HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2Article Published on 2022-10-282023-07-10 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), [키워드] COVID-19 HLA northwestern federal district Russia variants of concern [DOI] 10.3390/ijerph192114024 PMC 바로가기
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccinationArticle Published on 2022-10-282022-11-15 Journal: Science Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Antibody Response B.1.617.2 BAL Blood booster vaccination Breakthrough infection Bronchoalveolar lavage fluid cellular immunity circulating Combination convalescent COVID-19 COVID-19 vaccine D614G Delta demonstrated effective elicit hospitalized patients humoral immune response Immunity immunization individual induce Infection mRNA vaccination mucosal neutralizing antibody Neutralizing antibody response neutralizing antibody responses offer omicron Reinfection respiratory respiratory tract response robust SARS-CoV-2 severe disease significantly lower Support T cell T cell response the SARS-CoV-2 vaccinated individuals variant variants of concern virus VOCs with COVID-19 [DOI] 10.1126/sciimmunol.add4853 PMC 바로가기
SARS-CoV-2 Omicron variant is attenuated for replication in a polarized human lung epithelial cell modelArticle Published on 2022-10-272022-11-16 Journal: Communications Biology [Category] COVID19(2023년), SARS, 변종, [키워드] Air-liquid interface Analysis assessment Cell Culture D614G Delta Epidemic epidemiological epithelial Health human coronavirus human lung immortalized Infection Lower respiratory tract omicron pathogenicity reduced Replication respiratory virus risk SARS-CoV-2 Seasonal influenza significantly variant variants variants of concern virus virus infection [DOI] 10.1038/s42003-022-04068-3 PMC 바로가기
Early pathogenesis profiles across SARS-CoV-2 variants in K18-hACE2 mice revealed differential triggers of lung damagesArticle Published on 2022-10-272023-07-10 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] Cytokine storm immune response K18-hACE2 mice model SARS-CoV-2 variants of concern [DOI] 10.3389/fimmu.2022.950666 PMC 바로가기
Rapid Evaluation of Vaccine Booster Effectiveness against SARS-CoV-2 VariantsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 95% CI appear applied approach Blood booster booster vaccination Booster vaccine Cellulose country COVID COVID-19 pandemic decrease evaluate evaluated heterogeneity immune response Immunity immunological protection increase in indicated individual individual level induce median MONITOR NAb Neutralization antibody Neutralizing Neutralizing antibodies neutralizing antibody omicron Omicron variant pandemic POC point of care point-of-care point-of-care test population level predominant Protective Rapid regimen reported responses against SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants shown stick switching vaccination variant variants of concern variants of SARS-CoV-2 virus neutralization test VoC VOCs waning immunity wild-type [DOI] 10.1128/spectrum.02257-22 PMC 바로가기
Neutralizing SARS-CoV-2 Spike Antibodies against Omicron in Paired Samples after Two or Three Doses of mRNA VaccineArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] addition antibodies antibody Beta booster dose confounder COVID-19 death Delta demonstrated detect eliminated Hospitalization Immune escape mRNA mRNA vaccination mRNA vaccine neutralization neutralization activity Neutralizing neutralizing capacity Neutralizing titer omicron Omicron variant other variant protection provide reactive Sample SARS-CoV-2 SARS-CoV-2 antibody testing Seroprevalence Serum Neutralization significant increase significantly higher spike spike IgG tested the spike protein the vaccine unique utility Vaccine vaccine response variant variants of concern [DOI] 10.1128/spectrum.02046-22 PMC 바로가기
SARS-CoV-2 Spike-Binding Antibody Longevity and Protection from Reinfection with Antigenically Similar SARS-CoV-2 VariantsArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome advanced age analyzed antibodies antibody antibody durability Antibody titer circulation Cohort collected convalescent coronavirus coronavirus disease COVID-19 decrease detectable determine Effectiveness Enrollment exceptional female Health care worker highlight immune responses Increases Infection initial limit Longevity median modeling mounted new SARS-CoV-2 occurred Pandemics participant Participants protection public health crisis Rapid Reinfection risk SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 variant seronegative seropositive seropositive participant severe COVID-19 Sex spike-binding antibodies. stability Steady state vaccination variants of concern viruses [DOI] 10.1128/mbio.01784-22 PMC 바로가기
Differential Infectivity of Original and Delta Variants of SARS-CoV-2 in Children Compared to AdultsArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome Adults age aliquot B.1.617.2 Canada characteristic children circulating circulating SARS-CoV-2 variants coronavirus COVID-19 Culture cycle threshold Delta delta variant demographics determine dose driver implicated in viral Infection infectious titers infective Infectivity mechanism Mutation Nasopharyngeal swab nasopharyngeal swab sample original pediatric positive predominant provided RT-PCR SARS-CoV-2 SARS-CoV-2 RT-PCR screened statistical analysis susceptible TCID TCID50 TCID50. tissue Transmission variant variants of concern variety Viral RNA VoC [DOI] 10.1128/spectrum.00395-22 PMC 바로가기
B.1.351 SARS-CoV-2 Variant Exhibits Higher Virulence but Less Viral Shedding than That of the Ancestral Strain in Young Nonhuman PrimatesArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] addition Alpha animal model association B.1.351 Beta caused changes in Characteristics Chinese circulating Clinical signs contribute determine distribution drugs early stage Efficacy and safety elevated exhibited IFN-γ IL-17 Infection Inflammatory Inflammatory cytokine interferon gamma interleukin 17 investigated less Lower respiratory tract lung tissue mechanisms mutated Necrosis NHP NHPs nonhuman primate pathogenesis of SARS-CoV-2 pathogenic pathogenicity pathological changes primate provide pulmonary inflammation reduced replicated Research rhesus macaque SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants severe lung injury shedding spike-specific T-cell response strain Strains tissue TNF-α Transmission upper respiratory tract Vaccine variant variants of concern viral distribution viral shedding virulence virulent VoC VOCs were infected [DOI] 10.1128/spectrum.02263-22 PMC 바로가기
Towards the development of an epitope-focused vaccine for SARS-CoV-2Article Published on 2022-10-262022-11-15 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibodies BALB/c mice CD8+ T cell COVID-19 deficiency disease DNA effective effort epitope expression hamster hamsters IFN-γ immunogenic immunogenicity data in vitro Inclusion mice Mortality pandemic coronavirus peptide peptides platform predicted prevalent Protein Proteins RBD peptide regions reported RNA Safe SARS-CoV-2 SARS-CoV-2 virus sequence specific IgG antibody spread of COVID-19 starting point subcutaneous administration Support tested the Spike Vaccine Vaccine development Vaccines variant variants of concern Viral vector virus [DOI] 10.1016/j.vaccine.2022.09.059 PMC 바로가기