Clinical features and risk factors of COVID-19-associated liver injury and function: A retrospective analysis of 830 cases코로나19 관련 간 손상의 임상적 특징과 위험인자 및 기능: 830건의 후향적 분석Article Published on 2021-03-012022-09-11 Journal: Annals of hepatology [Category] MERS, SARS, 바이오마커, [키워드] 95% confidence interval abnormality Admission aims Alanine Alanine transaminase ALT Analysis aspartate Aspartate transaminase AST AST/ALT Betacoronavirus Biochemistry C-reactive protein C-reactive protein (CRP Causality change clinical Clinical features Cohort comparison Computed tomography COVID-19 patients CRP level CRP levels demographic determine Diagnostic Criteria drug Drug induced liver injury elevated exhibited Factor feature groups hepatic Hepatic insufficiency hospitalized COVID-19 patient hospitalized COVID-19 patients incidence information Laboratory testing liver Liver injury lymphocyte multivariable logistic regression Multivariable regression Odds ratio on admission outcome parameter Patient performed Pneumonia potential risk proportion ranged Retrospective analysis risk factor Risk factors tomography Triglyceride was used were used X-ray [DOI] 10.1016/j.aohep.2020.09.011 PMC 바로가기 [Article Type] Article
ACE/ACE2 balance might be instrumental to explain the certain comorbidities leading to severe COVID-19 casesCardiovascular System & Vascular Biology Published on 2021-02-262022-10-28 Journal: Bioscience Reports [Category] COVID-19, MERS, [키워드] ACE ACE/ACE2 ACE2 Angiotensin-converting enzyme Biochemistry Comorbidity cytokine explain host cell hypoxia Infection interferon Lungs mechanism organs outbreak protease raised receptor respiratory SARS-CoV-2 serious complication severe COVID-19 Stage the disease [DOI] 10.1042/BSR20202014 PMC 바로가기 [Article Type] Cardiovascular System & Vascular Biology
Prediction of COVID-19 severity using laboratory findings on admission: informative values, thresholds, ML model performance입원 시 실험실 결과를 사용한 COVID-19 심각도 예측: 유익한 값, 임계값, ML 모델 성능Article Published on 2021-02-262022-08-31 Journal: BMJ Open [Category] MERS, 바이오마커, [키워드] 95% CI activated activated partial thromboplastin time admitted to ICU Alanine alanine aminotransferase Algorithm aPTT aspartate Aspartate aminotransferase AUC Bilirubin Biochemistry bioinformatics Biomarker Biotechnology biotechnology & C reactive protein Clinical use comparable consecutive patient COVID-19 COVID-19 severity creatine creatine kinase CRP cut-off cut-off threshold D-dimer dataset Deterioration disease severity disproportion Dubai Features ferritin fibrinogen Free ICU identify Infectious diseases information information technology intensive care intensive care unit Laboratory Laboratory test Laboratory tests Lactate lactate dehydrogenase lymphocyte Lymphocyte count ML model non-severe cases online tool partial thromboplastin time Patient PCR predict prediction Predictive Prognosis prognosis of patient respiratory respiratory infections returned risk Stratification study cohort subjects threshold threshold value thresholds THROMBOPLASTIN total bilirubin troponin with COVID-19 worsening [DOI] 10.1136/bmjopen-2020-044500 PMC 바로가기 [Article Type] Article
Examining the utility of extended laboratory panel testing in the emergency department for risk stratification of patients with COVID-19: a single-centre retrospective service evaluationOriginal Research Published on 2021-02-192022-10-29 Journal: Journal of Clinical Pathology [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 28-day mortality 95% CI adjusted Admission Admissions age Analysis Biochemistry blood test C reactive protein clinical component composite endpoint conducted costs and cost analysis COVID-19 COVID-19 positive patient D-dimer Deprivation determine died Electrolytes Escalation estimate Examining ferritin First wave full blood count Gender global pandemic Haematology healthcare IMPROVE indications Infection infections Inflammation intensive care Laboratory Laboratory testing laboratory-confirmed lactate dehydrogenase Liver function test Local Mortality multivariable logistic regression outcome pathway Patient poor prognosis predict procalcitonin prognostic Prognostic value reached remains uncertain resource Result retrospective risk risk stratification SARS-CoV-2 the primary endpoint troponin I unique urea utility variable with COVID-19 [DOI] 10.1136/jclinpath-2020-207157 PMC 바로가기 [Article Type] Original Research
