Stable trimer formation of spike protein from porcine epidemic diarrhea virus improves the efficiency of secretory production in silkworms and induces neutralizing antibodies in miceResearch Article Published on 2021-07-072022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] cause contributing to coronavirus demonstrated diarrhea economic loss Efficiency elicit epidemic diarrhea evaluated expression expression vector Genetic high mortality rate homotrimer host cell Humoral immunity IgG immunization IMPROVE induce Infection intrinsically less mice motif mouse Neonatal neutralizing antibody pathogen PEDV platform Porcine epidemic diarrhea virus PROTECT protective effect Protein provide S protein S proteins sera serum Silkworm-baculovirus expression vector system Spike protein STABLE strain Subunit vaccine supplementary material the S protein trimer trimeric trimeric motif Vaccine Vaccine development Vero Cell viral membrane virus watery [DOI] 10.1186/s13567-021-00971-5 PMC 바로가기 [Article Type] Research Article
Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronavirusesResearch Article Published on 2021-07-022022-10-31 Journal: Computational and Structural Biotechnology Journal [Category] COVID-19, [키워드] Abstract antibody cross-reactivity bioinformatics Comparisons coronavirus coronavirus spike protein COVID-19 docking effort epitope example facilitate help highly pathogenic Host host protein Human human coronavirus human protein humans Infection Infectious disease Interaction interaction partner MERS-CoV motif motifs overlapping pathway Plasmodium falciparum Potential Protein Proteins receptor-binding motif returned SARS-CoV SARS-CoV-2 sequence homology shown Spike proteins structural bioinformatics the SARS-CoV-2 the spike protein Vaccine viral host mimicry virus [DOI] 10.1016/j.csbj.2021.06.041 PMC 바로가기 [Article Type] Research Article
Bioinformatics Analysis of Spike Proteins of Porcine Enteric CoronavirusesResearch Article Published on 2021-07-012022-10-27 Journal: BioMed Research International [Category] Coronavirus, [키워드] acute diarrhea Analysis analyzed antiviral drugs bioinformatics biological function coronavirus coronavirus spike protein Coronaviruses domain domains enteric epidemic diarrhea epitope Epitopes functional gastroenteritis glycosylation heptad repeat hydrophilicity hydrophobicity motif motifs PEDV Phosphorylation phosphorylation sites physical Porcine deltacoronavirus predicted profiles Protein S protein S2 subunit signal peptide spike syndrome TGEV transmembrane region virus [DOI] 10.1155/2021/6689471 PMC 바로가기 [Article Type] Research Article
Sequence and structural analysis of COVID-19 E and M proteins with MERS virus E and M proteins—A comparative studyResearch article Published on 2021-07-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 변종, [키워드] analyzed bat beta coronavirus Beta coronaviruses binding C-terminal domain catalytic caused conserved COVID-19 Critical demonstrated E protein envelope highlight humans Infection inhibitor Interaction lethal infection M protein MERS MERS virus motif occurred outbreak pandemic Phosphorylation Protein Proteins Region regions Research SARS virus sequence Sequence analysis sequence and structural analysis Serine serine proteases similarity Structural analysis the Spike Variation variations virus viruses [DOI] 10.1016/j.bbrep.2021.101023 [Article Type] Research article
The Antiviral Effect of the Chemical Compounds Targeting DED/EDh Motifs of the Viral Proteins on Lymphocytic Choriomeningitis Virus and SARS-CoV-2Article Published on 2021-06-242022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] A549 antivirals arenavirus arenaviruses cell lines Cell toxicity cells Chemical Choriomeningitis Compound compounds Concentration coronavirus Coronaviruses DED/EDh motif drug target Effect exhibited exonuclease exonuclease (ExoN) motif include indicated inhibited LCMV Lymphocytic choriomeningitis Lymphocytic choriomeningitis virus (LCMV) MERS-CoV motif motifs nsp14 pathogenic viruses performed SARS-CoV SARS-CoV-2 SARS-COV-2 infection Simulation study targeting these compound treat Vero Viral protein Viral proteins virus was used [DOI] 10.3390/v13071220 PMC 바로가기 [Article Type] Article
