Immunoinformatic approach to design a multiepitope vaccine targeting non-mutational hotspot regions of structural and non-structural proteins of the SARS CoV2
Bioinformatics
[키워드] 3D structure
Analysis
Antigen
antigen processing
antigenicity
approach
B cell
binding affinity
binding energy
calculated
caused
Cell
complex
coronavirus 2
cross-reactivity
database
demonstrated
docking
envelope protein
epitope
Epitopes
evaluated
Extracellular
high mortality
HLA
host cell
hotspot
IFN
immune response
Immune simulation
induce
Infection
injection
interacting residue
Interaction
leukocyte
linker
MDs
Membrane proteins
memory
Microbiome
Molecular dynamics simulation
morbidity
multiepitope vaccine
Mutation
mutations
non-structural protein
ORF1ab polyprotein
ORF3a protein
ORF8 protein
outbreak
pandemic
Physicochemical properties
predicted
Protein
proteomics
Region
respiratory
Result
SARS CoV2
screened
selected
sensitivity
Seven
similarity
strong immune response
Study design
Surface glycoprotein
T cell
the vaccine
TLR
TLRs
Toll-like receptor
Toxicity
vaccination
Vaccine
vaccine construct
virus
was performed
[DOI] 10.7717/peerj.11126 PMC 바로가기 [Article Type] Bioinformatics
[DOI] 10.7717/peerj.11126 PMC 바로가기 [Article Type] Bioinformatics