Clinical outcome of neurological patients with COVID-19: the impact of healthcare organization improvement between wavesCovid-19 Published on 2022-02-172022-10-30 Journal: Neurological Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] age analyses clinical Clinical outcome clinical presentation cohort study condition COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 severity Cox regression demographic difference disease severity evaluate exhibited explain healthcare Hospitalized Infection laboratory data less lower mortality management Mortality neurological Neurological disease objective outcome outcomes oxygen support pandemic Patient patients with SARS-CoV-2 predictor Result resulting second wave single-center steroid therapy steroid treatment supplementary material unit [DOI] 10.1007/s10072-022-05946-8 PMC 바로가기 [Article Type] Covid-19
Effectiveness and sustainability of the WHO multimodal hand hygiene improvement strategy in the University Hospital Bouaké, Republic of Côte d’Ivoire in the context of the COVID-19 pandemicResearch Published on 2022-02-172022-10-28 Journal: Antimicrobial Resistance and Infection Control [Category] Coronavirus, COVID19(2023년), Fulltext, MERS, SARS, [키워드] absence addition adverse event African AHRB Alcohol-based hand rub assessment Bouaké build Côte d’Ivoire Clean care is safer care Clean hands Compliance confirmed COVID-19 case control group COVID-19 pandemic Ebola effective Effectiveness First WHO Global Patient Safety Challenge Follow-up hand hand hygiene healthcare Healthcare-associated infections highest hygiene implementation Infection prevention and control infections Intervention knowledge knowledge score lack Local Local disinfectant production Nosocomial infections observation patient safety questionnaire remained resource Result robust significant increase significantly supplementary material the WHO university university hospital was performed West WHO WHO multimodal strategy [DOI] 10.1186/s13756-021-01032-4 PMC 바로가기 [Article Type] Research
Integrating single-cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19Research Published on 2022-02-172022-10-31 Journal: Genome Medicine [Category] COVID-19, MERS, [키워드] ABO airways alteration association calculate CCR1 CD8+ T cell CD8+T cell Cell cell types Cell-mediated immunity cells chemotaxis collected contribute Control COVID-19 COVID-19 infection COVID-19 pandemic CXCR6 cytokine detrimental disease severity dysregulated immune response Effect effective vaccine elevated epithelial cell expressed expressed gene expression facilitate Factor feature functional Genes Genetic genetic architecture genetic determinant GWAS GWAS summary statistics healthy control higher risk Host host genetics IFITM1 Immune cell immune cells immune response Immunity immunological increase in independent Inflammatory Inflammatory cytokines inflammatory storm Interaction involved lung tissues memory Migration Mild moderate mononuclear cell notable Patient PBMC Peripheral blood progression proliferation provide recruitment Result reveal risk S100A12 S100A8 S100A9 scRNA-seq dataset sequencing data severe COVID-19 Severe infection Severe patient severe patients severity of COVID-19 significantly single-cell single-cell sequencing subpopulation subset subtype supplementary material Symptom T cell understanding up-regulated [DOI] 10.1186/s13073-022-01021-1 PMC 바로가기 [Article Type] Research
Comparing different machine learning techniques for predicting COVID-19 severityResearch Article Published on 2022-02-172022-10-29 Journal: Infectious Diseases of Poverty [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Accuracy Admission adopted analyzed AUC Care Chest computed tomography Coronavirus disease 2019 correlation COVID-19 COVID-19 severity D-dimer Diagnosis effective enrolled facilitate feature highest identify Illness severity indicated interquartile laboratory feature Laboratory features lactate dehydrogenase Logistic regression lymphocyte machine learning median age neutrophil non-severe cases outcomes Patient performed predict Predictive random Random forest resources Result retrospective selected sensitivity Severe case severe COVID-19 severity specificity supplementary material Support support vector machine SVM were used [DOI] 10.1186/s40249-022-00946-4 PMC 바로가기 [Article Type] Research Article
