A Drug Repurposing Approach for Antimalarials Interfering with SARS-CoV-2 Spike Protein Receptor Binding Domain (RBD) and Human Angiotensin-Converting Enzyme 2 (ACE2)Article Published on 2021-09-232022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome antimalarial Antimalarial drugs artemisone bind binding binding affinity bio-layer interferometry Cell complex Compound coronavirus docking study drug Drug repurposing Human human Angiotensin-converting enzyme in silico in vitro indicated inhibit Interaction interaction pattern interfere Invasion Ligand molecular dynamics Molecular dynamics simulation predicted pyronaridine RBD RBD-ACE2 repurposing SARS-CoV-2 small molecule spike Spike protein stability the RBD the receptor-binding domain viral spike protein [DOI] 10.3390/ph14100954 PMC 바로가기 [Article Type] Article
COVID-19 Associated Mucormycosis: A Systematic Review from Diagnostic Challenges to ManagementReview Published on 2021-09-222022-11-01 Journal: Diseases [Category] COVID-19, [키워드] adopted Black fungus caused challenge Characteristics clinical manifestations Co-infection coronavirus disease COVID-19 COVID-19 associated Mucormycosis (CAM) COVID-19 patients curtail Diagnosis elevated Epidemic evaluate Evidence ferritin level Healthcare professional Healthcare system hyperglycemia Immunosuppression Invasion management Mucormycosis opportunistic Infections outbreak outcome pandemic recommendation recovered patients review severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) therapy Treatment worse prognosis [DOI] 10.3390/diseases9040065 PMC 바로가기 [Article Type] Review
Encephalopathy Due to COVID-19 With Great Response to GlucocorticoidsNeurology Published on 2021-09-092022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Anosmia cause caused Central nervous system CNS Complete Computerized tomography coronavirus disease corticoid covid 19 encephalitis COVID-19 COVID-19 cases COVID-19 symptom COVID-19 treatment described diagnosing discharged disorder Encephalitis encephalitis treatment FIVE glucocorticoid impairment Invasion manifestation Methylprednisolone mild respiratory Mild to moderate COVID-19 minor moderate neurological Neurological symptom occur pathology pathophysiology Patient proinflammatory pulse required response robust the cytokine storm therapy treated Treatment virus [DOI] 10.7759/cureus.17845 PMC 바로가기 [Article Type] Neurology
A New and Rare Presentation of Unilateral Recurrent Laryngeal Nerve Palsy in a COVID-19 Patient With No Recent History of Endotracheal IntubationInternal Medicine Published on 2021-09-032022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Abnormalities acute respiratory syndrome Admission affecting African American airway alveolar cell association Case report classical Computed tomography conducted coronavirus Coronavirus disease 2019 cough COVID 19 COVID-19 cranial diarrhea Dyspnea endotracheal fatigue Features fevers fiber history host immune system hypertension Hypothesis hypoxic respiratory failure ICU Infection Inflammatory response Injury intensive care Intratracheal intubation intravenous Intubated intubation Invasion laryngeal male mechanism nausea nerve neurologic New obstructive sleep apnea palsy paralysis pathophysiology Patient presentation presenting recent Recurrent Recurrent laryngeal nerve palsy resulting SARS-CoV-2 structures Symptom systemic inflammatory response syndrome the patient Type-2 diabetes mellitus Unilateral virus vocal cord dysfunction [DOI] 10.7759/cureus.17700 PMC 바로가기 [Article Type] Internal Medicine
Sterically confined rearrangements of SARS-CoV-2 Spike protein control cell invasionResearch Article Published on 2021-08-312022-10-31 Journal: eLife [Category] COVID-19, MERS, SARS, [키워드] absence acute respiratory syndrome Analysis Cell conformational conformational change conformations contagious control cell coronavirus COVID-19 Critical described endpoints energy landscapes fusion peptide glycan glycans glycosylation Host host cell induce Infection initial Invasion lack membrane membrane fusion pathogen post-translational modifications postfusion prefusion Protein provide regulate released remained reported reveal SARS-CoV-2 spike steric structural framework Structure the Spike transmembrane Transmission Vaccine viral genome viral particle virus was used while [DOI] 10.7554/eLife.70362 PMC 바로가기 [Article Type] Research Article
