BCG Vaccination and Mortality of COVID-19 across 173 Countries: An Ecological StudyArticle Published on 2020-08-032022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] adjust age Bacillus Bacillus Calmette–Guérin BCG BCG vaccination conducted confounders Coronavirus disease 2019 country Coverage COVID-19 early phase ecological Ecological study examined Factor Factors Hypothesis morbidity morbidity and mortality Mortality National outcomes pandemic physical activity randomized clinical trials reduced resources SARS-CoV-2 suggested urbanization vaccination Vaccine [DOI] 10.3390/ijerph17155589 PMC 바로가기 [Article Type] Article
Key recent advances in TB vaccine development and understanding of protective immune responses against Mycobacterium tuberculosisReview Published on 2020-08-012022-10-04 Journal: Seminars in Immunology [Category] 비임상, [키워드] Adaptive immunity adolescents and adult approach BCG candidate CD4+ CD8+ clinical evaluation correlates of protection diagnostics disease drug regimens effective Efficacy effort End endpoints Epidemic Factors high risk identify immune response immune responses include Infection Infectious disease Innate immunity Innate training Mycobacterium tuberculosis Next generation vaccine novel pathogen Population positive Protective protective immune response Protein Research revaccination stimulated Strategy sustained T cells Th1/Th17 Transmission Trial trials Tuberculosis Tuberculosis (TB) Vaccine vaccine candidate Vaccine development Vaccine(s) World Health Organization [DOI] 10.1016/j.smim.2020.101431 PMC 바로가기 [Article Type] Review
BCG vaccine protection from severe coronavirus disease 2019 (COVID-19)530 Published on 2020-07-282022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] age Analysis association BCG BCG vaccination BCG vaccination policy biological basis clinical evaluation clinical trial comparison confounding factor confounding factors coronavirus disease correlation country COVID-19 COVID-19 coronavirus COVID-19 epidemic COVID-19 mortality COVID-19 pandemic criteria cross-protection death diagnostic test Diseases Effect Effectiveness epidemiological Epidemiological study European country Evidence Health highlight implication increase in limit mitigate Mortality National null hypothesis pandemic Prevalence PROTECT protective effect Public reduce reduced reduction in required Result severe coronavirus disease severe COVID-19 severity of COVID-19 signal Significance spread of COVID-19 suggested Tuberculosis vaccination Vaccine [DOI] 10.1073/pnas.2008410117 PMC 바로가기 [Article Type] 530
New disease old vaccine: Is recombinant BCG vaccine an answer for COVID-19?Article Published on 2020-07-282023-06-15 Journal: Cellular immunology [Category] MERS, SARS, [키워드] BCG COVID-19 SARS-CoV-2 trained immunity Vaccine [DOI] 10.1016/j.cellimm.2020.104187 PMC 바로가기 [Article Type] Article
COVID-19 outbreak in Jordan: Epidemiological features, clinical characteristics, and laboratory findingsCohort Study Published on 2020-07-182022-10-28 Journal: Annals of Medicine and Surgery [Category] COVID-19, [키워드] 95% CI affected age applied asymptomatic patient asymptomatic patients BCG C-reactive protein caused Characteristics Chest Chronic diseases Clinical characteristics Clinical features contributed coronavirus COVID-19 COVID-19 infected patients COVID-19 infection COVID-19 outbreak D-dimer D-dimer level dry cough early stage elevated Endemic erythrocyte sedimentation erythrocyte sedimentation rate ESR explained Factor Features female females illnesses immunization individual Jordan Laboratory laboratory-confirmed majority marker measure Mild mild illness nasal congestion North outbreak Patient patients presenting symptom Protein radiologic radiological receiving reported Result Retrospective study RT-PCR SARS-CoV-2 sore throat Spread symptomatic symptomatic patient vaccination Variability [DOI] 10.1016/j.amsu.2020.07.020 PMC 바로가기 [Article Type] Cohort Study
Could the Induction of Trained Immunity by β-Glucan Serve as a Defense Against COVID-19?Immunology Published on 2020-07-142022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] β-glucan abrogate Against BCG boost Care clinical trial COVID-19 Cytokine storm death Effect effective Efficacy epidemiological Epigenetic evaluate General population Health Health care worker Heterologous immune dysregulation immune response inducer induction initial innate immune innate immune cell Innate immunity memory mitochondrial morbidity and mortality phenotype Population populations Prophylactic PROTECT recent SARS-CoV-2 shown Symptom the SARS-CoV-2 virus trained immunity Treatment undergo Vaccine viral infections [DOI] 10.3389/fimmu.2020.01782 PMC 바로가기 [Article Type] Immunology
The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19Letter to the Editor Published on 2020-07-112022-10-28 Journal: Respiratory Research [Category] COVID-19, [키워드] Bacillus BCG clinical trial conducted country COVID-19 Evidence limitation morbidity and mortality protective effect suggested vaccination Vaccine [DOI] 10.1186/s12931-020-01439-4 PMC 바로가기 [Article Type] Letter to the Editor
Significantly Improved COVID-19 Outcomes in Countries with Higher BCG Vaccination Coverage: A Multivariable AnalysisArticle Published on 2020-07-112022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] administration Analysis association BCG BCG vaccination China contribute coronavirus correlation country Coverage COVID-19 COVID-19 pandemic COVID-19 patients death demography dominant Epidemiology globe Hypothesis immunization Improved MMR vaccine multivariable Multivariable regression negative correlation outcome outcomes pandemic protocol Quantitative reveal SARS-CoV-2 severity Spread statistical significance tested threshold Tuberculosis vaccination Vaccine [DOI] 10.3390/vaccines8030378 PMC 바로가기 [Article Type] Article
BCG Against SARS-CoV-2: Second Youth of an Old Age Vaccine?Pharmacology Published on 2020-07-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Accuracy activated Administered Against Anti-viral immunity Bacillus BCG bcg vaccine caused clinical trials country COVID-19 COVID-19 pandemic Diseases dosage Final generate Heterologous IFN-γ IL-1β IL-1β IL-6 immune responses immune system immunization induce initial lower mortality mortality rate Mycobacterium bovis non-specific outbreak pro-inflammatory cytokines resolved SARS-CoV-2 second the disease TNF-α trained immunity Tuberculosis Vaccine Youth [DOI] 10.3389/fphar.2020.01050 PMC 바로가기 [Article Type] Pharmacology
BCG vaccination policy and preventive chloroquine usage: do they have an impact on COVID-19 pandemic?Article Published on 2020-07-082022-10-04 Journal: Cell Death & Disease [Category] SARS, 임상, [키워드] acute respiratory syndrome affected African Analysis antimalarial Bacillus BCG BCG vaccination caused Chloroquine coronavirus 2 Coronavirus disease 2019 country COVID-19 COVID-19 case COVID-19 disease COVID-19 patients Epidemiology hypothese immunization incidence inverse correlation less malaria Mortality pandemic performed Plasmodium positive Preclinical research reported SARS-CoV-2 severity shown the disease treat vaccination widespread World Health Organization [DOI] 10.1038/s41419-020-2720-9 PMC 바로가기 [Article Type] Article