The emotional side of post-traumatic stress reaction during COVID-19 pandemic: an Italian surveyResearch Published on 2022-02-162022-10-28 Journal: BMC Public Health [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] age alcohol Analysis approach association Care condition COVID-19 COVID-19 pandemic cross-sectional decrease domain domains emotional females Gender implementation increase increase in independent variable Italian lifestyle mental health modifications Older outcome pandemic physical activity physiological Poisson regression post-traumatic Prevalence Psychological distress questionnaire recruited respondent Result Sleep disturbance Sociodemographic characteristics Stress subject supplementary material was used younger people [DOI] 10.1186/s12889-022-12749-1 PMC 바로가기 [Article Type] Research
Differing pan-coronavirus antiviral potency of boceprevir and GC376 in vitro despite discordant molecular docking predictions불일치 분자 도킹 예측에도 불구하고 Boceprevir 및 GC376의 상이한 범-코로나 바이러스 항 바이러스 효능Brief Report Published on 2022-02-162022-09-10 Journal: Archives of Virology [Category] COVID19(2023년), Fulltext, SARS, 치료제, [키워드] 229E anti-SARS-CoV-2 Antiviral antiviral agent antiviral medication antiviral potency antiviral therapies boceprevir Cell culture comparable coronavirus Coronavirus infections CoV CoVs effective enzyme in silico in vitro inhibiting inhibitor investigated molecular docking molecular docking analysis MPro NL63 OC43 potency protease SARS-CoV-2 similarity suggested supplementary material Support Viral [DOI] 10.1007/s00705-022-05369-y PMC 바로가기 [Article Type] Brief Report
Antibody attributes that predict the neutralization and effector function of polyclonal responses to SARS-CoV-2Research Published on 2022-02-162022-10-27 Journal: BMC Immunology [Category] COVID-19, [키워드] activity antibody Antibody Response Antiviral attribute Characteristics complement contribute cytotoxicity defined disease effector function function humoral IgA IgG IgM Immunity mechanism natural infection neutralization neutralization activity neutralization potency phagocytosis polyclonal predict predicted profile raised response Result SARS-CoV-2 SARS-COV-2 infection supplementary material supported vaccination validation cohorts while [DOI] 10.1186/s12865-022-00480-w PMC 바로가기 [Article Type] Research
Stakeholders’ hopes and concerns about the COVID-19 vaccines in Southeastern Nigeria: a qualitative studyResearch Published on 2022-02-162022-10-28 Journal: BMC Public Health [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] addressed adverse effect Analysis approach Community Concerns conducted COVID COVID – 19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines Critical develop disseminate effective vaccine Effectiveness expressed Health health information health system help high uptake Hopes imperative IMPROVE include Intervention Local maintain Medicines Nigeria produced professionals Purposive sampling Result Safe selected SoutheasternNigeria stakeholders supplementary material the vaccine vaccination Vaccine Vaccines were used WHO’ zone [DOI] 10.1186/s12889-022-12754-4 PMC 바로가기 [Article Type] Research
Comparative analysis of antibody- and lipid-based multiplexing methods for single-cell RNA-seq단일 세포 RNA-seq에 대한 항체 및 지질 기반 다중화 방법의 비교 분석Comparative Study Published on 2022-02-162022-09-12 Journal: Genome Biology [Category] MERS, 진단, [키워드] 10x antibodies antibody approach batch effects Benchmarking Brain Cell cell line cell lines cells CITE-seq clinical sample Clinical studies Comparative analysis datasets demultiplexing Efficiency evaluated Genetic variation Genomics Hashing healthy human cell human PBMC indicate intrinsic Lipid lung MULTI-seq Multiplexing nuclei outperform PBMC protocol reagent reducing reduction Result RNA-Seq Sample multiplexing SARS-CoV-2 infected patients scRNA-seq Sequencing single-cell single-cell RNA-seq spleen Strains supplementary material tissue tissues [DOI] 10.1186/s13059-022-02628-8 PMC 바로가기 [Article Type] Comparative Study
Parent-adolescent agreement in reported moderate-to-vigorous intensity physical activity during the COVID-19 pandemicResearch Published on 2022-02-162022-10-28 Journal: BMC Public Health [Category] Coronavirus, COVID19(2023년), Fulltext, MERS, SARS, [키워드] Adolescent adolescents analyzed average Bland-Altman plot collected correlation coefficient COVID-19 COVID-19 pandemic determine development Future ICC intensity Intervention less mean difference measure median Moderate-to-vigorous intensity physical activity pandemic parent parental parents physical activity Physical activity measurement prospective cohort study quantified recall reported Research Result significant difference Sociodemographic factor supplementary material were used [DOI] 10.1186/s12889-022-12530-4 PMC 바로가기 [Article Type] Research