Targeting the Conserved Stem Loop 2 Motif in the SARS-CoV-2 GenomeSARS-CoV-2 게놈에서 보존된 줄기 루프 2 모티프 표적화Article Published on 2021-06-242022-09-12 Journal: Journal of Virology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome Antisense oligonucleotide Antisense oligonucleotides Antiviral Antiviral agents ASO assays astrovirus Cell culture cleavage conserved coronavirus Coronaviruses dose-dependent manner element gapmer Genome inhibit inhibit SARS-CoV-2 LNA loop motif noroviruses occur Occurrence oligonucleotides picornavirus plus-strand RNA virus Replication reporter Research RNA RNA viruses s2m SARS-CoV SARS-CoV-2 Sequence conservation single-stranded positive-sense STEM subgenomic transcript targeting the SARS-CoV-2 therapeutic therapeutic oligonucleotides. UTR variety viral infection [DOI] 10.1128/JVI.00663-21 PMC 바로가기 [Article Type] Article
The MERS-CoV N Protein Regulates Host Cytokinesis and Protein Translation via Interaction With EF1AMicrobiology Published on 2021-06-232022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Actin acute respiratory syndrome beta coronavirus C-terminal contribute coronavirus Coronavirus infections cytokinesis domain EF1A F-actin highlight Human immunoprecipitation in vitro inactive Interaction involved MERS-CoV MERS-CoV infection MERS-CoV N MERS-CoV-infected cells Middle East motif mRNA multiple nuclei nucleocapsid nucleocapsid protein pathogen Pathogenesis Protein protein translation provide reporter respiratory syndrome coronavirus SARS-CoV severe respiratory disease significantly the N protein translation Viral protein [DOI] 10.3389/fmicb.2021.551602 PMC 바로가기 [Article Type] Microbiology
Emergence and spread of a SARS-CoV-2 lineage A variant (A.23.1) with altered spike protein in Uganda우간다에서 스파이크 단백질이 변경된 SARS-CoV-2 계통 A 변이체(A.23.1)의 출현 및 확산Article Published on 2021-06-232022-09-10 Journal: Nature Microbiology [Category] MERS, SARS, 변종, 치료법, [키워드] A.23.1 addition African Amino acid amino acid change amino acid changes Analysis change changes in clinical impact consequence country COVID-19 vaccine East emergence furin furin cleavage site Genome genomes immunogenic Lineage motif N-terminal domain NSP6 ORF8 phylogenetic analyses position predominant Protein reported representing S protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 genomic surveillance SARS-CoV-2 infections SARS-CoV-2 lineage SARS-CoV-2 variant sequence Spike protein Spike proteins Spread the S protein the spike protein Uganda variant variants of concern viral infection VoC VOCs [DOI] 10.1038/s41564-021-00933-9 PMC 바로가기 [Article Type] Article
Deletion of ER-retention motif on SARS-CoV-2 spike protein reduces cell hybrid during cell–cell fusionResearch Published on 2021-06-232022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] 293T A549 ACE2 administration Affect angiotensin-converting enzyme 2 assays binding Cell Cell fusion Cell hybrid cell line cell membrane co-culture Combination combinations COVID-19 Deletion downstream Ebola Effect event expressed expressing expressing S protein expression vectors Formation global pandemic hACE2-expressing cell HIV host cell host cell receptor human ACE2 human cell line implication in vitro assays infecting Interaction investigated mechanism motif mRNA mRNA vaccine mutated nuclear occur parameters Protein reduce reported Result S protein SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 spike protein SARS-CoV-2 vaccine Spike protein Structure supplementary material Syncytia syncytia formation the S protein the SARS-CoV-2 virus tissue tissue damage transduced Vaccine variant virus wild-type [DOI] 10.1186/s13578-021-00626-0 PMC 바로가기 [Article Type] Research
T cell epitopes of SARS-CoV-2 spike protein and conserved surface protein of Plasmodium malariae share sequence homologyResearch Article Published on 2021-06-232022-10-28 Journal: Open Life Sciences [Category] COVID-19, [키워드] acute respiratory syndrome Amino acid Analysis approach B cell conserved coronavirus descendant epitope IEDB Immune Epitope Database immune response Immunity immunodominant epitope immunogenic profile information malaria MONITOR motif Pairwise comparison pathogen Phylogenetic analysis Phylogenetic relationship Plasmodium malariae proteome prototype replaced SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein sequence sequence homology Seven spike glycoprotein Spread surface protein T cell epitope the spike protein [DOI] 10.1515/biol-2021-0062 PMC 바로가기 [Article Type] Research Article