The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomesArticle Published on 2021-05-042022-10-31 Journal: Cell Discovery [Category] COVID-19, [키워드] acute respiratory syndrome autophagic flux autophagy binding caused cellular response clearance complex coronavirus coronavirus disease Degradation facilitate host cell indicated inhibit inhibited Innate immunity Interaction interfere lysosomal lysosome Lysosomes ORF3a pandemic pathway potential mechanism prevented Protein regulate SARS-CoV-2 SARS-CoV-2 protein screened Spread Viral protein virus viruses VPS39 [DOI] 10.1038/s41421-021-00268-z PMC 바로가기 [Article Type] Article
The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell functionSoftware Published on 2021-05-032022-10-27 Journal: BMC Bioinformatics [Category] COVID-19, [키워드] Activation approach approaches Biological functions clinical observations clinical trial co-morbidity COVID-19 COVID-19 pathogenesis curated Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence functional functions gene expression signature Host host cell host gene human host hypothese identify immunological Interaction interfere knowledge Knowledge graph modulated network network biology observation offer pathway potential mechanism Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software
The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell functionSoftware Published on 2021-05-032022-10-27 Journal: BMC Bioinformatics [Category] Coronavirus, COVID-19, Fulltext, SARS, [키워드] Activation approach approaches Biological functions clinical observations clinical trial co-morbidity COVID-19 COVID-19 pathogenesis curated Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence functional functions gene expression signature Host host cell host gene human host hypothese identify immunological Interaction interfere knowledge Knowledge graph modulated network network biology observation offer pathway potential mechanism Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software
The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell function코로나바이러스 네트워크 탐색기: SARS-CoV-2가 숙주 세포 기능에 미치는 영향에 대한 대규모 지식 그래프 마이닝Software Published on 2021-05-032022-09-10 Journal: BMC Bioinformatics [Category] 신약개발, 유전자 메커니즘, [키워드] Activation approach approaches Biological functions clinical observations clinical trial clinical trials co-morbidities co-morbidity coronavirus COVID-19 COVID-19 pathogenesis curated direction Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence exploration functional functions gene expression signature Host host cell host gene host genes human host hypothese identify immunological Interaction interfere knowledge Knowledge graph machine learning modulated morbidities network network biology observation offer pathway Pathways potential mechanism potential mechanisms Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Viral Viral proteins Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software
The Interference between SARS-CoV-2 and Tyrosine Kinase Receptor Signaling in Cancer암에서 SARS-CoV-2와 티로신 키나제 수용체 신호 전달 간의 간섭Review Published on 2021-05-022022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] accelerate activated addition approach Cancer cancer cell Cancer cells cell proliferation Characteristics clinically coronavirus correlation COVID-19 Critical diagnosed division downstream downstream signaling pathways drug Drug repurposing dysregulation dysregulations EGFR help identify infection rate information interact interfere Interference Invasion kinase management mechanism MERS metabolism pandemic pathogen Pathways Patient phenotypic produced receptor repurposing required Research research and development resource SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 Scientific community signaling pathway signaling pathways strongly related Structure therapeutic agent therapeutic agents Therapeutic compounds treat Treatment tyrosine tyrosine kinase tyrosine kinase receptor Viral viral infection Viral vector virus viruses [DOI] 10.3390/ijms22094830 PMC 바로가기 [Article Type] Review
