The impact of aging and COVID-19 on our immune system: a high-resolution map from single cell analysisHighlight Published on 2020-09-072022-10-29 Journal: Protein & Cell [Category] Coronavirus, MERS, SARS, [키워드] Analysis COVID-19 High-resolution immune Single Cell [DOI] 10.1007/s13238-020-00782-y PMC 바로가기 [Article Type] Highlight
Analysis of type I IFN response and T cell activation in severe COVID-19/HIV-1 coinfection A case report4850 Published on 2020-09-042022-10-30 Journal: Medicine [Category] COVID-19, SARS, [키워드] acute respiratory syndrome calculated Case report caused CD38 CD4 CD8 T cell Computed tomography coronavirus Coronavirus-2 COVID-19 described diagnosed enrolled expressing female female patient Fever FIVE flow cytometry Frequency greater Ground-glass opacities healthy individual healthy individuals High-resolution HLA-DR Human immunodeficiency virus human immunodeficiency virus-1 hydroxychloroquine therapy IFN IFN α immune dysregulation immunological individual infected with SARS-CoV-2 interferon leukocyte median mRNA level outcome oxygen Patient patient reported patients PCR assay performed positive Protease inhibitor protease inhibitors regimen respiratory rate reversed SARS-COV-2 infection severe acute respiratory syndrome coronavirus-2 severe pneumonia T cell activation T cell response Treatment Type I IFN uninfected women [DOI] 10.1097/MD.0000000000021803 PMC 바로가기 [Article Type] 4850
Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexesResearch Papers Published on 2020-09-012022-10-29 Journal: IUCrJ [Category] COVID-19, [키워드] ADP-ribose ADP-ribose phosphatase domain ADP-ribosylation adRP antiviral therapeutics apo form appear build complexes conformational change conserved coronavirus COVID-19 crystal structure domain ENCODE enzyme FIVE High-resolution homologue Host immune response hydrolysis interfere Ligand Mac1 macrodomain MES molecular target nonstructural protein Nsp3 phosphatase Protein Research respiratory RNA SARS-CoV-2 shown undergo viruses [DOI] 10.1107/S2052252520009653 PMC 바로가기 [Article Type] Research Papers
Artificial Intelligence-Assisted Loop Mediated Isothermal Amplification (AI-LAMP) for Rapid Detection of SARS-CoV-2Article Published on 2020-09-012022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acquisition Algorithm analytical sensitivity artificial artificial intelligence automated clinically coronavirus disease de novo detect detection Diagnosis diagnostic effective ENhance gold standard High-resolution implementation include Interpretation isothermal amplification LAMP lockdown loop Mediated NHS operator Patient platform point of care processed qRT-PCR Rapid reduce RNA-dependent RNA polymerase robust SARS-CoV-2 shown significantly more specificity tested this system Vaccine [DOI] 10.3390/v12090972 PMC 바로가기 [Article Type] Article
Progress in Developing Inhibitors of SARS-CoV-2 3C-Like ProteaseReview Published on 2020-08-182022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] 3CL pro acute respiratory syndrome adopted Antiviral antivirals applied caused cleavage cleaving coronavirus Coronavirus disease 2019 COVID-19 Developing drug design Drug discovery drug target ENCODE enzyme feasibility functional Genome Health High-resolution Infection inhibitor inhibitors M pro nonstructural proteins pandemic polyprotein Prevent processed Progress protease Protease inhibitor Proteases Protein protein structures Proteins SARS-CoV-2 Spread structures therapeutic option Vaccine viral genome viral outbreak Viral protein viral replication virus World Health Organization [DOI] 10.3390/microorganisms8081250 PMC 바로가기 [Article Type] Review
The “pandemic” increase in lung ultrasound use in response to Covid-19: can we complement computed tomography findings? A narrative reviewReview Published on 2020-08-172022-10-29 Journal: The Ultrasound Journal [Category] COVID-19, [키워드] acute respiratory syndrome affected caused chest HRCT complement Computed tomography coronavirus COVID-19 critical care patient Diagnosis disease emergency condition Evidence feature global pandemic Healthcare system High-resolution HRCT increase in Infectious disease intensive care less lung lung disorders management Multidetector computed tomography Patient Pneumonia point-of-care pulmonary conditions pulmonary involvement quantification Respiratory distress syndrome, adult SARS-CoV-2 Severe acute respiratory syndrome severity spread to Thorax Ultrasonography while [DOI] 10.1186/s13089-020-00185-4 PMC 바로가기 [Article Type] Review
