Bacterial sensing: A putative amphipathic helix in RsiV is the switch for activating σ V in response to lysozyme박테리아 감지: RsiV의 추정되는 양친매성 나선은 리소자임에 대한 반응으로 σ V를 활성화하는 스위치입니다.Research Article Published on 2018-07-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activating Activation addition Bacillus Bacillus subtilis Bacteria binding changes in charged residue cleavage cleavage site cleave cleaved Degradation Disruption domain Evidence Factor Firmicute firmicutes function Gene Expression hydrophobic inactive indicated inhibitor lysozyme membrane molecular peptidase PROTECT regulated required resistance genes respond responsible signal substrate substrates translocated Trigger triggering triggers unique [DOI] 10.1371/journal.pgen.1007527 PMC 바로가기 [Article Type] Research Article
Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations인간에서 Plasmodium Knowlesi의 핵 및 소기관 게놈 분석은 고대 개체군 구조와 숙주 특이적 하위 개체군 간의 최근 재조합을 보여줍니다Research Article Published on 2017-09-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] Analysis Appropriate Asia assist chromosome complex comprehensive analysis Contact contact with deforestation described Disruption ecological Evidence evidence of Evolution expected expressed genes encoding Genetic genetics Genome genome sequence genomic genotypes growth Host hosts Human human infection human population humans infecting Infection infections Interaction isolate Isolation likelihood Lineage lineages macaque macaques malaria malaria control Malaysia molecular nuclear organelle parasite parasites Plasmodium Population population growth Prevalence Protein Rapid Recombination reference genome Region resulting reveal sampling selected stages subpopulation subpopulations Surveillance switching traits Transmission [DOI] 10.1371/journal.pgen.1007008 PMC 바로가기 [Article Type] Research Article
Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarateα-케토글루타레이트의 항상성 조절을 통한 Caulobacter crescentus의 트리카르복실산 회로와 펩티도글리칸 합성 간의 누화Research Article Published on 2017-08-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation addition Alter Antibiotics approach approaches Bacteria bacterial cell bacterial cells biosynthetic block blocks building by-product Caulobacter crescentus caused Cell cell wall cell wall synthesis cellular cellular metabolism cellular processe cellular processes central metabolism characterized classical conserved CRISPRi Crosstalk deletion mutant Disruption drug design energy generate genetics growth highlight homeostasis homeostatic inhibit interfere Interference master regulator metabolism metabolite metabolomics Morphological morphology mutant peptidoglycan phenotype precursors property Replication required resulting reveal robust susceptibility susceptible synthesis TCA cycle the cell transcriptomics tricarboxylic acid while [DOI] 10.1371/journal.pgen.1006978 PMC 바로가기 [Article Type] Research Article
Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignanciesSchinzel-Giedion 증후군 및 혈액 악성 종양에서 중복 SETBP1 기능 획득 돌연변이Research Article Published on 2017-03-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation activating affecting alteration alterations Author Cancer caused cell proliferation cellular characterized clinical information clinical phenotype Clustering Cohort collected de novo de novo mutation Degradation developmental developmental disorder developmental disorders disrupt Disruption distribution Drawing driven by driving Effect event events ExoN functional gain-of-function genetics Genotype genotype-phenotype correlation germline Hematologic malignancy hotspot implicated in silico in vitro incidence increase in increased risk individual lead leukemia magnitude malformation malignancy Mendelian disorder Mendelian disorders molecular Mutation mutations neurological occur overlap Patient phenotype prenatal development Previous studies previous study Protein protein level protein levels Regulation required residue risk SETBP1 signal significantly more somatic mutation somatic mutations stability subject Substitution substitutions Support syndrome threshold [DOI] 10.1371/journal.pgen.1006683 PMC 바로가기 [Article Type] Research Article
