SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies검출 가능한 중화 항체의 존재에도 불구하고 의료 종사자의 SARS-CoV-2 재감염Communication Published on 2021-04-122022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] Blood COVID-19 disease course female healthcare worker immune response Immunity immunological Infection Infectious virus lack Live virus Mild moderate Mutation Neutralizing antibodies neutralizing antibody Presence Reinfection SARS-CoV-2 SARS-CoV-2 variant the patient variant Viral viral escape Virological virus worker [DOI] 10.3390/v13040661 PMC 바로가기 [Article Type] Communication
Construction and applications of SARS-CoV-2 pseudoviruses: a mini reviewSARS-CoV-2 슈도바이러스의 구성 및 적용: 미니 리뷰Review Published on 2021-04-102022-09-10 Journal: International Journal of Biological Sciences [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 biosafety biosafety level Biosafety Level 3 caused construction coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 effective gene sequence global public health infection mechanism investigated lack level 2 level 3 limitations live SARS-CoV-2 packaging system pandemic pathogenicity Pseudotyped viruses pseudovirus pseudoviruses Research respiratory SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses severe acute respiratory syndrome Coronavirus Spike protein stability Therapeutics Vaccine Virological virulent virus viruses [DOI] 10.7150/ijbs.59184 PMC 바로가기 [Article Type] Review
A desire for authoritative science? How citizens’ informational needs and epistemic beliefs shaped their views of science, news, and policymaking in the COVID-19 pandemicArticles Published on 2021-04-102022-10-29 Journal: Public Understanding of Science (Bristol, England) [Category] COVID-19, MERS, SARS, [키워드] age coronavirus COVID-19 pandemic epidemiological Gender German information interaction experts/publics knowledge management media media and science media representations pandemic policy and science question raise Result Risk communication science communication science in democracy science journalism View Virological [DOI] 10.1177/09636625211005334 PMC 바로가기 [Article Type] Articles
Liver injury is independently associated with adverse clinical outcomes in patients with COVID-19간 손상은 COVID-19 환자의 불리한 임상 결과와 독립적으로 연관되어 있습니다Article Published on 2021-04-012022-09-11 Journal: Gut [Category] SARS, 치료제, [키워드] 95% CI acute respiratory syndrome adjusted Admission admitted to ICU age Alanine alanine aminotransferase albumin ALT/AST aspartate Aspartate aminotransferase AST Beta Biochemistry cholestasis Clinical outcome coronavirus disease Coronavirus disease 2019 Corticosteroid Corticosteroids COVID-19 COVID-19 patient COVID-19 patients database death defined diabete diabetes Diagnosis died HCoV HCoVs Hepatitis Hong Kong human coronavirus hypertension ICU Injury intensive care intensive care unit interferon interferon beta Invasive mechanical ventilation limit liver Liver function Liver function test Liver injury Lopinavir Lopinavir-ritonavir men occurred Patient patients patients with COVID-19 primary end point retrospective cohort study ribavirin Ritonavir SARS patient SARS patients Severe acute respiratory syndrome Virological [DOI] 10.1136/gutjnl-2020-321726 PMC 바로가기 [Article Type] Article
Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protectionSARS-CoV-2에 대한 인간 중화 항체는 최적의 치료 보호를 위해 온전한 Fc 효과기 기능을 필요로 합니다Article Published on 2021-04-012022-09-11 Journal: Cell [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Administered antibody benefit caused CD8 CD8+ CD8+ T cells Cell clinical trials COVID-19 pandemic Depletion disease effector function function hamster hamsters Human human monoclonal antibodies Human monoclonal antibody IMPROVE in vivo Infection Inflammation innate immune loss-of-function lung Lung disease Lung infection lung; mAb mAbs mechanism of action mice mitigate monocyte Monocytes mouse model Neutralizing Neutralizing antibodies neutralizing antibody Pathogenesis phenotype preserved Prophylaxis reduce required respiratory Respiratory mechanics RNA RNA sequencing SARS-CoV-2 Signaling T cell T cells therapeutic therapy tissue repair transcriptional variant Virological [DOI] 10.1016/j.cell.2021.02.026 PMC 바로가기 [Article Type] Article
Epidemiological surveillance of SARS-CoV-2 by genome quantification in wastewater applied to a city in the northeast of France: Comparison of ultrafiltration- and protein precipitation-based methods프랑스 북동부 도시에 적용된 폐수 게놈 정량을 통한 SARS-CoV-2의 역학 감시: 한외여과 및 단백질 침전 기반 방법의 비교Article Published on 2021-04-012022-09-11 Journal: International journal of hygiene and environmental [Category] SARS, 치료기술, [키워드] addition alcohol applied approach circulation clinical setting clinical settings collected Community Concentration Concentration methods COVID-19 COVID-19 case COVID-19 outbreak decrease develop Diagnosis eight epidemiological epidemiological surveillance evaluate evaluated France Genome human population inhibitors lockdown MONITOR Patient phage predict Prevalence processing Protein purification quantification required Respiratory samples RNA RNA extract RNA extracts RT-PCR SARS-CoV-2 SARS-CoV-2 genome Surveillance the SARS-CoV-2 genome Ultrafiltration undetectable university viral genome viral genomes Virological wastewater were used [DOI] 10.1016/j.ijheh.2021.113692 PMC 바로가기 [Article Type] Article
