Repurposing the antibacterial drugs for inhibition of SARS-CoV2-PLpro using molecular docking, MD simulation and binding energy calculation분자 도킹, MD 시뮬레이션 및 결합 에너지 계산을 사용하여 SARS-COV2-PLPRO의 억제를위한 항균제를 재사용Article Published on 2022-08-012022-08-31 Journal: Molecular diversity [Category] SARS, 신약개발, [키워드] acetic acid Amino acid amino acids Antibacterial Antibacterial compounds aromatic rings benzofuran best binding energy cleavage collected complex Compound conserved docked downregulating downregulation drug effective effective inhibitor feature filtered function GRL0617 Host hydrophobic hydrophobic interaction immune system indol inhibitor Interaction interferon interferon-stimulated gene IRF3 ISG15 key amino acid key amino acids MD simulation molecular molecular docking molecular dynamics Molecular dynamics simulation non-structural protein novel corona virus Papain Papain-like protease Papain-like protease (PLpro) PLPro produced promoted protease Protein protein-ligand Proteins removal Replication reported repurposing SARS-CoV SARS-CoV-2 SARS-CoV-2 novel corona virus. SARS-CoV2 similarity stability type I interferon Viral viral growth Zinc ZINC database [DOI] 10.1007/s11030-021-10325-0 PMC 바로가기 [Article Type] Article
Cycle threshold responses in SARS-COV2 PCR tests depend on the method by which the samples were obtained and require strict global standardizationSARS-COV2 PCR 테스트의 주기 임계값 응답은 샘플을 얻은 방법에 따라 다르며 엄격한 글로벌 표준화가 필요합니다.Article Published on 2022-08-012022-09-11 Journal: Infection [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis CDC Ct values cycle cycle threshold detect determine emergency room Epidemic false negatives hospitals include PCR PCR test penetration platform reduce response risk SARS-CoV2 Schools Standardization Swab threshold Viral load virus [DOI] 10.1007/s15010-022-01772-4 PMC 바로가기 [Article Type] Article
Kinetics of SARS-CoV-2 antibody responses pre-COVID-19 and post-COVID-19 convalescent plasma transfusion in patients with severe respiratory failure: an observational case-control study중증 호흡부전 환자에서 코로나19 이전 및 코로나19 이후 회복기 혈장 수혈에 대한 SARS-CoV-2 항체 반응의 동역학: 관찰 사례-대조군 연구Observational Study Published on 2022-08-012022-09-12 Journal: Journal of Clinical Pathology [Category] MERS, SARS, 임상, 진단, [키워드] anti-RBD anti-RBD IgM antibodies antibody Antibody titre binding domain Blood blood draw Blood Transfusion case-control study CCP Clinical outcome clinical outcomes control patient controls convalescent plasma COVID-19 ECMO ELISA extracorporeal membrane oxygenation hospital ICU IgG IgG and IgM IMPROVE increase indicated individual intensive care Kinetics LOS median pandemic Patient patients patients with COVID-19 plasma Primary outcome RBD recipient SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody response SARS-CoV2 secondary outcome seronegative seropositive severe respiratory failure Support survival the SARS-CoV-2 titre Treatment vaccination ventilator ventilatory were measured while with COVID-19 [DOI] 10.1136/jclinpath-2020-207356 PMC 바로가기 [Article Type] Observational Study
Variant-specific SARS-CoV-2 within-host kinetics변이체 특이적 SARS-CoV-2 숙주 내 역학Article Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] alpha and delta variants Alpha variant Analysis caused Chain Reaction characterized Cohort contagiousness copy number Ct values cycle threshold ddPCR Delta determinant digital PCR Epidemic epidemiological Evidence France General population highlight hospital individual Infection Kinetics lineages no significant difference Older performed polymerase chain polymerase chain reaction populations Quantitative RT-qPCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV2 screening test significant difference significantly higher Swab translate Transmission upper respiratory tract variant variant of concern variants variations viral dynamics viral genome virus virus load VoC VOCs within-host [DOI] 10.1002/jmv.27757 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection and treatment in a cohort of patients with inborn errors of immunityArticle Published on 2022-08-012022-11-15 Journal: Pediatric allergy and immunology : official public [Category] SARS, 진단, [키워드] Abstract Antiviral antiviral drugs cohort of patient COVID-19 Immunity inborn errors of immunity monoclonal monoclonal antibodies Primary immunodeficiencies SARS-COV-2 infection SARS-CoV2 Treatment [DOI] 10.1111/pai.13833 PMC 바로가기
