Evaluation of minocycline combined with favipiravir therapy in coronavirus disease 2019 patients: A case-series study코로나바이러스 질환 2019 환자에서 파비피라비르 요법과 결합된 미노사이클린의 평가: 사례 시리즈 연구Article Published on 2022-01-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] SARS, 치료제, [키워드] acute respiratory syndrome adverse event anti-inflammatory activity antibacterial activity Antiviral Chain Reaction changes in chemokine combination therapy Control control group coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine cytokine and chemokine production Cytokines duration of fever duration of hospitalization Efficacy and safety Endpoint evaluated Favipiravir greater groups hospital Inflammatory cytokines interleukin interleukin-6 interleukin-8 Japan MIN Minocycline monotherapy Negative PCR no difference Patient PCR test polymerase chain polymerase chain reaction reduction reported Retrospective study SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe case severe cases significantly significantly shorter Support therapy Treatment treatment initiation [DOI] 10.1016/j.jiac.2021.09.016 PMC 바로가기 [Article Type] Article
Extracorporeal Blood Purification in Moderate and Severe COVID-19 Patients: A Prospective Cohort StudyClinical Trial Published on 2022-01-012022-10-05 Journal: Blood purification [Category] SARS, 임상, [키워드] acute respiratory distress Admission Analysis anticoagulation biochemical Blood Blood purification C-reactive protein characterized Coagulopathy Cohort Control coronavirus Coronavirus disease 2019 COVID-19 COVID-19 case COVID-19 patient Critical case Critically ill CRP cytokine cytopenias decrease develop disease distress EBP evaluated Extracorporeal ferritin fibrinogen haemofiltration heparin Hospitalization hyperinflammation IL-6 Inflammation Inflammatory inflammatory markers interleukin-6 Local longitudinal change mechanical ventilation Mild-to-moderate Mortality offer oXiris parameter Patient performed procalcitonin progressed Prospective recognizing reduction severe disease Severe patient Symptom syndrome systemic inflammatory marker systemic level therapeutic treated Treatment [DOI] 10.1159/000515627 PMC 바로가기 [Article Type] Clinical Trial
NSAIDs/nitazoxanide/azithromycin repurposed for COVID-19: potential mitigation of the cytokine storm interleukin-6 amplifier via immunomodulatory effectsNSAIDS/NITAZOXANIDE/AZITHROMYCIN COVID-19에 대한 용도 변경 : 면역 조절 효과를 통한 사이토 카인 폭풍 인터루킨 -6 앰프의 잠재적 완화Article Published on 2022-01-012022-08-31 Journal: Expert review of anti-infective therapy [Category] MERS, SARS, 신약개발, [키워드] Anti-inflammatory approach Area Aspirin Author Azithromycin benefit best Clinical studies clinical trials clinically Colchicine Combination Complication correlated COVID-19 COVID-19 complication COVID-19 complications COVID-19 pathogenesis COVID-19 patient COVID-19 patients Cytokines demonstrated Diclofenac double blind drug dysregulated dysrhythmia Effect expert Genetic ibuprofen IL-6 IL-6 amplifier Immunity immunological immunomodulatory effect immunomodulatory properties Inflammation Inflammatory response Inflammatory responses interferon interferon response interferons interleukin-6 low-dose management mediator mediators monocytic immunological dysrhythmia Mortality NF-kB nitazoxanide nitazoxanide. Non-steroidal anti-inflammatory drugs NSAIDS observational study Paracetamol positive Prevent randomized clinical trials researcher selected suggested survival the cytokine storm [DOI] 10.1080/14787210.2021.1939683 PMC 바로가기 [Article Type] Article
Osteopontin as a biomarker for COVID-19 severity and multisystem inflammatory syndrome in children: A pilot study어린이의 COVID-19 중증도 및 다기관 염증 증후군에 대한 바이오마커로서의 오스테오폰틴: 파일럿 연구Article Published on 2022-01-012022-09-11 Journal: Experimental Biology and Medicine [Category] SARS, 바이오마커, [키워드] age analyzed Asymptomatic Atlanta Biomarker blood sample C-reactive protein category center children Clinical data clinical utility conditions Control correlated COVID-19 COVID-19 severity diagnosis of COVID-19 disease control elevated ELISA kit erythrocyte sedimentation erythrocyte sedimentation rate evaluate ferritin Hospitalized Inflammation Inflammatory inflammatory condition Inflammatory marker inflammatory markers interleukin interleukin-6 lymphocyte marker MIS-C moderate Non-COVID-19 osteopontin Patient pediatrics pilot study plasma Platelet platelet counts Positive predictive value Predictive value prevention Research residual Retrospective analysis SARS-CoV-2 sedimentation rate severe COVID-19 severity significantly specificity symptomatic syndrome [DOI] 10.1177/15353702211046835 PMC 바로가기 [Article Type] Article
Beneficial effects of novel aureobasidium pullulans strains produced beta-1,3-1,6 glucans on interleukin-6 and D-dimer levels in COVID-19 patients; results of a randomized multiple-arm pilot clinical study새로운 아우레오바시디움 풀루란스 균주의 유익한 효과는 코로나19 환자의 인터루킨-6 및 D-이량체 수준에 대한 베타-1,3-1,6 글루칸을 생성했습니다. 무작위 다중군 파일럿 임상 연구 결과Randomized Controlled Trial Published on 2022-01-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 바이오마커, 임상, [키워드] adjunct Adjunct treatment Beta beta glucan Beta glucans Biomarker Biomarkers CD4 CD8 clinical study Coagulopathy Combination COVID-19 COVID-19 patients CRP cytokine Cytokine storm D-dimer D-dimer level D-dimer values decrease Effect ESR group groups IL-6 Immuno-modulation. increase in interleukin-6 LCR management Mortality NLR no difference Patient positive COVID-19 produced Randomized randomly divided recruited RT-PCR significantly Standard standard treatment steadily decreased strain subject syndrome T cell three group three groups Treatment Ventilation yeast [DOI] 10.1016/j.biopha.2021.112243 PMC 바로가기 [Article Type] Randomized Controlled Trial
