Neutralization of SARS-CoV-2 Variants by mRNA and Adenoviral Vector Vaccine-Elicited AntibodiesmRNA 및 아데노바이러스 벡터 백신 유도 항체에 의한 SARS-CoV-2 변이체의 중화Article Published on 2022-03-082022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S Adenoviral vector-based vaccine adenoviral vector-based vaccines antibody Antibody titers benefit Beta BNT162b2 Breakthrough infection breakthrough infections COV2.S decrease Delta Delta plus Effectiveness elicited fraction immunization Lambda less mRNA mRNA-1273 mRNA-based neutralization Neutralizing antibody titer neutralizing antibody titers Neutralizing titer Prevalence Pseudotyped virus raised SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 Surveillance vaccinated individual vaccinated individuals Vaccine variant variants vector viruses were measured [DOI] 10.3389/fimmu.2022.797589 PMC 바로가기 [Article Type] Article
Vaccination-infection interval determines cross-neutralization potency to SARS-CoV-2 Omicron after breakthrough infection by other variants백신 접종-감염 간격은 다른 변이체에 의한 돌발성 감염 후 SARS-CoV-2 Omicron에 대한 교차 중화 효능을 결정합니다.Clinical and Translational Report Published on 2022-03-042022-09-14 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Abstract acute respiratory syndrome AMED ancestors antibodies antibody approach blood sample BNT162b2 mRNA vaccine breadth Breakthrough infection breakthrough infections collected Combination complex complicate Context coronavirus correlated COVID-19 COVID-19 vaccine cross-neutralization Delta demonstrated determine development finding funding heterogeneity immune immune evasion Immune profile Immunity individual Infection Japan magnitude mRNA mRNA vaccine much higher neutralization Neutralizing activity neutralizing antibody omicron Omicron variant other variant overcome population immunity protective immunity resistance to infection robust SARS-CoV-2 sera several variants Significance significantly spike mutations suffered supported susceptibility time interval vaccinated individual vaccination Vaccine vaccinee variant variants [DOI] 10.1016/j.medj.2022.02.006 PMC 바로가기 [Article Type] Clinical and Translational Report
The interface of COVID-19, diabetes, and depressionReview Published on 2022-03-012022-11-01 Journal: Discover Mental Health [Category] COVID-19, [키워드] breakthrough infections communicable Comorbidities COVID-19 COVID-19 pandemic Depression diabete diabetes disease Health higher risk incidence increase in individual lockdown management non-communicable diseases overlapping Patient patients with diabete Prevalence problem quarantine severe COVID-19 survivor Symptom symptoms of depression type 2 diabete vicious cycle [DOI] 10.1007/s44192-022-00007-0 PMC 바로가기 [Article Type] Review
ACE2-Fc fusion protein overcomes viral escape by potently neutralizing SARS-CoV-2 variants of concernACE2-Fc 융합 단백질은 우려되는 SARS-CoV-2 변이체를 강력하게 중화하여 바이러스 탈출을 극복합니다Article Published on 2022-03-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2-Fc Analysis antibodies Antibody drugs approved binding Biotechnology breakthrough infections caused Clinical data Comprehensive COVID-19 dominant variant drug drug design drug resistance Efficiency EMA experiment FDA fusion protein Glycoproteins increasingly Infectious disease Interaction mechanism monoclonal antibodies monoclonal antibody Mutation neutralization neutralize Neutralizing not compromised omicron overcome Protein binding Proteins public health remained SARS-CoV-2 variant SARS-CoV-2 virus spike variants tested the SARS-CoV-2 virus therapeutic therapeutic agent therapeutic antibodies Therapeutic antibody treat Treatment vaccinated individual vaccinated individuals Vaccine variant variants Viral viral escape viral infection [DOI] 10.1016/j.antiviral.2022.105271 PMC 바로가기 [Article Type] Article
Breakthrough infections with the SARS-CoV-2 Delta variant: vaccinations halved transmission riskSARS-CoV-2 Delta 변종으로 인한 획기적인 감염: 예방접종으로 전염 위험이 절반으로 감소Article Published on 2022-03-012022-09-11 Journal: Public health [Category] SARS, 변종, [키워드] age association B.1.617.2 Breakthrough infection breakthrough infections case-control study Contact control group Delta delta variant estimate individuals Infection IPs less not significant number of infected onward transmission Patient populations reduced risk SARS-CoV-2 significantly the SARS-CoV-2 Transmission vaccinated individual vaccinated individuals vaccination Vaccination Status [DOI] 10.1016/j.puhe.2022.01.005 PMC 바로가기 [Article Type] Article
