Analysis of viral load in different specimen types and serum antibody levels of COVID-19 patientsCOVID-19 환자의 다양한 검체 유형 및 혈청 항체 수준의 바이러스 부하 분석Research Published on 2021-01-072022-09-10 Journal: Journal of Translational Medicine [Category] 진단, 치료기술, 치료법, [키워드] affected anal swab anal swabs anti-S Anti-spike antibody antibody levels be positive best binding domain Blood caused collected correlation Course COVID-19 COVID-19 patient death detection rate digital PCR disease domain droplet digital PCR ELISA Factors False negative false negative results followed by global pandemic had no highest IgG antibodies IgG antibody IgM and IgG information Nasopharyngeal swab nasopharyngeal swabs no correlation Other Patient positive Protein Result Saliva SARS-CoV-2 detection serum antibody serum sample specimen swabs symptoms onset tested Urine urine specimens Viral Viral load was measured [DOI] 10.1186/s12967-020-02693-2 PMC 바로가기 [Article Type] Research
Eastern Cape Healthcare Workers Acquisition of SARS-CoV-2 (ECHAS): Cross-Sectional (Nested Cohort) Study Protocol이스턴 케이프 의료 종사자 SARS-CoV-2(ECHAS) 획득: 횡단면(중첩 코호트) 연구 프로토콜Protocol Published on 2021-01-052022-09-10 Journal: International Journal of Environmental Research an [Category] 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition African Antenatal antibody antibody assay antibody levels Cape Chain Reaction Clinical characteristics Cluster CMIA Cohort cohort study Community community infection conducted Coronavirus-2 country COVID-19-related death cross-sectional cross-sectional study cumulative decay Department Eastern Cape Effectiveness Fatality rate finding HCW HCWs Health health facilities healthcare worker Healthcare workers highlight humoral immune response identify IgG antibodies IgG antibody immunoassay increased risk independent risk factor independent risk factors Infection Infection prevention infection rate logistic regression models longitudinal change longitudinal changes measure Microparticle offer pandemic participant polymerase chain polymerase chain reaction positive Prevention and control PROTECT Protein qualitative detection questionnaire recruited Regression model Reinfection respiratory reverse transcription reverse transcription polymerase chain reaction RT-PCR SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 RT-PCR SARS-CoV-2 serology SARS-CoV-2 seroprevalence second wave selected serology South South Africa tested the SARS-CoV-2 virulent women worker [DOI] 10.3390/ijerph18010323 PMC 바로가기 [Article Type] Protocol
Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescenceCOVID-19 및 회복기에 SARS-CoV-2 스파이크 및 뉴클레오캡시드 단백질에 대한 내구성 B 세포 메모리의 신속한 생성Reports Published on 2020-12-222022-09-10 Journal: Science Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] antibody antibody levels Antibody Response B cell memory B cells blood sample Blood samples CD27 Cell cells circulating convalescence correlated COVID-19 COVID-19 patient COVID-19 patients cytometric declining determine expressed Flow follicular functional helper T cell IgG1 IgM Immunity immunophenotype Infection long-term immune memory Longevity memory memory B cell memory B cells memory T nucleocapsid protein Nucleocapsid proteins patients Peripheral blood persistence post-symptom onset Rapid RBD RBD-specific IgG Receptor binding domain SARS-COV-2 infection SARS-CoV-2 spike serum antibodies serum antibody serum IgG significantly Spike receptor binding domain symptom onset T cell the SARS-CoV-2 vaccination while [DOI] 10.1126/sciimmunol.abf8891 PMC 바로가기 [Article Type] Reports
IgA2 Antibodies against SARS-CoV-2 Correlate with NET Formation and Fatal Outcome in Severely Diseased COVID-19 PatientsSARS-CoV-2에 대한 IgA2 항체는 중증 COVID-19 환자의 NET 형성 및 치명적인 결과와 상관 관계가 있습니다Communication Published on 2020-12-122022-09-11 Journal: Cells [Category] MERS, SARS, 바이오마커, 진단, [키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus Adaptive immune response anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody antibody level antibody levels C-reactive protein C-reactive protein (CRP characterized circulating contribute Control coronavirus correlated COVID-19 CRP level CRP levels extracellular DNA Formation Hospitalization Host ICU IgA IgA2 IgG response IgG responses Immune cell immune cells induce Infection Inflammation intensive care intensive care unit leads less marker mild symptoms moderate moderate symptoms NET neutrophil Neutrophil extracellular trap neutrophil extracellular trap (NET) organ injury outcome Patient patient groups patients plasma sample plasma samples respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2-infected patient SARS-CoV-2-infected patients SARS-CoV-2-specific IgG severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease severe SARS severe SARS-CoV-2 specific antibodies Spike protein Symptom the strongest These data TRAP were measured while [DOI] 10.3390/cells9122676 PMC 바로가기 [Article Type] Communication
Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome질병 중증도 및 결과와 관련된 SARS-CoV-2 감염에 대한 항체 반응의 특징 및 기간 정의Research Articles Published on 2020-12-072022-09-10 Journal: Science Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] ACE2 acute illness Affect analyzed angiotensin angiotensin-converting enzyme 2 antibody antibody levels Antibody Response Antibody responses Asymptomatic Asymptomatic individuals Clinical outcome clinical outcomes Cohort correlated COVID-19 COVID-19 patients decrease decreases disease severity ELISA feature FIVE hospitalized COVID-19 patient Host IgG IgG antibodies IgG antibody IgG titer illness Illness severity in viral increase Interaction mild illness Most patients Neutralization assay neutralize nucleocapsid antigen observation outcome outcomes Outpatient outpatients Patient patients patients died plasma antibody plasma sample Post-infection predict Pseudovirus neutralization assays RBD RBD domain RBD-ACE2 receptor Receptor binding domain responses SARS-CoV-2 antibodies SARS-COV-2 infection SARS-CoV-2-specific antibodies serological serological response severely ill patients severity specific antibodies specificity Viral viral spike virus [DOI] 10.1126/sciimmunol.abe0240 PMC 바로가기 [Article Type] Research Articles
Immunological imprint of COVID‐19 on human peripheral blood leukocyte populations인간 말초 혈액 백혈구 개체군에 대한 COVID-19의 면역학적 각인Original Article Published on 2020-11-222022-09-01 Journal: Allergy [Category] SARS, 진단, 치료법, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive addition antibody antibody levels B cells CD25 CD3 CD31 CD38 CD4 CD45 CD45RA CD8 Cell cells cellular Cellular immune response cellular immune responses central memory clinical immunology Cohort convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID‐19 COVID‐19 patient COVID‐19 patients determined by disease domain effector memory elevated ELISA expression flow cytometry FOXP3 healthy control HLA‐DR immune responses immune system immunological immunological change immunological changes immunosorbent Infection infections innate immune system investigated leukocyte population Lymphocytes Mild Mild disease multiparametric flow cytometry neutrophil Neutrophils nucleocapsid pandemic parameters Patient patients Peripheral blood qPCR Quantitative quantitative PCR RBD receptor receptor‐binding domain Recombination reduction reflected regression analysis respiratory responses Result SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‑CoV2 SARS‐CoV‐2 sense sense of taste severe acute respiratory syndrome Coronavirus significantly Spike protein subject T cell T cells T regulatory cell T regulatory cells T‐cell Taste thymic emigrant thymic emigrants transitional B cell transitional B cells triggered Viral [DOI] 10.1111/all.14647 PMC 바로가기 [Article Type] Original Article
Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19COVID-19로 입원한 환자의 혈청 내 전혈성 자가항체Research Article Published on 2020-11-182022-09-10 Journal: Science Translational Medicine [Category] 진단, 치료제, [키워드] accelerated activated neutrophil Activation antibodies antibody antibody level antibody levels antiphospholipid antibodies autoantibodies autoantibody Autoimmune diseases blood vessel blood vessels Case series Casting circulating Coagulation coagulation pathway COVID-19 COVID-19 patient serum Cutoff develop eight ELISA FIBRIN filtration rate fraction glomerular filtration rate glycoprotein healthy individuals high risk Histopathology hyperactivity IgG IgG and IgM IgM in vitro injected injection Lung histopathology Lupus mice Mouse models NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils Occlusion pathogenic pathogenic autoantibodies pathogenic autoantibody pathway Patient patients patients hospitalized patients with COVID-19 phenotype phospholipid Phospholipids Platelet platelet counts positive potential therapeutic target potentially life-threatening promoted Protein prothrombin prothrombotic purified respiratory Respiratory disease reveal serum serum sample serum samples severe COVID-19 severe respiratory disease small blood vessel small blood vessels syndrome the disease threshold Thrombophilia thrombosis thrombotic venous Venous thrombosis with COVID-19 [DOI] 10.1126/scitranslmed.abd3876 PMC 바로가기 [Article Type] Research Article
