transcriptomic – Page 14 – Communicable Diseases Research

Drug Repurposing for COVID-19 Treatment by Integrating Network Pharmacology and Transcriptomics

Article

Published on 2021-04-142022-10-28
Journal: Pharmaceutics [Category] COVID-19,

Secondary analysis of transcriptomes of SARS-CoV-2 infection models to characterize COVID-19

Article

Published on 2021-04-052022-10-28
Journal: Patterns [Category] COVID-19,

[키워드] Abstract Analysis association biological processe build changes Cluster Community Consensus coronavirus COVID-19 Data integration Data mining data-driven disease disease models driving elements feature Features functional Gene Expression gene expression signature gene signature Genome-wide association study heterogeneous host protein hypotheses Identified identify information Interaction interactions joint knowledge Meta-analysis model system module detection molecular molecular mechanism multiple model system network analysis outcome outcomes overcome pathophysiological pathophysiology pathway pattern search phenotype protein-protein interaction Research question SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteome secondary Single-cell RNA-sequencing Standard Support transcriptional Transcriptome transcriptomic transcriptomics translational utility viral-host protein
[DOI] 10.1016/j.patter.2021.100247 PMC 바로가기 [Article Type] Article

A COVID-19 Drug Repurposing Strategy through Quantitative Homological Similarities Using a Topological Data Analysis-Based Framework

Article

Published on 2021-04-022022-10-28
Journal: Pharmaceutics [Category] COVID-19,

Human coronaviruses in idiopathic Parkinson’s disease: Implications of SARS-CoV-2’s modulation of the host’s transcriptome

특발성 파킨슨병의 인간 코로나바이러스: SARS-CoV-2의 숙주 전사체 조절의 의미

Article

Published on 2021-04-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] among others analyses Analysis comparison Control coronavirus determine disease Diseases Effect enriched pathways enrichment analyses enrichment analysis false discovery rate FDR Gene Expression Gene ontology Gene Set Enrichment Analyses GSEA head Head-to-head comparisons Host Human human coronavirus human coronaviruses Huntington's disease immune response indicated modulation mononuclear cell motor nucleus mRNA NAFLD neurodegeneration neurodegenerative Neuroinvasive nigra not limited Ontology overlap overlapping parasitism parkinson s disease Parkinson's Disease Pathogenesis pathway Patient PBMC performed Peripheral blood Perturbation retrieved SARS-CoV-2 SARS-COV-2 infection scrutiny statistically significant substantia substantia nigra Surveillance tissue tissues Transcriptome transcriptomic Whole blood
[DOI] 10.1016/j.meegid.2021.104733 PMC 바로가기 [Article Type] Article

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

실행 가능한 약물 가능 게놈 전체 멘델식 무작위화, COVID-19의 용도 변경 기회 식별

Article

Published on 2021-04-012022-09-11
Journal: Nature Medicine [Category] MERS, SARS, 바이오마커, 변종, 비임상, 신약개발, 유전자 메커니즘, 임상, 진단, 치료법, 치료제,

Viral genomic, metagenomic and human transcriptomic characterization and prediction of the clinical forms of COVID-19

COVID-19의 임상 형태에 대한 바이러스 게놈, 메타게놈 및 인간 전사체 특성화 및 예측

Clinical Trial

Published on 2021-03-292022-09-10
Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, 임상, 치료기술,

[키워드] activate activating acute respiratory distress syndrome Acute respiratory failure Analysis antagonists Bacteria candidate Candidates caused Characteristics characterized clinical form collected COVID-19 COVID-19 pneumonia CXCR2 cytokine Diagnosis disease distress ENhance Factor feature female gender form fungi Genetic genomic high mortality rate Host identify IL-8 Immune cell immune cells infiltration Inflammatory response intensive care intensive care unit lower mortality metagenomic Mild Nasopharyngeal swab nasopharyngeal swabs neutrophil neutrophil infiltration outpatients overactive overexpression pandemic parasite parasites pathophysiology pathway Patient patients hospitalized Pneumonia pulmonary disease receptor respiratory respiratory distress Respiratory distress syndrome Respiratory failure respiratory symptom respiratory symptoms resulting SARS-CoV-2 Severe case severe COVID-19 Severe COVID-19 pneumonia severe pneumonia severity severity of COVID-19 shotgun syndrome T helper the disease tissue damage transcript transcriptomic transcriptomics Treatment turn upper respiratory Viral viruses was performed were used
[DOI] 10.1371/journal.ppat.1009416 PMC 바로가기 [Article Type] Clinical Trial

Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway

Article

Published on 2021-03-292022-10-04
Journal: Scientific Reports [Category] SARS, 신약개발, 임상, 치료제,

Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures

SARS-CoV-2 및 H1N1 폐 손상의 공간 매핑은 차등 전사 서명을 식별합니다

Report

Published on 2021-03-232022-09-10
Journal: Cell Reports Medicine [Category] MERS, SARS, 신종인플루엔자, 유전자 메커니즘, 진단,

[키워드] Abstract acute respiratory distress acute respiratory distress syndrome alveolar epithelium anti-viral response anti-viral responses antiviral response ARDS Autopsy both viruses cellular change Coagulopathy COVID-19 demonstrated double infection dual enhanced Extracellular gene signature H1N1 H1N1 influenza identify induced genes infected individual Influenza Injury leads lung Lung injury lung tissue Macrophage macrophage activation macrophages pathway patients with SARS-CoV-2 phenotype platform Post-mortem Region remodeling respiratory distress response SARS-CoV-2 SARS-CoV-2 ARDS SARS-COV-2 infection SARS-CoV-2 infections severe SARS skewed spatial transcriptomics squamous metaplasia syndrome therapeutic target therapeutic targets tissue tissue remodeling transcriptional transcriptional change Transcriptome transcriptomic Type II pneumocyte type II pneumocytes unique Vascular injury vascular tissue Viral viral infections
[DOI] 10.1016/j.xcrm.2021.100242 PMC 바로가기 [Article Type] Report

Identification of biomarkers and pathways for the SARS-CoV-2 infections that make complexities in pulmonary arterial hypertension patients

폐동맥 고혈압 환자에서 복잡성을 만드는 SARS-CoV-2 감염에 대한 바이오마커 및 경로 식별

Article

Published on 2021-03-222022-09-11
Journal: Briefings in Bioinformatics [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Arterial hypertension Biomarker carried caused Compound conditions coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic diagnosed differentially expressed gene EDN1 effective drugs epithelial cell epithelial cells Evidence evidence of expression level expression profiling Extensive gene expression profile Gene expression profiling Gene ontology genomic Genomic analysis human lung human lung epithelial cells hypertension identification identify immune response Infection infections Inflammatory response Inflammatory responses integration lung observation Ontology PAH pathway Patient performed Phylogenetic tree promoter protein-protein interaction provided pulmonary arterial hypertension Regulatory Research respiratory response Ribonucleic acid RNA virus RNA viruses S100A12 S100A8 S100A9 Saa1 SAA2 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe acute respiratory syndrome Coronavirus Signaling signaling pathway signaling pathways significant interaction the SARS-CoV-2 therapeutic these compound these compounds transcriptomic Transcriptomic analyses transcriptomic analysis Transcriptomic profiling Transferrin viruses
[DOI] 10.1093/bib/bbab026 PMC 바로가기 [Article Type] Article

Diseasome and comorbidities complexities of SARS-CoV-2 infection with common malignant diseases

일반적인 악성 질환과 SARS-CoV-2 감염의 질병 및 동반 질환 복잡성

Article

Published on 2021-03-222022-09-11
Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘,

[키워드] ACTB APCDD1 approach bioinformatics Bioinformatics analysis Cancer cancer patient Cancer patients cancers CASP1 cell activation chemokine CHI3L1 CLEC1B COL6A3 Colon Comorbidities Comorbidity conditions COVID-19 CXCL10 CXCL8 cytokine cytokine production dataset DDIT4 deregulated develop disease diseasome dysregulated FABP5 FN1 GAPDH Gene Expression Omnibus Genes GPNMB higher risk HMOX1 identify IGFBP3 immune systems JUND kidney LGALS1 Lungs malignant disease malignant tumors Marco molecular Mortality MSH3 MYO10 NPC2 OAS2 Ontology outcome pathway Pathways PRDX3 ribosome biogenesis S100A8 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections semantic similarity severity signaling pathway synergistic SYTL2 the disease Thyroid Timp1 transcriptomic transcriptomic data tumors VCAN Wnt signaling pathway
[DOI] 10.1093/bib/bbab003 PMC 바로가기 [Article Type] Article