Mechanical activation of spike fosters SARS-CoV-2 viral infection스파이크의 기계적 활성화는 SARS-CoV-2 바이러스 감염을 촉진합니다Article Published on 2021-08-312022-09-11 Journal: Cell Research [Category] MERS, SARS, 변종, 진단, [키워드] accelerate ACE2 ACE2 binding Activation Anti-S1 antibody binding binding domain blocking antibody caused complex convalescent COVID-19 patient convalescent COVID-19 patients COVID-19 pandemic D614G Detachment domain faster force host cell host cell membrane Host receptors Invasion Mechanical Molecular biology mutant Neutralizing outbreak Prevent Receptor-binding domain recognize reduce Rotation S1 subunit S1/S2 S2 subunit SARS-CoV-2 SARS-CoV-2 viral infection SARS2 Spike protein structural biology tensile tensile force therapeutic strategy variant Viral viral entry [DOI] 10.1038/s41422-021-00558-x PMC 바로가기 [Article Type] Article
Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B.1.1.7 emergenceSARS-CoV-2 계보 B.1.1.7 출현의 시공간 침입 역학Article Published on 2021-08-202022-09-11 Journal: Science (New York, N.y.) [Category] Coronavirus, SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 asymmetric attack rates B.1.1.7 cause causes Chain Reaction consequence coronavirus dominant Effect epidemiological growth rate human behavior Immunity intrinsic Invasion investigated Lineage Lineage B.1.1.7 nonpharmaceutical intervention Nonpharmaceutical interventions pandemic polymerase chain polymerase chain reaction relative growth SARS-CoV-2 SARS-CoV-2 lineage severe acute respiratory syndrome Coronavirus Spread Transmissibility understanding variants variants of concern Variation virus genomes [DOI] 10.1126/science.abj0113 PMC 바로가기 [Article Type] Article
Structural Dissection of Viral Spike-Protein Binding of SARS-CoV-2 and SARS-CoV-1 to the Human Angiotensin-Converting Enzyme 2 (ACE2) as Cellular ReceptorArticle Published on 2021-08-182022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] ACE2 ACE2 protein ACE2 sequence acute respiratory syndrome amino acid residue Betacoronavirus binding Binding interface cellular receptor complexes COVID-19 Dissection evidenced experimental structure Host host cells Human human ACE2 implication in silico analysis Interaction Invasion K417 molecular interaction Mutagenesis N-terminal new coronavirus SARS-CoV-2 outbreak outcome R426 RBD Receptor-binding domain (RBD) reported residue SARS-CoV-1 SARS-CoV-2 Spread Support viral spike-protein [DOI] 10.3390/biomedicines9081038 PMC 바로가기 [Article Type] Article
Acceptability of COVID-19 Certificates: A Qualitative Study in Geneva, Switzerland, in 2020Public Health Published on 2021-08-172022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] acceptability activities acute respiratory syndrome age anti-SARS-CoV-2 serology coded conducted consequence Coronavirus-2 COVID-19 COVID-19 immunity COVID-19 vaccine debate Deleterious discrimination favor General population group identify Immunity immunity certificates implementation interview Invasion knowledge lockdown Major outcomes pandemic participant public health measure public health policy Qualitative qualitative study Re-infection reliability SARS-CoV-2 Serological testing social acceptability Switzerland took place transcript vaccination Vaccine [DOI] 10.3389/fpubh.2021.682365 PMC 바로가기 [Article Type] Public Health
Natural Bioactive Molecules as Potential Agents Against SARS-CoV-2Pharmacology Published on 2021-08-172022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 3CL pro ACE2 acting Against agent Antiviral agents antiviral drug Characteristics clinically coronavirus COVID-19 death develop Helicase host proteins human cells information Invasion mechanisms MERS-CoV molecule natural natural bioactive molecules Pandemics plants Potential public health RdRP reported resource SARS-CoV SARS-CoV-2 Stage target therapeutic agents therapeutic targets Till TMPRSS2 Treatment viral infection viral life cycle [DOI] 10.3389/fphar.2021.702472 PMC 바로가기 [Article Type] Pharmacology