Folic acid as placebo in controlled clinical trials of hydroxychloroquine prophylaxis in COVID-19: Is it scientifically justifiable?COVID-19에서 하이드록시클로로퀸 예방에 대한 통제된 임상 시험에서 위약으로서의 엽산: 과학적으로 정당화될 수 있습니까?Article Published on 2021-04-012022-08-31 Journal: Medical Hypotheses [Category] MERS, 임상, 치료제, [키워드] ACE2 benefit Clinical studies Combination complicate Controlled clinical trial COVID-19 cyanocobalamin disease severity domains Efficacy Factor failure Folic acid furin Hydroxychloroquine hypertension Hypothesis Interpretation Laboratory lowest Mild moderate disease MTHFR Other parameters Placebo placebo controlled trial polymorphism Prevalence Prophylaxis protease pulmonary hypertension Pyridoxine RCT reported SARS-CoV-2 Severe patient severe patients Trial Variation [DOI] 10.1016/j.mehy.2021.110539 PMC 바로가기 [Article Type] Article
Impact of COVID-19 on the social, economic, environmental and energy domains: Lessons learnt from a global pandemicReview article Published on 2021-04-012022-10-05 Journal: Sustainable Production and Consumption [Category] 신약개발, [키워드] affected Analysis benefit comprehensive analysis coronavirus vaccine COVID-19 COVID-19 outbreak Delay domain domains ecological Efficacy Environmental pollution expected global pandemic globe growth Health Impact information lesson NO2 emission pandemic PM emission preventive measure quarantine reduce response robust SARS-CoV-2 significantly Spread Transmission virus Waste generation [DOI] 10.1016/j.spc.2020.10.016 [Article Type] Review article
Persistent neurologic symptoms and cognitive dysfunction in non‐hospitalized Covid‐19 “long haulers”Research Article Published on 2021-03-302022-10-27 Journal: Annals of Clinical and Translational Neurology [Category] COVID-19, [키워드] Affect age America analyzed Anosmia assessments Autoimmune disease cognitive Comorbidity consecutive patient develop disease onset domains dysfunction evaluated exhibited fatigue female Frequency group headache Hospitalization Hospitalized Hypoxemia individual individuals Infectious disease limitations manifestation measure memory MOST myalgia neurologic no correlation objective pandemic Patient performed persistent Pneumonia presenting Prospective Study Quality of life recorded Result SARS‐CoV‐2 SARS‐CoV‐2‐infected Society Symptom Symptoms [DOI] 10.1002/acn3.51350 PMC 바로가기 [Article Type] Research Article
Online Survey of the Impact of COVID-19 Risk and Cost Estimates on Worry and Health Behavior Compliance in Young AdultsPublic Health Published on 2021-03-292022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, [키워드] Adults Anxiety Behavior Compliance consequence contribute cost COVID-19 COVID-19 pandemic COVID-19 virus Decision making develop directive domains elevated emotional estimate event Factor greater Health Impact implication infected with COVID-19 Interaction involved mechanism Novel coronavirus pandemic Perceived risk physical Probability psychoeducational public health reducing Research shown state survey Symptom was measured WHO World Health Organization Worry [DOI] 10.3389/fpubh.2021.612725 PMC 바로가기 [Article Type] Public Health
Precision therapeutic targets for COVID-19COVID-19에 대한 정밀 치료 표적Review Published on 2021-03-292022-09-10 Journal: Virology Journal [Category] SARS, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered antiviral drug antiviral drugs approved benefit caused convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 cough COVID-19 deaths demonstrated develop Dexamethasone disease domains drug drugs Dyspnea Effect Efficacy evaluate fatigue Fever General population Glucocorticoids High-dose Hospitalization hospitalized patients hypercoagulability individual infected with SARS-CoV-2 inhibiting less limitation M pro MPro main protease management multi-organ failure mutate myocarditis Pneumonia Pro protease proteolytic activation RdRP reducing mortality Remdesivir Replication respiratory respiratory distress RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus Severe case severe cases Spike protein Spread subset supplementary material supportive care Symptom syndrome the SARS-CoV-2 the spike protein therapeutic target therapy Transcription Viral viral replication [DOI] 10.1186/s12985-021-01526-y PMC 바로가기 [Article Type] Review
Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Based Novel Epitopes Induce Potent Immune Responses in vivo and Inhibit Viral Replication in vitroImmunology Published on 2021-03-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome Analysis angiotensin-converting enzyme 2 antiviral activity binding candidate cellular immune responses coronavirus coronavirus 2 develop domain domains effort epitope functional heptad repeat host cell humoral immune response implication in vitro in vivo Infection inhibit inhibitors inhibitory effect initiate murine model N-terminal domain novel NTD peptide peptides potent RBD receptor receptors Region replication of SARS-CoV-2 respiratory response responsible S glycoprotein S1 subunit SARS-CoV-2 shown spike spike (S) glycoprotein spike glycoprotein Spike-based vaccine subunits the receptor-binding domain the SARS-CoV-2 therapeutic Trimers Vaccine virion virus virus entry wild-type virus [DOI] 10.3389/fimmu.2021.613045 PMC 바로가기 [Article Type] Immunology
Shedding Light on the Inhibitory Mechanisms of SARS-CoV-1/CoV-2 Spike Proteins by ACE2-Designed PeptidesACE2 설계 펩티드에 의한 SARS-CoV-1/CoV-2 스파이크 단백질의 억제 메커니즘에 대한 조명Article Published on 2021-03-222022-09-11 Journal: Journal of Chemical Information and Modeling [Category] MERS, SARS, 신약개발, 치료제, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding binding affinities binding affinity can be used cellular receptor comparable Contact coronavirus COVID-19 COVID-19 pandemic demonstrated domain domains Efficiency enzyme full-length Host host cells human ACE2 Interaction involved kinetic analysis LIGHT mechanism neutralization novel peptide peptides Previous studies previous study protocol responsible route SARS Coronavirus SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike sequence shedding shown spike Spike protein Spike proteins surface protein the spike protein thermodynamic virus entry virus infection [DOI] 10.1021/acs.jcim.0c01320 PMC 바로가기 [Article Type] Article
COVID-19 and Health-Related Quality of Life: A Community-Based Online Survey in Hong KongArticle Published on 2021-03-202022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] addition adverse impact affecting association bother collected Complete COVID-19 COVID-19 pandemic domains evaluated Evidence examined Factor Health status health-related quality of life Hong Kong Impact individual lack Masks Measures mental health multifactorial Multiple linear regression pandemic participant physical Population Psychological psychological health public health Quality Quality of life questionnaire Randomly recruited Research surgical survey t-test were used World Health Organization [DOI] 10.3390/ijerph18063228 PMC 바로가기 [Article Type] Article
Multiple domains of functioning in older adults during the pandemic: design and basic characteristics of the Longitudinal Aging Study Amsterdam COVID-19 questionnaireArticle Published on 2021-03-152022-10-28 Journal: Aging Clinical and Experimental Research [Category] COVID-19, SARS, [키워드] Adults aging Characteristics cohort study coronavirus COVID-19 COVID-19 pandemic COVID-19 situation domain domains Epidemiology exceptional First wave longitudinal measure Mental Multiple Netherlands Older Older adults pandemic physical provided questionnaire respondent supplementary material [DOI] 10.1007/s40520-021-01829-8 PMC 바로가기 [Article Type] Article
Immunity, virus evolution, and effectiveness of SARS-CoV-2 vaccinesReview Published on 2021-03-152022-10-28 Journal: Brazilian Journal of Medical and Biological Resear [Category] COVID-19, MERS, SARS, [키워드] accessory protein Analysis antiviral effects cellular chemokine clinical symptom complexes coronavirus coronavirus strain COVID-19 COVID-19 patient Cytokines storm DNA repair domains driven by Effectiveness Evolution facilitate Factor Frame function functional Genome Genome sequences global pandemic help Host host cell host cells Immunity immunological resistance independent Inflammation inhibit innate immune cell interferon Lung injury mutated Mutation Non-synonymous ORF ORF1b Pathogenesis patients Perspective Protein provided receptor Recombination recruit Replication RNA RNA genome SARS-CoV SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 vaccine specific mutation Spread strain structures suppress the spike protein translation understanding Vaccine Vaccines Viral RNA viral RNA synthesis virion virus virus entry Virus evolution virus infection [DOI] 10.1590/1414-431X202010725 PMC 바로가기 [Article Type] Review