SARS-CoV-2 infection associated with hepatitis in an infant with X-linked severe combined immunodeficiencyX-연관 중증 복합 면역결핍증이 있는 유아의 간염과 관련된 SARS-CoV-2 감염Case Reports Published on 2021-03-012022-09-11 Journal: Clinical immunology (Orlando, Fla.) [Category] SARS, 치료기술, [키워드] adaptive Adaptive immunity Allogeneic Antigen B cells caused CD34 Cell clinically combined immunodeficiency Conditioning convalescent plasma COVID-19 deficiencies deficiency disorder Donor dysfunction Gene therapy Hepatitis IL-2 receptor Immunity immunodeficiency Inborn error inborn errors of immunity Infant infected with SARS-CoV-2 Mutation Nasopharyngeal swab nasopharyngeal swabs Natural killer cells NK cells opportunistic Infections Patient respiratory respiratory symptom respiratory symptoms resulting RT-PCR SARS CoV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 specific antibodies SCID selected severe combined immunodeficiency specific antibodies stem cell Transplant transplantation treated X-linked [DOI] 10.1016/j.clim.2020.108662 PMC 바로가기 [Article Type] Case Reports
Stem cells and COVID-19: are the human amniotic cells a new hope for therapies against the SARS-CoV-2 virus?줄기 세포와 COVID-19: 인간 양막 세포는 SARS-CoV-2 바이러스에 대한 치료법에 대한 새로운 희망입니까?Review Published on 2021-03-012022-09-10 Journal: Stem Cell Research & Therapy [Category] 임상, [키워드] Amnion amniotic anti-inflammatory properties applied caused Cell Cell therapy clinical trial clinical trials coronavirus COVID-19 COVID-19 treatment cytokine Diseases effective epithelial cell epithelial cells hAEC Health Human amniotic epithelial cells Human amniotic mesenchymal stromal cells in some in vivo models Inflammatory response Lung disease Lung diseases Lung infection Lung injury membrane Mesenchymal stem cells MSC MSCs New coronavirus pandemic Patient patients with COVID-19 Placenta positioned preclinical studies preclinical study problems producing Proinflammatory cytokine reduced regenerative respiratory Respiratory disease respiratory diseases restored Safe SARS-CoV-2 SARS-CoV-2 virus severe patients stem cell Stem cell therapy stem cells stromal cell stromal cells suggested term tested the SARS-CoV-2 the SARS-CoV-2 virus therapy therapy for COVID-19 tissue Treatment Trigger triggers [DOI] 10.1186/s13287-021-02216-w PMC 바로가기 [Article Type] Review
SARS-CoV-2 Infection and Disease Modelling Using Stem Cell Technology and Organoids줄기 세포 기술 및 오르가노이드를 사용한 SARS-CoV-2 감염 및 질병 모델링Review Published on 2021-02-262022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, 진단, [키워드] ACE2 airway epithelial cells alveolar Apoptosis cardiovascular system Cell cell damage cells Central nervous system Choroid plexus Clinical studies clinical study colonic contribute demonstrated Direct disease Endothelial cell endothelial cells Enterocyte enterocytes epithelial epithelial cells gastrointestinal tract highlighting human host Hypothesis immunological impairing in vitro model indirect effect indirect effects infect infected individuals Inflammation innate immune response intestinal organoid lung lung alveolar lung epithelia mechanism Neurological symptom Neurological symptoms Neuron neurons Organoid organoids organs Pathogenesis pathogenesis of SARS-CoV-2 replicate review SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 pathogenesis STEM stem cell surfactant susceptible systemic inflammatory target technology Trigger triggers tropism type I variance Vascular damage Viral viral damage viral infection virus [DOI] 10.3390/ijms22052356 PMC 바로가기 [Article Type] Review
Mechanistic and Therapeutic Implications of Extracellular Vesicles as a Potential Link Between Covid-19 and Cardiovascular Disease ManifestationsCell and Developmental Biology Published on 2021-02-112022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] accompanied ACE2 Affect Angiogenesis biogenesis Cardiomyopathy cardiosphere-derived cell cardiovascular cardiovascular disease Cardiovascular function CD9 Cell cell entry cells circulating contribute coronavirus disease COVID–19 disease docking endocytic EVs Exosomes Extracellular extracellular vescicles fibrosis highlight infected cell information manifestation Manifestations mechanisms membrane MSC derived exosomes Particles pathological conditions physiological Potential promote RAS receptor released renin—angiotensin—aldosterone system responsible SARS-CoV-2 secretion secretory pathway Signaling stem cell Therapies transfer uninfected cells Vesicle virus [DOI] 10.3389/fcell.2021.640723 PMC 바로가기 [Article Type] Cell and Developmental Biology
Is There an Effect of Fetal Mesenchymal Stem Cells in the Mother–Fetus Dyad in COVID-19 Pregnancies and Vertical Transmission?Physiology Published on 2021-02-112022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] Admission approved Asymptomatic Case report Cell circulating contribute coronavirus disease Course COVID-19 Dexamethasone dyad Effect fetal Hospitalized hypoxia immunomodulatory Infection intensive care majority mechanical ventilation mechanism mesenchymal Mild mother MSCs Neonate pandemic pregnancies Pregnancy pregnant patient required risk SARS-CoV-2 STEM stem cell the disease Therapeutic approach therapy Transmission vertical with COVID-19 [DOI] 10.3389/fphys.2020.624625 PMC 바로가기 [Article Type] Physiology
Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial중증 COVID-19 환자의 폐 손상에 대한 인간 탯줄 유래 중간엽 줄기세포의 효과: 무작위, 이중 맹검, 위약 대조 2상 시험Clinical Trial Published on 2021-02-102022-08-13 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, MERS, 바이오마커, 임상, 치료제, [키워드] 6-minute walk test 6-MWT 95% CI administration adverse event adverse events analyzed assigned baseline Cell China coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients diffusing diffusing capacity double-blind Effect effective Efficacy and safety evaluate incidence infusion long-term pulmonary disability lung lung damage lung lesion median MSCs Other outcomes patients treated performed Phase 1 Phase 2 phase 2 trial phase 3 trial Placebo placebo-controlled placebo-controlled trial primary endpoint Program proportion proportions pulmonary disability Randomized Randomly receive recruited reduced reducing mortality required Safe severe coronavirus disease severe COVID-19 severe COVID-19 patient severe COVID-19 patients significantly solid component stem cell stem cells the median Therapeutic approach treat Treatment two groups UC-MSC UC-MSCs umbilical vital capacity Volume were recorded [DOI] 10.1038/s41392-021-00488-5 PMC 바로가기 [Article Type] Clinical Trial
Therapeutic Potential of Mesenchymal Stem Cells and Their Products in Lung Diseases—Intravenous Administration versus InhalationReview Published on 2021-02-072022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome addressed administration caused cell damage cohorts coronavirus COVID-19 decrease extracellular vesicle Extracellular vesicles extracorporeal membrane oxygenation feasible heterogeneity Infection inhalation inhalation treatment inhalers Intravenous injection intravenous treatment lack limitation Lung disease Lung diseases Major Mesenchymal stem cells MSC MSCs Non-invasive Potential Prevent product repeated respiratory diseases SARS-CoV-2 STEM stem cell Stress syndrome target cell the patient therapeutic use thrombus formation Treatment Treatment protocol vasculature [DOI] 10.3390/pharmaceutics13020232 PMC 바로가기 [Article Type] Review
Human Dental Pulp Stem Cells Modulate Cytokine Production in vitro by Peripheral Blood Mononuclear Cells From Coronavirus Disease 2019 PatientsCell and Developmental Biology Published on 2021-02-052022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] activated acute respiratory syndrome co-culture Concentration conditions Contact coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients cytokine dental dental pulp stem cells deregulated DPSC DPSCs form GM-CSF granulocyte healthy subject Human hyper-inflammation IFNγ IL-10 IL-12 IL-13 IL-17A IL-18 IL-1β IL-2 IL-21 IL-22 IL-23 IL-27 IL-4 IL-5 IL-6 IL-9 immune response immunomodulation in vitro interleukin investigated Macrophage mechanism mesenchymal stem cell Mesenchymal stem cells modulate modulation mononuclear cell MSC MSCs Multi-organ damage not affected Patient PBMC PBMCs peripheral Peripheral blood Pneumonia Production promote Pulp Real-time PCR Result SARS-CoV-2 STEM stem cell subset supernatant tissue regeneration TNFα [DOI] 10.3389/fcell.2020.609204 PMC 바로가기 [Article Type] Cell and Developmental Biology
ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular ResponseApoE-Isoform-Dependent SARS-CoV-2 Neurotropism 및 세포 반응Article Published on 2021-02-042022-09-11 Journal: Cell Stem Cell [Category] Fulltext, MERS, 진단, 치료제, [키워드] Alter Alzheimer disease Alzheimer's disease ApoE APOE4 Astrocyte astrocytes Brain brain organoids Cell co-culture COVID-19 COVID-19 severity COVID-19 susceptibility Culture cultures direct viral infection Effect elevated exhibited genetic risk factor help increased risk induced pluripotent stem cells Infection inhibit iPSCs Neuron neuron-astrocyte co-culture neurons nuclear fragmentation organoids Patient pluripotent stem cells populations Remdesivir response risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neurotropism SARS-CoV2 SARS-CoV2 infection severe COVID-19 severity stem cell tested Treatment understanding Viral viral infection [DOI] 10.1016/j.stem.2020.12.018 PMC 바로가기 [Article Type] Article
Does the Global Outbreak of COVID-19 or Other Viral Diseases Threaten the Stem Cell Reservoir Inside the Body?COVID-19 또는 기타 바이러스성 질병의 세계적 발병이 신체 내부의 줄기 세포 저장소를 위협합니까?Review Published on 2021-02-012022-09-12 Journal: Stem cell reviews and reports [Category] MERS, 진단, [키워드] Activation Anti-viral Anti-viral defense system Antiviral Cell cells contributed COVID-19 COVID-19 pandemic Critical Defense dimensions expected fraction Government help highlight intrinsic lack Mature cells mechanism molecular mechanism mortality rates Other pandemic pathogenicity Prevalence public health question reservoir spread of COVID-19 STEM stem cell stem cells tissues viral infection virus [DOI] 10.1007/s12015-020-10108-4 PMC 바로가기 [Article Type] Review