Antibody response following the third and fourth SARS-CoV-2 vaccine dose in individuals with common variable immunodeficiencyObservational Study Published on 2022-07-282022-10-05 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 임상, [키워드] Affect antibody Antibody Response booster booster doses Capsule clinical Concentration corona vaccination COVID-19 CVID dose examined IgG antibody immunodeficiency immunoglobulin replacement therapy IMPROVE increase in individual Kruskal-Wallis tests median monoclonal antibody mounted mRNA Multiple non-responder non-responders Patient patients proportion SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV2 Seroconversion seroconverted spike receptor-binding domain stimulate the antibody response Treatment vaccination Vaccinations Vaccine vaccine dose [DOI] 10.3389/fimmu.2022.934476 PMC 바로가기 [Article Type] Observational Study
Identifying factors associated with COVID-19 related deaths during the first wave of the pandemic in EuropeArticle Published on 2022-07-282023-07-10 Journal: Frontiers in Public Health [Category] COVID19(2023년), [키워드] Europe (central) influenza vaccination Non-pharmaceutical interventions SARS-CoV2 Vitamin D [DOI] 10.3389/fpubh.2022.922230 PMC 바로가기
MIS-C and co-infection with P. vivax and P. falciparum in a child: a clinical conundrum소아에서 MIS-C 및 P. vivax 및 P. falciparum과의 동시 감염: 임상적 수수께끼Case Reports Published on 2022-07-272022-09-11 Journal: Italian Journal of Pediatrics [Category] COVID19(2023년), SARS, 말라리아, 치료기술, [키워드] Case report children clearance clinical condition Co-infection coronavirus disease Coronavirus disease 2019 COVID 19 COVID-19 COVID-19 symptom criteria Critical Diagnosis Early detection effective Endemic Epidemic Health Health Organization Infection infections Inflammatory Intravenous immunoglobulin malaria management Methylprednisolone MIS-C Multisystem inflammatory syndrome nasopharyngeal occur P. falciparum Patient patients with SARS-CoV-2 PCR Plasmodium Plasmodium vivax risk SARS CoV2 SARS-COV-2 infection SARS-CoV2 Symptom syndrome the patient were used WHO World Health Organization worsened [DOI] 10.1186/s13052-022-01311-9 PMC 바로가기 [Article Type] Case Reports
Multidrug-Resistant Klebsiella pneumoniae in a Patient with SARS-Cov-2 Pneumonia in an Intensive Care Unit in Guayaquil, Ecuador: A Case Report에콰도르 Guayaquil의 중환자실에서 SARS-Cov-2 폐렴 환자의 다제내성 Klebsiella pneumoniae: 증례 보고Case Reports Published on 2022-07-222022-09-11 Journal: The American journal of case reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] Admission admitted to ICU antibiotic Antibiotics Bacterial Blood blood culture broad-spectrum antibiotic carbapenem case study Chain Reaction Chest computed tomography Comorbidities Computed tomography Corticosteroid corticosteroid treatments Corticosteroids COVID-19 COVID-19 pandemic Culture Department Dyspnea Emergency emergency department ESBL health problem ICU ICUs incidence increase in intensive care unit intensive care units intravenously Invasive mechanical ventilation Klebsiella Klebsiella pneumoniae Klebsiella pneumoniae carbapenemase KPC Laboratory management medical history meropenem microorganism multidrug-resistant Nasopharyngeal swab NDM New past medical history pathogen Pathogens Patient polymerase chain polymerase chain reaction positive public health pulmonary infiltrate report reported reverse transcription risk factor Risk factors RT-PCR SARS-CoV2 secretion strain superinfection Swab tracheal Treatment use of corticosteroids vancomycin [DOI] 10.12659/AJCR.936498 PMC 바로가기 [Article Type] Case Reports
A comprehensive evaluation of the immune system response and type-I Interferon signaling pathway in hospitalized COVID-19 patients입원한 코로나19 환자의 면역 체계 반응 및 I형 인터페론 신호 전달 경로에 대한 종합 평가Article Published on 2022-07-162022-09-12 Journal: Cell Communication and Signaling : CCS [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Abstract association autoantibody B lymphocyte CD4 CD8 conditions conducted COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients cytokine decrease downstream dysregulation ELISA enrolled enzyme-linked immunosorbent evaluate evaluated expression expression level Factor flow cytometry Frequency healthy controls healthy individual hospitalized COVID-19 patient IFN-I IFN-I signaling IFN-α IFN-β IL-10 IL-17 IL-1β IL-6 illness Illness severity Immune cell immune system Immune-phenotype investigated IRF life-threatening material Mild Mild symptom NK cell NK cells Numerous Pathogenesis pathway Patient positive Protein protein levels Real-time PCR reduced Regulatory RNA SARS-CoV2 sera severity signaling molecule signaling molecules signaling pathway significant decrease Th17 TNF-α Treatment Treg Treg cell Vaccines virus [DOI] 10.1186/s12964-022-00903-6 PMC 바로가기 [Article Type] Article