Safety and immunogenicity of a multivalent HIV vaccine comprising envelope protein with either DNA or NYVAC vectors (HVTN 096): a phase 1b, double-blind, placebo-controlled trialDNA 또는 NYVAC 벡터(HVTN 096)가 있는 외피 단백질을 포함하는 다가 HIV 백신의 안전성 및 면역원성: 1b상, 이중 맹검, 위약 대조 시험Article Published on 2019-10-072022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] active treatment Administered administration adverse event allergy antibodies antibody Antibody Response Antibody responses antibody-dependent cell-mediated cytotoxicity approach assigned binding binding antibody boost Cell-mediated cytotoxicity Combination component computer-generated Coverage cranial cytotoxicity died DNA dose doses double-blind early administration effective Efficacy enrolled envelope protein epitope finding followed by foundation funding glycoprotein gp120 healthy healthy volunteer healthy volunteers HIV infection HIV vaccine IgG IgG response IgG responses immunogenicity individual Infection Infectious diseases injection Lymphadenopathy marker measure Melinda Gate Melinda Gates motor vehicle Neutralising Antibodies outcome participant Participants Placebo placebo group placebo-controlled placebo-controlled trial Primary outcomes priming product Protein purified random Randomly reactogenicity regimen Registered responses risk Safety screened Serious Adverse Event Serious Adverse Events Switzerland the placebo group the vaccine trauma Treatment treatment group treatment groups Trial trials vaccination vaccination schedule Vaccinations Vaccine vector Volunteer [DOI] 10.1016/S2352-3018(19)30262-0 PMC 바로가기 [Article Type] Article
A self-adjuvanted nanoparticle based vaccine against infectious bronchitis virusResearch Article Published on 2018-09-142022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] addition Affect age Antibody Response B cell epitope bronchitis buffer chicken demonstrated Efficacy Ex vivo group heptad repeat IBV immunized Infectious Bronchitis Virus M41 mononuclear cell nanoparticle negative control PBMC PBMCs platform proliferation receiving reduction renal reproductive significantly higher Spike protein the vaccine tracheal trimeric Vaccine virus [DOI] 10.1371/journal.pone.0203771 PMC 바로가기 [Article Type] Research Article
Subtype C ALVAC-HIV and bivalent subtype C gp120/MF59 HIV-1 vaccine in low-risk, HIV-uninfected, South African adults: a phase 1/2 trial저위험 HIV 감염되지 않은 남아프리카 성인을 대상으로 한 아형 C ALVAC-HIV 및 2가 아형 C gp120/MF59 HIV-1 백신: 1/2상 시험Article Published on 2018-06-182022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 95% CI added adjuvant advancement African allergy Antigen assigned binding antibody CD4+ T-cell changed circulating clinical Community component computer-generated Critical double-blind trial Efficacy enrolled exceeded Express finding foundation funding glycoprotein gp120 HIV HIV infection HIV vaccine HIV-1 HIV-uninfected IgG IgG response immune response immune responses immunogenicity IMPROVE Infectious disease Infectious diseases Intramuscular injection investigators Melinda Gate Melinda Gates MF59 network NIAID outcome participant per-protocol per-protocol analysis Placebo predicted Primary outcomes Protein provided random randomisation randomised controlled Randomly recipient regimen Registered registry reported Research responders response risk significantly higher South South Africa strain Strains subtype T-cell Response tested the vaccine threshold titre Trial vaccination Vaccine Vaccine development was done [DOI] 10.1016/S2352-3018(18)30071-7 PMC 바로가기 [Article Type] Article
Efficacy of genogroup 1 based porcine epidemic diarrhea live vaccine against genogroup 2 field strain in JapanResearch Published on 2018-02-022022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] Administered Antibody titer caused Clinical sign conditions control group diarrhea Efficacy epidemic diarrhea evaluated exhibited immune response Immunity Infectious disease Japan lactogenic Lactogenic immunity mortality rate negative control Newborn PEDV Porcine epidemic diarrhea Porcine epidemic diarrhea virus pregnant prevalent reduced Result serum significantly supplementary material survival rate Symptom the vaccine vaccination Vaccine virus Virus neutralization watery [DOI] 10.1186/s12985-018-0940-8 PMC 바로가기 [Article Type] Research
