Intubated – Page 15 – Communicable Diseases Research

Anti-IL6 treatment of serious COVID-19 disease A monocentric retrospective experience

심각한 COVID-19 질병의 항IL6 치료 단일 중심적 후향적 경험

4900

Published on 2021-01-082022-09-12
Journal: Medicine [Category] 진단,

Predictors of Poor Outcomes for COVID-19-Associated Pneumonia in a Minority Population

Internal Medicine

Published on 2021-01-022022-10-31
Journal: Cureus [Category] COVID-19,

[키워드] Admission age C-reactive protein China city Clinical characteristics correlation COVID-19 COVID-19 diagnosis COVID-19 infection D-dimer D-dimer level demonstrated died etiology ferritin Healthcare provider high-risk population Hospital stay ICU increased mortality infected patients Inflammatory marker Intubated intubation Laboratory lactate dehydrogenase minority population New York City non-survivor Novel coronavirus objective outbreak outcome pandemic Patient Pneumonia Poor Population predict predictors procalcitonin proportion Result significant difference significantly higher statistically significant difference study population survivor Survivors the patient WHO World Health Organization Wuhan
[DOI] 10.7759/cureus.12431 PMC 바로가기 [Article Type] Internal Medicine

Observational study on off-label use of tocilizumab in patients with severe COVID-19

중증 COVID-19 환자에서 토실리주맙의 오프라벨 사용에 대한 관찰 연구

Observational Study

Published on 2021-01-012022-09-11
Journal: European Journal of Hospital Pharmacy [Category] 임상, 진단, 치료제,

[키워드] 95% CI age Alanine alanine aminotransferase aspartate Aspartate aminotransferase average respiratory rate baseline best binding C-reactive protein candidate carried caused clinical conditions clinical impact clinical medicine cohort study collected control group Course COVID-19 Critical Critical care CRP cytokine Cytokine storm cytolysis deaths diagnosed with COVID-19 Efficacy Fewer patient Fewer patients Follow-up France Gender greater decrease had more Hospital stay hyperinflammation IL-6 IL-6 receptor impairment Inclusion infected with COVID-19 Inflammatory inhibit initial interleukin interleukin 6 interleukin 6 (IL-6) Intubated laboratory parameter Laboratory parameters lack less Ligand limit lung damage mechanical ventilation Novel coronavirus Observational cohort study observational study off-label off-label use oxygen oxygen supplementation Oxygen therapy pandemic Paris Patient pharmaceutical preparations Potential treatment pulmonary impairment pulmonary medicine Randomised clinical trials required respiratory respiratory rate SARS-CoV-2 SARS-COV-2 infection severe COVID-19 significant decrease significant difference Spread symptoms of COVID-19 syndrome TCZ the cytokine storm the disease the patient therapy Tocilizumab treated treated patient treated patients two groups Virology
[DOI] 10.1136/ejhpharm-2020-002414 PMC 바로가기 [Article Type] Observational Study

Hemoperfusion with CytoSorb as Adjuvant Therapy in Critically Ill Patients with SARS-CoV2 Pneumonia

SARS-CoV2 폐렴이 있는 중환자에서 보조 요법으로 CytoSorb를 사용한 혈액관류

Observational Study

Published on 2021-01-012022-09-11
Journal: Blood purification [Category] SARS, 임상, 진단, 치료제,

[키워드] acute respiratory distress acute respiratory distress syndrome adjuvant adjuvant therapy Anticoagulant Antiviral approved ARDS Blood Blood purification C-reactive protein cartridge Case report Clinical course Clinical outcome conducted consecutive patient Continuous Positive Airway Pressure control patient control patients coronavirus coronavirus 2 coronavirus disease Course COVID COVID-19 COVID-19 patients Critical illness Critical illness cytokines Cytokines Cytosorb develop diagnosed died Effectiveness effector Evidence greater Hemoperfusion Hospital admission Hospitalized IL-10 IL-6 IL-8 Ill IMPROVE include Inflammation inflammatory state intensive care unit Intubated intubation limited sample size lymphocytopenia Measures mechanism medical emergency observational study oxygen oxygen supplementation pathogenic Patient patients Pneumonia positive airway pressure randomized clinical trial remained required respiratory respiratory distress Respiratory function respiratory specimens reverse transcription-PCR SARS-CoV2 scenario sequence severe acute respiratory distress syndrome Severe acute respiratory syndrome severe pneumonia Study design survived syndrome therapeutic therapeutic strategy therapy tissue injury TNF-α treated treated patient treated patients Treatment virus worsened
[DOI] 10.1159/000511725 PMC 바로가기 [Article Type] Observational Study

Compassionate use of tocilizumab in severe SARS-CoV2 pneumonia

중증 SARS-CoV2 폐렴에서 토실리주맙의 동정적 사용

Article

Published on 2021-01-012022-09-11
Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 신약개발, 진단,

