DeepR2cov: deep representation learning on heterogeneous drug networks to discover anti-inflammatory agents for COVID-19DeepR2Cov : Covid-19에 대한 항 염증제를 발견하기위한 이종 약물 네트워크에 대한 심층 표현 학습Article Published on 2021-11-052022-08-31 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 신약개발, 유전자 메커니즘, [키워드] accelerate addition anti-inflammatory agent approach approaches association binding characteristic clinical trial complex coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients death deep representation learning demonstrated docking downloaded drug Drug discovery eight excessive inflammatory response FIVE heterogeneous heterogeneous drug networks. inflammation storm Inflammatory Inflammatory response Inflammatory responses interleukin interleukin-6 molecular Necrosis outperform patients predict recent significantly source code therapeutic transcriptomics transcriptomics data Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α unique vector [DOI] 10.1093/bib/bbab226 PMC 바로가기 [Article Type] Article
A transferable deep learning approach to fast screen potential antiviral drugs against SARS-CoV-2SARS-COV-2에 대한 빠른 스크린 잠재적 항 바이러스 약물에 대한 양도 가능한 딥 러닝 접근Article Published on 2021-11-052022-08-31 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 신약개발, 치료제, [키워드] accelerate anti-SARS-CoV-2 antiviral drug applied approach binding build can be used cause Compound coronavirus COVID-19 COVID-19 pandemic database deep learning demonstrated disease Docking studies docking study drug candidate drug candidates Drug discovery Drug repurposing effective enzyme FDA-approved drug FDA-approved drugs fine-tune inhibit list proof protease reported SARS-CoV-2 Seven tested transfer Treatment Virtual screening [DOI] 10.1093/bib/bbab211 PMC 바로가기 [Article Type] Article
A method to estimate probability of disease and vaccine efficacy from clinical trial immunogenicity dataArticle Published on 2021-11-042022-10-04 Journal: NPJ Vaccines [Category] 바이오마커, 임상, [키워드] accelerate assessment association Bayesian Biomarker candidate clinical trial Clinical trial design collected confidence interval contributing to COVID-19 pandemic dengue virus disease Drug development Efficacy effort estimate example help immune response immunogenicity data immunological indicate Influenza information Predictive Predictive markers Probability quantitative framework Trial vaccination Vaccine Vaccine development vaccine efficacy Vaccines [DOI] 10.1038/s41541-021-00377-6 PMC 바로가기 [Article Type] Article
Structural Biology of Nanobodies against the Spike Protein of SARS-CoV-2Review Published on 2021-11-032022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] accelerate Amino acid antibody antiviral therapy Biology Blood camelid COVID-19 Culture disorder expression feature high affinity Infection molecular multiple study nanobody neutralisation pandemic Protein protein complexes pseudovirus reagent Receptor binding domain reported SARS-CoV-2 single-chain antibodies spike Spread stability tested the SARS-CoV-2 virus the Spike Treatment Trial unique virus [DOI] 10.3390/v13112214 PMC 바로가기 [Article Type] Review
The seroprevalence of SARS-CoV-2 during the first wave in Europe 2020: A systematic reviewResearch Article Published on 2021-11-022022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] accelerate age Community country COVID-19 pandemic database death Europe European Evidence First wave Gender group HCW HCWs healthcare worker heterogeneity increase in Infection Intervention majority Meta-analysis no significant difference not differ objective Outbreaks performed population immunity populations Pregnancy public health public health measure random effect reported required Result review SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 seroprevalence searched significantly stratified subgroup subgroups systematic review vaccination Web of Science [DOI] 10.1371/journal.pone.0250541 PMC 바로가기 [Article Type] Research Article
