantly Spread upregulated while World Health Organization [DOI] 10.1186/1471-2164-6-132 PMC 바로가기 [Article Type] Research Article
Generation of human antibody fragments recognizing distinct epitopes of the nucleocapsid (N) SARS-CoV protein using a phage display approachResearch Article Published on 2005-09-192022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome antibody antibody fragment Antiviral compound approach cause characterized coated with antigen described detect diagnostic test disease domain ELISA epitope Generation high mortality rate Human immunocytochemistry immunohistochemistry in vitro Infected Isolation MONITOR N protein neutralizing antibody nucleocapsid Particle Prevent Protein reagent recognize recognizing Result SARS epidemic SARS virus SARS-CoV SARS-CoV N protein scFv selected severe Spread target cells treat Vaccine Vero cells virus was used [DOI] 10.1186/1471-2334-5-73 PMC 바로가기 [Article Type] Research Article
Chloroquine is a potent inhibitor of SARS coronavirus infection and spreadResearch Published on 2005-08-222022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] abrogate acute respiratory syndrome addition angiotensin-converting enzyme 2 Antiviral compounds Antiviral effect appear binding caused Cell Cell culture cellular receptor Chloroquine clinically concentrations coronavirus described effective Elevation endosomal pH function immunofluorescence assay Infection inhibition inhibitor inhibitory effect interfere NO primate cells Prophylactic Result resulting SARS Coronavirus SARS CoV SARS-CoV SARS-CoV infection severe severe acute respiratory syndrome Coronavirus Spread terminal glycosylation therapeutic therapy treated virus virus spread [DOI] 10.1186/1743-422X-2-69 PMC 바로가기 [Article Type] Research
G0/G1 arrest and apoptosis induced by SARS-CoV 3b protein in transfected cellsShort Report Published on 2005-08-172022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] amino acids Analysis Annexin Apoptosis apoptosis induction Atypical Cell cell cycle arrest cells apoptosis characterized coronavirus COS-7 cell COS-7 cells ENCODE expression found fusion protein Genome immune induce infect labeling life-threatening liver lung mechanism Necrosis non-structural protein non-structural proteins organ organs over-expression Pathogenesis Pneumonia predicted Protein Proteins related Replication respiratory SARS pathogenesis SARS-CoV severe similarity structural protein Till transfected cell Vero virulence viruses [DOI] 10.1186/1743-422X-2-66 PMC 바로가기 [Article Type] Short Report
SARS-associated Coronavirus Transmitted from Human to PigDispatch Published on 2005-03-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] Analysis coronavirus Epidemiology Human Infected pig SARS epidemic SARS-CoV severe suggested Viral transmission [DOI] 10.3201/eid1103.040824 PMC 바로가기 [Article Type] Dispatch
The Severe Acute Respiratory Syndrome (SARS)-coronavirus 3a protein may function as a modulator of the trafficking properties of the spike proteinHypothesis Published on 2005-02-102022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] addition biochemically Cell Coronaviruses cytoplasmic cytoplasmic tail decrease different domain Effect examined expressed expression genetics Genome homologue Hypothesis Impact in vitro in vivo infected cell Infection Interaction mechanism methodology modulate motif Open reading frame other coronaviruses pathway presentation Protein Replication reported respiratory resulting RNA SARS-CoV severe shown significantly Spike protein Testing the spike protein undergo unique viral infection viral pathogenesis Viral protein viral spread [DOI] 10.1186/1743-422X-2-5 PMC 바로가기 [Article Type] Hypothesis
Molecular mechanisms of severe acute respiratory syndrome (SARS)Review Published on 2005-01-202022-10-28 Journal: Respiratory Research [Category] Coronavirus, [키워드] acute respiratory syndrome approach caused contribute coronavirus Deleterious Effect effort Epidemics Features Genome Health immune immune system indirect effect infections Infectious disease Interaction Laboratory mechanism molecular mechanisms morbidity and mortality mutability Novel coronavirus Occurrence offer Open reading frame outbreak Pathogenesis Prevent pulmonary pathological Region required Research Respiratory disease SARS SARS-CoV severe Severe acute respiratory syndrome target cell the disease therapy vaccination Vaccine viral genome virulence virus widespread [DOI] 10.1186/1465-9921-6-8 PMC 바로가기 [Article Type] Review
Virus-specific RNA and Antibody from Convalescent-phase SARS Patients Discharged from HospitalResearch Published on 2004-10-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome analyzed antibody caused collected conjunctival convalescence cross-sectional determined discharged patient ELISA enzyme immunoassay immunofluorescence assay Indirect immunofluorescence assay MOST Novel coronavirus occurred Patient polymerase chain polymerase chain reaction positive Prevalence Research RNA SARS SARS-CoV Seroconversion seroconverted serology seropositive serum serum sample severe specimen Stool tested throat swab Two patient Urine Viral RNA virus was determined [DOI] 10.3201/eid1010.040026 PMC 바로가기 [Article Type] Research