Detection and phylogenetic analyses of spike genes in porcine epidemic diarrhea virus strains circulating in China in 2016–2017Short Report Published on 2017-10-102022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] addition Amino acid Analysis analyzed Characteristics China Chinese circulating classical collected Complete contribute detection diarrhea epidemic diarrhea Epidemiology gastroenteritis Genetic genetic diversity Hainan identity indicated insertion island knowledge Molecular epidemiology nucleotide outbreak Pathogens PCR PEDV Phylogenetic analysis Porcine deltacoronavirus positive Result S gene sequenced Sequencing spike gene strain TGEV the epidemic the vaccine vaccine strain virulent virus virus strain [DOI] 10.1186/s12985-017-0860-z PMC 바로가기 [Article Type] Short Report
Epidemiology and characterization of avian infectious bronchitis virus strains circulating in southern China during the period from 2013–2015Article Published on 2017-07-262022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] accounted Amino acid amino acid sequence Analysis antigenic China circulating disease Evolution Genotype homology IBV indicated Infectious Bronchitis Virus isolate nucleotide observation period Prevalence ranged Recombination serologic serology serotype Seven strain Strains Surveillance the vaccine variant [DOI] 10.1038/s41598-017-06987-2 PMC 바로가기 [Article Type] Article
A Single-Dose Recombinant Parainfluenza Virus 5-Vectored Vaccine Expressing Respiratory Syncytial Virus (RSV) F or G Protein Protected Cotton Rats and African Green Monkeys from RSV ChallengeArticle Published on 2017-05-122022-10-06 Journal: Journal of Virology [Category] 진단, [키워드] African African green monkey African green monkeys animal model Antibody Response Antibody titer boost challenge Clinical symptoms Complete cotton dose Efficacy elicited evaluated expressing glycoprotein green Human Immunity immunization immunized immunocompromised individuals indicated Infants Infection intranasal less Lower respiratory tract Lung pathology Lung protection Monkey mucosal neutralization neutralization titer parainfluenza virus pediatric PIV5 vectors platform Population produced PROTECT Protective Protein provided RAT recombinant Replication respiratory respiratory syncytial virus RSV Safe serum serum antibody severe respiratory disease single dose Support systemic and local tested the vaccine Vaccine vaccine candidate Vaccines vector virus [DOI] 10.1128/JVI.00066-17 PMC 바로가기 [Article Type] Article
Development of the full-length cDNA clones of two porcine epidemic diarrhea disease virus isolates with different virulenceResearch Article Published on 2017-03-162022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 48 hours BAC Bacterial caused Cell culture Chinese chromosome clone Cluster CMV promoter development diarrhea disease Epidemic epidemic diarrhea fatality full-length cDNA genetics Genome intestinal epithelium isolate isolates pandemic parental PEDV platform replicate rescued virus Strains survived tested the vaccine tissue damage variant virulence virulent virus virus isolate [DOI] 10.1371/journal.pone.0173998 PMC 바로가기 [Article Type] Research Article
Detection and phylogenetic analysis of porcine epidemic diarrhea virus in central China based on the ORF3 gene and the S1 geneResearch Published on 2016-11-252022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] addition Amino acid analysed Analysis China Chinese clinical samples Clustal detection diarrhea epidemic diarrhea full-length Genes genetic diversity glycoprotein insertion/deletion intestinal tissue isolate Japanese Korean Molecular epidemiology Mutation ORF3 ORF3 gene PEDV Phylogenetic analysis Phylogenetic tree Prevalence prevalent processed Protein provided Receptor binding Receptor binding domain Research Result RT-PCR S1 gene sequence Sequence analysis sequenced severity strain Strains supplementary material the disease the vaccine Vaccine variant variants virus [DOI] 10.1186/s12985-016-0646-8 PMC 바로가기 [Article Type] Research
Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccinesArticle Published on 2016-11-222022-10-29 Journal: Nature Communications [Category] Coronavirus, [키워드] determine Du et al effective Efficacy elicit eliminated epitope evaluate host immune responses immune responses immunodominant life-threatening MERS coronavirus MERS-CoV Neutralizing non-neutralizing epitope probe significantly subunit Subunit vaccine the receptor-binding domain the vaccine transgenic mice Vaccine Vaccine design variant viruses [DOI] 10.1038/ncomms13473 PMC 바로가기 [Article Type] Article