Tocilizumab for coronavirus disease 2019 in pregnancy and lactation: a narrative review임신과 수유 중 코로나바이러스 질병 2019에 대한 토실리주맙: 서술적 검토Review Published on 2022-01-012022-09-12 Journal: Clinical microbiology and infection : the official [Category] SARS, 진단, [키워드] adverse outcome appear approval document available data Breastfeeding clinical trial Complete confounding variable coronavirus disease Corticosteroid COVID-19 Critical Critically ill downstream drug Effect effective European Medicines Agency excluded food General population Guidance help highest highlight immune system include Inclusion indications Inflammation innate immune response interleukin-6 Interpretation interrupt knowledge lactation limit limitation literature monoclonal antibody outcome Patient patients with COVID-19 Population Pregnancy pregnant Premature raise reduce mortality reducing Regulatory reported Research SARS-CoV-2 searched Seven shown spontaneous abortion Tocilizumab Transport with COVID-19 [DOI] 10.1016/j.cmi.2021.08.016 PMC 바로가기 [Article Type] Review
Pilot Study on the Impact of a Home-Based Exercise Program on Inflammatory Cytokines and Quality of Life in Men with Prostate Cancer Under Active SurveillanceArticle Published on 2022-01-012022-11-15 Journal: Cancer control : journal of the Moffitt Cancer Cen [Category] 바이오마커, [키워드] 6-minute walk test 6MWT 6MWT distance Active surveillance aerobic Alpha baseline Biomarker Biomarkers body mass index collected control group COVID-19 decrease emotional endothelial exercise Exercise intervention functional Future growth factor IL-12 IL-1α IL-5 IL-6 Impact increase in INF-γ Inflammatory biomarker Inflammatory cytokine interferon-γ interleukin-6 Intervention intervention group Isolation life marker men Necrosis parallel group physical Program Prostate Prostate cancer Quality Quality of life Randomized Significant significantly increased TNF-α translation tumor progression Vascular VEGF was used [DOI] 10.1177/10732748221130964 PMC 바로가기
Tocilizumab in COVID-19 pneumonia: Practical proposals based on a narrative review of randomised trialsCOVID-19 폐렴의 토실리주맙: 무작위 시험의 서술적 검토를 기반으로 한 실용적인 제안Review Published on 2022-01-012022-09-11 Journal: Reviews in Medical Virology [Category] MERS, SARS, 임상, 진단, [키워드] Administered Analysis anti-interleukin-6 benefit clinical trial coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia Critically ill Critically ill patient critically ill patients death effective Efficacy Endpoint Express heterogenous High flow nasal cannula incidence Inflammatory Initiating interleukin-6 intubation mechanical ventilation Mortality nasal nasal cannula Noninvasive ventilation on mechanical ventilation outcome Patient Pneumonia Population randomised randomised clinical trial Randomised trial recovery reduce REMAP-CAP Respiratory failure review subgroup analysis to define Tocilizumab tocilizumab administration tocilizumab) Treatment Trial trials [DOI] 10.1002/rmv.2239 PMC 바로가기 [Article Type] Review
Determinants of severity among hospitalised COVID-19 patients: Hospital-based case-control study, India, 2020Research Article Published on 2021-12-292022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] Admission age C-reactive protein case control study case-control study characterising Chronic kidney disease Clinical management Clinical Management Protocol conducted COVID-19 COVID-19 disease Critical death Degradation determinant early stage Factor finding help high risk hospital hospitalised identify India interleukin-6 lactate dehydrogenase Liver function Mortality nine NLR outcome parameter Patient pro-calcitonin Prothrombin time renal function reported serum electrolyte Serum ferritin severe COVID-19 severe COVID-19 disease severe disease severity [DOI] 10.1371/journal.pone.0261529 PMC 바로가기 [Article Type] Research Article
Demographic and Clinical Overview of Hospitalized COVID-19 Patients during the First 17 Months of the Pandemic in PolandArticle Published on 2021-12-262022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Admitted Patient age Analysis Anosmia baseline C-reactive protein changes in clinical Clinical characteristics Clinical course Clinical data Clinical outcome Cohort conducted COVID-19 COVID-19 patient database demographic demographics diarrhea died disease severity Dyspnea Epidemiology Fatality rate Fever Frequency Gastrointestinal symptom Gender help Hospitalized hospitalized patient Infection interleukin-6 Laboratory parameters later phase male mechanical ventilation men Month National nausea occur outcome Oxygenation pandemic pathogenicity Patient Poland presenting required SARS-CoV-2 SARS-CoV-2 variants significantly lower statistically Symptomatology symptoms of infection the disease vomiting women [DOI] 10.3390/jcm11010117 PMC 바로가기 [Article Type] Article