epitope – Page 15 – Communicable Diseases Research

Serological testing for SARS-CoV-2 antibodies in clinical practice: A comparative diagnostic accuracy study

임상 실습에서 SARS-CoV-2 항체에 대한 혈청 검사: 비교 진단 정확도 연구

Article

Published on 2022-07-012022-09-11
Journal: Allergy [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법,

A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS-Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape

상어 유래 단일 도메인 항체 클래스는 SARS 관련 코로나바이러스와 중화 및 오미크론 탈출의 구조적 기초를 광범위하게 중화할 수 있습니다

Article

Published on 2022-07-012022-09-11
Journal: Small methods [Category] COVID19(2023년), SARS, 변종,

[키워드] administration affinity Alpha antibodies antibody Basis bat Beta beta variants bind binding class complementary conserved coronavirus Delta disrupt domain epitope escape hidden impair Interaction Lambda mice motif Mutation neutralization Neutralizing activity offer omicron Omicron variant pangolin Prophylactic PROTECT RBD Receptor binding domain receptor binding domain (RBD) reported sarbecovirus Sarbecoviruses SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus therapeutic option unique variant variants variants of concern variants of concerns (VOCs). VOCs Wuhan β-sheet
[DOI] 10.1002/smtd.202200387 PMC 바로가기 [Article Type] Article

Persistence of infectious SARS-CoV-2 particles for up to 37 days in patients with mild COVID-19

경증 COVID-19 환자에서 최대 37일 동안 전염성 SARS-CoV-2 입자 지속

Article

Published on 2022-07-012022-09-11
Journal: Allergy [Category] COVID19(2023년), SARS, 치료기술,

[키워드] amplified Analysis antibodies antibodies binding carried characterization characterized clade COVID-19 COVID-19 patient Diagnosis electron microscopy ELISA epitope Epitopes humoral immune response immune response immunofluorescence microscopy infected patients Infection infectious Infectious virus investigated isolate isolates lack Microscopy Mild Mutation mutations non-infectious ORF8 Patient PCR-based testing PCR-positive peptide persistence pharyngeal Pharyngeal swab quarantine RBD Receptor-binding domain remained Replication replication-competent virus RT-PCR SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 particles SARS-CoV2 sequence Symptom termination the receptor-binding domain Vero E6 Vero E6 cell VERO E6 cells virus virus replication WGS whole-genome sequencing
[DOI] 10.1111/all.15138 PMC 바로가기 [Article Type] Article

Advances in the Omicron variant development

Omicron 변종 개발의 발전

Review

Published on 2022-07-012022-09-11
Journal: Journal of internal medicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition advance Alpha Amino acid amino acids Antiviral antiviral agent Antiviral agents antiviral drugs approved Beta booster dose booster doses Casirivimab circulating coronavirus COVID-19 Delta disease dominant dose drug effective entry of SARS-CoV-2 Epidemiology epitope Epitopes Gamma greater greater transmissibility growth advantage Health Organization humoral Imdevimab Immune escape incidence Infection inhibit Mild mild illness molecular molnupiravir monoclonal monoclonal antibodies monoclonal antibody mutations offer omicron Omicron variant pandemic Paxlovid pharmacological agent pharmacological agents Remdesivir Research respiratory SARS-CoV-2 SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus Spike protein Spread the spike protein therapeutic to define Transmissibility vaccination Vaccine Vaccines variant variants Viral viral replication VoC WHO World Health Organization
[DOI] 10.1111/joim.13478 PMC 바로가기 [Article Type] Review

Immunoinformatic approach for the construction of multi-epitopes vaccine against omicron COVID-19 variant

