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[키워드] Activation acute disease acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Affect affected age antiviral immunity Asymptomatic auto-Ab auto-Abs autoantibodies autoantibody autoantibody system Autoimmune Autoimmunity B cell Beck binding can not candidate gene approach cause causes Clinical course clinical phenotype clinical phenotypes clinical variability collected complex component components Concentration conditions coronavirus coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 COVID-19 pandemic COVID-19 patients COVID-19 pneumonia Critical Critical disease cytokine Cytokines damage dampen death determine disease Diseases downstream enrichment enrolment epidemiological excess explain Genes genetics genomics study had milder phenotype healthy control healthy individual healthy individuals highest Human Hypothesis identify IFN IFN response IFN-stimulated genes IFN-α IFN-α/β IFN-α2 IFN-β IFN-γ IFNAR IFNs IgG IL-17A IL-6 immune system Immunity Immunoglobulin Immunoglobulin G immunological impair impairing in healthy individuals in vitro Inborn errors increase in individual infected with SARS-CoV-2 Infection Infectious diseases interferon interferon regulatory factor interferon-γ interferons interferons (IFNs) interleukin interleukin-6 intrinsic involved IRF ISGs lack life-threatening life-threatening coronavirus disease likelihood male mechanism men mild SARS-CoV-2 infection morbidity morbidity and mortality mucocutaneous candidiasis Mutation mycobacterial disease neutralize Neutralizing outcomes pandemic pathogen pathogen-induced inflammation pathway Patient patients patients hospitalized Perspective phosphorylated Plasmapheresis Pneumonia Prevent pSTAT receptor receptors Regulation respiratory rising risk risk factor SARS-CoV-2 SARS-COV-2 infection Science searched serum IFN-α level severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 Severe COVID-19 pneumonia shown silent infection staphylococcal susceptible tested the patient this system TLR Toll-like receptor Transcription Treatment trials type 1 interferon type 1 interferons type I Type I IFN type I IFNs underlie undetectable Vaccine Viral viral infections viral respiratory diseases while women
[DOI] 10.1126/science.abd4585 PMC 바로가기 [Article Type] Research Article