SARS-CoV-2 Omicron Induces Enhanced Mucosal Interferon Response Compared to other Variants of Concern, Associated with Restricted Replication in Human Lung TissuesSARS-CoV-2 오미크론은 인간 폐 조직의 제한된 복제와 관련하여 우려되는 다른 변이체에 비해 향상된 점막 인터페론 반응을 유도합니다Article Published on 2022-07-212022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] Antiviral characterized Clinical severity concern COVID-19 Culture Delta enhanced ex vivo infection Human innate immune innate immune response Interaction interferon interferon response lung lung involvement lung organ culture lung tissue lung tissues mucosal surface mucosal surfaces nasal nasal organ culture omicron organ organ culture pathogenicity question raising reduced Replication respiratory tract response restored Restricted SARS-CoV-2 SARS-CoV-2 variant Signaling susceptibility tissue tissues variant VoC [DOI] 10.3390/v14071583 PMC 바로가기 [Article Type] Article
Investigation of CD4 and CD8 T cell-mediated protection against influenza A virus in a cohort studyArticle Published on 2022-07-212023-06-14 Journal: BMC Medicine [Category] Fulltext, 신종인플루엔자, [키워드] Influenza susceptibility T cell-mediated immunity. [DOI] 10.1186/s12916-022-02429-7 PMC 바로가기
Proceedings of the Clinical Microbiology Open 2018 and 2019 – a Discussion about Emerging Trends, Challenges, and the Future of Clinical Microbiology임상 미생물학 공개 2018 및 2019의 회보 - 임상 미생물학의 새로운 추세, 도전 과제 및 미래에 대한 토론Review Published on 2022-07-202022-09-12 Journal: Journal of Clinical Microbiology [Category] MERS, 진단, [키워드] agency clinical Collaborative effort Committee Community coronavirus disease Council COVID COVID-19 COVID-19 pandemic Critical diagnostic diagnostics expand Future Laboratory Microbiology molecular Next-generation sequencing organizations pandemic Pandemics Planning platform POCT point of care point of care testing Proceeding provide Public resource resources respond Society staffing stewardship supported susceptibility unique utilization [DOI] 10.1128/jcm.00092-22 PMC 바로가기 [Article Type] Review
Rapid decline in vaccine-boosted neutralizing antibodies against SARS-CoV-2 Omicron variantSARS-CoV-2 오미크론 변이체에 대한 백신 강화 중화 항체의 급격한 감소Clinical Trial Published on 2022-07-192022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Ad26 Ad26.COV2.S Ad26.COV2.S vaccine Adenovirus BA.2.12.1 BA.4/BA.5 boost booster Combination conducted coronavirus COVID-19 D614G variant exhibit generate Heterologous homologous implication magnitude mRNA mRNA vaccine neutralization titer neutralization titers Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody omicron Omicron variant PROTECT protective immunity Rapid recombinant adenovirus recombinant adenovirus vaccine reduced respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus sublineage. susceptibility Trial Vaccines variant variants of SARS-CoV-2 [DOI] 10.1016/j.xcrm.2022.100679 PMC 바로가기 [Article Type] Clinical Trial
Applying fluorescent dye assays to discriminate Escherichia coli chlorhexidine resistance phenotypes from porin and mlaA deletions and efflux pumps Research Published on 2022-07-152022-10-05 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] alteration Applying assays AST caused Cell cells change Concentration controls deleted deleterious mutation Deletion deletion mutants deletions E. coli E. coli cell Escherichia coli examination fluorescent greater identify isolate K-12 membrane integrity Microscopy over-expressed overexpression phenotype resistance gene resistance mechanisms Result SEM shown susceptibility tested transformant Transport [DOI] 10.1038/s41598-022-15775-6 [Article Type] Research
Vitamins C and D and COVID-19 Susceptibility, Severity and Progression: An Evidence Based Systematic ReviewReview Published on 2022-07-152023-07-10 Journal: Medicina [Category] COVID19(2023년), [키워드] coronavirus COVID-19 SARS-CoV-2 susceptibility Vitamin C Vitamin D [DOI] 10.3390/medicina58070941 PMC 바로가기 [Article Type] Review
COVID-19 and risk of neurodegenerative disorders: A Mendelian randomization study Research Published on 2022-07-142022-10-05 Journal: Translational Psychiatry [Category] Coronavirus, 바이오마커, 유전자 메커니즘, [키워드] alleviate Alzheimer’s disease Analysis association complications of COVID-19 conducted correlation COVID-19 Dementia demonstrated Evidence frontotemporal dementia Future Genetic Genome-wide association study higher risk Hospitalization Lewy body mendelian randomization multiple sclerosis neurodegenerative neurodegenerative disorder neurodegenerative disorders Parkinson’s disease positive risk robust Sensitivity analyses severity severity of COVID-19 significantly suggested susceptibility therapeutic intervention [DOI] 10.1038/s41398-022-02052-3 [Article Type] Research
Targeting ACLY efficiently inhibits SARS-CoV-2 replicationACLY를 표적으로 SARS-CoV-2 복제를 효율적으로 억제Article Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] ACLY acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyses Analysis ATP caused citrate coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Delta Factor help Host identify in vitro in vivo inhibit Intervention involved metabolome metabolomic metabolomics Mutation omicron pandemic public health replication of SARS-CoV-2 required SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus susceptibility targeting targets Therapeutics Transmissibility Treatment Vaccine variants variants of concern virulence virus replication VOCs wild-type [DOI] 10.7150/ijbs.72709 PMC 바로가기 [Article Type] Article
Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: A systematic review and meta-analysisCOVID-19 질병 및 중증도에 대한 감수성과 관련된 유전적 다형성: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-07-062022-09-11 Journal: PLoS ONE [Category] 변종, [키워드] 95% CI ACE1 advanced age allele alleles analyzed ApoE article association C allele calculated candidate gene CCR5 clinical symptom Clinical symptoms Comorbidities contribute COVID-19 COVID-19 disease COVID-19 infection COVID-19 pathogenesis COVID-19 severity disease eligible fixed form forms Genetic polymorphism genetic polymorphisms Genetic variant genetic variants GWAS HLA HLA-A HLA-B HLA-C identify investigated involved loci Meta-analysis polymorphism Polymorphisms presence of comorbidity random Repository risk searched severe forms of COVID-19 severity of COVID-19 significantly Stata software suggested susceptibility systematic review the disease TMPRSS2 Variation [DOI] 10.1371/journal.pone.0270627 PMC 바로가기 [Article Type] Meta-Analysis
Evaluation of Bi-Lateral Co-Infections and Antibiotic Resistance Rates among COVID-19 Patients in Lahore, PakistanObservational Study Published on 2022-07-062022-10-05 Journal: Medicina [Category] 임상, [키워드] Acinetobacter antibiotic Antibiotic resistance antibiotic stewardship Bacteria Bacterial bacterial co-infection Bacterial infections carbapenem resistant Enterobacteriaceae Care clinical sample collected Complication conducted coronavirus COVID-19 COVID-19 patient Critically ill cultures diagnosed diagnostic methods diffusion E. coli Enterobacteriaceae Enterococcus Escherichia coli gold standard highest hospital hospital acquired infections. Hospital admission illnesses increase in Infection infections Influenza inhibitory concentration isolate isolates material methicillin morbidity and mortality MRSA National oxygen Patient positive Prevalence protective role Rate resistance Result Risk factors shown Staphylococcus aureus susceptibility tested Treatment viral respiratory [DOI] 10.3390/medicina58070904 PMC 바로가기 [Article Type] Observational Study