Pro-inflammatory microenvironment and systemic accumulation of CXCR3+ cell exacerbate lung pathology of old rhesus macaques infected with SARS-CoV-2CXCR3+ 세포의 염증 유발 미세 환경 및 전신 축적은 SARS-CoV-2에 감염된 늙은 붉은털 원숭이의 폐 병리를 악화시킵니다.Article Published on 2021-09-012022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal model Apoptosis autophagy both lungs CD8+ cell CD8+ cells Cell cells changes in Chemokine receptor coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 CXCR3 demonstrated elevated exacerbate feature FFPE formalin formalin-fixed paraffin-embedded IFN-α IL-6 immunopathological immunopathology infected with SARS-CoV-2 Infection Infectious diseases interferon interleukin interleukin 6 lung Lung pathology lung tissue Lungs microenvironment motif multiplex immunofluorescence NF-κB nuclear paraffin Peripheral blood pro-inflammatory protein expression Quantitative analysis respiratory rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 significantly staining T cell T-box tissue Treatment understanding [DOI] 10.1038/s41392-021-00734-w PMC 바로가기 [Article Type] Article
A trade‐off: Antimicrobial resistance and COVID‐19Covid‐19 Published on 2021-08-312022-10-28 Journal: Bioethics [Category] COVID-19, MERS, SARS, [키워드] antimicrobial antimicrobial resistance benefit contribute COVID‐19 COVID‐19 determine distribution distributive justice Effects exacerbate exacerbating expected help highlight involved magnitude measure Measures pandemic pandemic ethics populations PROTECT trade‐off [DOI] 10.1111/bioe.12928 PMC 바로가기 [Article Type] Covid‐19
Profile of Bacterial Infections in COVID-19 Patients: Antimicrobial Resistance in the Time of SARS-CoV-2Article Published on 2021-08-242022-10-28 Journal: Biology [Category] COVID-19, [키워드] acute respiratory syndrome AMR anti-inflammatory property antibiotic Antibiotic resistance Antibiotics antimicrobial approach Atypical Bacterial Bacterial infections bacterial pathogen bacterial species bacterial specy characteristic Characteristics contribute coronavirus correlation COVID COVID-19 COVID-19 negative COVID-19 outbreak COVID-19 pandemic COVID-19 patient distribution drug drugs effective evaluate exacerbate Frequency hospital Immunocompromised patients Infection infections investigated isolate Italian Laboratory test microbial microbial infection no difference non-COVID-19 patient pandemic Patient patients Pneumonia positive predicted profile Prophylactic resistance response SARS-CoV-2 significantly higher similarity simple specimen Spread strain Symptoms tested the SARS-CoV-2 therapeutic approaches therapeutic purposes time treat treatments of COVID-19 virus infection [DOI] 10.3390/biology10090822 PMC 바로가기 [Article Type] Article
Adaptive Immunity and the Risk of Autoreactivity in COVID-19COVID-19의 적응 면역 및 자가반응 위험Review Published on 2021-08-202022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] adaptive affecting antigens association autoantibodies Autoimmune disease Autoimmune diseases Autoimmunity autoreactivity Complication COVID-19 COVID-19 patients disease exacerbate expressed Immune cell immune cells immune responses immune system Immunity Infection insight lupus erythematosus mechanism molecular mimicry multiple organs multiple sclerosis Occurrence Pathogens Pathologies PROTECT reported respiratory infection respond response responses SARS-CoV-2 SARS-COV-2 infection self-antigens Side effect Side effects SLE systemic lupus erythematosus target the disease viral infections while [DOI] 10.3390/ijms22168965 PMC 바로가기 [Article Type] Review
Emotional adaptation during a crisis: decline in anxiety and depression after the initial weeks of COVID-19 in the United StatesArticle Published on 2021-08-202022-10-29 Journal: Translational Psychiatry [Category] Coronavirus, MERS, SARS, [키워드] age Anxiety being contributing to correlated COVID-19 COVID-19 pandemic COVID-19 severity declined Depression emotional enrolled Evidence exacerbate exacerbated Factor female First wave fluctuation increase in initial inventory longitudinal change media mixed-effects model overlapping pandemic Predictive markers psychiatric diagnosis the United State trajectory were assessed were used worsening [DOI] 10.1038/s41398-021-01552-y PMC 바로가기 [Article Type] Article