Flexibility and mobility of SARS-CoV-2-related protein structuresSARS-CoV-2 관련 단백질 구조의 유연성 및 이동성Article Published on 2021-02-192022-08-31 Journal: Scientific Reports [Category] MERS, 신약개발, 치료제, [키워드] antiviral drug Biochemistry Biological physics Biophysics Complete Computational biology and bioinformatics database develop Docking studies docking study domain drugs example flexibility identify in silico in vitro in vivo information movement pandemic PDB Protein protein structures Proteins resolved rigidity S1 subunit SARS-CoV-2 drug SARS-CoV-2 spike SARS-CoV-2 spike protein Scientific community Structure structures targets the S1 subunit the SARS-CoV-2 Vaccine Viral proteins [DOI] 10.1038/s41598-021-82849-2 PMC 바로가기 [Article Type] Article
Structure–function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesisArticle Published on 2021-02-162023-08-30 Journal: Communications Biology [Category] E형 간염, [키워드] Biochemistry Plant sciences [DOI] 10.1038/s42003-021-01739-5 PMC 바로가기 [Article Type] Article
Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody단량체, 서브나노몰 친화성 나노바디에 의한 SARS-CoV-2 D614 및 G614 변이체의 임상 분리물의 강력한 중화Article Published on 2021-02-082022-09-01 Journal: Scientific Reports [Category] MERS, 변종, 진단, [키워드] ACE-2 receptor alpaca antibody Antiviral antiviral agent applicability Bacterial bind binding Biochemistry Biotechnology Cell Biology centrifugation Critical D614G variant density gradient density gradient centrifugation develop Diagnosis E. coli G614 variant global effort health systems IC50 immunization immunology include isolate Isolation Molecular biology monomeric nanobodies nanobody neutralization neutralize potent prophylactic measure prophylactic measures Protein RBD reduce regimen required S RBD SARS-CoV-2 SARS-CoV-2 spike protein selected situation spike Spike protein the SARS-CoV-2 therapeutic Treatment wild type [DOI] 10.1038/s41598-021-82833-w PMC 바로가기 [Article Type] Article
Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19Article Published on 2021-02-032022-10-04 Journal: Scientific Reports [Category] MERS, 치료제, [키워드] acute respiratory syndrome Affect alarmin Analysis approach Biochemistry biogenesis Biotechnology carried caused Cell cellular pathway characterized complementary coronavirus Coronavirus disease 2019 Coronavirus replication correlated COVID-19 COVID-19 disease COVID-19 patient Critical cytokine Disease progression Diseases identify IL-17 Inflammation intensive care involved key factor Lipid lipid metabolism Mild moderate modulate Molecular medicine Pathogenesis pathway patients with COVID-19 profiles progression Proinflammatory cytokine SARS-CoV-2 SARS-CoV-2 infections serum severe symptom severity Spread therapeutic targets TSLP Vesicle virus virus entry virus propagation were measured [DOI] 10.1038/s41598-021-82426-7 PMC 바로가기 [Article Type] Article
Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamicsArticle Published on 2021-01-272022-10-04 Journal: Nature Communications [Category] 변종, [키워드] Analysis biochemical Biochemistry catalytic cleavage conformational conserved coronavirus Coronaviruses Critical cryo-EM cryo-EM structure Cryoelectron microscopy crystal structure dataset Defense determine enzyme evade experiments facilitate Host mass spectrometry mechanism molecular Molecular dynamics simulation phosphate phosphodiester bond recognize regulate residue RNA RNA decay SARS-CoV-2 shown specificity structural framework Structure the SARS-CoV-2 uridine viral infection Viral RNA [DOI] 10.1038/s41467-020-20608-z PMC 바로가기 [Article Type] Article
First principle simulation of coated hydroxychloroquine on Ag, Au and Pt nanoparticlesAg, Au 및 Pt 나노 입자에 코팅된 하이드록시클로로퀸의 첫 번째 원리 시뮬레이션Comparative Study Published on 2021-01-222022-09-10 Journal: Scientific Reports [Category] 신약개발, 치료제, [키워드] Adsorption Antiviral antiviral properties antiviral property applied approach AuNP Biochemistry Candidates Chloroquine classical clinical test Clinical tests coated coating Computational biology and bioinformatics COVID-19 pandemic Density functional theory drug Effect experimental group First principle functional HCQ help highest affinity Hydroxychloroquine modeling molecular molecular dynamics Molecular medicine Nanoscience and technology reducing Safe SARS-CoV-2 Side effect Side effects suggested therapeutic Therapies [DOI] 10.1038/s41598-021-81617-6 PMC 바로가기 [Article Type] Comparative Study