A New and Rare Presentation of Unilateral Recurrent Laryngeal Nerve Palsy in a COVID-19 Patient With No Recent History of Endotracheal IntubationInternal Medicine Published on 2021-09-032022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Abnormalities acute respiratory syndrome Admission affecting African American airway alveolar cell association Case report classical Computed tomography conducted coronavirus Coronavirus disease 2019 cough COVID 19 COVID-19 cranial diarrhea Dyspnea endotracheal fatigue Features fevers fiber history host immune system hypertension Hypothesis hypoxic respiratory failure ICU Infection Inflammatory response Injury intensive care Intratracheal intubation intravenous Intubated intubation Invasion laryngeal male mechanism nausea nerve neurologic New obstructive sleep apnea palsy paralysis pathophysiology Patient presentation presenting recent Recurrent Recurrent laryngeal nerve palsy resulting SARS-CoV-2 structures Symptom systemic inflammatory response syndrome the patient Type-2 diabetes mellitus Unilateral virus vocal cord dysfunction [DOI] 10.7759/cureus.17700 PMC 바로가기 [Article Type] Internal Medicine
Challenges and Lessons Learned From COVID-19 Trials: Should We Be Doing Clinical Trials Differently?COVID-19 시험에서 배운 도전과 교훈: 우리는 임상 시험을 다르게 해야 합니까?Review Published on 2021-09-012022-09-11 Journal: The Canadian journal of cardiology [Category] SARS, 신약개발, 임상, [키워드] accelerated adaptive administration adopted Analysis challenge clinical clinical care Clinical research clinical trial Consent COVID-19 COVID-19 crisis database diffusion dissemination diver English Evidence facilitate French integration Intervention large trial lesson meta-analyses Meta-analysis MOST mounted nonrandomized observation pragmatism pressure producing promotion provided randomized trial randomized trials recruitment Registered regulatory agencies regulatory agency Research Sample size Structure structures systematic review systematic reviews Trial trials [DOI] 10.1016/j.cjca.2021.05.009 PMC 바로가기 [Article Type] Review
SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte eliminationSARS-CoV-2 스파이크 단백질은 합포체 매개 림프구 제거를 지시합니다Article Published on 2021-09-012022-09-11 Journal: Cell Death and Differentiation [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-viral drug Anti-viral drugs cause cells cellular cellular structure contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapy death expression identify induce inhibit lung tissue lung tissues lymphocyte Lymphocytes lymphocytopenia mechanism membrane fusion molecular motif patients polybasic prevalent respiratory S1/S2 cleavage site SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus spike glycoprotein Structure structures Surface glycoprotein Syncytia syncytium target the SARS-CoV-2 therapy unique virus viruses [DOI] 10.1038/s41418-021-00782-3 PMC 바로가기 [Article Type] Article
Post-viral effects of COVID-19 in the olfactory system and their implications후각 시스템에 대한 COVID-19의 바이러스 후 영향 및 그 의미Review Published on 2021-09-012022-09-12 Journal: The Lancet. Neurology [Category] 진단, [키워드] accelerate acute phase Autopsy Brain brain region chemosensory clinical CNS Course COVID-19 Critical disease Effect evaluate Evidence Glia histological histopathological identify impair impairment implication Infection infection control Inflammation Inflammatory knowledge likelihood localised inflammation marker mechanism molecular molecular data nasal neurodegenerative neurodegenerative disorder Neuroimaging neurological Neurological deficit Neurological disease Neuron olfactory olfactory bulb olfactory dysfunction Olfactory epithelium patients with COVID-19 persistent Prevalence prognostic progression provide radiological recent replication of SARS-CoV-2 Research risk SARS-CoV-2 SARS-COV-2 infection small sample size specimen Spread structures subset symptomatic Trial upper respiratory viral infection virus [DOI] 10.1016/S1474-4422(21)00182-4 PMC 바로가기 [Article Type] Review
Reconstitution and functional characterization of SARS-CoV-2 proofreading complexSARS-CoV-2 교정복합체의 재구성 및 기능적 특성화Article Published on 2021-09-012022-09-11 Journal: Protein expression and purification [Category] SARS, 치료법, [키워드] activated acute respiratory syndrome coronavirus base pair base pairs characterized complex coronavirus 2 COVID-19 double-stranded RNA function functional functions in vitro inhibited metabolism mismatch nsp10 nsp14 NSP8 Nuclease pandemic primer Proofreading purified Replication replication of SARS-CoV-2 replication-transcription complex respiratory RNA RNA genome RNA replication RNAs RNase RTC SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA severe acute respiratory syndrome coronavirus 2 Structure structures the SARS-CoV-2 while [DOI] 10.1016/j.pep.2021.105894 PMC 바로가기 [Article Type] Article
Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions생체 내 SARS-CoV-2 상호 작용의 포괄적 인 매핑은 기능적 바이러스-숙주 상호 작용을 나타냅니다Article Published on 2021-08-252022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] approach bind Cell cells cellular Comprehensive element epigenomics functional Genome global health Health Host host mRNA identify Illumina in viral in vivo Interaction interactions Methylation mitochondrial molecular mutant observé pathogenicity platform regions report reveal RNA RNA sequencing RNA-RNA interaction RNA-RNA interactions RNAs SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 viral secondary structure Sequencing small nucleolar RNA structures subgenomic RNA subgenomic RNAs targeted therapy the SARS-CoV-2 genome untranslated regions Viral viral genome virus virus genome virus infection Virus-host interaction Virus-host interactions wildtype Δ382 [DOI] 10.1038/s41467-021-25357-1 PMC 바로가기 [Article Type] Article
The spreading of SARS-CoV-2: Interage contacts and networks degree distributionResearch Article Published on 2021-08-252022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] age Clustering confounding factors Contact degree distribution diffusion distribution driving Effect effective European face-to-face contact feature Germany Great Britain groups infection rate Italian Italy Mortality occur populations responsible social contact structures turn virus propagation [DOI] 10.1371/journal.pone.0256036 PMC 바로가기 [Article Type] Research Article
Targeted in situ cross-linking mass spectrometry and integrative modeling reveal the architectures of three proteins from SARS-CoV-2408 Published on 2021-08-242022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] 40S acute respiratory syndrome application applied approach approaches atomic average binding site Cell cellular complex coronavirus determine domain Effectiveness full-length full-length protein generate highlight in-cell techniques information integrative modeling interactions mass spectrometry methodology Microscopy nucleocapsid nucleocapsid protein occur probe Protein Regulation residues reveal RNA SARS-CoV-2 sequence Significance structural biology Structure structures the N protein Topology Viral protein [DOI] 10.1073/pnas.2103554118 PMC 바로가기 [Article Type] 408
Fundamental challenges in assessing the impact of research infrastructureCommentary Published on 2021-08-182022-10-31 Journal: Health Research Policy and Systems [Category] COVID-19, MERS, SARS, [키워드] addition addressed approach block build caused clinical Community complex COVID-19 COVID-19 pandemic develop ecosystem Evaluation impact assessment Impact frameworks linear maintain majority methodological methodology Metrics NIHR BRC outcome outcomes Pipeline platform progression Quantitative Realist evaluation Research Research infrastructure significant level structures supplementary material Support sustained Time lags translation United Kingdom [DOI] 10.1186/s12961-021-00769-z PMC 바로가기 [Article Type] Commentary
A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variantsSARS-CoV-2 변이체에 대한 광범위 중화 인간화 ACE2 표적 항체Article Published on 2021-08-172022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료제, [키워드] ACE2 complexes acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered against SARS-CoV alleviate angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 angiotensin-converting enzyme-2 antibody Antibody therapy blocking antibody blood pressure circulating complexes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 domain dosage effective therapy epitope event exhibit hACE2 hindrance humanized in vitro Infection inhibitory activity injection Injections Intervention Isolation limit Lineage lineages monoclonal antibody morbidity morbidity and mortality Neutralizing pandemic Prevent prophylactically RBD receptor Receptor-binding domain respiratory risk SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 replication SARS-CoV-2 variant SARS-related coronavirus SARS-related coronaviruses SARSr-CoVs significant changes in Spread Structure structures therapeutic Transmission variants [DOI] 10.1038/s41467-021-25331-x PMC 바로가기 [Article Type] Article