Group B streptococcus vaccination in pregnant women with or without HIV in Africa: a non-randomised phase 2, open-label, multicentre trial아프리카에서 HIV가 있거나 없는 임산부를 대상으로 한 그룹 B 연쇄상구균 백신: 비무작위 2상, 공개 라벨, 다기관 시험Articles Published on 2016-05-012022-09-06 Journal: The Lancet. Infectious Diseases [Category] Communicable Disease, [키워드] (no infection adverse event Adverse reaction Analysis Antenatal antibody antibody concentration Antibody concentrations Birth Blood CD4 cell Cell clinics collected Concentration died disease dose enrolled event finding Fold change Follow-up funding geometric geometric mean gestation GlaxoSmithKline group groups HIV HIV infection HIV-uninfected immunogenic immunogenicity increased risk Infant Infants Infection intramuscularly invasive Italy less life maternal antibody Medical Research Council Meningeal mother multicentre Neonate Neonates no infection Novartis Open-label participant Pathogens Phase 2 placental pregnant women Primary outcome Primary outcomes Protective provided recruited reduce Registered reported respiratory resulting safety analyses serotype-specific serotypes serum serum sample Siena South Africa stillborn the vaccine three group three groups transfer transferred Trial trivalent unit vaccination Vaccine Wellcome Trust were measured with HIV women [DOI] 10.1016/S1473-3099(15)00484-3 PMC 바로가기 [Article Type] Articles
Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable VaccineResearch Article Published on 2015-10-292022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] addition against SARS-CoV analyzed biosafety carboxy-terminal region causing Cell culture chimeric contributed coronavirus Coronaviruses CoVs deleted Deletion duplication E gene E protein effective epidemic diarrhea full-length Genetic Host identification immune response in vitro in vivo indicated induce insertion interferon response introduced Live attenuated vaccine manuscript mechanism membrane MERS-CoV mice Middle East molecular mechanism morbidity and mortality motif mutant virus mutated Mutation not affect parental passage pathogenicity PEDV phenotype Protective Protein provided recombinant remained restored resulting reversion Safe SARS-CoV SARS-CoV vaccine sequence stability STABLE syndrome the vaccine therapy transmembrane protein understanding Vaccine vaccine candidate Vaccines variant virulence virulent virus virus attenuation virus genome [DOI] 10.1371/journal.ppat.1005215 PMC 바로가기 [Article Type] Research Article
Phylodynamic analysis of avian infectious bronchitis virus in South AmericaShort Communication Published on 2015-06-012022-10-30 Journal: The Journal of General Virology [Category] Coronavirus, MERS, [키워드] America Analysis Asia bronchitis cause coding region coronavirus full-length Genetic Genotype genotypes IBV Infectious Bronchitis Virus introduced isolate Lineage Massachusett N gene performed sequence South South America strain Strains the vaccine virus [DOI] 10.1099/vir.0.000077 PMC 바로가기 [Article Type] Short Communication
A respiratory syncytial virus (RSV) vaccine based on parainfluenza virus 5 (PIV5)Article Published on 2014-05-232022-10-06 Journal: Vaccine [Category] 진단, [키워드] antigen-specific antibody BALB/c mice cause children Efficacy evaluate exacerbate expressing glycoprotein Histopathology Hospitalization Human immune individuals Infant Infection lung lung lesion mice morbidity and mortality parainfluenza virus Parainfluenza virus 5 platform protective immunity Protein respiratory respiratory syncytial virus responses RSV severe respiratory disease the vaccine vaccination Vaccine Vaccine development vaccine strain virus were used wild-type [DOI] 10.1016/j.vaccine.2014.03.049 PMC 바로가기 [Article Type] Article
Genetic Variability and Phylogeny of Current Chinese Porcine Epidemic Diarrhea Virus Strains Based on Spike , ORF3 , and Membrane GenesResearch Article Published on 2014-01-222022-10-29 Journal: The Scientific World Journal [Category] Coronavirus, MERS, [키워드] amplified Analysis analyzed antigenicity changed Characteristics China Chinese conserved current death demonstrated different epidemic diarrhea Frame Gene Genes homology hydrophobicity Immunity isolate M gene membrane Mutation ORF ORF3 outbreak PEDV S gene sequence sequenced spike Spread strain subgroup suggested the disease the S protein the vaccine variant Variation virulence virulent virus widespread [DOI] 10.1155/2014/208439 PMC 바로가기 [Article Type] Research Article
