Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infectionArticle Published on 2021-12-222022-10-30 Journal: Nature Immunology [Category] COVID-19, Fulltext, SARS, [키워드] Adaptive immunity Adults antibody Antibody Response Asymptomatic Beta biological basis cellular immunity cellular response children comparable cross-reactive Delta develop generally mild generate help immune response Infection Infectious diseases neutralize occur occurred outcome pediatric regimens response responses against retained robust S2 domain SARS-CoV-2 SARS-COV-2 infection seasonal coronaviruses Seroconversion seronegative specificity Spike protein sustained T cell response the spike protein vaccination variants viral infection viral variant [DOI] 10.1038/s41590-021-01089-8 PMC 바로가기 [Article Type] Article
A randomized controlled study of convalescent plasma for individuals hospitalized with COVID-19 pneumoniaCOVID-19 폐렴으로 입원한 개인을 위한 회복기 혈장의 무작위 대조 연구Randomized Controlled Trial Published on 2021-12-152022-09-12 Journal: The Journal of Clinical Investigation [Category] SARS, 임상, 진단, [키워드] 28-day mortality Adaptive immunity Administered adults hospitalized anti-SARS-CoV-2 anti-SARS-CoV-2 antibody benefit CCP clinical clinical severity score clinical trials Comorbidities convalescent plasma COVID-19 disease Efficacy enrolled Evidence Hospitalization Hospitalized hospitalized patient Immunosuppression include individual interquartile range majority mechanical ventilation median outcome measure Oxygenation participant performed Pneumonia populations primary efficacy endpoint Randomized randomized controlled study randomized trial Result risk factor Safe SARS-CoV-2 RNA secondary outcome seronegative seronegative participant severe COVID-19 shown standard care Symptom those with comorbidity treated Treatment Trial WHO with COVID-19 [DOI] 10.1172/JCI155114 PMC 바로가기 [Article Type] Randomized Controlled Trial
Cross-protective immunity following coronavirus vaccination and coronavirus infectionResearch Article Published on 2021-12-152023-07-01 Journal: The Journal of Clinical Investigation [Category] SARS, [키워드] Adaptive immunity Cellular immune response COVID-19 Vaccines [DOI] 10.1172/JCI151969 PMC 바로가기 [Article Type] Research Article
Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks내피 기능 장애는 조절 이상 림프구 반응 및 사이토카인 네트워크와 함께 심각한 COVID-19에 기여합니다Observational Study Published on 2021-12-102022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 임상, 진단, 치료법, [키워드] activated Activation acute disease Adaptive immunity addition analyses Analysis change Clustering Combination contribute convalescent patient Convalescent patients COVID-19 cytokine disease Disease progression driven by dysfunction dysregulated dysregulation endothelial endothelial injury endothelial integrity expansion flow cytometry granulocyte Granulocytes hallmark hallmarks Hannover ICU patient ICU Patients Immune cell immune cells immune response immune responses immune signature Infectious diseases Inflammatory Inflammatory response Injury involved life-threatening lymphocyte response lymphopenia manifestation medical school microenvironment NK cell observational study plasma protein plasma proteins plasmablast plasmablasts proteomics data regeneration SARS-COV-2 infection SARS-CoV-2-specific antibodies School Seven severe COVID-19 terminally differentiated [DOI] 10.1038/s41392-021-00819-6 PMC 바로가기 [Article Type] Observational Study
Signature of long-lived memory CD8 + T cells in acute SARS-CoV-2 infection급성 SARS-COV-2 감염에서 장기 기억 CD8 + T 세포의 시그니처Article Published on 2021-12-072022-08-31 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] accelerated acute infection acute SARS-CoV-2 infection acute viral infection adaptive Adaptive immunity Blood CCR7 CD45 CD45RA CD8 cells cellular characterized circulating clone clones COVID-19 pandemic effector memory evidence of Express facilitate flow cytometry hallmark IL-7 immune response Immunity Immunological memory Infection interferon low expression maintain memory memory T cell memory T cells outbreak pathogen patients with COVID-19 precursor precursors proliferation question Rapamycin Re-infection SARS-COV-2 infection SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells Sequencing signature stimulated T cell T cell receptor T cells transcriptional Transcriptome transcriptomes Viral viral infection [DOI] 10.1038/s41586-021-04280-x PMC 바로가기 [Article Type] Article
Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients경증 COVID-19 환자에서 공개 cTfh 클론형을 확장하는 보존된 SARS-CoV-2 스파이크 에피토프 식별Article Published on 2021-12-062022-09-11 Journal: The Journal of Experimental Medicine [Category] MERS, SARS, 변종, 진단, [키워드] activate activated T cell activated T cells activating Adaptive immunity Antigen booster CD4+ T cell CD4+ T cells Cell characterized circulating commensal bacteria conserved COVID-19 epitope Epitopes expand follicular healthy donors HLA identification mild COVID-19 patient mild symptoms Patient prevalent Protective protective antibodies SARS-CoV-2 epitopes SARS-CoV-2 S SARS-CoV-2 spike subset T cell T cells TCR TCRs Tfh Tfh cell Tfh cells the SARS-CoV-2 variants [DOI] 10.1084/jem.20211327 PMC 바로가기 [Article Type] Article
Lymph node swelling combined with temporary effector T cell retention aids T cell response in a model of adaptive immunityArticle Published on 2021-12-012023-08-30 Journal: Journal of the Royal Society Interface [Category] E형 간염, [키워드] Adaptive immunity agent-based model effector T cells Lymph node T cell dynamics [DOI] 10.1098/rsif.2021.0464 PMC 바로가기
Corticosteroid treatment in COVID-19 modulates host inflammatory responses and transcriptional signatures of immune dysregulationCOVID-19의 코르티코스테로이드 치료는 숙주의 염증 반응과 면역 조절 장애의 전사 신호를 조절합니다Article Published on 2021-12-012022-09-11 Journal: Journal of leukocyte biology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute SARS-CoV-2 infection adaptive Adaptive immunity age Analysis antibodies apoptotic causative agent cell death characterized clinical care Comorbidity condition conducted coronavirus coronavirus disease coronavirus disease-2019 Corticosteroid corticosteroid therapy corticosteroid treatment Corticosteroids COVID-19 COVID-19 patient COVID-19 patients COVID19 cross-sectional diabetes Diabetic disease severity driver expression Hospitalized host inflammatory response host response hypertension immune immune dysregulation Immunity increased expression indicate Inflammation Inflammatory investigated longitudinal analysis male Male sex mechanism mediators Mild modulate molecular obesity Pathogenesis Patient pro-apoptotic receiving reduced respiratory Respiratory disease responses risk factor robust SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severe disease severity Standard of care steroid Steroids systemic inflammation These data transcriptional transcriptional profile transcriptional profiles transcriptional response transcriptional responses transcriptional. Treatment underlie use of corticosteroid while [DOI] 10.1002/JLB.4COVA0121-084RR PMC 바로가기 [Article Type] Article
Widely heterogeneous humoral and cellular immunity after mild SARS-CoV-2 infection in a homogeneous population of healthy young men균질한 건강한 젊은 남성 집단에서 가벼운 SARS-CoV-2 감염 후 광범위하게 이질적인 체액성 및 세포성 면역Article Published on 2021-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] SARS, 진단, 치료기술, 치료법, [키워드] adaptive Adaptive immunity anti-nucleoprotein antibodies antibody Antibody detection cellular immunity cellular response Cellular responses Cohort conducted COVID-19 cross-sectional survey detect detectable Diagnosis Frequency healthy heterogeneity heterogeneous homogeneous humoral humoral and cellular immunity Humoral and cellular responses Humoral response humoral responses implication individual Infection magnitude median median age men Mild Mild disease mild SARS-CoV-2 infection Neutralizing antibodies nine observation Patient persistence recruited reduction SARS-CoV-2 SARS-CoV-2 protein serological test Serological tests South Asian spike study population Surveillance T cell T cell response T cells Vaccination strategies was tested were used with mild disease [DOI] 10.1080/22221751.2021.1999777 PMC 바로가기 [Article Type] Article
Immune ageing at single-cell resolutionReview Article Published on 2021-11-232024-09-04 Journal: Nature reviews. Immunology [Category] 대상포진, [키워드] Adaptive immunity Inflammation Innate immune cells [DOI] 10.1038/s41577-021-00646-4 PMC 바로가기 [Article Type] Review Article