Comparative assessment of multiple COVID-19 serological technologies supports continued evaluation of point-of-care lateral flow assays in hospital and community healthcare settings여러 COVID-19 혈청 기술에 대한 비교 평가는 병원 및 지역사회 의료 환경에서 현장 진료 측면 흐름 분석의 지속적인 평가를 지원합니다.Research Article Published on 2020-09-242022-08-13 Journal: PLoS Pathogens [Category] COVID-19, Medicine and Health Sciences, SARS, [키워드] Analysis Anti-spike antibody antibody levels Antibody test antibody test kits Antibody testing antibody tests approved Asymptomatic best binding domain Blood chemiluminescence chemiluminescence-based platform colloidal gold Community Comparative complement conducted COVID-19 delayed-onset syndrome delayed-onset syndromes dependent on determine Diagnosis diagnostic diagnostic antibody diagnostic antibody test diagnostic capabilities diagnostic capability disease ELISA evaluated gold head Head-to-head comparison healthcare hospital house in-house ELISA in-house ELISAs individual Inflammatory lateral flow lateral flow immunoassay Lateral flow immunoassays London management Mild multiple sero-diagnostic assay multiple sero-diagnostic assays nose swab Novel coronavirus nucleocapsid onset of symptoms paediatric inflammatory multisystem syndrome past Patient Patient management PCR-based throat and nose swab tests PIMS platform point-of-care point-of-care technology rapid lateral flow immunoassays RBD Receptor binding domain sampling SARS-CoV-2 SARS-CoV-2 antibody test SARS-CoV-2 infections sensitivities sensitivity serological Seven shown specificity Support Symptoms syndrome the epidemic utility Variation variety virus with COVID-19 [DOI] 10.1371/journal.ppat.1008817 PMC 바로가기 [Article Type] Research Article
The genetic architecture of helminth-specific immune responses in a wild population of Soay sheep ( Ovis aries )Soay 양의 야생 개체군에서 기생충 특이적 면역 반응의 유전적 구조( Ovis aries )Research Article Published on 2019-11-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Adults Affect antibody antibody level antibody levels blood plasma chromosome CIITA class CLEC16A collected complex condition conditions Containing contribute driver Drivers ecological Effect Evidence evidence of Genetic genetic architecture genetic control Genetic variation genomic region heritable variation histocompatibility Host hosts humans identify IgA IgA level IgA levels IgE IgG IgG antibodies IgG antibody IgG level IgG levels IGH immune Immune profile immune response immune responses Immunity Immunoglobulin immunological Infection influence investigated knowledge Laboratory lectin loci maintain Major major histocompatibility complex MHC natural populations natural selection nematodes offer Organisms Ovis parasite parasites Population prevalent provide response sheep significantly the major histocompatibility traits understanding Variation while [DOI] 10.1371/journal.pgen.1008461 PMC 바로가기 [Article Type] Research Article
Antibody Kinetics and Response to Routine Vaccinations in Infants Born to Women Who Received an Investigational Trivalent Group B Streptococcus Polysaccharide CRM 197 -Conjugate Vaccine During Pregnancy조사 3가 그룹 B 연쇄상구균 다당류 CRM 197 -임신 중 접합 백신을 받은 여성에게서 태어난 영아의 항체 동역학 및 정기 예방 접종에 대한 반응Articles and Commentaries Published on 2017-12-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, 백일해, 파상풍, [키워드] age antenatal vaccination antibody antibody level antibody levels Birth capsular clinical clinically Combination detectable Diphtheria diphtheria toxoid disease dosage dosages dose during pregnancy elicited enrolled geometric mean geometric mean concentration group group B Streptococcus conjugate vaccine groups Haemophilus influenzae Haemophilus influenzae type b immune response immune responses Infant Infants invasive investigated Kinetics Maternal mother not affect pediatric Placebo placebo group pneumococcal pneumococcal vaccination Pregnancy Randomized receive Received recipients Registration response Result routine routine immunization serotype serotype-specific serotypes significantly higher single-center study Streptococcus Tetanus the placebo group timepoint transferred trivalent vaccination Vaccine were assessed women [DOI] 10.1093/cid/cix666 PMC 바로가기 [Article Type] Articles and Commentaries