Overwhelming COVID-19 Sepsis in a Patient With Idiopathic Pulmonary FibrosisInternal Medicine Published on 2020-07-212022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 24 hours acute respiratory syndrome Admission advanced age antifibrotic medication arterial blood attack Blood caused Computed tomography Confusion coronavirus COVID-19 Definitive Diagnosis died disease Dyspnea exacerbated Fever ground-glass opacity had no headache high risk High-resolution highlight HRCT idiopathic Idiopathic pulmonary fibrosis Infection Initially IPF Lungs Lymphocyte count Mild nasal organ pandemic pathogen Patient Pharyngeal swab Platelet Pneumonia presenting pulmonary pulmonary fibrosis RT-PCR SARS-CoV-2 SARS-COV-2 infection Sepsis Septic shock severe sepsis specimens Symptom thought Treatment White blood cell [DOI] 10.7759/cureus.9320 PMC 바로가기 [Article Type] Internal Medicine
From the index case to global spread: the global mobility based modelling of the COVID-19 pandemic implies higher infection rate and lower detection ratio than current estimatesEpidemiology Published on 2020-07-102022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] 95% confidence interval addition Analytic parametrization Asymptomatic basic reproduction number characteristic Compliance Concordance conducted confirmation country COVID-19 cases COVID-19 pandemic COVID19 diagnosed Diagnosis effective effort epidemiological estimate FIVE Global COVID19 model help High-resolution index case infection rate Mild symptom Mobility mortality rate New York non-infectious number of infected outbreak outbreak modelling outcome overcome pandemic pandemic modelling parameter parameters pregnant women presenting presymptomatic Prevalence Probability random Research Result SARS-CoV-2 screening test selected severe symptom severe symptoms Spread the disease Transmissibility Transmission model Travel virus Wuhan, China [DOI] 10.7717/peerj.9548 PMC 바로가기 [Article Type] Epidemiology
Revealing COVID-19 transmission in Australia by SARS-CoV-2 genome sequencing and agent-based modeling Research Published on 2020-07-092022-10-05 Journal: Nature Medicine [Category] SARS, 치료기술, [키워드] acute respiratory syndrome added arising attribute city Cluster Contact coronavirus coronavirus disease COVID-19 COVID-19 case COVID-19 transmission disease epidemiological link etiological agent family Coronaviridae generate Genome sequencing genomic genomic data High-resolution independent individual infected patient Infection lifted novel Betacoronavirus pneumonia case proportion representing SARS-CoV-2 SARS-CoV-2 genome sequencing SARS-COV-2 infection sequenced Sequencing significantly source of infection Spread subpopulation Surveillance the disease Transmission Travel worldwide pandemic Wuhan [DOI] 10.1038/s41591-020-1000-7 [Article Type] Research
High Contagiousness and Rapid Spread of Severe Acute Respiratory Syndrome Coronavirus 2중증급성호흡기증후군 코로나바이러스 2의 높은 전염성과 빠른 확산Research Published on 2020-07-012022-09-06 Journal: Emerging Infectious Diseases [Category] Communicable Disease, COVID-19, SARS, [키워드] 2019 novel coronavirus disease 95% CI Active surveillance acute respiratory syndrome acute respiratory syndrome coronavirus approach basic reproductive number calculated Case report causative agent China collected Contact tracing coronavirus coronavirus 2 coronavirus disease COVID-19 doubling effort estimate High-resolution Incubation period Infection mathematical median modeling number of infected outbreak pandemic parameters quarantine Rapid respiratory respiratory infections Result SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 social distancing suggested the epidemic Transmission transmission potential Travel virus viruses Wuhan Wuhan, China zoonoses [DOI] 10.3201/eid2607.200282 PMC 바로가기 [Article Type] Research