오미크론 COVID-19 변이체에 대한 다중 에피토프 백신 구축을 위한 면역정보학적 접근

Article

Published on 2022-07-012022-09-11
Journal: Virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] added adjuvant antigenic antigenic epitope antigenic epitopes applied approach B cell epitope B cell epitopes B-cell B.1.1.529 CD4 CD8 chimeric Chimeric vaccine model codon optimization complexes computational tool computational tools concern construction country COVID-19 COVID-19 omicron variant effective epitope Epitopes expression Final flexible Health Organization help highly antigenic Host IFN-γ immune mechanism immunogenic in-silico increasingly inducer initiative linker MEV MHC-II molecular molecular docking molecular dynamics mutagenic N-terminal non-allergenic non-toxic omicron Omicron variant overlapping peptide peptide-based planet Protein reverse vaccinology SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 variant Scientific community Simulation spike Spike protein stability suggested T-cell T-cell epitopes TLR TLR2 TLR4 TLRs toxic treat unique vaccination Vaccine vaccine candidate variant VoC WHO World Health Organization
[DOI] 10.1016/j.virol.2022.05.001 PMC 바로가기 [Article Type] Article

Omicron variant receptor-binding domain phylogenetics and molecular dynamics

오미크론 변이체 수용체 결합 도메인 계통발생학 및 분자 역학

Article

Published on 2022-07-012022-09-11
Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종,

[키워드] addition Alpha alpha and delta variants Amino acid analyses angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 receptor anticipated antigenic antigenic epitope antigenic epitopes antigenic site arithmetic mean Beta binding changes in Clustering conformation conserved COVID-19 Delta deviation domain epitope Epitopes evolutionary relationships expected FIVE fluctuation Gamma greater immune reactions investigated MD simulations molecular molecular dynamics Mutation mutations omicron Omicron variant other variants Phylogenetic Phylogenetic relationship phylogenetics predicted RBD RBD binding RBD mutation RBD of SARS-CoV-2 receptor Receptor-binding domain residue residues Root-mean-square deviation SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 variants sequence significantly suggested surface area tested the receptor-binding domain the SARS-CoV-2 variant variants
[DOI] 10.1016/j.compbiomed.2022.105633 PMC 바로가기 [Article Type] Article

Low-frequency variants in mildly symptomatic vaccine breakthrough infections presents a doubled-edged sword

경미한 증상이 있는 백신 획기적인 감염의 저주파 변이는 양날의 검을 제시합니다

Article

Published on 2022-07-012022-09-11
Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종,

[키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Ad26 association BNT162b2 case study characterized coronavirus Critical Efficacy Epidemiology epitope Epitopes Evolution Genetic Genetic variation genetics highlight immune individual Infection L18F Mutation Pfizer Phylogenetic question raised reduced reducing replicative SARS Coronavirus SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe symptoms Symptom symptomatic the vaccine Transmission vaccination Vaccination Status Vaccine vaccine breakthrough infection Vaccines variant variants of concern virus virus classification VoC VOCs widespread
[DOI] 10.1002/jmv.27726 PMC 바로가기 [Article Type] Article

Immunoinformatic paradigm predicts macrophage and T-cells epitope responses against globally conserved spike fragments of SARS CoV-2 for universal vaccination

면역 정보 패러다임은 보편적 백신 접종을 위해 SARS CoV-2의 전 세계적으로 보존된 스파이크 단편에 대한 대식세포 및 T 세포 에피토프 반응을 예측합니다

Article

Published on 2022-07-012022-09-11
Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종,

[키워드] allele antigenicity bioinformatics CD4+ CD4+ cells conserved country COVID-19 COVID-19 case COVID-19 cases D614G Delta develop Effect epitope Epitopes examined facilitated glycosylation H-bonding help highest HLA-DRB5 IC50 IEDB immunogenicity In silico mutation and antigenicity in some in-silico Inconclusive increase interactions introduced Macrophage MHC class MHC class and CD4+ cells MHC class II MHC-II mutant Mutation omicron predict Proteases reactivity receptors representation response responses against RMSD RMSD plot SARS CoV SARS CoV-2 SARS CoV-2 spike protein SARS-CoV-2 SARS-CoV-2 spike screened Screening sequence Spike protein stability SVMTriP T-cell Universal universal vaccination vaccination Vaccination strategy Vaccine variants Variation VaxiJen V2.0
[DOI] 10.1016/j.intimp.2022.108847 PMC 바로가기 [Article Type] Article

Recent advances on smart glycoconjugate vaccines in infections and cancer

Article

Published on 2022-07-012022-11-15
Journal: The Febs Journal [Category] COVID19(2023년), SARS, 진단,

Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2

Research

Published on 2022-06-302022-10-05
Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,