Interferon antagonism by SARS-CoV-2: a functional study using reverse geneticsSARS-CoV-2에 의한 인터페론 길항작용: 역유전학을 이용한 기능적 연구Article Published on 2021-05-012022-09-11 Journal: The Lancet. Microbe [Category] Fulltext, SARS, 변종, 치료제, [키워드] Activation acute respiratory syndrome adaptive Amino acid amino acid substitution amino acid substitutions amino acids analysed Analysis antagonistic backbone Bildung Calu Calu-3 cell calu-3 cells camostat camostat mesilate Cell cell entry cell line cellular entry receptor changes COVID-19 cytokine domain ENCODE Epidemic evaluate evaluated expressed fitness Frame functional gene induction Genes Genetic genetic engineering genetics homologous homology host cell host cells interfere interferon interferon antagonism interferon treatment interferon-stimulated gene interferon-stimulated genes investigated IRF3 less luciferase Mutagenesis mutant MX1 nuclear translocation Open reading frame ORF6 phenotype phenotypic Protein Replication residue residues RT-PCR SARS-CoV SARS-CoV-2 SARS-CoV-2 protein sensitivity Severe acute respiratory syndrome strain Strains suppressed TMPRSS2 transcription factor transmission efficiency Treatment type I interferon Vero E6 Vero E6 cell VERO E6 cells virus wild-type [DOI] 10.1016/S2666-5247(21)00027-6 PMC 바로가기 [Article Type] Article
Single‐cell analyses reveal SARS‐CoV‐2 interference with intrinsic immune response in the human gutArticle Published on 2021-04-272022-10-31 Journal: Molecular Systems Biology [Category] COVID-19, MERS, SARS, [키워드] ACE2 activated Analysis Antiviral autocrine bystander cell Cell cell sequencing Chromatin, Epigenetics, Genomics & Functional Genomics contribute COVID‐19 curtail Enterocyte Evidence expression Gut highlight Host human intestinal epithelial cells identify immune response immunology infecting Infection innate immune response interfere interferon intestinal organoid Intestinal Organoids intrinsic intrinsic immune response lack Microbiology, Virology & Host Pathogen Interaction multiplex organ Pathogenesis pathology performed positive correlation produced RNA SARS‐CoV‐2 SARS‐CoV‐2‐infected SARS‐CoV‐2 single‐cell RNA sequencing subpopulation susceptibility transcriptomics triggered virus [DOI] 10.15252/msb.202110232 PMC 바로가기 [Article Type] Article
An analysis of inhibition of the severe acute respiratory syndrome coronavirus 2 RNA-dependent RNA polymerase by zinc ion: an in silico approachShort Communication Published on 2021-04-262022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] Abstract acute respiratory syndrome Analysis approach binding binding site bioinformatics caused coronavirus Coronavirus disease 2019 COVID-19 docking enzyme functional in silico inhibitor interfere material mechanism predicted RdRP Region reported residue residues RNA polymerase RNA-dependent RNA polymerase SARS-CoV SARS-CoV-2 Zinc [DOI] 10.2217/fvl-2020-0369 PMC 바로가기 [Article Type] Short Communication
Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza virusesArticle Published on 2021-04-222022-10-04 Journal: Scientific Reports [Category] SARS, 신종인플루엔자, 치료제, [키워드] ACE2 acute respiratory syndrome addition Analysis angiotensin-converting enzyme 2 Antimicrobials Antiviral agents binding block viral entry characterized clade Concentration coronavirus Cytopathic effect demonstrated Effect effective Efficacy H1N1 H5N1 in vitro Influenza virus influenza viruses inhibit inhibited inhibiting interfere isolates nanoparticle Nanoparticles opportunistic Infections Prevent Prophylactic receptor reduced SARS-CoV-2 SARS-CoV-2 spike protein scattering shown syncytium formation transmission electron microscopy viral infection virus wild-type [DOI] 10.1038/s41598-021-87254-3 PMC 바로가기 [Article Type] Article
Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?Cardiovascular System & Vascular Biology Published on 2021-04-212022-10-31 Journal: Clinical Science (London, England : 1979) [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 expression ACE2 receptor acute respiratory syndrome ADAM17 addressed angiotensin II type 1 receptor blocker angiotensin-converting enzyme inhibitor candesartan Clin coronavirus COVID-19 COVID-19 pandemic COVID-19 patients Culture entry receptor enzyme humans inhibitor interfere lung tissue pathophysiological pathway Pneumocytes Protective RAS RAS inhibitor receptor reduced SARS-CoV-2 SARS-CoV-2 spike protein up-regulated [DOI] 10.1042/CS20210182 PMC 바로가기 [Article Type] Cardiovascular System & Vascular Biology