interferon – Page 15 – Communicable Diseases Research

BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike protein

SARS-CoV-2의 BSL2 호환 치명적인 마우스 모델 및 Spike 단백질을 표적으로 하는 치료제 평가를 위한 우려 변종

Article

Published on 2022-07-282022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종,

Coordinated innate and T-cell immune responses in mild COVID-19 patients from household contacts of COVID-19 cases during the first pandemic wave

첫 번째 대유행 기간 동안 COVID-19 사례의 가정 접촉에서 경미한 COVID-19 환자의 조정된 타고난 및 T 세포 면역 반응

Article

Published on 2022-07-272022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, 치료법,

[키워드] absence Alpha anti-N antibodies anti-RBD antibody B-cell cell-mediated response Concordance Contact COVID-19 COVID-19 case COVID-19 cases Cycle threshold value cytokine detectable early immune response early immune responses ELISA enrolled evaluated Factor Follow-up greater high accuracy household household contact household contacts IFN-α IFN-γ IL-1ra IL-1β IL-9 immune responses immunofluorescence Immunopathogenesis indirect immunofluorescence individual innate response interferon interferon-alpha Interferon-alpha (IFN-α) Interferon-gamma Interferon-gamma (IFN-γ) release assay (IGRA) IP-10 MCP-1 membrane mild COVID-19 patient MIP-1β moderate Nasopharyngeal swab Neutralizing antibodies nucleocapsid pandemic peptide peptide pools plasma plasma samples positive positive swab Proteins RANTES RBD reported response returned RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 swab screened Seroconversion serological serological response significant negative correlation Spike protein stimulated subject Surveillance Swab Swab test swabs T-cell T-cell immune response T-cell Response T-cell specific virus Whole blood
[DOI] 10.3389/fimmu.2022.920227 PMC 바로가기 [Article Type] Article

A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions

액세서리 단백질이 결실된 생약독화 SARS-CoV-2 백신 후보

Article

Published on 2022-07-272022-09-11
Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제,

Transient and durable T cell reactivity after COVID-19

COVID-19 이후 일시적이고 지속적인 T 세포 반응성

Article

Published on 2022-07-262022-09-11
Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 진단, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analyzed Antigen antigens Cell convalescent patient Convalescent patients coronavirus correlated COVID-19 cytokine Cytokines determine Ex vivo followed by IL-12 IL-13 IL-17 IL-2 Infection interferon interferon-γ interleukin long-lasting Longevity median N-terminal nucleocapsid protein Patient peptide peptides Polarity Protein reactivity remained respiratory retrieved SARS-CoV-2 severe acute respiratory syndrome Coronavirus stimulated synchronous T cell T cell cytokines T cell memory T helper T helper cells Transient triggered whole blood sample
[DOI] 10.1073/pnas.2203659119 PMC 바로가기 [Article Type] Article

Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity

Research

Published on 2022-07-252022-10-05
Journal: Nature Immunology [Category] 변종,

SARS-CoV-2 Omicron Induces Enhanced Mucosal Interferon Response Compared to other Variants of Concern, Associated with Restricted Replication in Human Lung Tissues

SARS-CoV-2 오미크론은 인간 폐 조직의 제한된 복제와 관련하여 우려되는 다른 변이체에 비해 향상된 점막 인터페론 반응을 유도합니다

Article

Published on 2022-07-212022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 변종,

Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses

신종 바이러스에 대해 활성을 나타내는 광범위한 항바이러스제로서 타고난 면역 신호의 인핸서 식별

Article

Published on 2022-07-212022-09-11
Journal: Cell chemical biology [Category] COVID19(2023년), SARS, 치료제,

[키워드] active against acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity boost broad-spectrum antiviral broad-spectrum antivirals Compound coronavirus Defense dependent on Drug screening emerging viruses enhancer Factors Gilteritinib identifying Immunity immunomodulatory molecules immunostimulatory IMPROVE increasingly Infection Innate innate immune innate immune activation Innate immunity innate response interferon interferon regulatory factor interferon regulatory factors. IRF7 IRFs Kinase inhibitor kinase inhibitors library nuclear translocation outbreak Pandemics pathogenic virus pathogenic viruses Pathogens proof proof of concept Regulatory RNA viruses SARS-CoV-2 screened severe acute respiratory syndrome Coronavirus Signaling viral infection virus
[DOI] 10.1016/j.chembiol.2022.05.009 PMC 바로가기 [Article Type] Article

Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2

바이러스 E 단백질은 SARS-CoV-2의 BET 단백질 매개 진입 후 길항작용을 중화합니다

Article

Published on 2022-07-192022-09-11
Journal: Cell Reports [Category] COVID19(2023년), SARS, 치료제,

[키워드] ACE2 ACE2 expression acetylated acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral antiviral response BET BET inhibitors BET proteins bind BRD2 BRD3 BRD4 bromodomain Cell coronavirus COVID-19 CP: Microbiology Critical Depletion domain downregulate E protein enzyme exacerbate Factor histone histone mimetic inactivated inactivation Infection inhibitor inhibitors interferon interferon response mice Microbiology Mortality neutralization neutralize overexpressing Protein Replication SARS-CoV-2 SARS-COV-2 infection Support suppresse treated Treatment viral replication
[DOI] 10.1016/j.celrep.2022.111088 PMC 바로가기 [Article Type] Article

Platelet proteome reveals features of cell death, antiviral response and viral replication in covid-19

Research

Published on 2022-07-162022-10-05
Journal: Cell Death Discovery [Category] 치료기술,

Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M protein

SARS-CoV-2 유전자 ORF8, ORF10 및 M 단백질에 대한 세포 사멸 및 세포 인터페론 및 인터페론 자극 유전자 반응에 대한 칸나비디올의 효과

Article

Published on 2022-07-152022-09-11
Journal: Life sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,

[키워드] 2′-5′-oligoadenylate synthetase (OAS) family activating acute respiratory syndrome acute respiratory syndrome coronavirus anti-viral response Apoptosis cannabidiol cause Cell cellular Combination component control cell control cells coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 Effect expressing expression HEK293 cell HEK293 cells IFNγ immune responses Innate innate immune response innate immune system Innate immunity interferon interferon-stimulated gene interferons M protein marker membrane protein OAS OAS1 OAS2 OAS3 OASL ORF10 ORF8 Plasmid plasmids Prophylaxis Protein readiness respond response SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 genes severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the SARS-CoV-2 transfected cells transfected with treated Treatment vehicle viral gene viral genes viral infection
[DOI] 10.1016/j.lfs.2022.120624 PMC 바로가기 [Article Type] Article