Cardiovascular Disease Complicating COVID-19 in the ElderlyReview Published on 2021-08-172022-10-30 Journal: Medicina [Category] COVID-19, MERS, SARS, [키워드] alcohol angiotensin-converting enzyme 2 Atherosclerosis atherosclerotic plaque binding can be used cardiac myocyte cardiovascular cardiovascular disease cause Comorbidity Complication connection coronavirus disease COVID-19 COVID-19 patient Cytokines elderly Endothelial dysfunction exacerbate expressed Health human cell hypercoagulable hypertension Inflammation Intervention lung tissue mitigate Mortality obesity offer Patient patients with COVID-19 platelet activation promote prothrombotic state raise receptor risk RNA coronavirus SARS-CoV-2 self-care significantly single-stranded social isolation Spike protein telehealth thrombosis Vascular endothelium virus [DOI] 10.3390/medicina57080833 PMC 바로가기 [Article Type] Review
COVID-19 at the Deep End: A Qualitative Interview Study of Primary Care Staff Working in the Most Deprived Areas of England during the COVID-19 PandemicArticle Published on 2021-08-172022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] analysed Analysis Area Care Community conducted COVID-19 deep Deprived End England exacerbate Factor General practice general practitioner Health health care inequalities Health inequalities health/healthcare inequity implication interview marginalised communities measure MOST Nurses outcome pandemic participant Patient Perspective Practitioner primary care Qualitative Quantitative data recruited remote consulting risk social determinant social determinants of health social distancing Social prescribing staff thematic analysis unique working worsened [DOI] 10.3390/ijerph18168689 PMC 바로가기 [Article Type] Article
Biocide-tolerance and antibiotic-resistance in community environments and risk of direct transfers to humans: Unintended consequences of community-wide surface disinfecting during COVID-19?커뮤니티 환경의 살생물제 내성 및 항생제 내성 및 인간에게 직접 전염 위험: COVID-19 동안 커뮤니티 전체 표면 소독의 의도하지 않은 결과?Review Published on 2021-08-152022-09-11 Journal: Environmental pollution (Barking, Essex : 1987) [Category] SARS, 변종, 유전자 메커니즘, [키워드] Ammonium antibiotic Antibiotic resistance antimicrobial antimicrobial resistance Bacteria Bacterial Bacterial pathogens biocide Community compounds consequence Contact Contact surface coronavirus COVID-19 disinfectant drug drug resistance Ethanol Evidence exacerbate feasible fingers gene transfer growth hands highlight horizontal gene Horizontal gene transfer humans hydrogen hydrogen peroxide hypochlorite impacted infection control ingredient Intensive intrinsic Laboratory linkage LIPS mechanism membrane mitigate Mutation Novel coronavirus pandemic Pathogens REALITY Regulatory risk risk factor SARS-CoV-2 scenario sodium sodium hypochlorite suggested these compounds Tolerance transfer upregulation virus spread while [DOI] 10.1016/j.envpol.2021.117074 PMC 바로가기 [Article Type] Review
Impact of university re-opening on total community COVID-19 burdenResearch Article Published on 2021-08-122022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] Admissions average benefit Community Contact COVID-19 COVID-19 infections Critical care cumulative death deaths evaluated exacerbate General population Impact increase Infection infection rate infections Intervention Prevent provide public health reduce Result Screening student the timing Transmission model university student [DOI] 10.1371/journal.pone.0255782 PMC 바로가기 [Article Type] Research Article
A model of the innate immune response to SARS-CoV-2 in the alveolar epitheliumMathematics Published on 2021-08-112022-10-28 Journal: Royal Society Open Science [Category] COVID-19, [키워드] ACE2 expression alveolar epithelial cells alveolar epithelium antiviral therapy basic reproductive number benefit binding affinity Cell chemokines Control Course deleterious effect determinant epithelial exacerbate host response Impact individual variation Infection Innate immune cells innate immune response interferon interferons Model moderate parameters predicted Prognosis reduce robust SARS-CoV-2 SARS-CoV-2 spike protein significantly suppresse Therapies therapy tissue damage toxin type I Variability viral dynamics Viral load while within-host [DOI] 10.1098/rsos.210090 PMC 바로가기 [Article Type] Mathematics