Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains인도 SARS-CoV-2 균주의 구조 단백질 관련 유전자를 침묵시키는 효과적인 siRNA의 계산 연구 및 설계Article Published on 2022-06-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] absence acute respiratory disease Ago2 Algorithm animal models antiviral drug antiviral drugs Antiviral treatment binding candidate collected complementary Consensus COVID-19 deaths docking Effect effective envelope protein feature free energy GC content gene silencing Genes Genome Health Organization heat capacity Human Human genome in vitro in vivo India melting temperature membrane protein molecular docking analysis nucleic acid nucleocapsid nucleotide nucleotides outbreak pandemic parameter pathogenic coronavirus pathway Post-transcriptional gene silencing Protein public health Region reported Respiratory disease RNA RNA interference RNAi SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains selected sequence sequenced siRNA siRNA molecule siRNA molecules siRNAs structural protein structural proteins Surface glycoprotein target target gene target mRNA temperature Therapeutic treatment triggered viral pathogenesis WHO World Health Organization [DOI] 10.1016/j.compbiolchem.2022.107687 PMC 바로가기 [Article Type] Article
Game of transmissions (GoT) of SARS-CoV-2: Second wave of COVID-19 is here in IndiaReview article Published on 2022-06-012022-10-05 Journal: Current Opinion in Environmental Science & Health [Category] 변종, [키워드] Airborne transmission caused concerning Corona virus coronavirus 2 COVID-19 disease game globe India infectious agent information investigated knowledge MOST organization pandemic pathway Precision provided Rapid respiratory SARS-CoV-2 SARS-CoV-2 transmission second second wave selective Spread temporal variation trajectory Transmission transmission pathway transmissions virus WBE while WHO World Health Organization Worldwide WWTPs [DOI] 10.1016/j.coesh.2022.100355 [Article Type] Review article
Role of Serum Ferritin in Predicting Outcomes of COVID-19 Infection Among Sickle Cell Disease Patients: A Systematic Review and Meta-AnalysisArticle Published on 2022-05-302022-10-06 Journal: Front Med (Lausanne) [Category] 진단, [키워드] 95% CI Admission Analysis article Case series Cell Cochrane Library Cohort conducted COVID-19 COVID-19 infection critical appraisal database determine disease ferritin higher risk ICU ICU admission identify Joanna Briggs Institute marker Meta-analysis Mortality outcome Patient predict proportion ProQuest required review risk role SCD Serum ferritin serum ferritin level Severe COVID-19 Infection Sickle Sickle cell disease systematic review Web of Science WHO [DOI] 10.3389/fmed.2022.919159 PMC 바로가기 [Article Type] Article
Inhaled nitric oxide as temporary respiratory stabilization in patients with COVID-19 related respiratory failure (INOCOV): Study protocol for a randomized controlled trialCOVID-19 관련 호흡 부전(INOCOV) 환자의 일시적인 호흡 안정화로서 흡입된 산화질소: 무작위 대조 시험을 위한 연구 프로토콜Article Published on 2022-05-272022-09-11 Journal: PLoS ONE [Category] 임상, [키워드] Acute respiratory failure adjunct airway anaesthesia blinded Blood cause of death COVID-19 death deoxygenated described End-Expiratory Pressure EudraCT fraction global public health High-flow oxygen Hypoxemia hypoxia Inhaled initial intubation life-threatening lung Lungs management margin measure mechanical ventilation nitric oxide no difference null hypothesis oxygen oxygen saturation pandemic Patient patients with COVID-19 PEEP pharmacological Positive end-expiratory pressure predominant preoxygenation primary outcome measure protocol Randomized Randomized controlled trial reduce Respiratory failure safety margin sequence severe hypoxia Shunt SpO2 Standard of care Trial Two-arm Ventilation WHO [DOI] 10.1371/journal.pone.0268822 PMC 바로가기 [Article Type] Article
Evaluating the performance characteristics of five lateral flow assays for the detection of the SARS-CoV-2 nucleocapsid antigenSARS-CoV-2 뉴클레오캡시드 항원 검출을 위한 5가지 측면 유동 분석의 성능 특성 평가Article Published on 2022-05-252022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] 95% CI Accuracy acquisition age assays caution Chain Reaction Characteristics China collected Community complement complementary costly COVID-19 COVID-19 negative COVID-19 pandemic diagnostic Diagnostic accuracy early diagnosis ENCODE Evaluating facilitate female FIVE hospitalised individuals with COVID-19 Infection Inpatient Italy lateral flow MHRA nucleocapsid antigen outcomes Oxygenation Participants Patient patients with COVID-19 PCR testing performed polymerase chain polymerase chain reaction protocol ranged reverse-transcriptase polymerase chain reaction Rome RT-PCR RT-PCR assay RT-PCR assays RT-PCR testing SARS-CoV-2 SARS-CoV-2 antigen sensitivity swabbing the SARS-CoV-2 thresholds variable Variation was performed WHO [DOI] 10.1038/s41598-022-12805-1 PMC 바로가기 [Article Type] Article
Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses코로나19 입원 환자를 위한 렘데시비르 및 기타 3가지 약물: WHO 연대 무작위 시험의 최종 결과 및 업데이트된 메타 분석Meta-Analysis Published on 2022-05-212022-09-11 Journal: Lancet (London, England) [Category] 신약개발, 임상, 치료제, [키워드] 1:1 allocation Analysis antiviral drugs assigned average both groups Characteristics Compliance controls country COVID-19 COVID-19 diagnosis database death died discharge discharged disease severity drug drugs eligible patient Endpoint enrolled exclusion Final futility hospital Hospital mortality hospitalised hospitalised patient Hospitalised patients Hydroxychloroquine in both groups in-hospital mortality Inpatient Inpatients interferon ISRCTN Kaplan-Meier Local Lopinavir meta-analyses Meta-analysis Mortality mortality analysis mortality rate ratio no significant effect occurred Open-label outcome oxygen participant Patient patients patients with COVID-19 Placebo placebos primary endpoint progressed progression proportion randomisation Randomised trial Randomly rate ratio receive recruited regions Registered Remdesivir reported secondary Secondary endpoints solidarity Solidarity trial Standard of care study drug the WHO treatment period Trial Ventilated Ventilation were given WHO [DOI] 10.1016/S0140-6736(22)00519-0 PMC 바로가기 [Article Type] Meta-Analysis
Role of COVID-19 Vaccines in SARS-CoV-2 VariantsSARS-CoV-2 변이체에서 COVID-19 백신의 역할Review Published on 2022-05-202022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 affected Antigen approach AstraZeneca caused coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 vaccine COVID-19 vaccines Delta delta variant Effectiveness effort Emergency Health Mutation omicron Omicron variant Pathogenesis pathogenesis of SARS-CoV-2 Pfizer role SARS-CoV-2 SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Sinovac Treatment Vaccine Vaccines variant variants WHO [DOI] 10.3389/fimmu.2022.898192 PMC 바로가기 [Article Type] Review
Evaluation of Host Protein Biomarkers by ELISA From Whole Lysed Peripheral Blood for Development of Diagnostic Tests for Active Tuberculosis활동성 결핵 진단 테스트 개발을 위한 전 용해 말초 혈액에서 ELISA에 의한 숙주 단백질 바이오마커 평가Article Published on 2022-05-202022-09-11 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] analyses assay associative barrier Biomarker Biomarkers blood sample CALCOCO2 capture cause of death caused CD274 CD52 collected combinations complex conducted confirmatory tests consequence Control correlation country COVID-19 pandemic death defined development diagnosing Diagnosis diagnostic diagnostic test differentially expressed disease Diversity downregulated ELISA ENhance eradication evaluate expression GBP1 group groups Health Health crisis IFIT3 IFITM3 improvement Improvements incidence India individuals infected individuals Infection Infectious disease information investigated Key priorities key priority Laboratory Lateral flow device lysed negative controls nine Patient peripheral profile Protein protein expression Protein target protein targets qPCR Rapid reducing required ROC SAMD9L significantly SNX10 Stratification Test the WHO Tuberculosis validation study WHO World Health Organisation [DOI] 10.3389/fimmu.2022.854327 PMC 바로가기 [Article Type] Article
Establishing a framework towards monitoring HCV microelimination among men who have sex with men living with HIV in Germany: A modeling analysis독일에서 HIV에 감염된 남성과 성관계를 가진 남성의 HCV 미세 제거 모니터링을 위한 프레임워크 구축: 모델링 분석Article Published on 2022-05-122022-09-11 Journal: PLoS ONE [Category] 치료제, [키워드] Analysis COVID-19 pandemic diagnosed direct-acting antiviral Direct-acting antivirals early treatment effort Establishing evaluate expected Germany greater HCV Health Organization hepatitis C hepatitis C virus HIV HIV infection Impact incidence increase in Infection men Prevalence Prospective reducing reduction risk risk reduction Sex track Transmission model treat Treatment WHO with HIV World Health Organization [DOI] 10.1371/journal.pone.0267853 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron (B.1.1.529) Variant: No Time to Wait!SARS-CoV-2 오미크론(B.1.1.529) 변형: 기다릴 시간이 없습니다!Article Published on 2022-05-112022-09-11 Journal: Acta bio-medica : Atenei Parmensis [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect B.1.1.529 coronavirus coronavirus disease Coronavirus disease 2019 disease Health Organization help Immunity International Mutation NEWS omicron outbreak pandemic raised SARS-CoV-2 Spread spreading the disease time variant VoC WHO World Health Organization [DOI] 10.23750/abm.v93i2.12712 PMC 바로가기 [Article Type] Article