[키워드] acute respiratory distress acute respiratory distress syndrome Administered administration age analyzed ARDS benefit C-reactive protein compassionate-use COVID-19 CRS cytokine Cytokine release syndrome D-dimer death dose drug Evolution Factor FiO2 high oxygen support High-sensitivity C-reactive protein Hospitalized hsCRP IL-6 intensive care interleukin-6 interleukin-6 receptor intravenous Intubated intubation Lymphocytes male Older age oxygen oxygen support Patient patients Pneumonia primary endpoint Prognostic factors receiving receptor antagonist required respiratory distress SARS-CoV-2 SARS-CoV-2 pneumonia SARS-CoV2 saturation severe disease severe SARS severe SARS-CoV-2 significantly syndrome TCZ Tocilizumab Treatment
[DOI] 10.1016/j.ijid.2020.10.045 PMC 바로가기 [Article Type] Article

Critically ill COVID-19 patients attended by anesthesiologists in northwestern Spain: a multicenter prospective observational study

Observational Study

Published on 2021-01-012022-10-04
Journal: Revista española de anestesiología y reanimació [Category] 임상,

[키워드] acute respiratory distress syndrome (ARDS) Admission Anesthesia anesthesiologist Anticoagulant Anticoagulants Antiviral antiviral medication Complication complications Corticoïdes Corticosteroid Corticosteroids Course COVID-19 COVID-19 patient Critically ill critically ill patients Deceased Decúbito prono discharged distress evaluated event Final Follow-up High dose hospital ICU Infection information intensive care Intubated mechanical ventilation median Mortality multicenter nine outcome outcomes Pacientes críticos pandemic Patient patients prone prone positioning proportion prospective observational study required SARS-CoV-2 Seven Síndrome de distrés respiratorio agudo (SDRA). Spain syndrome thrombosis Thrombotic events Tocilizumab Treatment was used
[DOI] 10.1016/j.redar.2020.08.004 PMC 바로가기 [Article Type] Observational Study

Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial

COVID-19 폐렴으로 입원한 환자의 임상 악화에 대한 Tocilizumab 대 표준 치료의 효과: 무작위 임상 시험

Randomized Controlled Trial

Published on 2021-01-012022-09-12
Journal: JAMA Internal Medicine [Category] 임상, 진단,

[키워드] 95% CI age benefit blinded C-reactive protein causes clinical Clinical Center control arm control group coronavirus disease COVID-19 criteria death defined died Disease progression Effect elevated EudraCT evaluate evaluate the effect experimental arm experimental group Fever fraction groups hospital Hospitalized inflammatory phenotype intensive care Intention-to-treat analyses interim analysis interquartile range intravenous tocilizumab Intubated Invasive mechanical ventilation Italy less majority male median Nasopharyngeal swab NCT04346355 Open-label outcome oxygen pandemic Patient patients hospitalized patients with COVID-19 placebo-controlled Pneumonia polymerase chain Prospective protocol radiologic imaging randomization Randomized randomized clinical trial randomized patient receive Retrospective study safety profile second dose shown Stage Standard standard care standard care group Standard of care Standard therapy supportive care the disease therapy Tocilizumab tocilizumab administration Trial Two patient with COVID-19 worsening
[DOI] 10.1001/jamainternmed.2020.6615 PMC 바로가기 [Article Type] Randomized Controlled Trial

Tocilizumab for the Treatment of COVID-19-Induced Cytokine Storm and Acute Respiratory Distress Syndrome: A Case Series From a Rural Level 1 Trauma Center in Western Pennsylvania

COVID-19 유발 사이토카인 폭풍 및 급성 호흡곤란 증후군 치료를 위한 토실리주맙: 서부 펜실베니아의 농촌 1급 외상 센터의 사례 시리즈

Case Reports

Published on 2021-01-012022-09-12
Journal: Journal of investigative medicine high impact case [Category] Coronavirus, 진단,

[키워드] acute respiratory distress acute respiratory syndrome antibody ARDS case sery caused center Clinical improvement coronavirus coronavirus disease Coronavirus-2 cough COVID-19 COVID-19 patient cytokine Cytokine storm dose female Fever hospital Hospitalized Hyperinflammatory syndrome hypoxia ICU ICU admission intensive care interleukin-6 interleukin-6 receptor intravenous Intubated intubation level 1 life-threatening nasal nausea outbreak Oxygen requirement patients treated patients with COVID-19 Pneumonia respiratory Sery Shortness of breath Spread storm supplemental oxygen syndrome therapeutic Tocilizumab transferred transitioned treated worsening Wuhan, China
[DOI] 10.1177/23247096211019557 PMC 바로가기 [Article Type] Case Reports

The Effect of Exogenous Surfactant on Moderate and Severe Stages of COVID-19 Induced ARDS: the Pilot Study of a Clinical Trial

Original Article

Published on 2021-01-012022-10-30
Journal: Iranian Journal of Pharmaceutical Research : IJPR [Category] COVID-19,

Comparison of the Efficacy and Safety of Atazanavir/Ritonavir Plus Hydroxychloroquine with Lopinavir/Ritonavir Plus Hydroxychloroquine in Patients with Moderate COVID-19, A Randomized, Double-blind Clinical Trial

Original Article

Published on 2021-01-012022-10-30
Journal: Iranian Journal of Pharmaceutical Research : IJPR [Category] COVID-19,