Breakthrough SARS-CoV-2 infections among BBV-152 (COVAXIN®) and AZD1222 (COVISHIELD TM ) recipients: Report from the eastern state of IndiaBBV-152(COVAXIN®) 및 AZD1222(COVISHIELD TM ) 수혜자 사이의 획기적인 SARS-CoV-2 감염: 인도 동부 주에서 보고Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome Antibody titer Antibody titers Antigen AZD1222 be positive breakthrough Breakthrough infection breakthrough infections collected Complete coronavirus 2 coronavirus disease Coronavirus disease-19 COVAXIN® COVID-19 COVISHIELDTM detect dose healthcare facility highlight Home isolation Hospitalization hospitalized patients IgG titer value Immunity India individual interquartile range less median median age MONITOR Nasopharyngeal swab Older age Patient positive Postinfection Quantitative receiving Receptor binding domain recipient recipients report reported required respiratory SARS-CoV-2 SARS-COV-2 infection Seropositivity serum sample serum samples severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly significantly higher Swab symptomatic vaccinated individual vaccinated individuals vaccination Vaccine Vaccine development Vaccines variant variants virus infection [DOI] 10.1002/jmv.27382 PMC 바로가기 [Article Type] Article
Discovery of SARS-CoV-2 3CL Pro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein–Ligand InteractionsArticle Published on 2022-02-212022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), SARS, [키워드] 3CL accumulating acute respiratory syndrome anti-SARS-CoV-2 Antiviral assays binding energy breakthrough infections catalytic dyad cellular conserved coronavirus coronavirus disease covalent inhibitor drug candidate drug design dyad Efficacy effort etiological agent examined exhibited FIVE High-resolution histidine inhibitor inhibitors inhibitory Medicines molecular dynamics simulations molecule design Pro protease residue SARS-CoV-2 significantly structures Vaccine development Viral load viral replications [DOI] 10.3390/ijms23042392 PMC 바로가기 [Article Type] Article
Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variantsSARS-CoV-2 감염 전후에 백신 접종은 강력한 체액 반응과 변이체를 효과적으로 중화시키는 항체로 이어집니다.Article Published on 2022-02-182022-09-11 Journal: Science Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] age antibody Antibody Response Antibody responses antigen exposure boost breadth Breakthrough infection breakthrough infections coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 current Effect groups humoral humoral immune response immune immune response immune responses Immunity individual Infection morbidity and mortality natural infection neutralize Neutralizing antibody response neutralizing antibody responses no correlation no infection occur pandemic quantity reduce respiratory Respiratory Coronavirus robust SARS-CoV-2 SARS-COV-2 infection sera vaccinated individuals vaccination Vaccine variant [DOI] 10.1126/sciimmunol.abn8014 PMC 바로가기 [Article Type] Article
Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lungDiltiazem은 SARS-CoV-2 세포 부착 및 내재화를 억제하고 마우스 폐의 바이러스 감염을 감소시킵니다Research Article Published on 2022-02-172022-09-10 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] ACE2 Affect affecting anti-SARS-CoV-2 antiviral drug antiviral drugs appear approved attachment Author binding blocker Breakthrough infection breakthrough infections calcium calcium channel Cell Clinical practice coronavirus COVID-19 COVID-19 treatment decrease Diltiazem drug drugs Effectiveness Emergency use FDA-approved drug highlight hospitalized COVID-19 patients indications inhibit interact internalization L-type lung occurred raise recipient recipients Remdesivir Research research and development respiratory Respiratory Coronavirus Safe SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 vaccines severe acute respiratory coronavirus Spike protein subunit Support the vaccine the vaccines treat Treatment US FDA variant variants variants of SARS-CoV-2 Viral viral entry viral infection [DOI] 10.1371/journal.ppat.1010343 PMC 바로가기 [Article Type] Research Article
Multiple COVID-19 Waves and Vaccination Effectiveness in the United States미국의 여러 COVID-19 물결 및 예방 접종 효과Article Published on 2022-02-172022-09-10 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Alpha Alpha variant approach B.1.1.7 B.1.617.2 Breakthrough infection breakthrough infections calculate caused classic coronavirus Coronavirus 2019 COVID-19 death delta variant District Effect Effectiveness Efficacy fatality Infection infectious less median mitigate Multiple number of deaths pandemic Reinfection reported respiratory SARS-CoV-2 SEIR severe acute respiratory syndrome Coronavirus the District the United State the vaccine United States vaccinated individual vaccinated individuals vaccination vaccination effectiveness vaccine efficacy Wave while wild strain [DOI] 10.3390/ijerph19042282 PMC 바로가기 [Article Type] Article