inhibitory – Page 15 – Communicable Diseases Research

The Repurposed Drugs Suramin and Quinacrine Cooperatively Inhibit SARS-CoV-2 3CL pro In Vitro

Article

Published on 2021-05-102022-10-28
Journal: Viruses [Category] COVID-19, SARS,

Analysis of natural compounds against the activity of SARS-CoV-2 NSP15 protein towards an effective treatment against COVID-19: a theoretical and computational biology approach

COVID-19에 대한 효과적인 치료를 위한 SARS-CoV-2 NSP15 단백질의 활성에 대한 천연 화합물 분석: 이론 및 컴퓨터 생물학 접근

Article

Published on 2021-05-082022-09-11
Journal: Journal of molecular modeling [Category] SARS, 치료제,

COVID-19 patients often show high-titer non-platelet-activating anti-PF4/heparin IgG antibodies

COVID-19 환자는 종종 고역가의 비혈소판 활성화 항 PF4/헤파린 IgG 항체를 나타냅니다.

Article

Published on 2021-05-012022-09-11
Journal: Journal of thrombosis and haemostasis : JTH [Category] MERS, SARS, 진단, 치료기술,

[키워드] activating Adverse reaction antibodies antibody Anticoagulants Antigen antigen tests caused clinically clinically suspected confirmation cornerstone COVID-19 COVID-19 patient COVID-19 patients COVID-19 sera Critically ill critically ill COVID-19 patients fraction functional functional test functional tests heparin heparin-induced thrombocytopenia HIPA IgG IgG antibody inhibit inhibitory investigated marker monoclonal antibody nine overdiagnosis overtreatment Platelet platelet activation platelet factor 4 Platelets positive purified reactivity remained sera serum serum/plasma tested thrombocytopenia thrombosis Treatment unlikely
[DOI] 10.1111/jth.15262 PMC 바로가기 [Article Type] Article

Olive-Derived Triterpenes Suppress SARS COV-2 Main Protease: A Promising Scaffold for Future Therapeutics

올리브에서 추출한 트리테르펜은 SARS COV-2 주요 프로테아제를 억제합니다: 미래 치료제를 위한 유망한 스캐폴드

Communication

Published on 2021-05-012022-09-10
Journal: Molecules [Category] SARS, 변종, 치료제,

Computational Identification of Potential Anti-Inflammatory Natural Compounds Targeting the p38 Mitogen-Activated Protein Kinase (MAPK): Implications for COVID-19-Induced Cytokine Storm

Article

Published on 2021-04-292022-10-28
Journal: Biomolecules [Category] COVID-19, MERS,

[키워드] Activation aggregation Anti-inflammatory anti-inflammatory activity anti-inflammatory compounds Antiviral AUC AutoDock binding energy characteristic China Compound Concentration coronavirus coronavirus disease COVID-19 Critical Cytokine storm elevated elicit exhibit exhibited greater identification identify immunosuppressive in vitro Inflammation inhibitor inhibitors inhibitory kinase kinase inhibitors MAPK mitigate molecular molecular docking Molecular dynamics simulation natural natural products p38 MAPK Patient PDB ID pharmacological Platelet platelet activation Potential predicted pro-inflammatory cytokine pro-inflammatory cytokines profile receptor reported residue ROC screened storm targeting the cytokine storm therapeutic target Toxicity with COVID-19 X-ray
[DOI] 10.3390/biom11050653 PMC 바로가기 [Article Type] Article

SARS-CoV-2 infection activates a subset of intrinsic pathways to inhibit type I interferons in vitro and in vivo

SARS-CoV-2 감염은 시험관 내 및 생체 내에서 I형 인터페론을 억제하기 위해 고유 경로의 하위 집합을 활성화합니다

Research Paper

Published on 2021-04-282022-09-10
Journal: International Journal of Medical Sciences [Category] MERS, SARS, 유전자 메커니즘,

[키워드] activate Analysis antiviral response Cell circadian rhythm correlated epithelial evade Evidence expression facilitate ferrets Health Host host cell host cells IFNB1 IFNs immune immune evasion in vitro in vivo inhibit inhibitory inhibitory effect innate antiviral responses interferons intrinsic intrinsic pathway limit Longitudinal data mechanism NHBE pathway Pathways Pearson correlation performed peroxisome phosphatidylinositol Previous studies previous study SARS-CoV-2 SARS-COV-2 infection Signaling subset TNF signaling type I IFNs type I interferon type I interferons Viral viral infection virus
[DOI] 10.7150/ijms.56630 PMC 바로가기 [Article Type] Research Paper

NeutrobodyPlex—monitoring SARS‐CoV‐2 neutralizing immune responses using nanobodies

NeutrobodyPlex—나노바디를 사용하여 SARS-CoV-2 중화 면역 반응 모니터링

Article

Published on 2021-04-272022-09-12
Journal: EMBO Reports [Category] MERS, SARS, 진단,

Identification of tuna protein-derived peptides as potent SARS-CoV-2 inhibitors via molecular docking and molecular dynamic simulation

분자 도킹 및 분자 역학 시뮬레이션을 통한 강력한 SARS-CoV-2 억제제로서의 참치 단백질 유래 펩타이드 식별

Article

Published on 2021-04-162022-09-11
Journal: Food chemistry [Category] SARS, 치료제,

Extensive activation, tissue trafficking, turnover and functional impairment of NK cells in COVID-19 patients at disease onset associates with subsequent disease severity

Research Article

Published on 2021-04-162022-10-29
Journal: PLoS Pathogens [Category] COVID-19, MERS,

[키워드] activating Activation adaptive antibody production approaches Bone marrow cause CD56 CD69 Cell circulating circulation Clinical deterioration Cohort conserved expression contribute Course COVID-19 COVID-19 patient cytokine production cytotoxicity death decrease Defense disease onset Disease progression disease severity disease trajectory downstream dysregulation early phase evidence of expression Extensive flow cytometry functional future therapeutic HLA-DR hospital IFN-γ immune Impaired impairment Inflammatory information inhibitory inhibitory receptor initial investigated KIR lack margination mechanism NK cell NK cell response NK cells NKG2A occur Patient patients patients hospitalized peripheral tissues precursor proportion receptor recruitment regulate Regulation responses SARS-COV-2 infection Strategy subsequent subset T cell responses the disease tissue Treatment turn Vaccine vascular leakage virus virus replication viruses
[DOI] 10.1371/journal.ppat.1009448 PMC 바로가기 [Article Type] Research Article

The antigenic anatomy of SARS-CoV-2 receptor binding domain

SARS-CoV-2 수용체 결합 도메인의 항원 해부학

Article

Published on 2021-04-152022-09-12
Journal: Cell [Category] MERS, SARS, 진단,

[키워드] Abstract ACE2 blockers Anatomy animal models antibody antibody binding site antigenic bind binding binding domain binding mode complex coronavirus, SARS-CoV-2, anti-RBD antibody, receptor binding domain, antibody, immune responses, virus structure data-driven dissect Emergency use epitope example Fab glycosylated human antibody response Human monoclonal antibody identify immune protection inhibitory inhibitory antibody Interaction mAb mAbs Map mapped Microscopy MOST N-terminal domain neutralize Neutralizing neutralizing antibody NTD panel of antibody prophylactically PROTECT Protein RBD RBD binding receptor Receptor binding domain recognizing Recovered COVID-19 patients SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor structures the RBD unique Virus spike X-ray crystallography
[DOI] 10.1016/j.cell.2021.02.032 PMC 바로가기 [Article Type] Article