NF-YB Regulates Spermatogonial Stem Cell Self-Renewal and Proliferation in the Planarian Schmidtea mediterraneaNF-YB는 Planarian Schmidtea 지중해에서 정자 줄기 세포 자가 재생 및 증식을 조절합니다Research Article Published on 2016-06-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] balance carrier causative agent Cell cell population cell proliferation cells combating complex component conserved coordination developmental differentiation disease Disruption etiology Factor fecundity Gamete genetic information germ cell germ cells help homolog identification implication Implications infertility inhibited involved lead life maintenance male mechanism morbidity observation open organism Organisms parasite Pathogenesis Planarian proliferation Propagation reproductive required Schistosoma mansoni schistosome Schistosomiasis Sperm SSC STEM stem cell stem cells testes transcription factors Transmission tropical tropical disease Tumor tumorigenesis tumors [DOI] 10.1371/journal.pgen.1006109 PMC 바로가기 [Article Type] Research Article
Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 ComplexBeclin 1은 뉴런 생존에 필요하고 UVRAG-VPS34 복합체를 통해 엔도솜 경로를 조절합니다Research Article Published on 2014-10-022022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity addition animal model assembly autophagosome autophagy Beclin 1 Brain cause cell line cellular characterized Complete complex complexes conditions Coordinate deficiency disease Diseases Disruption distribution EEA1 endocytosis endosome Endosomes Evidence failure function Genetic human disease impair impairment implicated in addition to in vivo Infectious disease Interaction involved leads maintain mammalian maturation membrane molecular mechanism mutant neurodegeneration neurodegenerative Neuron neuronal neurons nucleation organelle overexpressed p40 pathway Pathways phosphatidylinositol phosphatidylinositol 3-kinase physiological PI3K Previous studies previous study Protein recent recruit recruitment regulate Regulation required rescued reveal RUBICON survival tumorigenesis UVRAG viability [DOI] 10.1371/journal.pgen.1004626 PMC 바로가기 [Article Type] Research Article
An Essential Nonredundant Role for Mycobacterial DnaK in Native Protein Folding천연 단백질 폴딩에서 마이코박테리아 DnaK의 필수 비중복 역할Research Article Published on 2014-07-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a minor absence accompanied accumulation aggregate antibiotic Bacterial pathogens bacterium Cell cell growth cells cellular chaperone chaperones characterized daughter cells Degradation denaturation Disruption domain E. coli Essential examined expand expression Factor foci genus growth heat Host Hsp70 identify include insoluble lack less life Loss membrane minor mycobacteria mycobacterial Mycobacterium Native organism paradigm Pathogens peptide peptides Prevent Protein protein folding Protein misfolding Proteins redundancy required role solubility stationary stationary phase Stress susceptibility synthases translation Trigger unique viability [DOI] 10.1371/journal.pgen.1004516 PMC 바로가기 [Article Type] Research Article
Disruption of Mouse Cenpj, a Regulator of Centriole Biogenesis, Phenocopies Seckel Syndrome중심소체 생합성, Phenocopies Seckel 증후군의 조절자인 마우스 Cenpj의 교란Research Article Published on 2012-11-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Abnormalities addition allele Apoptosis Author Birth Brain cause Cell cell death CENPJ centriole characteristic chromosomal abnormalities chromosomal abnormality chromosome chromosomes clinical feature Clinical features clinical manifestations compared conserved contribute CPAP damaged disorder Disruption DNA damage dwarfism elevated Embryo embryonic embryonic development exhibited expresse expressed feature fibroblast found Frequency Gene genomic growth growth failure hypomorphic immunohistochemistry impairment in addition to Increased J gene lead majority mechanism memory memory impairment Mental mental retardation mice microcephaly mitotic mono mouse Mutation ocular phenocopy proliferation Protein reduced reduction in regulator Seckel Seckel syndrome Signaling skeletal specific mutation specific mutations syndrome wild-type cells [DOI] 10.1371/journal.pgen.1003022 PMC 바로가기 [Article Type] Research Article
Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated SignalingResearch Article Published on 2012-02-012022-10-06 Journal: PLoS ONE [Category] 진단, [키워드] Activation acute respiratory syndrome Antiviral block catalytic catalytically active Cell cells complex complexes contributing to coronavirus CoV Defense disrupting Disruption domain Endoplasmic reticulum evade expressing expression form found HCoV-NL63 Host IFN IKKε inactive Infected inhibit Innate innate immune innate immune response interferon MAVS mechanism membrane mutant NL63 nuclear translocation Papain-like protease PLP promoters Protein reduced regulate required response RIG-I SARS-CoV Signaling signaling molecule subsequent TBK1 wild type [DOI] 10.1371/journal.pone.0030802 PMC 바로가기 [Article Type] Research Article