Dominant clade‐featured SARS‐CoV‐2 co‐occurring mutations reveal plausible epistasis: An in silico based hypothetical modelResearch Article Published on 2021-11-012022-10-04 Journal: Journal of medical virology [Category] MERS, SARS, 변종, [키워드] accelerate acute respiratory syndrome Affect Analysis binding circulating clade clades co‐occurring mutations coronavirus COVID‐19 decrease docking dominant Effect Efficiency eight evade event explain favor fitness flexible help hypothetical Immunity in silico in silico Approach infection paradox Interaction interactions modulate molecular MOST mutant Mutation mutations N protein nucleocapsid ORF3a P323L phenotypic effect polymerase prevalent Prospective Study Protein Q57H RdRP Replication retrospective RNA RNA stability SARS‐CoV‐2 SARS‐CoV‐2 sentinel significantly increased silent spike mutation stability Structural variation Superior translational Transmission variant viral replication virulence virus [DOI] 10.1002/jmv.27416 PMC 바로가기 [Article Type] Research Article
Knowledge, Attitudes and Perception toward COVID-19 Vaccines among Adults in Jazan Province, Saudi ArabiaArticle Published on 2021-11-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] accelerate Attitude collected Community concerning conducted country Coverage COVID-19 COVID-19 vaccine COVID-19 vaccines cross-sectional demographic data Effectiveness evaluated female Healthcare system Hesitancy include Influenza initiated International majority massive median age Mortality MOST National participant Perception Population positive proportion questionnaire receiving reduce reducing response to vaccination Retrospective study risk of infection SARS-CoV-2 Saudi Arabia significantly study participant the vaccine vaccination Vaccine [DOI] 10.3390/vaccines9111259 PMC 바로가기 [Article Type] Article
SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges소아 집단에 대한 SARS-CoV-2 백신 테스트 및 시험: 생물학적, 윤리적, 연구 및 구현 과제Article Published on 2021-11-012022-09-11 Journal: Pediatric Research [Category] SARS, 임상, [키워드] accelerate adaptive addressed Adolescence Adults Affect affected allocation approach biologic Care changes in childhood children chronic conditions chronic disease clinical trial clinical trials Community conditions COVID-19 COVID-19 disease COVID-19 pandemic developmental developmental disorder developmental disorders Diseases Effect effective Effectiveness enrolled equity ethical concerns Health health inequities health system immune immune system Immunity implementation include innate and adaptive immunity knowledge majority maturation nation other disease other diseases pediatric populations rationale required Research risk SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines symptomatic threshold Trial unique vaccination Vaccinations Vaccine Vaccine hesitancy variety weighed [DOI] 10.1038/s41390-021-01402-z PMC 바로가기 [Article Type] Article
Five probable factors responsible for the COVID-associated mucormycosis outbreak in India인도에서 COVID-관련 점막진균증 발병에 책임이 있는 5가지 가능한 요인Article Published on 2021-11-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 변종, [키워드] accelerate accounted Awareness B.1.617.2 cause conditions Contagion coronavirus COVID-19 COVID-19 patient COVID-associated mucormycosis creating delta variant diabete diabetes Diabetes Mellitus Diseases Factor Factors fungal help hospital ward Hospital wards Hospitalization Immunosuppression impacted include increase in India iron Mucormycosis outbreak overdose oxygen patients Physicians preventive measure reduced reported required responsible restrict second wave Spread steroid steroid overdose. Symptom unhygienic variant [DOI] 10.1016/j.ijid.2021.09.057 PMC 바로가기 [Article Type] Article
A triple-blind, placebo-controlled, randomized clinical trial to evaluate the effect of curcumin-containing nanomicelles on cellular immune responses subtypes and clinical outcome in COVID-19 patientsRandomized Controlled Trial Published on 2021-11-012022-10-05 Journal: Phytotherapy research : PTR [Category] SARS, 임상, [키워드] accelerate administration Cellular immune response changes in Clinical outcome Clinical sign clinical trial COVID-19 COVID-19 patient COVID-19 patients Curcumin cytokine Cytokine storm effective evaluate the effect excessive immune response FOXP3 GATA3 Gene Expression IFN-γ IL-17 IL-4 Immunity Inflammation Inflammatory diseases inflammatory immune responses inflammatory phase Inflammatory responses investigated modulating per day Placebo placebo group placebo-controlled placebo-controlled study Randomized randomized clinical trial RORC Serum level severe complications significantly Signs and symptoms subtype suggested Symptoms TBX21 TGF-β triple-blind two group was done were measured [DOI] 10.1002/ptr.7294 PMC 바로가기 [Article Type] Randomized Controlled Trial