The Weight of Obesity in Immunity from Influenza to COVID-19인플루엔자에서 COVID-19까지의 면역에서 비만의 무게Review Published on 2021-03-172022-09-12 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 진단, [키워드] acute respiratory syndrome addressed amplify cardiovascular disease cardiovascular risk clinical complication Comorbidity Complication complications condition coronavirus coronavirus disease COVID-19 COVID-19 hospitalization death develop diabetes Endocrine Factor favor greater Health hemodynamic instability highlight hypertension immune Immunity immunopathological immunopathology Increased individual Influenza influenza infection influenza pneumonia involved low-grade inflammation mechanism metabolic dysfunction Mortality obesity pathophysiology persistence Pneumonia poor prognosis respiratory manifestations response risk risk factor SARS-CoV-2 severe COVID-19 severe influenza susceptibility Symptom Virological weight [DOI] 10.3389/fcimb.2021.638852 PMC 바로가기 [Article Type] Review
Invasive pulmonary aspergillosis in critically ill patients with severe COVID-19 pneumonia: Results from the prospective AspCOVID-19 study중증 COVID-19 폐렴이 있는 중환자의 침습성 폐 아스페르길루스증: 전향적 AspCOVID-19 연구 결과Research Article Published on 2021-03-172022-09-10 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] affected age Analysis APACHE II score approach both groups bronchial lavage clinical parameter Clinical parameters Cohort collected Combination Complication controls COVID-19 COVID-19 cohort COVID-19 pneumonia Critically ill Critically ill patient critically ill patients defined diagnosed diagnostic early stage evaluate finding galactomannan help high mortality rate ICU ICU admission identify incidence invasive Invasive pulmonary aspergillosis IPA Laboratory Logistic regression Logistic regression analyses matched controls mechanical ventilation median Mortality not different outcome Patient Pneumonia prevalent pulmonary aspergillosis regression analysis Result risk factor Risk factors screened severe COVID-19 Severe COVID-19 pneumonia severe viral pneumonia Study protocol timepoint Viral Viral pneumonia Virological [DOI] 10.1371/journal.pone.0238825 PMC 바로가기 [Article Type] Research Article
Lopinavir-ritonavir versus hydroxychloroquine for viral clearance and clinical improvement in patients with mild to moderate coronavirus disease 2019경증에서 중등도의 코로나바이러스 질환 환자의 바이러스 제거 및 임상 개선을 위한 로피나비르-리토나비르 대 하이드록시클로로퀸 2019Comparative Study Published on 2021-03-012022-09-11 Journal: The Korean journal of internal medicine [Category] SARS, 치료제, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted hazard ratio age baseline Clinical improvement clinical response clinical responses comparable coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients duration of symptom Efficacy Follow-up Hydroxychloroquine hydroxychloroquine treatment hyperbilirubinemia less Lopinavir Lopinavir-ritonavir lymphopenia median men Mild mild to moderate Mild to moderate COVID-19 moderate Moderate COVID-19 Negative conversion no significant difference outcome oxygen oxygen support Patient patients patients with COVID-19 randomized, controlled trials required retrospective cohort study Ritonavir severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant difference significantly shorter single center time treated Treatment viral clearance Viral RNA Virological were assessed were excluded [DOI] 10.3904/kjim.2020.224 PMC 바로가기 [Article Type] Comparative Study
Modeling SARS-CoV-2 viral kinetics and association with mortality in hospitalized patients from the French COVID cohort프랑스 COVID 코호트의 입원 환자에서 SARS-CoV-2 바이러스 역학 및 사망률과의 연관성 모델링422 Published on 2021-02-232022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis analyzed association average build characterization chronic pulmonary disease Cohort collected coronavirus COVID death disease Effect effective Evolution French Gender hazard ratio High-risk patients Hospital admission hospitalized patient hospitalized patients identify independent infected cells information joint male mathematical mathematical model median median time modeling Mortality mortality rate Multivariate analysis nasopharyngeal viral occur older patients outcome Patient pharmacological intervention predict predicted prolonged viral shedding pulmonary disease reduce reduction respiratory risk factor Risk factors risk of death SARS-CoV-2 SARS-CoV-2 viral kinetics severe acute respiratory syndrome Coronavirus Significance Strategy survival symptom onset translate Treatment Treatment strategies Viral viral clearance viral dynamics viral kinetics Viral load Virological virus virus pathogenesis younger patient younger patients [DOI] 10.1073/pnas.2017962118 PMC 바로가기 [Article Type] 422