Outcomes of Cancer Surgery During the COVID-19 Pandemic: Preparedness to Practising Continuous Cancer CareOriginal Article Published on 2020-10-192022-10-29 Journal: Indian Journal of Surgical Oncology [Category] COVID-19, [키워드] adverse outcome age analysed Asymptomatic case Cancer cancer care cancer patient cancer surgery complex Continuous COVID 19 COVID-19 COVID-19 pandemic COVID-19 situation database Deleterious Department evaluate healthcare services Hospital stay Major median morbidity morbidity and mortality mortality rate outcome outcomes pandemic Patient postoperative SARS-CoV-2 Society surgery surgical Surgical outcomes suspected patient tested undergo [DOI] 10.1007/s13193-020-01250-z PMC 바로가기 [Article Type] Original Article
ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19Immunology Published on 2020-10-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE2 Activation ADAM17 angiotensin-converting enzyme 2 cardiovascular caused Clinical outcome coagulation cascade Comorbidities Comorbidity Course COVID-19 COVID-19 pathophysiology death Deleterious diabete disease domain exacerbated explain expression Factor Genetic host protein hypertension IL-6R infection rate inflammatory immune response Interaction Lung disease male mechanism men and women metalloproteinase Occurrence outcome pathophysiological patients RAS SARS-CoV-2 secretion the disease TMPRSS2 TNF-α transmembrane serine protease [DOI] 10.3389/fimmu.2020.576745 PMC 바로가기 [Article Type] Immunology
ACE2, COVID-19 Infection, Inflammation, and Coagulopathy: Missing Pieces in the PuzzlePhysiology Published on 2020-10-062022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] ACE ACE inhibitor ACE2 ACE2 expression Ang II angiotensin angiotensin converting enzyme 2 ARBs association binding blocker Cell cell membrane circulating clinical manifestation Coagulopathy consequence coronavirus disease COVID-19 COVID-19 disease COVID-19 infection COVID-19 pandemic Critical Degradation Deleterious diabetics Diseases domain Effect endothelial damage enzyme explain facilitated generate highlight homing host cells Infection Inflammation initial intestinal loci males management membrane missing outcome pandemic Patient piece predisposition pro-inflammatory protease puzzle RAS inhibition Replication SARS-CoV-2 severe disease spike-protein subsequent tissue translocation unique viral entry viral invasion virulence [DOI] 10.3389/fphys.2020.574753 PMC 바로가기 [Article Type] Physiology
Unemployment and Psychological Distress among Young People during the COVID-19 Pandemic: Psychological Resources and Risk FactorsArticle Published on 2020-09-302022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] association conducted consequence coronavirus COVID-19 Deleterious develop distress employment examined Factor greater Health help Hierarchical Intervention Linear model loneliness Measures mental health optimism outbreak Perceived promote Psychological Psychological distress psychological resources public health resource resources risk factor Risk factors unemployment [DOI] 10.3390/ijerph17197163 PMC 바로가기 [Article Type] Article
The Social Distancing Imposed To Contain COVID-19 Can Affect Our Microbiome: a Double-Edged Sword in Human HealthPerspective Published on 2020-09-162022-10-30 Journal: mSphere [Category] COVID-19, SARS, [키워드] acting acute respiratory syndrome addition Antibiotic resistance Bacteria Bacterial bacterial diversity Can consequence coronavirus COVID-19 COVID-19 disease decrease Deleterious disparate Dysbiosis effective Health Host Human Infection intestinal measure microbial Microbiome microbiota New Oropharyngeal pandemic person-to-person transmission Prognosis progression pulmonary viral Research SARS-CoV-2 shown social distancing Spread Sword Transmission [DOI] 10.1128/mSphere.00716-20 PMC 바로가기 [Article Type] Perspective
Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 BindingResource Published on 2020-09-032022-10-31 Journal: Cell [Category] COVID-19, [키워드] ACE2 ACE2 binding ACE2 receptor Affect Amino acid Analysis Antibody therapeutics COVID-19 dataset deep deep mutational scanning Deleterious determine dominant Effect ENhance Evidence expression facilitate folded protein functional annotation host range identify interface residue isolate isolates MOST Mutation Neutralizing antibodies pandemic RBD RBD expression Receptor binding domain Receptor-binding domain Region SARS-CoV-2 SARS-CoV-2 pandemic SARS-related coronaviruses scanning selected spike glycoprotein Spike protein Substitution Surveillance target the RBD the SARS-CoV-2 Vaccine Vaccine design virus [DOI] 10.1016/j.cell.2020.08.012 PMC 바로가기 [Article Type] Resource
Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2)Research Published on 2020-08-242022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, MERS, [키워드] ACE2 acute respiratory syndrome Affect Alter analyzed applied Asian binding catalytic caused characterized coronavirus coronavirus disease COVID-19 COVID-19 susceptibility decrease Deleterious disrupt enzyme evaluate Evidence functional Genetic variation Genome Aggregation Database humans Infection interface investigation Missense missense variant Novel coronavirus outbreak populations receptor Result S-protein SARS-CoV-2 secondary structure Seven spike glycoprotein structural flexibility systemically the SARS-CoV-2 Treatment variants [DOI] 10.1186/s12967-020-02486-7 PMC 바로가기 [Article Type] Research
Extracorporeal Hemoperfusion as a Potential Therapeutic Option for Severe COVID-19 patients; a Narrative ReviewReview Article Published on 2020-08-222022-10-27 Journal: Archives of Academic Emergency Medicine [Category] COVID-19, [키워드] 2019 novel coronavirus Acute kidney injury acute respiratory syndrome Adult AKI Blood purification caused Complication conditions contribute coronavirus coronavirus disease COVID-19 COVID-19 patient Critically ill CSS Cytokine release syndrome Cytokine storm Cytokine storm syndrome death Deleterious develop epidemiological surveys Extracorporeal Hemoperfusion immune impairment incidence inflammatory mediator Influenza International MERS Middle East multiple organ failure narrative option outbreak outcomes poor prognosis Potential reducing Respiratory distress syndrome Respiratory system review SARS-CoV2 severe COVID-19 Severe infection syndrome the disease therapeutic option treat WHO World Health Organization Wuhan, China PMC 바로가기 [Article Type] Review Article
SARS-CoV-2 Codon Usage Bias Downregulates Host Expressed Genes With Similar Codon UsageCell and Developmental Biology Published on 2020-08-202022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] acute respiratory syndrome Analysis Bia Cell characteristic codon codon optimality codon usage Codon usage bias contribute Deleterious Effectiveness etiology evade expressed gene functional Host host protein immune response implication infect infected cell infected cells mechanism New coronavirus nucleotide observation observé pandemic pathogenic pathogeny protein synthesis proteomic reduced reveal SARS-CoV-2 Spread the SARS-CoV-2 translation translational control tRNA Usage Vaccine Vaccine design Viral protein viral replication virus WHO World Health Organization [DOI] 10.3389/fcell.2020.00831 PMC 바로가기 [Article Type] Cell and Developmental Biology
Intolerance of Uncertainty and Loneliness in Older Adults During the COVID-19 PandemicPsychiatry Published on 2020-08-192022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] acute phase age AIS Anxiety anxiety symptom Athens Insomnia Scale contribute COVID-19 COVID-19 pandemic cross-sectional Deleterious Depression depressive symptom emotional facilitate Factor fear GAD-7 Generalized Greece implementation inclusion criteria intolerance intolerance of uncertainty limit loneliness moderate modulate objective Older older adult Older adults pandemic participant PHQ-9 proportion Psychological public health emergency quarantine question reported Result risk scale shown significantly higher Sociodemographic Uncertainty [DOI] 10.3389/fpsyt.2020.00842 PMC 바로가기 [Article Type] Psychiatry