Sequence Heterogeneity of the ORF3 Gene of Porcine Epidemic Diarrhea Viruses Field Samples in Fujian, China, 2010–2012Brief Report Published on 2013-09-302022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Analysis antigenic variation China collected diarrhea different field FIVE Genotype group help heterogeneity inefficient investigated involved management mutations ORF3 outbreak PEDV Phylogenetic analysis Porcine epidemic diarrhea virus positive Prevent Sample strain the disease the vaccine unique Vaccine Vaccine development Variation virulence [DOI] 10.3390/v5102375 PMC 바로가기 [Article Type] Brief Report
Sequence and phylogenetic analysis of nucleocapsid genes of porcine epidemic diarrhea virus (PEDV) strains in ChinaOriginal Article Published on 2013-02-072022-10-28 Journal: Archives of Virology [Category] Coronavirus, MERS, [키워드] acute diarrhea addition amino acid sequence amplified Analysis cause China Chinese cloned Cluster compared composed conserved early diagnosis epidemic diarrhea GenBank high mortality rate identity increasingly Korean less N gene nucleocapsid Nucleocapsid gene nucleotide nucleotide sequence PEDV peptide Phylogenetic analysis Protein RT-PCR selected sequence identity sequenced strain Strains the vaccine Vaccine development virus [DOI] 10.1007/s00705-012-1592-4 PMC 바로가기 [Article Type] Original Article
Recombinant parainfluenza virus 5 vaccine encoding the influenza virus hemagglutinin protects against H5N1 highly pathogenic avian influenza virus infection following intranasal or intramuscular vaccination of BALB/c miceArticle Published on 2013-01-012022-10-06 Journal: Journal of Virology [Category] 진단, [키워드] administration Antigen approach BALB/c BALB/c mice booster contraindication different effectively controlled Efficacy ENCODE expressing H5N1 highly pathogenic immune responses immunization inactivated Infection Influenza Influenza virus intramuscular intramuscular vaccination intranasal lung mucosal IgA response Neutralizing New pandemic parainfluenza virus Prevent PROTECT Protective recombinant required robust serum antibody response shown single vaccine tested the vaccine threat vaccination Vaccine Vaccine development Vaccines virion Virology virus virus replication viruses while [DOI] 10.1128/JVI.02330-12 PMC 바로가기 [Article Type] Article
Genetic variation analysis of reemerging porcine epidemic diarrhea virus prevailing in central China from 2010 to 2011Article Published on 2012-12-272022-10-28 Journal: Virus Genes [Category] Coronavirus, [키워드] 2003 Amino acid amplified Analysis analyzed changed China Chinese cloned collected compared different epidemic diarrhea European Evolution exhibit Gene Genetic Genotype isolate Korean M gene Molecular epidemiology nucleotide ORF3 ORF3 gene outbreak PEDV phylogenetic analyses Phylogenetic analysis polymerase chain Porcine epidemic diarrhea virus separated sequenced strain the vaccine transcriptase Variation virus [DOI] 10.1007/s11262-012-0867-x PMC 바로가기 [Article Type] Article
In vitro inhibition of transmissible gastroenteritis coronavirus replication in swine testicular cells by short hairpin RNAs targeting the ORF 7 geneResearch Published on 2012-08-282022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Apoptosis approach assays Cell cell proliferation characterized contagious Coronavirus replication Cytopathic effect demonstrated diarrhea effective Efficiency Evidence examined expressing expression expression plasmid expression plasmids gastroenteritis Genome high mortality in vitro indicated Infection inhibit inhibited inhibitory effect N gene ORF ORF 7 Quantitative Replication reporter Result RNA RNA interference RT-PCR analysis selected sequence short hairpin RNA shown significantly specificity STABLE target gene TCID TGEV the vaccine therapeutic transmissible gastroenteritis virus Treatment viral disease viral infections viral replication virus virus replication virus titer vomiting [DOI] 10.1186/1743-422X-9-176 PMC 바로가기 [Article Type] Research